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MDMA (Ecstasy) - cloudfront.net
MDMA (Ecstasy) - cloudfront.net

... subgroups. According to the 2004 National Survey on Drug Use and Health, more than 11 million people have tried MDMA at least once. Myths abound about both the acute effects and long-term consequences of this drug, often called ecstasy or "X". Indeed, one reason for the rapid rise in the drug’s popu ...
Product Information: Taladafil
Product Information: Taladafil

... Attachment 1: Product information for AusPAR Tadafil Cialis Eli Lilly Australia Pty Ltd PM-2011-03166-3-3 Final 22 July 2013. This Product Information was approved at the time this AusPAR was published. ...
Core Defects of Type 2 Diabetes
Core Defects of Type 2 Diabetes

... Upper limit of normal range (6.2%) ...
Valproic acid metabolism and its effects on mitochondrial fatty acid
Valproic acid metabolism and its effects on mitochondrial fatty acid

... young children may be at higher risk because of immature hepatic function and, most probably, because of a recognized (or undiagnosed) metabolic abnormality that could trigger the hepatic failure. However, adults with VPA-associated fatal hepatotoxicity (17–62 years) have also been reported (König ...
PRODUCT MONOGRAPH FLECAINIDE Flecainide
PRODUCT MONOGRAPH FLECAINIDE Flecainide

... PR interval increases on average about 25% (0.04 seconds) and as much as 118% in some patients. Approximately one-third of patients may develop new first degree AV heart block (PR interval 0.20 seconds). The QRS complex increases on average about 25% (0.02 seconds) and as much as 150% in some patien ...
Modafinil Bluefish Tablet ENG SmPC
Modafinil Bluefish Tablet ENG SmPC

... regulation of sleep/wake states (e.g., adenosine, benzodiazepine, dopamine, GABA, histamine, melatonin, norepinephrine, orexin, and serotonin). Modafinil also does not inhibit the activities of adenylyl cyclase, catechol-O-methyltransferase, glutamic acid decarboxylase MAO-A or B, nitric oxide synth ...
CO-DIOVAN - GuildLink
CO-DIOVAN - GuildLink

... with a history of dry cough during ACE inhibitor therapy, 19.5% of trial subjects receiving valsartan and 19.0% of those receiving a thiazide diuretic experienced cough, compared to 68.9% of those treated with an ACE inhibitor (P < 0.05). Valsartan does not bind to or block other hormone receptors o ...
R.W. Moreadith, T.X. Viegas, M.D. Bentley, J.M. Harris, Z. Fang, K
R.W. Moreadith, T.X. Viegas, M.D. Bentley, J.M. Harris, Z. Fang, K

... by experts in the field. This feature article provides a case study which describes the chemistry and preclinical studies underlying the Investigational New Drug Application for SER-214, a POZ conjugate of rotigotine, for the treatment of Parkinson’s disease. We report the chemistry, preclinical saf ...
Product Information - Therapeutic Goods Administration
Product Information - Therapeutic Goods Administration

... Tenofovir disoproxil fumarate, emtricitabine and elvitegravir/cobicistat: The triple combination of tenofovir, emtricitabine, and elvitegravir demonstrated synergistic antiviral activity in cell culture. Antiviral synergy was maintained for tenofovir, emtricitabine, and elvitegravir when tested in t ...
Monte Carlo Simulation: Sense and Non-sense
Monte Carlo Simulation: Sense and Non-sense

... Sense and Non-Sense Required Factors for Rational Dose/Drug ...
Quand le sommeil ne vient pas…
Quand le sommeil ne vient pas…

... 2008 National Sleep Foundation (NSF) Sleep Poll found that 65% of patients polled had sleep problems at least a few times a week… Only 4% diagnosed (told by physician that they had a sleep problem) Only 2% currently receiving treatment for sleep problem ...
MCS Sense and Non-Se..
MCS Sense and Non-Se..

