Hypericum for Depression
... fetal development. In 1998, there were reports on 2 women who took hypericum in their pregnancies to avoid the use of conventional synthetic medications. Both cases seemed to reveal no concerns. One of these cases was of a 38-year-old woman who started hypericum at 24 weeks gestation. The pregnancy ...
... fetal development. In 1998, there were reports on 2 women who took hypericum in their pregnancies to avoid the use of conventional synthetic medications. Both cases seemed to reveal no concerns. One of these cases was of a 38-year-old woman who started hypericum at 24 weeks gestation. The pregnancy ...
Dissolution Stability of Cephalexin Extemporaneous Suspensions
... as Dissolution Stability (19). This concept is a critical biopharmaceutical parameter because of the potential impact it may have on the bioavailability of the product. Therefore, it is essential that the dissolution characteristics of a pharmaceutical formulation, whether tablet, capsule, or even s ...
... as Dissolution Stability (19). This concept is a critical biopharmaceutical parameter because of the potential impact it may have on the bioavailability of the product. Therefore, it is essential that the dissolution characteristics of a pharmaceutical formulation, whether tablet, capsule, or even s ...
How Effective Is Algorithm-Guided Treatment for Depressed
... of >8 or >30% without achieving remission), a 2-week prolongation of the current treatment step was allowed (only once per step). Nonresponse was defined as not meeting remission or partial response criteria. These patients moved to the next treatment step. CDES used individual patients’ information ...
... of >8 or >30% without achieving remission), a 2-week prolongation of the current treatment step was allowed (only once per step). Nonresponse was defined as not meeting remission or partial response criteria. These patients moved to the next treatment step. CDES used individual patients’ information ...
prescribing information - Purdue Pharma (Canada)
... and death. Therefore, DILAUDID should be prescribed and handled with caution. This risk is increased if DILAUDID is taken with alcohol or other CNS depressants. Patients should be assessed for their clinical risks for opioid abuse or addiction prior to being prescribed opioids. All patients receivin ...
... and death. Therefore, DILAUDID should be prescribed and handled with caution. This risk is increased if DILAUDID is taken with alcohol or other CNS depressants. Patients should be assessed for their clinical risks for opioid abuse or addiction prior to being prescribed opioids. All patients receivin ...
The treatment of cyanide poisoning
... and, therefore, relatively safe for administration when unsure of cyanide intoxication. A change in formulation had overcome the difficulty of getting it into solution, but cost remained high at $600 per dose. [It should be recorded that cost should not be considered a hindrance given the rarity of ...
... and, therefore, relatively safe for administration when unsure of cyanide intoxication. A change in formulation had overcome the difficulty of getting it into solution, but cost remained high at $600 per dose. [It should be recorded that cost should not be considered a hindrance given the rarity of ...
Comparative pharmacognosy of Pashanbhed
... coronary vasodilatory effects accompanied by gradual decrease in heart rate.[27,28] Saponins are also known to have several physiologic activities, depending on their chemical structures, such as hemolytic properties, alteration of membrane permeability, particularly the modulation of renal sodium e ...
... coronary vasodilatory effects accompanied by gradual decrease in heart rate.[27,28] Saponins are also known to have several physiologic activities, depending on their chemical structures, such as hemolytic properties, alteration of membrane permeability, particularly the modulation of renal sodium e ...
summation of decisions concerning marketing of prescription
... Novartis Finland Oy did not comply with an agreement between the parties about not using certain clinical study for marketing purposes before it was properly published. Because the marketing letter to doctors had been mailed after the research was published as an article, the agreement had not been ...
... Novartis Finland Oy did not comply with an agreement between the parties about not using certain clinical study for marketing purposes before it was properly published. Because the marketing letter to doctors had been mailed after the research was published as an article, the agreement had not been ...
