Product Information: Nanoparticle albumin
... Randomised comparative study A multicenter, randomized, open-label study was conducted in 1052 chemonaive patients with Stage IIIb/IV non-small cell lung cancer to compare ABRAXANE in combination with carboplatin versus solvent-based paclitaxel in combination with carboplatin as first-line treatment ...
... Randomised comparative study A multicenter, randomized, open-label study was conducted in 1052 chemonaive patients with Stage IIIb/IV non-small cell lung cancer to compare ABRAXANE in combination with carboplatin versus solvent-based paclitaxel in combination with carboplatin as first-line treatment ...
Product Monograph
... PHARMACOLOGY, Special Populations and Conditions - Pediatrics). Therefore, until further data are available, use of linezolid in this age group is not recommended Geriatrics: Of the 2046 patients treated with ZYVOXAM in phase III comparator-controlled clinical trials, 589 (29%) were 65 years or olde ...
... PHARMACOLOGY, Special Populations and Conditions - Pediatrics). Therefore, until further data are available, use of linezolid in this age group is not recommended Geriatrics: Of the 2046 patients treated with ZYVOXAM in phase III comparator-controlled clinical trials, 589 (29%) were 65 years or olde ...
Warfarin Management - Adult - Ambulatory Clinical Practice Guideline
... shown improved time in therapeutic INR range and clinical outcomes in patients managed by trained staff using standardized procedures and dosing decision support tools.2 Warfarin works by inhibiting the reduction of vitamin K epoxide and limiting the activation of vitamin K dependant clotting factor ...
... shown improved time in therapeutic INR range and clinical outcomes in patients managed by trained staff using standardized procedures and dosing decision support tools.2 Warfarin works by inhibiting the reduction of vitamin K epoxide and limiting the activation of vitamin K dependant clotting factor ...
Determination of Carbamazepine in Pharmaceutical
... pharmaceutical preparations. The most striking features of derivative spectrophotometric methods described here are their simplicity and rapidity, no requiring time-consuming sample preparation such as filtration, degassing that are need for HPLC procedure and also chromatographic methods need expen ...
... pharmaceutical preparations. The most striking features of derivative spectrophotometric methods described here are their simplicity and rapidity, no requiring time-consuming sample preparation such as filtration, degassing that are need for HPLC procedure and also chromatographic methods need expen ...
NEW ZEALAND DATA SHEET TOPIRAMATE ACTAVIS 15, 25, 50
... observed as early as one week after starting the anti-epileptic medicine and continued through 24 weeks. The results were generally consistent among the eleven medicines. As most trials included in the analysis did not extend beyond 24 weeks, the risk of suicidal thoughts or behaviour beyond 24 wee ...
... observed as early as one week after starting the anti-epileptic medicine and continued through 24 weeks. The results were generally consistent among the eleven medicines. As most trials included in the analysis did not extend beyond 24 weeks, the risk of suicidal thoughts or behaviour beyond 24 wee ...
Product Monograph
... Pharmacokinetic studies of ADDERALL XR (mixed salts amphetamine extended-release capsules) have been conducted in healthy adult and pediatric (aged 6-12 years) subjects, and adolescent (aged 13-17 years) and pediatric patients with ADHD. ADDERALL XR capsules contain dextroamphetamine (d-amphetamine) ...
... Pharmacokinetic studies of ADDERALL XR (mixed salts amphetamine extended-release capsules) have been conducted in healthy adult and pediatric (aged 6-12 years) subjects, and adolescent (aged 13-17 years) and pediatric patients with ADHD. ADDERALL XR capsules contain dextroamphetamine (d-amphetamine) ...
What’s special about methadone?
... body to a toxic level if it is taken too often, if the amount taken is too high, or if it is taken with certain other medicines or supplements. Methadone has specific toxic effects on the heart (QT prolongation and Torsades de Pointes). Physicians prescribing methadone should be familiar with methad ...
... body to a toxic level if it is taken too often, if the amount taken is too high, or if it is taken with certain other medicines or supplements. Methadone has specific toxic effects on the heart (QT prolongation and Torsades de Pointes). Physicians prescribing methadone should be familiar with methad ...
Chemotherapy-induced lung disease
... risky, although the hazard may extend for month or years beyond this period. High-inspired oxygen concentrations should be avoided whenever possible. In addition, there seems to be synergistic toxicity between bleomycin and concomitant administration of cyclophosphamide. Bleomycin pulmonary toxicity ...
