NIH Public Access
... critical in therapies for anxiety disorders. We tested whether findings with respect to the Nmethyl-D-aspartate (NMDA) and cannabinoid receptor (CB) systems in animals carry over to healthy human subjects. To that end, we administered selected doses of D-cycloserine (partial NMDA receptor agonist, 2 ...
... critical in therapies for anxiety disorders. We tested whether findings with respect to the Nmethyl-D-aspartate (NMDA) and cannabinoid receptor (CB) systems in animals carry over to healthy human subjects. To that end, we administered selected doses of D-cycloserine (partial NMDA receptor agonist, 2 ...
... Abnormal hepatic function has been reported rarely and has been caused by both the oral and parenteral administration of tetracyclines, including doxycycline. Use in patients with renal impairment: Excretion of doxycycline by the kidney is about 40%/72 hours in individuals with normal renal function ...
RIVM rapport 370030002 Trends in drug substances detected in
... In order to survey the drug substances used in illegal weight-loss medicines and dietary supplements from 2002-2007, a database of suspect products was constructed based on the analyses of four Dutch laboratories. Each laboratory contributed suspect weight-loss products that had been brought in for ...
... In order to survey the drug substances used in illegal weight-loss medicines and dietary supplements from 2002-2007, a database of suspect products was constructed based on the analyses of four Dutch laboratories. Each laboratory contributed suspect weight-loss products that had been brought in for ...
Liposomal drug delivery systems: From concept to clinical applications
... the survival times of mice bearing L1210 leukemia [29,30], and this became a popular ‘model system’ for testing the effects of a wide variety of liposome characteristics on therapeutic outcomes. Other liposomal small molecule therapeutics were also being tested in vivo, with improvements in disease ...
... the survival times of mice bearing L1210 leukemia [29,30], and this became a popular ‘model system’ for testing the effects of a wide variety of liposome characteristics on therapeutic outcomes. Other liposomal small molecule therapeutics were also being tested in vivo, with improvements in disease ...
A Retrospective Study of Buprenorphine and
... It has been suggested that at least one of the major routes of drug incorporation into hair is via distribution from plasma into growing hair cells (1,2). Recent data from Kuhlman et al. (32) demonstrated that NBPR accumulates in plasma after chronic administration of BPR and that the plasma concent ...
... It has been suggested that at least one of the major routes of drug incorporation into hair is via distribution from plasma into growing hair cells (1,2). Recent data from Kuhlman et al. (32) demonstrated that NBPR accumulates in plasma after chronic administration of BPR and that the plasma concent ...
Submission Guidelines for the CADTH Common Drug Review
... applications for the review of submissions and resubmissions for drugs through the CADTH Common Drug Review (CDR) process. The Submission Guidelines for the CADTH Common Drug Review is a companion document to the Procedure for the CADTH Common Drug Review, a document that describes CDR procedures to ...
... applications for the review of submissions and resubmissions for drugs through the CADTH Common Drug Review (CDR) process. The Submission Guidelines for the CADTH Common Drug Review is a companion document to the Procedure for the CADTH Common Drug Review, a document that describes CDR procedures to ...
consumer medicine information
... No evidence of teratogenicity or embryotoxicity was observed when erythromycin base was given by oral gavage to pregnant rats and mice at 700 mg/kg/day (approximately 9 times the maximum human dose), and to pregnant rabbits at 125 mg/kg/day (approximately 1.5 times the maximum human dose). A slight ...
... No evidence of teratogenicity or embryotoxicity was observed when erythromycin base was given by oral gavage to pregnant rats and mice at 700 mg/kg/day (approximately 9 times the maximum human dose), and to pregnant rabbits at 125 mg/kg/day (approximately 1.5 times the maximum human dose). A slight ...
Pain Management - Pain Medications and Over-The
... Pain is an unpleasant sensation in animals that is caused by actual or perceived injury to body tissues and produces physical and emotional reactions. Presumably, pain sensation has evolved to protect our bodies from harm by causing us to perform certain actions and avoid others. Pain might be calle ...
... Pain is an unpleasant sensation in animals that is caused by actual or perceived injury to body tissues and produces physical and emotional reactions. Presumably, pain sensation has evolved to protect our bodies from harm by causing us to perform certain actions and avoid others. Pain might be calle ...
Tamsulosin and dry mouth Introduction Reports
... seven days. This is in accordance with the proposed mechanism. Of the six cases three had a positive dechallenge and one patient continued the medication and did not recover. One patient had a positive rechallenge. Various studies report dry mouth as the adverse reaction most frequently seen in pati ...
