Targeting the dopamine D receptor in schizophrenia
... antipsychotic drugs. The research in this field started with the synthesis of antihistamines after World War II, particularly with H Laborit using such compounds to enhance surgical analgesia. In patients receiving these various antihistamines, Laborit noticed a ‘euphoric quietude’, and that the pat ...
... antipsychotic drugs. The research in this field started with the synthesis of antihistamines after World War II, particularly with H Laborit using such compounds to enhance surgical analgesia. In patients receiving these various antihistamines, Laborit noticed a ‘euphoric quietude’, and that the pat ...
Adrenal suppression: A practical guide to the screening and
... these concerns is the risk of adrenal suppression (AS). AS is a condition characterized by the inability to produce adequate amounts of the glucocorticoid, cortisol, which is critical during periods of physiological stress. It is a proven, yet under-recognized, complication of most forms of glucocor ...
... these concerns is the risk of adrenal suppression (AS). AS is a condition characterized by the inability to produce adequate amounts of the glucocorticoid, cortisol, which is critical during periods of physiological stress. It is a proven, yet under-recognized, complication of most forms of glucocor ...
Systematic Review of Combined Angiotensin
... effective, thereby increasing angiotensin II levels, which could be inhibited by the addition of an angiotensin receptor blocker. We conducted a meta-analysis of randomized trials with searches of MEDLINE, EMBASE, and Cochrane databases. Overall, the combination of an ACE inhibitor and an angiotensi ...
... effective, thereby increasing angiotensin II levels, which could be inhibited by the addition of an angiotensin receptor blocker. We conducted a meta-analysis of randomized trials with searches of MEDLINE, EMBASE, and Cochrane databases. Overall, the combination of an ACE inhibitor and an angiotensi ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
... noninvasive route with a high bioavailability. However,cooperation is still required and it may be more difficult in younger children. Oral administration may be even more difficult in uncooperative children and compliance is easier with intranasal route than oral.Intranasal midazolam produces local ...
... noninvasive route with a high bioavailability. However,cooperation is still required and it may be more difficult in younger children. Oral administration may be even more difficult in uncooperative children and compliance is easier with intranasal route than oral.Intranasal midazolam produces local ...
PrKETOTIFEN OPHTHALMIC SOLUTION
... was the most common ocular adverse reaction related to therapy, with a reported incidence of 7.0%. Headache was the most common non-ocular adverse reaction related to therapy, with a reported incidence of 1.5%. The occurrence of these side effects were generally mild and did not result in discontinu ...
... was the most common ocular adverse reaction related to therapy, with a reported incidence of 7.0%. Headache was the most common non-ocular adverse reaction related to therapy, with a reported incidence of 1.5%. The occurrence of these side effects were generally mild and did not result in discontinu ...
Full Prescribing Information
... one and unrelated to muscle innervation, and the muscle still responds to drugs and other stimuli causing contraction. Papaverine has minimal actions on the central nervous system, although very large doses tend to produce some sedation and sleepiness in some patients. In certain circumstances, mild ...
... one and unrelated to muscle innervation, and the muscle still responds to drugs and other stimuli causing contraction. Papaverine has minimal actions on the central nervous system, although very large doses tend to produce some sedation and sleepiness in some patients. In certain circumstances, mild ...
Extract from Clinical Evaluation Report: Riociguat
... include sections from the CER regarding product documentation or post market activities. ...
... include sections from the CER regarding product documentation or post market activities. ...
The FDA’s Continuing Incapacity on Livestock Antibiotics *
... administered through animals’ water, the FDA is asking makers to switch from OTC status to prescription-only status,29 as drugs administered through drinking water are, by law, not subject to veterinary feed directives. The second document published in December 2013 is a proposed rule relaxing the r ...
... administered through animals’ water, the FDA is asking makers to switch from OTC status to prescription-only status,29 as drugs administered through drinking water are, by law, not subject to veterinary feed directives. The second document published in December 2013 is a proposed rule relaxing the r ...
Novel pharmacotherapeutic treatments for cocaine addiction R E V I E W
... has been associated with relapse into substance abuse and there are currently no proven pharmacologic treatment options for this form of insomnia [28]. Modafinil continues to represent an area of exciting promise in the pharmacologic management of cocaine dependence, since it appears to have limited ...
... has been associated with relapse into substance abuse and there are currently no proven pharmacologic treatment options for this form of insomnia [28]. Modafinil continues to represent an area of exciting promise in the pharmacologic management of cocaine dependence, since it appears to have limited ...