... risky, although the hazard may extend for month or years beyond this period. High-inspired oxygen concentrations should be avoided whenever possible. In addition, there seems to be synergistic toxicity between bleomycin and concomitant administration of cyclophosphamide. Bleomycin pulmonary toxicity ...
... The drug and internal standard were extracted from plasma with heptan : isoamyl alcohol (95:5) and re-extracted with 200 µL of orthophosphoric acid (0.3% v/v). The organic layer was discharged and analysis was performed on C8 reverse phase ODS2 HPLC column with a mobile phase, acetonitrile : water ( ...
Quality Control, Screening, Toxicity, and Regulation of Herbal Drugs 2
... Are there rigorous trials to show that herbal treatments work? With many of these herbal medicines we do not fully understand how they work. Nor do we always know which component is pharmacologically active. Even though herbal remedies may be effective, do their benefits outweigh their risks? In som ...
... Are there rigorous trials to show that herbal treatments work? With many of these herbal medicines we do not fully understand how they work. Nor do we always know which component is pharmacologically active. Even though herbal remedies may be effective, do their benefits outweigh their risks? In som ...
How to Treat COPD: Choosing the Right Device for Maintenance
... • George smoked a pack of cigarettes a day for 50 years, but quit at diagnosis of COPD. He has osteoarthritis, particularly in the hands, and also suffers from type 2 diabetes mellitus (DM). He has had several transient ischemic strokes over the last few years. • Medications: – LABA using a dry powd ...
... • George smoked a pack of cigarettes a day for 50 years, but quit at diagnosis of COPD. He has osteoarthritis, particularly in the hands, and also suffers from type 2 diabetes mellitus (DM). He has had several transient ischemic strokes over the last few years. • Medications: – LABA using a dry powd ...
ISOPTIN Ò SR 240mg
... course, different. In a randomised, single dose, crossover study using healthy volunteers, administration of 240mg Isoptin SR with food produced peak plasma verapamil concentrations of 63ng/mL, time to peak plasma verapamil concentration of about 12 hours, and AUC (0-) of 1,300ng-hr/mL. When Isopti ...
... course, different. In a randomised, single dose, crossover study using healthy volunteers, administration of 240mg Isoptin SR with food produced peak plasma verapamil concentrations of 63ng/mL, time to peak plasma verapamil concentration of about 12 hours, and AUC (0-) of 1,300ng-hr/mL. When Isopti ...
Vedani Nicola
... Mortality: The results of the Cardiac Arrhythmia Suppression Trial (CAST) in post-myocardial infarction patients with asymptomatic ventricular arrhythmias showed a significant increase in mortality and in non-fatal cardiac arrest rate in patients treated with encainide or flecainide compared with a ...
... Mortality: The results of the Cardiac Arrhythmia Suppression Trial (CAST) in post-myocardial infarction patients with asymptomatic ventricular arrhythmias showed a significant increase in mortality and in non-fatal cardiac arrest rate in patients treated with encainide or flecainide compared with a ...
tolerabiijty of multiple administration of intramuscular meloxicam
... serious adverse events were reported in either group. The overall safety profile was similar to that previously observed with this class of drug and consisted mainly of GI events (gastric pain, nausea and diarrhoea), skin reactions (pruritus and rash), and central or peripheral nervous system side-e ...
... serious adverse events were reported in either group. The overall safety profile was similar to that previously observed with this class of drug and consisted mainly of GI events (gastric pain, nausea and diarrhoea), skin reactions (pruritus and rash), and central or peripheral nervous system side-e ...
full document
... thesis. It is therefore rather questions concerning patient safety, which are currently inhibiting a wider clinical acceptance. In fact, several clinical studies, including [Absalom and Kenny, 2003] and [Haddad et al., 2011], report poor robustness, manifested as oscillatory response of the control ...
... thesis. It is therefore rather questions concerning patient safety, which are currently inhibiting a wider clinical acceptance. In fact, several clinical studies, including [Absalom and Kenny, 2003] and [Haddad et al., 2011], report poor robustness, manifested as oscillatory response of the control ...
Opioid Substitution Therapy toolkits: Advocacy for a scaled
... • OST in HIV settings is primarily to prevent HIV and improve ART adherence; often benefits go beyond HIV related issues • The identified gaps in OST in Asia can be effectively addressed in future through scaled-up efforts (in community & custodial settings) and multi-sectoral collaboration • The re ...