Pharmacology - Jhalawar Medical College
... Teaching summary of Opioid analgesics (class to be held on 12/09/2015) Classification, pharmacokinetics and pharmacodynamic property of each drugs, uses, ADRs, drug interactions, various Opioid receptors, Opioid agonist and antagonists, current status, endogenous Opioid peptide ...
... Teaching summary of Opioid analgesics (class to be held on 12/09/2015) Classification, pharmacokinetics and pharmacodynamic property of each drugs, uses, ADRs, drug interactions, various Opioid receptors, Opioid agonist and antagonists, current status, endogenous Opioid peptide ...
Tree-structured gatekeeping procedures for multiple objectives in
... An important feature of the multiple testing framework considered in [1–3] is that each family of null hypotheses is examined only if all of the tests carried out before are significant. Dmitrienko et al. [4] discussed an alternative scenario in which one sequentially tests families of hypotheses pr ...
... An important feature of the multiple testing framework considered in [1–3] is that each family of null hypotheses is examined only if all of the tests carried out before are significant. Dmitrienko et al. [4] discussed an alternative scenario in which one sequentially tests families of hypotheses pr ...
Quinidine Revisited
... ular tachycardia events in the antiarrhythmic groups (placewhile taking quinidine was significantly higher compared bo ⫽ 2, high-dose quinidine plus verapamil ⫽ 5, low-dose with the other 4 drugs. Proarrhythmia also was reported in quinidine plus verapamil ⫽ 4, sotalol ⫽ 7). There were no 20 patient ...
... ular tachycardia events in the antiarrhythmic groups (placewhile taking quinidine was significantly higher compared bo ⫽ 2, high-dose quinidine plus verapamil ⫽ 5, low-dose with the other 4 drugs. Proarrhythmia also was reported in quinidine plus verapamil ⫽ 4, sotalol ⫽ 7). There were no 20 patient ...
Document
... Open-label midazolam use: DXM 63% vs. midaz 49% (p=0.02) Fentanyl use: DXM 73.8% vs. midaz 97% (p=0.25) 30 day mortality: DXM 22.5% vs. midaz 25.4% (p=0.6) Bradycardia: DXM 42.2% vs. midaz 18.9% (p<0.01) Hyperglycemia: DXM 56.6% vs. midaz 42.6% (p=0.02) Conclusion No difference in time at target sed ...
... Open-label midazolam use: DXM 63% vs. midaz 49% (p=0.02) Fentanyl use: DXM 73.8% vs. midaz 97% (p=0.25) 30 day mortality: DXM 22.5% vs. midaz 25.4% (p=0.6) Bradycardia: DXM 42.2% vs. midaz 18.9% (p<0.01) Hyperglycemia: DXM 56.6% vs. midaz 42.6% (p=0.02) Conclusion No difference in time at target sed ...
STABILITY INDICATING HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF DROTAVERINE AND ACECLOFENAC Research Article
... stability indicating nature of the assay method16 while Singh and Bakshi, in their article on stress testing suggested a target degradation of 20‐80%17. Though conditions used for forced degradation were attenuated to achieve degradation in the range of 10‐80%, this ...
... stability indicating nature of the assay method16 while Singh and Bakshi, in their article on stress testing suggested a target degradation of 20‐80%17. Though conditions used for forced degradation were attenuated to achieve degradation in the range of 10‐80%, this ...
AusPAR: Vernakalant - Therapeutic Goods Administration
... This work is copyright. You may reproduce the whole or part of this work in unaltered form for your own personal use or, if you are part of an organisation, for internal use within your organisation, but only if you or your organisation do not use the reproduction for any commercial purpose and reta ...
... This work is copyright. You may reproduce the whole or part of this work in unaltered form for your own personal use or, if you are part of an organisation, for internal use within your organisation, but only if you or your organisation do not use the reproduction for any commercial purpose and reta ...
Secundum Artem
... samples should be performed; more if feasible. 5. Conclusions must fit the obtained data. It is improper to expand the results into areas not covered by the project. For example, stability studies done in glass containers cannot be extrapolated or applied to plastic containers. STABILITY STUDY DESIG ...
