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WELLBUTRIN SR
WELLBUTRIN SR

... placebo-controlled trials in adults with MDD or other psychiatric disorders included a total of 295 short-term trials (median duration of 2 months) of 11 antidepressant drugs in over 77,000 subjects. There was considerable variation in risk of suicidality among drugs, but a tendency toward an incre ...
Ketofol_in_the_ED
Ketofol_in_the_ED

... Willman EV, Andolfatto G. A Prospective Evaluation of “Ketofol” (Ketamine/Propofol Combination) for Procedural Sedation and Analgesia in the Emergency Department. Ann Emerg Med. 2007; 49(1): 23-30. Andolfatto G, Willman E. A Prospective Case Series of Single-syringe Ketamine-Propofol (Ketofol) for E ...
uniformity (a required drug dose). This led to the develop-
uniformity (a required drug dose). This led to the develop-

... and intensive investigations for the design of degradable materials, intelligent delivery systems, and approaches for delivery through different portals in the body. Recent efforts have led to development of a new approach in the field of controlled drug delivery with the creation of responsive poly ...


... approved by the MHRA since the products were first licensed. The table includes an update that has been added as an annex to this PAR. This is not a complete list of the post-authorisation changes that have been made to these Marketing Authorisations. Date Application submitted type ...
attenuation of hemodynamic response to extubation with injection
attenuation of hemodynamic response to extubation with injection

... airway assessment of Mallampatti grade 1 and 2, between the age group of 18-60 years, scheduled for elective surgeries under general anaesthesia posted for General Surgery, ENT (ear, nose and throat), Orthopaedic, Gynaecological, Plastic and Neurosurgical procedures requiring oral intubation. Patie ...
PRODUCT INFORMATION ISOPTIN INJECTION SOLUTION
PRODUCT INFORMATION ISOPTIN INJECTION SOLUTION

... should be given critical consideration. In acute coronary insufficiency intravenous administration is only admissible with careful indication and continuous monitoring of the patient. Where heart failure is present, full compensation with cardiac glycosides must be achieved before the administration ...
Zyprexa/Zyprexa Zydis (olanzapine)
Zyprexa/Zyprexa Zydis (olanzapine)

... Zyprexa may induce significant weight gain. This may be due to increased appetite or to some underlying metabolic changes. The major concern of excessive weight gain is the health consequence to the patient, including the potential for developing diabetes and increasing cholesterol and other lipids, ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)

Epinephrine and local anesthesia revisited
Epinephrine and local anesthesia revisited

... last several years, at least 2 articles have addressed the specific drug-drug interactions related to epinephrine in local anesthetic formulations.40,41 A possible drug-drug interaction related to local anesthetic formulations and tricyclic antidepressants (TCAs) was presented.40,41 Both articles qu ...
TASTE MASKED CHEWABLE DISPERSIBLE TABLET OF ATOMOXETINE HYDROCHLORIDE  Research Article HUDA.I.G*
TASTE MASKED CHEWABLE DISPERSIBLE TABLET OF ATOMOXETINE HYDROCHLORIDE Research Article HUDA.I.G*

NOACS - West Suffolk Clinical Commissioning Group
NOACS - West Suffolk Clinical Commissioning Group

lustral - Pharmaline
lustral - Pharmaline

... Exposure during late pregnancy to SSRIs may have an increased risk for persistent pulmonary hypertension of the newborn (PPHN). PPHN occurs in 1-2 per 1,000 live births in the general population and is associated with substantial neonatal morbidity and mortality. In a retrospective case-control stud ...
NIDA Research Report - MDMA
NIDA Research Report - MDMA

... properties, is often taken for the feelings of well-being, stimulation, and the distortions in time and sensory perceptions that it produces. MDMA first became popular in the “rave” and all-night party scene, but its use has now spread to a wide range of settings and demographic subgroups. According ...
Inves2ga2ng and Predic2ng how Biology Changes Molecules and
Inves2ga2ng and Predic2ng how Biology Changes Molecules and