... Sense and Non-Sense Required Factors for Rational Dose/Drug ...
Oncologist®
Oncologist®

... malignant GISTs. It is also approved by European regulatory authorities for use in pediatric patients with CML in all phases. Promising results of imatinib treatment have been reported in cases of other diseases, such as hypereosinophilic syndrome (HES) and dermatofibrosarcoma protuberans. In light ...
Bactericidal Activity and Resistance
Bactericidal Activity and Resistance

... when they were exposed to ⱖ1 ␮g/ml of dalbavancin for 24 h. Two strains (one MSSA strain and one MRSA strain) were also killed to that extent by the lowest dalbavancin concentration tested, 0.25 ␮g/ml. The data for three of the S. aureus isolates (one isolate each of MSSA, MRSA, and VISA) are shown ...
Full Prescribing Information
Full Prescribing Information

... doses 40 times the human dose. In some rabbit studies, the overall increase in fetal loss (dead and resorbed and malformed conceptuses) was associated with doses 6 times the human therapeutic dose. While there are no large well-controlled studies on the use of trimethoprim in pregnant women, Brumfit ...
Outline - leader
Outline - leader

... • Frailty is important for many reasons. Today, I will show how to recognize and grade frailty and show how this informs decisions on ...
(2000) Confidence interval criteria for assessment of dose
(2000) Confidence interval criteria for assessment of dose

... that the CI for ␤1, denoted (L, U), is included entirely within the interval defined by Eq. (4). Second, a dose ratio ␳2 can sometimes be calculated such that (L, U) lies completely outside the acceptance interval. The value of ␳1 or ␳2 may be larger or may be smaller than the actual dose range stud ...
Managing Anal Furunculosis in Dogs
Managing Anal Furunculosis in Dogs

... gators mentioned that resolution of associated clinical skin have improved, maintenance therapy should be inisigns alone was a satisfactory outcome to owners for tiated. It may consist of the lowest effective dose of oral most cases in which lesions did not resolve. It is notetherapy administered du ...
Universidade de Lisboa Faculdade de Farmácia Assessing drug
Universidade de Lisboa Faculdade de Farmácia Assessing drug

... When assessing Summaries of Product Characteristics (SmPCs), we found that their content on clinical pharmacology information is insufficient. Information on this topic was found to be very similar to the content of the US Physicians’ Desk Reference. Completeness and applicability of the information ...
Title 32: PROFESSIONS AND OCCUPATIONS
Title 32: PROFESSIONS AND OCCUPATIONS

... 2-B. Collaborative practice agreement. "Collaborative practice agreement" means a written and signed agreement between one or more pharmacists with training and experience relevant to the scope of the collaborative practice and a practitioner that supervises or provides direct consultation to the ph ...
a drug by any other name ?: paradoxes in dietary supplement risk
a drug by any other name ?: paradoxes in dietary supplement risk

... 14. See 21 U.S.c. § 321(s)(6). The FDCA subjects food additives to premarket review in order to determine whether such substances are safe for use. See id. § 348(a)-(c). The FDA has, however, exempted from premarket approval requirements these substances added to food that are "generally recognized ...


... phenobarbitol and paracetamol being an exception. Use of CAP and phenobarbital results in unexpectedly high levels of phenobarbitol in serum ( Koup, J. R. , et al., 1978 (a)). Paracetamol has no effect on CAP metabolism ( Paap, C.H., Nahata, H. C., 1990 ) with no change in its half-life and plasma c ...
ANALYTICAL METHOD DEVELOPMENT AND METHOD VALIDATION FOR THE ESTIMATION
ANALYTICAL METHOD DEVELOPMENT AND METHOD VALIDATION FOR THE ESTIMATION

... Linearity of this method was evaluated by linear regression analysis and calculated by least square method and studied by preparing standard solutions of Pioglitazone HCl at different concentration levels. Absorbance of resulting solutions was measured and the calibration curve was plotted between a ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)

... noninvasive route with a high bioavailability. However,cooperation is still required and it may be more difficult in younger children. Oral administration may be even more difficult in uncooperative children and compliance is easier with intranasal route than oral.Intranasal midazolam produces local ...
Pregnancy and Cardiovascular Disease
Pregnancy and Cardiovascular Disease

... good maternal and neonatal outcomes  candidates for non-drug therapy  there is no evidence that pharmacological treatment results in improved neonatal outcome. ...
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Bad Pharma



Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.
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