Sinemet® CR Product Monograph
... While dose reduction clearly reduces the degree of somnolence, there is insufficient information to establish that dose reduction will eliminate episodes of falling asleep while engaged in activities of daily living. Episodes of falling asleep while engaged in activities of daily living have also be ...
... While dose reduction clearly reduces the degree of somnolence, there is insufficient information to establish that dose reduction will eliminate episodes of falling asleep while engaged in activities of daily living. Episodes of falling asleep while engaged in activities of daily living have also be ...
Australian public assessment for Thyroxine Sodium
... In relation to the proposed dissolution test method, this is not considered acceptable as it is not sufficiently discriminative. The method is based on Dissolution Tests 1-3 in the USP monograph for Levothyroxine Sodium Tablets. This is also the dissolution method of the current tablets. More recent ...
... In relation to the proposed dissolution test method, this is not considered acceptable as it is not sufficiently discriminative. The method is based on Dissolution Tests 1-3 in the USP monograph for Levothyroxine Sodium Tablets. This is also the dissolution method of the current tablets. More recent ...
sodium lactate - Pfizer Injectables
... Pregnancy Category C. Animal reproduction studies have not been conducted with sodium lactate. It is also not known whether sodium lactate can cause fetal harm when administered to a ...
... Pregnancy Category C. Animal reproduction studies have not been conducted with sodium lactate. It is also not known whether sodium lactate can cause fetal harm when administered to a ...
Needle Free Injection Systems - The Pharma Innovation Journal
... gets into the bloodstream and provokes the body to create antibodies that are carried throughout the entire body. In the United States, children may get over 13 vaccine injections by the age of 16. Unfortunately, there are a variety of problems associated with the hypodermic needles used for these i ...
... gets into the bloodstream and provokes the body to create antibodies that are carried throughout the entire body. In the United States, children may get over 13 vaccine injections by the age of 16. Unfortunately, there are a variety of problems associated with the hypodermic needles used for these i ...
Ibogaine
... In the US : a patient died 25 days after treatment. The cause was an aortic clott. It was established that Ibogaine had no causal relationshiop to death The patient got 4 Ibogaine treatments in the year and a half previous to death ...
... In the US : a patient died 25 days after treatment. The cause was an aortic clott. It was established that Ibogaine had no causal relationshiop to death The patient got 4 Ibogaine treatments in the year and a half previous to death ...
Extract from the Clinical Evaluation Report for Ceftobiprole
... Ceftobiprole has demonstrated in vitroactivity against daptomycin-nonsusceptible, tigecyclineresistant and linezolid-resistant S. aureus. Ceftobiprole’s potent activity against MRSA and PRSP extends the predominantly gram-negative spectrum of the well-established fourth-generation cephalopsorins (su ...
... Ceftobiprole has demonstrated in vitroactivity against daptomycin-nonsusceptible, tigecyclineresistant and linezolid-resistant S. aureus. Ceftobiprole’s potent activity against MRSA and PRSP extends the predominantly gram-negative spectrum of the well-established fourth-generation cephalopsorins (su ...
New horizons in pulmonary arterial hypertension therapies
... 6MWD continued to improve with a mean increase in the overall cohort (n5214) of 48¡72 m compared with baseline [39]. Functional class also continued to improve and 68% of the overall cohort were in functional class I/II after 1 year of treatment (versus 38–49% at baseline); 36% and 57% of patients s ...
... 6MWD continued to improve with a mean increase in the overall cohort (n5214) of 48¡72 m compared with baseline [39]. Functional class also continued to improve and 68% of the overall cohort were in functional class I/II after 1 year of treatment (versus 38–49% at baseline); 36% and 57% of patients s ...
Effexor ℞
... While there were no efficacy studies focusing specifically on an elderly population, elderly patients were included among the patients studied. Overall, approximately 2/3 of all patients in these trials were women. Exploratory analyses for age and gender effects on outcome did not suggest any diffe ...
... While there were no efficacy studies focusing specifically on an elderly population, elderly patients were included among the patients studied. Overall, approximately 2/3 of all patients in these trials were women. Exploratory analyses for age and gender effects on outcome did not suggest any diffe ...
Part II: Contact Dermatitis & Drug Eruptions
... after allopurinol has been stopped About 25% of pts die as a consequence Dialysis does not accelerate resolution of this syndrome- ...
