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Profile Documents Logout
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Laboratory Testing for HIV Tropism
Laboratory Testing for HIV Tropism

... members, unless separate Medicare Advantage criteria are indicated. If the criteria are not met, reimbursement will be denied and the patient cannot be billed. Please note that payment for covered services is subject to eligibility and the limitations noted in the patient’s contract at the time the ...
Plavix - Sanofi Canada
Plavix - Sanofi Canada

... In patients with recent transient ischaemic attack (TIA) or stroke and who are at high risk of recurrent ischemic events, the combination of ASA and PLAVIX has not been shown to be more effective than PLAVIX alone, but the combination has been shown to increase major bleeding (see DRUG INTERACTIONS ...
metronidazole
metronidazole

... adverse reactions have involved the gastrointestinal tract, particularly nausea, sometimes accompanied by headache, anorexia and occasionally vomiting, diarrhoea, epigastric distress and abdominal cramping; constipation and oral mucositis have also been reported. A metallic, sharp unpleasant taste i ...
Potential Drug Interactions with Grapefruit Evidence and Advice You Can Trust... CHART: CHART
Potential Drug Interactions with Grapefruit Evidence and Advice You Can Trust... CHART: CHART

... gut CYP3A4 occurs with just 200 mL48 (less than a typical serving), and even lesser amounts can interact.49 This study gives a clearer picture of the duration of the impact of grapefruit juice on CYP3A4 activity. The pharmacokinetic parameters appear to be affected for at least three days following ...
Document
Document

... The large number of prescribing problems with oral Methotrexate supported the case to develop a structured electronic prescribing pathway. This was developed by a team comprising the electronic prescribing pharmacists, specialist clinical pharmacists and the rheumatology team. It was decided that, u ...
METRONIDAZOLE INTRAVENOUS INFUSION
METRONIDAZOLE INTRAVENOUS INFUSION

... because of the possibility of a disulfiram-like reaction. Disulfiram: Administration of disulfiram with metronidazole has been associated with acute psychoses and confusion in some patients; therefore the two drugs should not be administered. Metronidazole should not be given to patients who have ta ...
Review
Review

... previous surgery and the insertion of invasive devices. The aging population, with more contact with healthcare services and often more antimicrobial use, represents a significant population at risk of colonization and subsequent infection. By contrast, CA-MRSA differs from HA-MRSA in that it tends ...
Always refer to full prescribing information.
Always refer to full prescribing information.

... of the potential for serious adverse reactions in nursing infants from pimecrolimus, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. 8.4 Pediatric Use ELIDEL Cream, 1% is not indicated for use in chil ...
Paroxetine
Paroxetine

... antidepressants. There is also some evidence that paroxetine may be of therapeutic value in patients who have failed to respond to standard therapy. In general, improvement in patients starts after one week but does not become superior to placebo until the second week of therapy. Nevertheless, there ...
A Study of Abrupt Phentermine Cessation in Patients in
A Study of Abrupt Phentermine Cessation in Patients in

... a weight management program. Thirty-five patients in a weight management program who abruptly stopped taking prescribed phentermine on their own initiative were examined using the 18-item Kampman Cocaine Selective Severity Assessment scale modified for phentermine. The Kampman Cocaine Selective Seve ...
ramelteon
ramelteon

... slightly decreased. Based on the above study results, a storage condition of “store at room temperature in well-closed containers” and a retest period of 3 years have been proposed for the drug substance. 2.A.(2) Drug product The drug product is available as pale orange-yellow, film-coated tablets c ...
THE USE OF PURE AND IMPURE PLACEBO INTERVENTIONS IN
THE USE OF PURE AND IMPURE PLACEBO INTERVENTIONS IN

... this are often treated by complementary and alternative therapies and these, too, are associated with placebo effects. However, all PCPs felt that the ethical aspects of such treatment were unclear and they were unsure as to how to communicate the use of placebos to their patients. Most of them woul ...
The New High: Designer Drugs and New Trends
The New High: Designer Drugs and New Trends