... • OST in HIV settings is primarily to prevent HIV and improve ART adherence; often benefits go beyond HIV related issues • The identified gaps in OST in Asia can be effectively addressed in future through scaled-up efforts (in community & custodial settings) and multi-sectoral collaboration • The re ...
Eco-directed sustainable prescribing
... jeopardizing the quality of delivered health care if prescribing guidelines are altered. Long-deemed infeasible has been the optimization of the therapeutic use of medications for preventing pollution at its source. This stance, however, has been shown to be unfounded in at least one instance, where ...
... jeopardizing the quality of delivered health care if prescribing guidelines are altered. Long-deemed infeasible has been the optimization of the therapeutic use of medications for preventing pollution at its source. This stance, however, has been shown to be unfounded in at least one instance, where ...
The Benzo Manual
... depressive illness before they were prescribed benzodiazepines. The depression lifted in these patients after benzodiazepine withdrawal and none took further overdoses during the 10 months to 3.5 years follow-up period after withdrawal. In 1988 the Committee on Safety of Medicines in the UK recommen ...
... depressive illness before they were prescribed benzodiazepines. The depression lifted in these patients after benzodiazepine withdrawal and none took further overdoses during the 10 months to 3.5 years follow-up period after withdrawal. In 1988 the Committee on Safety of Medicines in the UK recommen ...
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... mutations in the genome of the bacteria associated with resistance against individual drugs can be used. Table 1 provides the definitions of MDR-TB and XDR-TB, based on the results of bacteriological methods [18]. Recently, WHO has revised the case definitions of TB and drug-resistant TB so that als ...
... mutations in the genome of the bacteria associated with resistance against individual drugs can be used. Table 1 provides the definitions of MDR-TB and XDR-TB, based on the results of bacteriological methods [18]. Recently, WHO has revised the case definitions of TB and drug-resistant TB so that als ...
Document
... and low nonspecific toxicity to normal cells. Unfortunately, the clinical realization of its potential is limited due to its extremely low aqueous solubility (11ng/ml), instability at physiological pH associated with low systemic bioavailability after oral administration (8g/kg). An intriguing appro ...
... and low nonspecific toxicity to normal cells. Unfortunately, the clinical realization of its potential is limited due to its extremely low aqueous solubility (11ng/ml), instability at physiological pH associated with low systemic bioavailability after oral administration (8g/kg). An intriguing appro ...
DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR ASSAY AND DISSOLUTION... METOPROLOL SUCCINATE EXTENDED RELEASE TABLETS
... profiling of metoprolol in different dissolution media. This paper presents simple, accurate and reproducible an RP-HPLC method for determination of metoprolol in tablet dosage form in different dissolution media. The reported method is helpful in determination of metoprolol during dissolution study ...
... profiling of metoprolol in different dissolution media. This paper presents simple, accurate and reproducible an RP-HPLC method for determination of metoprolol in tablet dosage form in different dissolution media. The reported method is helpful in determination of metoprolol during dissolution study ...
Management of obesity: improvement of health-care training
... that break down traditional professional silos. Such recommendations are directly relevant to health professional education in obesity. The challenge has been in implementation of these recommendations. A scarcity of information exists for undergraduate medical education in obesity, and even less in ...
... that break down traditional professional silos. Such recommendations are directly relevant to health professional education in obesity. The challenge has been in implementation of these recommendations. A scarcity of information exists for undergraduate medical education in obesity, and even less in ...
UTILITY OF BROMOSUCCINIMIDE AS AN ENVIRONMENTAL-FRIENDLY REAGENT FOR SENSITIVE Innovare
... Procedure for pharmaceutical formulations (tablets) The contents of twenty aripiprex tablets (10 mg aripiprazole per tablet) were weighed accurately and ground into a fine powder. An accurate weight equivalent to 10 mg aripiprazole was dissolved in 20 mL of 0.2 M HCl with shaking for 5.0 min and fil ...
... Procedure for pharmaceutical formulations (tablets) The contents of twenty aripiprex tablets (10 mg aripiprazole per tablet) were weighed accurately and ground into a fine powder. An accurate weight equivalent to 10 mg aripiprazole was dissolved in 20 mL of 0.2 M HCl with shaking for 5.0 min and fil ...
Bad Pharma
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Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.