... seven days. This is in accordance with the proposed mechanism. Of the six cases three had a positive dechallenge and one patient continued the medication and did not recover. One patient had a positive rechallenge. Various studies report dry mouth as the adverse reaction most frequently seen in pati ...
CMS Manual System Pub 100-04 Medicare Claims Processing
... a bypass of the ESRD PPS consolidated billing requirements for ESRD-related laboratory services furnished to ESRD patients in an emergency room or emergency department on the same date of service as the emergency visit. Subsequent to the issuance of CR 7471, CMS found that there are situations wher ...
... a bypass of the ESRD PPS consolidated billing requirements for ESRD-related laboratory services furnished to ESRD patients in an emergency room or emergency department on the same date of service as the emergency visit. Subsequent to the issuance of CR 7471, CMS found that there are situations wher ...
Pulmonary Drug Absorption
... of the respiratory tract in rats in vivo. The high pulmonary bioavailability of the efflux transporter substrates losartan and talinolol provides functional evidence for an insignificant role of efflux transporters such as P-glycoprotein in limiting the absorption of these drugs from the rat lung. T ...
... of the respiratory tract in rats in vivo. The high pulmonary bioavailability of the efflux transporter substrates losartan and talinolol provides functional evidence for an insignificant role of efflux transporters such as P-glycoprotein in limiting the absorption of these drugs from the rat lung. T ...
EASL Recommendations on Treatment of Hepatitis C 2015
... genotypes 2 (12 weeks) or 3 (24 weeks), yielding SVR rates of the order of 80–95%. The IFN-free combination of sofosbuvir and simeprevir, with or without ribavirin, was used based on the results of the small-size Phase II COSMOS study in patients infected with genotype 1 who achieved SVR in 93–100% ...
... genotypes 2 (12 weeks) or 3 (24 weeks), yielding SVR rates of the order of 80–95%. The IFN-free combination of sofosbuvir and simeprevir, with or without ribavirin, was used based on the results of the small-size Phase II COSMOS study in patients infected with genotype 1 who achieved SVR in 93–100% ...
SEVREDOL tablets
... SEVREDOL tablets should be given every four hours. The dosage is dependent upon the nature and severity of the pain, the patient's condition and their previous history of analgesic therapy. A patient initially presenting with severe and intractable pain will normally be started on SEVREDOL 10 mg eve ...
... SEVREDOL tablets should be given every four hours. The dosage is dependent upon the nature and severity of the pain, the patient's condition and their previous history of analgesic therapy. A patient initially presenting with severe and intractable pain will normally be started on SEVREDOL 10 mg eve ...
Effects of ciclesonide and fluticasone on cortisol secretion in patients with
... persistent asthma for .6 months, as defined by the Global Initiative for Asthma, were allowed to participate in the study. Patients were included if their current treatment consisted of a constant dose of a moderate-to-high daily dosage of ICS alone (beclomethasone dipropionate f1,000 mg?day-1 or eq ...
... persistent asthma for .6 months, as defined by the Global Initiative for Asthma, were allowed to participate in the study. Patients were included if their current treatment consisted of a constant dose of a moderate-to-high daily dosage of ICS alone (beclomethasone dipropionate f1,000 mg?day-1 or eq ...
Professional Competencies for Canadian Pharmacy Technicians at
... distribution, and use of medications. Pharmacists will play an increasingly important role in medication management, spending more time managing drug therapy issues and monitoring drug therapy outcomes in collaboration with patients, caregivers, physicians, and other health care providers. The Canad ...
... distribution, and use of medications. Pharmacists will play an increasingly important role in medication management, spending more time managing drug therapy issues and monitoring drug therapy outcomes in collaboration with patients, caregivers, physicians, and other health care providers. The Canad ...
tWallace B. Mendelson, tHerbert Weingartner
... The indications for prescribing them are uncertain, and the nature and nosology of the disorder for which they are most commonly prescribed-insomnia-are unclear. The relative benefits and liabilities of the various available hypnotics have not been well established. It is generally agreed that benzo ...
... The indications for prescribing them are uncertain, and the nature and nosology of the disorder for which they are most commonly prescribed-insomnia-are unclear. The relative benefits and liabilities of the various available hypnotics have not been well established. It is generally agreed that benzo ...