... after allopurinol has been stopped About 25% of pts die as a consequence Dialysis does not accelerate resolution of this syndrome- ...
as zoledronic acid monohydrate
... possible, but should continue with regular dental cleaning and oral hygiene. For patients requiring oral surgery, there are no data available to suggest whether discontinuation of bisphosphonate treatment reduces the risk of ONJ. In patients who develop ONJ while on bisphosphonate therapy, surgery a ...
... possible, but should continue with regular dental cleaning and oral hygiene. For patients requiring oral surgery, there are no data available to suggest whether discontinuation of bisphosphonate treatment reduces the risk of ONJ. In patients who develop ONJ while on bisphosphonate therapy, surgery a ...
Anti-Rheumatic Medications - Contra Costa Health Services
... 3. Urgent PAs are processed within 4 hours if the clinical information is complete. For an emergency medication during off hours pharmacists can give up to a 5 day supply (at their discretion) before receiving the PA approval. We will monitor “Urgent” requests to make sure they are appropriately urg ...
... 3. Urgent PAs are processed within 4 hours if the clinical information is complete. For an emergency medication during off hours pharmacists can give up to a 5 day supply (at their discretion) before receiving the PA approval. We will monitor “Urgent” requests to make sure they are appropriately urg ...
Cardizem LA
... muscle and dilation of both large and small coronary arteries at drug levels which cause little or no negative inotropic effect. The resultant increases in coronary blood flow (epicardial and subendocardial) occur in ischemic and nonischemic models and are accompanied by dose-dependent decreases in ...
... muscle and dilation of both large and small coronary arteries at drug levels which cause little or no negative inotropic effect. The resultant increases in coronary blood flow (epicardial and subendocardial) occur in ischemic and nonischemic models and are accompanied by dose-dependent decreases in ...
Antihistamines in the treatment of asthma J . B
... Seasonal asthma Difficulties in designing the studies. There are several drawbacks in the studies examining the effects of antihistamines in the treatment of seasonal asthma. Seasonal asthma is mainly caused by pollens and the major symptoms of pollinosis are usually related to rhinoconjunctivitis, ...
... Seasonal asthma Difficulties in designing the studies. There are several drawbacks in the studies examining the effects of antihistamines in the treatment of seasonal asthma. Seasonal asthma is mainly caused by pollens and the major symptoms of pollinosis are usually related to rhinoconjunctivitis, ...
Intramuscular aripiprazole for the treatment of agitation in
... propensity for several adverse effects that sometime limit the clinical use of other drugs 19. The efficacy of oral aripiprazole on the positive and negative symptoms of schizophrenia and its tolerability have been extensively reviewed elsewhere 11 20. As reported for oral aripiprazole 11, the pharm ...
... propensity for several adverse effects that sometime limit the clinical use of other drugs 19. The efficacy of oral aripiprazole on the positive and negative symptoms of schizophrenia and its tolerability have been extensively reviewed elsewhere 11 20. As reported for oral aripiprazole 11, the pharm ...
digoxin - DavisPlus
... ing therapy. Notify health care professional before giving dose if patient is hypokalemic. Hypokalemia, hypomagnesemia, or hypercalcemia may make the patient more susceptible to digitalis toxicity. Pedi: Neonates may have falsely elevated serum digoxin concentrations due to a naturally occurring sub ...
... ing therapy. Notify health care professional before giving dose if patient is hypokalemic. Hypokalemia, hypomagnesemia, or hypercalcemia may make the patient more susceptible to digitalis toxicity. Pedi: Neonates may have falsely elevated serum digoxin concentrations due to a naturally occurring sub ...
Advances in Aromatase Inhibition
... different mode of action against breast tumors in postmenopausal women from that of tamoxifen. The first clinically available aromatase inhibitor, aminoglutethimide, was introduced for the second-line treatment of advanced breast cancer in the late 1970s (10). But despite proven efficacy in this set ...
... different mode of action against breast tumors in postmenopausal women from that of tamoxifen. The first clinically available aromatase inhibitor, aminoglutethimide, was introduced for the second-line treatment of advanced breast cancer in the late 1970s (10). But despite proven efficacy in this set ...
HIGHLIGHTS OF PRESCRIBING INFORMATION These
... diabetes, in patients with diabetic nerve disease, in patients using medications that block the sympathetic nervous system (e.g., beta-blockers) [see Drug Interactions (7)], or in patients who experience recurrent hypoglycemia. Risk Factors for Hypoglycemia The risk of hypoglycemia after an injectio ...
... diabetes, in patients with diabetic nerve disease, in patients using medications that block the sympathetic nervous system (e.g., beta-blockers) [see Drug Interactions (7)], or in patients who experience recurrent hypoglycemia. Risk Factors for Hypoglycemia The risk of hypoglycemia after an injectio ...
