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NOACs in NVAF
NOACs in NVAF

... CHADS2 = congestive heart failure, hypertension, age, diabetes, prior stroke or TIA; CHF = congestive heart failure; CNS = ...
STUDIES ON THE PHYSICO-PHYTOCHEMICAL PROPERTIES AND HEPATOPROTECTIVE EFFECT SOLANUM TORVUM
STUDIES ON THE PHYSICO-PHYTOCHEMICAL PROPERTIES AND HEPATOPROTECTIVE EFFECT SOLANUM TORVUM

... Modern medicines have little to offer for alleviation of hepatic diseases and it is chiefly the plant based preparations which are employed for the treatment of liver disorders18. A number of plants have been shown to posses hepatoprotective property by improving antioxidant status19. Natural remedi ...
Fentanyl Buccal Lozenges (Actiq®)
Fentanyl Buccal Lozenges (Actiq®)

... managed with this dose of fentanyl sublingual spray, a patient may use a second dose as directed by their health care provider, with no more than two doses being used to treat any breakthrough pain episode. Again, patients must wait at least four hours before treating subsequent breakthrough pain e ...
psychiatric aspects of marihuana intoxication
psychiatric aspects of marihuana intoxication

... Marihuana has been known as a passport to euphoria since ancient times. It has fascinated men of imagination, and descriptions of its effects upon the mind and body have been given in popular and scientific literature countless times. The literature has been adequately considered by Walton (1) and b ...
Anti-Nicotine Vaccine: An Insight
Anti-Nicotine Vaccine: An Insight

... gaps and the brain.8,11 Thus, it increases the level of intracellular dopamine in the nucleus accumbens in the brain.5 This further inhibits the enzymatic catabolism of dopamine (Figure 1).11 The continued stimulation leads to tobacco dependence. Withdrawal from nicotine creates a decreased function ...
LMX4 SmPC SOP FPL21 Appendix version-3
LMX4 SmPC SOP FPL21 Appendix version-3

... if symptoms persist unaltered for more than seven days or clear up and occur again within only a few days, discontinue use of this product and consult a doctor. Do not use in large quantities, particularly over raw or blistered areas. LMX 4 contains propylene glycol which may cause skin irritation. ...
Information for patients and healthcare providers
Information for patients and healthcare providers

... normal functions; they are seen only after administration of large therapeutic doses of the drug. The pharmacological effects of prednisolone which are due to its glucocorticoid properties include: promotion of gluconeogenesis; increased deposition of glycogen in the liver; inhibition of the utiliza ...
Evaluating Steroid Inhalers Used to Treat: Asthma and
Evaluating Steroid Inhalers Used to Treat: Asthma and

... Important safety and risk issues have been raised in the last several years about the long-acting bronchodilators. Some studies have linked them to a higher risk of death during asthma attacks, although a cause and effect relationship has not yet been confirmed. For this reason, the FDA in November ...
Part I: Summary of Product Information
Part I: Summary of Product Information

... patient has a serious adverse reaction potentially related to this drug, the peginterferon alfa dose should be reduced or discontinued. Refer to the leaflet of peginterferon alfa for additional information about how to reduce and/or discontinue the peginterferon alfa dose . If a patient has a seriou ...
HIV Research Inventory
HIV Research Inventory

... lymphoma. On highly active antiretroviral therapy. Non- detectable viral load <50. ...
Curriculum - TARGET Center
Curriculum - TARGET Center

... abuse of pain relievers ranked second (after marijuana) among illicit drug use in the past year. Heroin ranked fifth. º National data, as well as clinical experience from a SPNS Buprenorphine Initiative grantee suggest that prescription opioid abuse may be proportional to the number of opioid presc ...
Update on Serotonin - Mayo Medical Laboratories
Update on Serotonin - Mayo Medical Laboratories

... removal of the offending agent(s). Once the inciting agent(s) has been removed, recovery is usually rapid. Other agents may be used to shorten the duration of symptoms, although most patients recover in 24 hours with supportive care alone. Prevention is the goal for this potentially serious disorder ...
HIGHLIGHTS OF PRESCRIBING INFORMATION
HIGHLIGHTS OF PRESCRIBING INFORMATION