... samples should be performed; more if feasible. 5. Conclusions must fit the obtained data. It is improper to expand the results into areas not covered by the project. For example, stability studies done in glass containers cannot be extrapolated or applied to plastic containers. STABILITY STUDY DESIG ...
Review of application by Expert Committee Member
... such as different ages of the patients, preexisting bacterial infection and positive culture blunting the drop in temperature during the study period or antibiotherapy intake before the drug administration, these previous factors changing the antipyretic efficacy were not always taken into account i ...
... such as different ages of the patients, preexisting bacterial infection and positive culture blunting the drop in temperature during the study period or antibiotherapy intake before the drug administration, these previous factors changing the antipyretic efficacy were not always taken into account i ...
The Medical History of Psychedelic Drugs
... The aim of this dissertation is to describe the way in which psychedelics have interacted with medicine over the years whilst analysing the historical interplay between science, law and society. It will question how psychedelics came to be used in medicine and the initial role they filled. By lookin ...
... The aim of this dissertation is to describe the way in which psychedelics have interacted with medicine over the years whilst analysing the historical interplay between science, law and society. It will question how psychedelics came to be used in medicine and the initial role they filled. By lookin ...
In vivo and in vitro studies on drug metabolism and
... The in vivo studies were carried out as randomized, placebo-controlled, double-blind crossover studies in 9-12 healthy volunteers. After pretreatment with an active drug or a placebo, followed by a single oral dose of the studied compound, blood samples were taken at fixed time intervals for kinetic ...
... The in vivo studies were carried out as randomized, placebo-controlled, double-blind crossover studies in 9-12 healthy volunteers. After pretreatment with an active drug or a placebo, followed by a single oral dose of the studied compound, blood samples were taken at fixed time intervals for kinetic ...
Chloral hydrate has general CNS depressant effects believed to be
... Trichloroethanol is 70 to 80% bound to plasma proteins and is widely distributed to all body tissues including CSF, breast milk and placenta. The half-life of trichloroacetic acid is longer, up to 100 hours. It is highly plasma protein bound (94%), primarily to albumin and may be responsible for int ...
... Trichloroethanol is 70 to 80% bound to plasma proteins and is widely distributed to all body tissues including CSF, breast milk and placenta. The half-life of trichloroacetic acid is longer, up to 100 hours. It is highly plasma protein bound (94%), primarily to albumin and may be responsible for int ...
Antimicrobial resistance - WHO archives
... Challenges of definition of herbal medicines Definition Finished herbal products Finished herbal products consist of herbal preparations made from one or more herbs. If more than one herb is used, the term mixture herbal product can also be used. Finished herbal products and mixture herbal products ...
... Challenges of definition of herbal medicines Definition Finished herbal products Finished herbal products consist of herbal preparations made from one or more herbs. If more than one herb is used, the term mixture herbal product can also be used. Finished herbal products and mixture herbal products ...
Eryped 200 (erythromycin ethylsuccinate) Suspension
... immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by Ery-Ped or other antibacterial drugs in the future. Diarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued. Sometime after startin ...
... immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by Ery-Ped or other antibacterial drugs in the future. Diarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued. Sometime after startin ...
of EZN-2208, a novel anticancer agent, in patients
... tumors, resistant tumors (including an in vivo model of CPT-11 resistance), and sensitive tumors, EZN-2208 had a significantly enhanced therapeutic effect compared with CPT-11.2 The antitumor activity is attributed to higher exposure of tumors to SN38 via the preferential accumulation of EZN-2208 in ...
... tumors, resistant tumors (including an in vivo model of CPT-11 resistance), and sensitive tumors, EZN-2208 had a significantly enhanced therapeutic effect compared with CPT-11.2 The antitumor activity is attributed to higher exposure of tumors to SN38 via the preferential accumulation of EZN-2208 in ...
Bad Pharma
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Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.