Core-Shell Type Lipid-Polymer Hybrid Nanoparticles as
... nogenic for systemic and nonsystemic administration if their component lipids are from natural sources. 7 However, liposomal drug products have several limitations from the viewpoint of physical and chemical stability, batch-to-batch reproducibility, sterilization, drug entrapment, and manufacturing ...
... nogenic for systemic and nonsystemic administration if their component lipids are from natural sources. 7 However, liposomal drug products have several limitations from the viewpoint of physical and chemical stability, batch-to-batch reproducibility, sterilization, drug entrapment, and manufacturing ...
Drugs and Human Performance Fact Sheets
... Mathematical models have been developed to estimate the time of marijuana exposure within a 95% confidence interval. Knowing the elapsed time from marijuana exposure can then be used to predict impairment in concurrent cognitive and psychomotor effects based on data in the published literature. Inte ...
... Mathematical models have been developed to estimate the time of marijuana exposure within a 95% confidence interval. Knowing the elapsed time from marijuana exposure can then be used to predict impairment in concurrent cognitive and psychomotor effects based on data in the published literature. Inte ...
ANTIBACTERIAL AND SYNERGISTIC ACTIVITY OF ETHANOLIC AJWAIN (TRACHYSPERMUM
... MBLs are bacterial zinc enzymes that are able to hydrolyze most βlactam antibiotics [6, 7]. In addition, they also show a high degree of resistance to other groups of antibiotics [8]. The emergence of everincreasing Multiple Drug Resistant (MDR) microbial strains has become a severe health threat to ...
... MBLs are bacterial zinc enzymes that are able to hydrolyze most βlactam antibiotics [6, 7]. In addition, they also show a high degree of resistance to other groups of antibiotics [8]. The emergence of everincreasing Multiple Drug Resistant (MDR) microbial strains has become a severe health threat to ...
Cognitive function in opioid substitution treated patients
... ISBN 978-952-302-223-2 (printed); ISBN 978-952-302-224-9 (online publication) Opioid-substitution treatment (OST) with the long-acting opioid agonist buprenorphine or methadone has proven to be the most effective treatment for opioid-dependence. The duration of treatment is typically years or even d ...
... ISBN 978-952-302-223-2 (printed); ISBN 978-952-302-224-9 (online publication) Opioid-substitution treatment (OST) with the long-acting opioid agonist buprenorphine or methadone has proven to be the most effective treatment for opioid-dependence. The duration of treatment is typically years or even d ...
Drugs and Human Performance Fact Sheets
... Mathematical models have been developed to estimate the time of marijuana exposure within a 95% confidence interval. Knowing the elapsed time from marijuana exposure can then be used to predict impairment in concurrent cognitive and psychomotor effects based on data in the published literature. Inte ...
... Mathematical models have been developed to estimate the time of marijuana exposure within a 95% confidence interval. Knowing the elapsed time from marijuana exposure can then be used to predict impairment in concurrent cognitive and psychomotor effects based on data in the published literature. Inte ...
Azithromycin for Injection, USP
... The pharmacokinetics of azithromycin in subjects with hepatic impairment has not been established. Gender There are no significant differences in the disposition of azithromycin between male and female subjects. No dosage adjustment is recommended based on gender. Geriatric Patients Pharmacokinetic ...
... The pharmacokinetics of azithromycin in subjects with hepatic impairment has not been established. Gender There are no significant differences in the disposition of azithromycin between male and female subjects. No dosage adjustment is recommended based on gender. Geriatric Patients Pharmacokinetic ...
Pathophysiology in the Treatment of Type 2
... Exenatide: Adverse Events • ~50% experience nausea or other GI events – Early in course, decrease over time – ~5% stop therapy due to nausea or vomiting – To minimized – • Start low dose bid for 4 weeks, then titrate to 10 μg bid • administer exenatide just before meals until well tolerated ...
... Exenatide: Adverse Events • ~50% experience nausea or other GI events – Early in course, decrease over time – ~5% stop therapy due to nausea or vomiting – To minimized – • Start low dose bid for 4 weeks, then titrate to 10 μg bid • administer exenatide just before meals until well tolerated ...
Guidelines for the Biological Treatment of Substance Use and
... worldwide prevalence of 0.4% among individuals aged 15–64 years (United Nations Office on Drugs and Crime 2006). In Europe, the average prevalence of problematic opioid use is estimated to be 3.6–4.4 cases per 1000 population aged 15–64 years (EMCDDA 2010). This corresponds to approximately 1.35 mil ...