... discontinued prior to starting therapy with VIEKIRA PAK [see Contraindications (4)]. Alternative methods of contraception (e.g, progestin only contraception or non-hormonal methods) are recommended during VIEKIRA PAK therapy. Ethinyl estradiol-containing medications can be restarted approximately 2 ...
Current and Potential Drugs for Treatment of Obesity
Current and Potential Drugs for Treatment of Obesity

... This section deals with the criteria for evaluating the efficacy of treatment for obesity. The initial criteria proposed after World War II were to estimate the amount of weight loss either in absolute terms or relative to initial weight. In any comparison the weight loss should be compared with a p ...
ASMANEX™ TWISTHALER™ PRODUCT MONOGRAPH
ASMANEX™ TWISTHALER™ PRODUCT MONOGRAPH

... Twisthaler® inhaler, it should be treated immediately with a fast-acting inhaled bronchodilator. Treatment with the ASMANEX® Twisthaler® inhaler should be discontinued and alternative therapy instituted. Special Populations Pregnant Women: There are no adequate and well-controlled studies in pregnan ...
Probenecid
Probenecid

... increments of 500 mg every four weeks, but usually not beyond 2000 mg daily, if symptoms of gouty arthritis are not controlled or the 24-hour urate excretion is not above 700 mg. In chronic renal insufficiency particularly when the glomerular filtration rate is 30 mL/minute or less probenecid may no ...
PRESCRIBING INFORMATION AND CONSUMER
PRESCRIBING INFORMATION AND CONSUMER

... The parenteral administration of hyoscine butylbromide, particularly of higher doses, has been reported to cause transient disturbances of accommodation which recede spontaneously. Therefore, patients should be cautioned about potential visual problems and the need to exercise care while driving or ...
Combined use of nonsteroidal anti-inflammatory drugs with diuretics
Combined use of nonsteroidal anti-inflammatory drugs with diuretics

... or older), the incidence of community-acquired AKI measured using laboratory data was 68/10,000 patient years, which was much higher than in previous studies in the general population relying on hospital discharge coding of AKI (0.25 to 7/10,000 patient years).4,5,7–9 Of those developing AKI in this ...
Multiple-Drug Toxicity Caused by the Coadministration of 4
Multiple-Drug Toxicity Caused by the Coadministration of 4

... Based on user experiences, the stimulant and euphoriant effects of mephedrone are comparable to drugs such as cocaine, ecstasy, and amphetamine (5). The most common routes of administration for mephedrone are oral and insufflation, although there have been some reports of intravenous and suppository ...
The use of antiviral drugs for influenza
The use of antiviral drugs for influenza

... 7. As treatment for persons with a high risk of morbidity and mortality who have not received the influenza vaccine for that influenza season. 8. For unvaccinated persons who provide care for people at high risk during an outbreak, until two weeks postvaccination of the caregiver. 9. As treatment fo ...
PRODUCT MONOGRAPH Cipralex Escitalopram Oxalate
PRODUCT MONOGRAPH Cipralex Escitalopram Oxalate

... Depression is associated with an increased risk of suicidal thoughts, self harm and suicide (suicide-related events). This risk persists until significant remission occurs. As improvement may not occur during the first few weeks or more of treatment, patients should be closely monitored until such i ...
Introduction
Introduction

... Once the values were confirmed to be normal, the patients were made to receive a first dose of 3 mg/kg/day of ranitidine by intravenous route. A sample of 0.5 mL of whole blood was extracted from each infant either at 0.5, 0.75, 1, 2, 4, or 8 hrs following drug administration. For ethical reasons, n ...
Kwartaalbericht
Kwartaalbericht

... PPIs can probably induce tongue discolouration due to their ability to decrease saliva production and increase the pH of the oral mucosa and therefore cause an altered microbial flora. Six cases of tongue discoloration were reported in association with PPIs, including one patient with a positive rec ...
Opiates and American Society
Opiates and American Society

... In 1996, he helped write a consensus statement stating that there was little risk of addiction or overdose in pain patients. ...
A Probable Case of Clarithromycin-Digoxin
A Probable Case of Clarithromycin-Digoxin

... the population converts up to 40% of a digoxin dose to DRPs.18 This population is at an increased risk for developing toxic digoxin levels when gastrointestinal flora are altered by antibiotic use.1 Clarithromycin-induced digoxin toxicity is not widely reported in the literature; however, several st ...
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Bad Pharma



Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.
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