DOCEtaxel - Cancer Care Ontario
... may be severe with ascites, pleural or pericardial effusions. Peripheral edema can be treated with standard measures (e.g. sodium restriction, diuretics). Premedication with oral corticosteroids has been reported to delay the onset and decrease the severity of fluid retention, and all patients sho ...
... may be severe with ascites, pleural or pericardial effusions. Peripheral edema can be treated with standard measures (e.g. sodium restriction, diuretics). Premedication with oral corticosteroids has been reported to delay the onset and decrease the severity of fluid retention, and all patients sho ...
Patient-Derived Xenograft Models: An Emerging
... usually established only from the more aggressive tumors and hence are not representative of complex tumor heterogeneity evident in the clinic. For all these reasons, the establishment of cell lines is not an appropriate strategy for personalized medicine applications. Novel approaches, such as shor ...
... usually established only from the more aggressive tumors and hence are not representative of complex tumor heterogeneity evident in the clinic. For all these reasons, the establishment of cell lines is not an appropriate strategy for personalized medicine applications. Novel approaches, such as shor ...
WORLD HEALTH ORGANIZATION ORGANISATION MONDIALE DE LA SANTE 31ST EXPERT COMMITTEE
... Since 1990, WHO’s review of psychoactive substances has been carried out in two steps, in accordance with the Revised Guidelines for the WHO Review of DependenceProducing Psychoactive Substances for International Control adopted by the Executive Board that same year. The first step is referred to as ...
... Since 1990, WHO’s review of psychoactive substances has been carried out in two steps, in accordance with the Revised Guidelines for the WHO Review of DependenceProducing Psychoactive Substances for International Control adopted by the Executive Board that same year. The first step is referred to as ...
Psychopharmacotherapy of anorexia nervosa, bulimia nervosa and
... follow-up study on 33 patients with restricting anorexia nervosa who were receiving an average dosage of 34 mg fluoxetine per day, Strober et al49 found that fluoxetine had no significant effect on the maintenance of target weight, the risk of sustained weight loss or other clinical measures of outc ...
... follow-up study on 33 patients with restricting anorexia nervosa who were receiving an average dosage of 34 mg fluoxetine per day, Strober et al49 found that fluoxetine had no significant effect on the maintenance of target weight, the risk of sustained weight loss or other clinical measures of outc ...
The relationship between methamphetamine use and violent
... methamphetamine. These new ways of marketing methamphetamine emerged in 1999 and rapidly became popular. By 2003, 38 per cent of the injecting drug users surveyed through the Illicit Drug Reporting System, and 48 per cent of ecstasy users surveyed through the Party Drugs Initiative, in Sydney, had r ...
... methamphetamine. These new ways of marketing methamphetamine emerged in 1999 and rapidly became popular. By 2003, 38 per cent of the injecting drug users surveyed through the Illicit Drug Reporting System, and 48 per cent of ecstasy users surveyed through the Party Drugs Initiative, in Sydney, had r ...
PRAG
... • No specific regulation existing for TCM Products • European new legislation on Traditional Herbal Medicines difficult for CMM registration ...
... • No specific regulation existing for TCM Products • European new legislation on Traditional Herbal Medicines difficult for CMM registration ...
Pharmacology - Jhalawar Medical College
... Teaching summary of Opioid analgesics (class to be held on 12/09/2015) Classification, pharmacokinetics and pharmacodynamic property of each drugs, uses, ADRs, drug interactions, various Opioid receptors, Opioid agonist and antagonists, current status, endogenous Opioid peptide ...
... Teaching summary of Opioid analgesics (class to be held on 12/09/2015) Classification, pharmacokinetics and pharmacodynamic property of each drugs, uses, ADRs, drug interactions, various Opioid receptors, Opioid agonist and antagonists, current status, endogenous Opioid peptide ...
How Effective Is Algorithm-Guided Treatment for Depressed
... of >8 or >30% without achieving remission), a 2-week prolongation of the current treatment step was allowed (only once per step). Nonresponse was defined as not meeting remission or partial response criteria. These patients moved to the next treatment step. CDES used individual patients’ information ...
... of >8 or >30% without achieving remission), a 2-week prolongation of the current treatment step was allowed (only once per step). Nonresponse was defined as not meeting remission or partial response criteria. These patients moved to the next treatment step. CDES used individual patients’ information ...
Bad Pharma
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Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.