... worldwide prevalence of 0.4% among individuals aged 15–64 years (United Nations Office on Drugs and Crime 2006). In Europe, the average prevalence of problematic opioid use is estimated to be 3.6–4.4 cases per 1000 population aged 15–64 years (EMCDDA 2010). This corresponds to approximately 1.35 mil ...
FULL PRESCRIBING INFORMATION HIGHLIGHTS OF
... of 11 different AEDs showed that patients randomized to one of the AEDs had approximately twice the risk (adjusted Relative Risk 1.8, 95% CI:1.2, 2.7) of suicidal thinking or behavior compared to patients randomized to placebo. In these trials, which had a median treatment duration of 12 weeks, the ...
... of 11 different AEDs showed that patients randomized to one of the AEDs had approximately twice the risk (adjusted Relative Risk 1.8, 95% CI:1.2, 2.7) of suicidal thinking or behavior compared to patients randomized to placebo. In these trials, which had a median treatment duration of 12 weeks, the ...
PRODUCT MONOGRAPH Pr LAMISIL® Terbinafine tablets 250 mg
... Fertility: No effect of terbinafine on fertility has been seen in animal studies (see section TOXICOLOGY) and there are no data to suggest an effect on fertility in humans. Geriatrics: Plasma concentrations and drug half-life appear to be slightly higher in elderly patients than in the general popul ...
... Fertility: No effect of terbinafine on fertility has been seen in animal studies (see section TOXICOLOGY) and there are no data to suggest an effect on fertility in humans. Geriatrics: Plasma concentrations and drug half-life appear to be slightly higher in elderly patients than in the general popul ...
Guidelines for TEaching Pain Control and Sedation to Dentists and
... drugs enterally, parenterally and by inhalation as supplements to local anesthesia. The predoctoral curriculum should provide instruction, exposure and/or experience in anxiety and pain control, including minimal and moderate sedation. The predoctoral program must also provide the knowledge and skil ...
... drugs enterally, parenterally and by inhalation as supplements to local anesthesia. The predoctoral curriculum should provide instruction, exposure and/or experience in anxiety and pain control, including minimal and moderate sedation. The predoctoral program must also provide the knowledge and skil ...
PRODUCT MONOGRAPH Pr ZYLOPRIM® Allopurinol Tablets USP
... Since ZYLOPRIM® and its metabolites are excreted only by the kidney, accumulation of the drug can occur in renal failure and the dose of ZYLOPRIM® should consequently be reduced. With a creatinine clearance of 20 to 10 mL/min, a daily dosage of 200 mg of ZYLOPRIM® is suitable. When the creatinine cl ...
... Since ZYLOPRIM® and its metabolites are excreted only by the kidney, accumulation of the drug can occur in renal failure and the dose of ZYLOPRIM® should consequently be reduced. With a creatinine clearance of 20 to 10 mL/min, a daily dosage of 200 mg of ZYLOPRIM® is suitable. When the creatinine cl ...
Selective Suppression of Cocaine- versus Food
... Operation of the operant panel and pellet dispenser and data collection were accomplished with custom-written software operating on microprocessors and software purchased from MED Associates (St. Albans, VT) and located in a separate room. Discrimination Training. Subjects were trained to discrimina ...
... Operation of the operant panel and pellet dispenser and data collection were accomplished with custom-written software operating on microprocessors and software purchased from MED Associates (St. Albans, VT) and located in a separate room. Discrimination Training. Subjects were trained to discrimina ...
Bicompartmental model Kinetic disposition of a parent drug and its
... Visual inspection of these different fittings indicates severe misfits. It also suggests that none of the classical compartmental models will be able to fit these data and so we decided to carry out only an NCA of the metabolite plasma kinetics. Before proceeding to this NCA, add a time point to the ...
... Visual inspection of these different fittings indicates severe misfits. It also suggests that none of the classical compartmental models will be able to fit these data and so we decided to carry out only an NCA of the metabolite plasma kinetics. Before proceeding to this NCA, add a time point to the ...
Practicalities in the Use of Obesity Pharmacologic Agents
... • If <3% weight loss after 12 wks, either discontinue or advance to full dose phentermine 15/ topiramate ER 92 (transition dose phentermine 11.25/ topiramate ER 69 for 2 wks) • If <5% weight loss after 12 wks on full dose, discontinue (take every other day for 1 wk) Phentermine and topiramate extend ...
... • If <3% weight loss after 12 wks, either discontinue or advance to full dose phentermine 15/ topiramate ER 92 (transition dose phentermine 11.25/ topiramate ER 69 for 2 wks) • If <5% weight loss after 12 wks on full dose, discontinue (take every other day for 1 wk) Phentermine and topiramate extend ...
Bad Pharma
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Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.