... pKa  -­‐  Xing,  Li;  Glen,  Robert  C.  Novel  methods  for  the  predic&on  of  logP,  pKa,  and  logD.  J.  Chem.  Inf.  Model.  2002,  42(4),  796-­‐805.     Virtual  screening  -­‐  David  Rogers  and  Mathew  Hahn.  Extended-­‐C ...
Japanese Journal of Ophthalmology Vol.43 No.6
Japanese Journal of Ophthalmology Vol.43 No.6

... brown irides under cycloplegia. The results showed that the brown irides group lost accommodation slower than the blue irides group. Chan and Edwards17 showed that people with heavily pigmented irides required more time to achieve full cycloplegia. In the literature, the recommended waiting time var ...
The Antidepressants - Consumer Health Choices
The Antidepressants - Consumer Health Choices

... mirtazapine, nefazodone, paroxetine, sertraline, and venlafaxine—are now available as less-costly generic drugs in some dosage forms. Several are also available in liquid formulations. Good to know: In late 2012, the FDA ordered the withdrawal of the 300 mg dose of generic bupropion, sold under the ...
Functional Group Characteristics and Roles
Functional Group Characteristics and Roles

... an example, let’s consider the wheels. This part of the automobile is essential to allow it to move quickly and smoothly over hundreds and thousands of miles. In contrast, the wheels found on most modern refrigerators are helpful in moving it a few feet for cleaning purposes or perhaps to remodel a ...
Roger`s Phat Pharm Notes II
Roger`s Phat Pharm Notes II

... mechanism is to block regeneration of KH2 (active hydroquinone form of Vit K) by an epoxide reductase. Delayed onset of action depending on drug pharmK and t1/2 of the 4 Vit K dep clotting factors, which must be catabolized first before anticoag effect evident. Action potentiated by  intake of vit ...
Retrospective Review of Voluntary Reports of Nonsurgical
Retrospective Review of Voluntary Reports of Nonsurgical

... such research may not be straightforward. Adverse effects from local anesthetics used in dentistry are generally thought to be so rare that few statistical data are available.16 Moreover, certain (prospective) experimental designs may have difficulty getting approval from institutional review boards ...
Prescribing Information
Prescribing Information

... ----------------------- WARNINGS AND PRECAUTIONS ---------------------- ALT elevations: Perform hepatic laboratory testing prior to therapy, at treatment week 8, and as clinically indicated. For patients receiving 16 weeks of therapy, perform additional hepatic laboratory testing at treatment week ...


... same time of day. Inhaled GC therapy was continued unchanged. If the FEV1 had not improved by >30% of baseline, patients were prescribed prednisolone, 40 mg daily, for an additional 7 days. Consumption of tablets was verified by careful tablet counting by the attending physician rather than by measu ...
The incentive sensitization theory of addiction
The incentive sensitization theory of addiction

... pattern of drug-seeking and drug-taking behaviours, which occupies an inordinate amount of an individual’s time and thoughts, and persists despite adverse consequences (Hasin et al. 2006). Addicts also find it difficult to reduce or terminate drug use, even when they desire to do so. Finally, addict ...
Pharmacotherapy Treatment Options for Insomnia
Pharmacotherapy Treatment Options for Insomnia

... pregnancy and breast feeding avoids the exposure of a fetus/newborn to medication. Also, many patients prefer CBT-I, avoiding difficulties in swallowing pills, and avoiding the concept of using a pharmacological approach. Unfortunately, CBT services are extremely limited (particularly amongst genera ...
diclofenac - Endo Pharmaceuticals
diclofenac - Endo Pharmaceuticals

... necrosis, jaundice, fulminant hepatitis with and without jaundice, and liver failure. Some of these reported cases resulted in fatalities or liver transplantation. Physicians should measure transaminases periodically in patients receiving long-term therapy with diclofenac, because severe hepatotoxic ...
BCBSM Prior Authorization and Step Therapy Guidelines
BCBSM Prior Authorization and Step Therapy Guidelines

... Off-Label / High-Cost Specialty program-Off-label means a drug is being used in a way that has not been approved by the U.S. Food and Drug Administration. Drugs with potential for off-label use and high-cost specialty drugs on this list require prior authorization for Blue Cross to cover them. ...
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Bad Pharma



Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.
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