... she helped take the man to his destination, and they drank juice together. ‘You can guide them wherever you want. It’s like they’re a child.’ She took the man to her house and helped him gather all of her belongings, including her boyfriend’s cameras and ...
AusPAR: Zonisamide
AusPAR: Zonisamide

... dosed to steady state at 1, 7 or 12mg/kg daily, in divided doses, are similar to those observed in adults, after adjustment for bodyweight. Other characteristics No clear zonisamide dose-concentration-response relationship has been defined. When comparing the same dose level, subjects of higher tota ...
PPT - IAS-USA
PPT - IAS-USA

... longer-term data with TDF, particularly in studies in treatment naïve patients. • More favorable lipid effects. • Renal and bone marker advantages of TAF not yet known to translate into better clinical outcomes. • TDF-regimens likely to be cheaper than TAF when TDF goes generic. ...
Antiretroviral Agents presentation
Antiretroviral Agents presentation

DEVELOPMENT AND VALIDATION OF SIMULTANEOUS EQUATION SPECTROPHOTOMETRIC
DEVELOPMENT AND VALIDATION OF SIMULTANEOUS EQUATION SPECTROPHOTOMETRIC

... Hydrochloride (TOL) and Diclofenac Sodium (DFS) in its combined tablet dosage form by using methanol as a solvent. The method involves solving of simultaneous equation based on measurement of absorbance at two wavelengths at 254 nm and 282 nm. Method follows Beer’s linearity in the range of 5-35μg/m ...
Ritalin LA - Novartis Pharmaceuticals Corporation
Ritalin LA - Novartis Pharmaceuticals Corporation

... Renal Insufficiency: Ritalin LA has not been studied in renally-impaired patients. Renal insufficiency is expected to have minimal effect on the pharmacokinetics of methylphenidate since less than 1% of a radiolabeled dose is excreted in the urine as unchanged compound, and the major metabolite (rit ...
Factors leading to PPI overuse Despite FDA alerts/concerns of PPI
Factors leading to PPI overuse Despite FDA alerts/concerns of PPI

... the PPI. But as mentioned in the previous graph, 80% of residents that did not tolerate an abrupt discontinuation did so when tapered off. ...
Product Monograph
Product Monograph

... An increase in the risk of bleeding may occur following sorafenib administration. In the phase III NEXAVAR RCC clinical trial, bleeding, regardless of the cause, was found in 15% of sorafenib-treated patients and in 8% of patients in the placebo group. Pulmonary hemorrhages were observed in 4.7% of ...
75/2009 - Repatriation Medical Authority
75/2009 - Repatriation Medical Authority

... death from a terminal event or condition that was contributed to by the person’s adrenal insufficiency; "equivalent glucocorticoid therapy" means a glucocorticoid in the following table, at the doses specified in the table, or a therapeutically equivalent dose of another glucocorticoid: ...
Comparison of the effects of cimetidine and hyoscine-n
Comparison of the effects of cimetidine and hyoscine-n

... [13,14], have all been shown to reduce gastric emptying. Gastric emptying is rate limiting in the absorption of many orally administered drugs [15, 16, 17, 18]. It has been shown that negligible absorption of Paracetamol occurs in the stomach, the bulk of an orally administered dose of been absorbed ...
322 PHT Tablet
322 PHT Tablet

... It is very important for tablets because they come in contact with taste buds. Ideally API should have no taste. Sometimes it might have unpleasant taste like bitter e.g. Chloramphenicol, Clindamycin, etc. The following taste masking options can be tried: i) Use of prodrug to decrease API solubility ...
Scabies
Scabies

CIR Report Data Sheet - Cosmetic Ingredient Review
CIR Report Data Sheet - Cosmetic Ingredient Review

... cosmetics, food, dietary supplements, drugs for internal and external use (with and without certification for use around the eyes), and medical devices (i.e., bone cement, surgical sutures). These colors are created by applying the color to an alumina substrate. All lakes are subject to certificatio ...
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Bad Pharma



Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.
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