LDN August Newsletter
... approximately 4.5 mg a day. Over time, in some patients LDN is being used.. LDN helps significantly relieve symptoms. For some patients, there is a measurable drop in antibodies along with the The challenge is that many doctors are not aware of the offsymptom relief. In a few cases, patients' antibo ...
... approximately 4.5 mg a day. Over time, in some patients LDN is being used.. LDN helps significantly relieve symptoms. For some patients, there is a measurable drop in antibodies along with the The challenge is that many doctors are not aware of the offsymptom relief. In a few cases, patients' antibo ...
Treatment of Narcolepsy with Methamphetamine
... (Abbott Laboratories). Tablets were fractured and placed in unmarked, opaque gelatin capsules, surDesign and protocol rounded by powdered sucrose. Placebo capsules conThe study used a four-condition, double-blind, ran- tained only powdered sucrose. During the placebo and domized crossover design. Su ...
... (Abbott Laboratories). Tablets were fractured and placed in unmarked, opaque gelatin capsules, surDesign and protocol rounded by powdered sucrose. Placebo capsules conThe study used a four-condition, double-blind, ran- tained only powdered sucrose. During the placebo and domized crossover design. Su ...
- Seminars in Nephrology
... antihypertensive treatment in pregnant women. Our practice is to initiate treatment when blood pressure is 150 systolic or greater or 90 to 100 mm Hg diastolic. Other clinicians may wait until diastolic BPs reach 100 mm Hg before treating. One should note that in the presence of any signs of end-org ...
... antihypertensive treatment in pregnant women. Our practice is to initiate treatment when blood pressure is 150 systolic or greater or 90 to 100 mm Hg diastolic. Other clinicians may wait until diastolic BPs reach 100 mm Hg before treating. One should note that in the presence of any signs of end-org ...
Oral Cyclophosphamide Confounds the Relationship between
... women the risk of premature ovarian failure (POF) is high due to the already diminished primary follicles. In an attempt to balance the need to induce remission, while limiting drug toxicity intravenous cyclophosphamide is administered as monthly pulse doses. However pulse dosing still poses a consi ...
... women the risk of premature ovarian failure (POF) is high due to the already diminished primary follicles. In an attempt to balance the need to induce remission, while limiting drug toxicity intravenous cyclophosphamide is administered as monthly pulse doses. However pulse dosing still poses a consi ...
Rational Pharmacology
... ulcer, duodenal ulcer after selective proximal vagotomy, and nonspecific abdominal pain). The frequency of increased plasma histamine levels was between 19% and 28%, the highest occurrence rate being observed in the group with esophageal varices. The highest plasma histamine concentration was 6 ng/m ...
... ulcer, duodenal ulcer after selective proximal vagotomy, and nonspecific abdominal pain). The frequency of increased plasma histamine levels was between 19% and 28%, the highest occurrence rate being observed in the group with esophageal varices. The highest plasma histamine concentration was 6 ng/m ...
Guidelines for warfarin management in the community
... The CHADS2 scoring system (Gage et al. 2001) is a simple system that can be used to assess the annual risk of stroke in AF. In the CHADS2 scoring system (see Table 2) each point increases the annual risk of stroke by a factor of 1.5. Treatment with warfarin is recommended for a CHADS2 or CHA2DS2VASc ...
... The CHADS2 scoring system (Gage et al. 2001) is a simple system that can be used to assess the annual risk of stroke in AF. In the CHADS2 scoring system (see Table 2) each point increases the annual risk of stroke by a factor of 1.5. Treatment with warfarin is recommended for a CHADS2 or CHA2DS2VASc ...
Technical considerations for pen injectors
... relevant when developing a pen, jet, or related injector regardless of the regulatory provisions that apply (i.e., device, drug, or biological product provisions). It provides considerations applicable to a general use injector and to an injector intended for a product class, product line, or a spec ...
... relevant when developing a pen, jet, or related injector regardless of the regulatory provisions that apply (i.e., device, drug, or biological product provisions). It provides considerations applicable to a general use injector and to an injector intended for a product class, product line, or a spec ...
Full-Text - Academic Journals
... extract that has a greater affinity with hemin maintains more hemin in solution and is thus more effective. This ...
... extract that has a greater affinity with hemin maintains more hemin in solution and is thus more effective. This ...
NOACs in NVAF
... CHADS2 = congestive heart failure, hypertension, age, diabetes, prior stroke or TIA; CHF = congestive heart failure; CNS = ...
... CHADS2 = congestive heart failure, hypertension, age, diabetes, prior stroke or TIA; CHF = congestive heart failure; CNS = ...
Bad Pharma
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Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.