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Potential for methotrexate exposure through contamination during
Potential for methotrexate exposure through contamination during

... the 24-h period. This is 500 times below the recommended serum concentration for which folinic acid supplementation is recommended. There was also no significant increase in homocysteine level to suggest MTX toxicity. The only adverse effects were mild local dermal reactions in three female voluntee ...
Critical Management of Status Epilepticus
Critical Management of Status Epilepticus

... lorazepam (0.1 mg/kg) becoming a clear drug of choice for initial treatment of SE [7]. Phenytoin (PHT), valproic acid (VPA), or levetiracetam (LEV) are commonly used as second-line treatment of status epilepticus (SE), but comparative studies are not available. Our protocol to treat SE starts with i ...
Herbal Remedies: The Design of a New Course in Pharmacy
Herbal Remedies: The Design of a New Course in Pharmacy

... need for training our students in the area of herbal remedies but also the positive impact that this training will have on pharmaceutical care practice well into the 21st century. The idea for designing this new course originated following a continuing education program, entitled “The Risks of Herba ...
nitropress
nitropress

... reported at levels from 300 to 3000 µmol/L (8–80 mg/L). Put another way, a patient with a normal red-cell mass (35 mL/kg) and normal methemoglobin levels can buffer about 175 mcg/kg of CN¯, corresponding to a little less than 500 mcg/kg of infused sodium nitroprusside. Some cyanide is eliminated fro ...
SCIENTIFIC DISCUSSION 1. Introduction Fungal infections have
SCIENTIFIC DISCUSSION 1. Introduction Fungal infections have

... Stability of the Product before first opening Chemical and physical stability-indicating parameters were tested. Under long-term conditions (25ºC/60% R.H. - packaging intended for commercialisation – upright and inverted position), 2-year data are available. Up to 6-month data under accelerated cond ...
Spiractin - Medicines.org.au
Spiractin - Medicines.org.au

... In animal studies, spironolactone was devoid of teratogenic effects in mice and rabbits at oral doses up to 20mg/kg/day, and in rats at dietary doses up to 50 mg/kg/day. However, increased resorption rate was seen at 20 mg/kg/day in rabbits, and the incidence of stillbirths was increased in rats dos ...
PRODUCT MONOGRAPH Pr CILOXAN® 0.3% Ciprofloxacin
PRODUCT MONOGRAPH Pr CILOXAN® 0.3% Ciprofloxacin

... Anaphylactic reactions following the first dose, have been reported in patients receiving therapy with quinolones by systemic administration. Some reactions were accompanied by cardiovascular collapse, loss of consciousness, tingling, pharyngeal or facial edema, dyspnea, urticaria, and itching. Only ...
DRUG INTERACTIONS WITH INTEGRASE INHIBITORS
DRUG INTERACTIONS WITH INTEGRASE INHIBITORS

... for 5 days followed by DTG 50 mg and efavirenz 600 mg QD for 14 days. In the presence of efavirenz, DTG AUC ↓ 57%, Cmax ↓ 39% and Ctrough ↓ 75%, likely via enzyme induction of UGT1A1 and CYP3A4. Dolutegravir concentrations remained 4-5 fold higher than the protein27 adjusted IC90 for WT virus. A dos ...
Doctoral Thesis
Doctoral Thesis

... very optimistic without justification that bacterial infections were controlled sufficiently and they would be eradicated. Unhappily, the inappropriate use of antibiotics and chemotherapeutics was very frequent. During next years, many bacterial species have developed a resistance to widely applied ...
Protective Effects of Aqueous and Alcoholic Extracts of Piper longum
Protective Effects of Aqueous and Alcoholic Extracts of Piper longum

... of Piper longum root is used after birth to induce expulsion of the placenta [2]. The whole plants as well as plant parts such as the fruit are used traditionally. This plant is inexpensive, readily available, and effective for many diseases, including cancer, inflammation, depression, diabetes, obe ...
PRODUCT INFORMATION MS Contin® modified release tablets 5
PRODUCT INFORMATION MS Contin® modified release tablets 5

... In the absence of a clear indication for a strong opioid analgesic, drug-seeking behaviour must be suspected and resisted, particularly in individuals with a history of, or propensity for, drug abuse. Withdrawal symptoms may occur following abrupt discontinuation of morphine therapy or upon adminis ...
NIDA for Teens Ecstasy Quiz
NIDA for Teens Ecstasy Quiz

... Quiz: MDMA (Ecstasy) These materials are produced by the National Institute on Drug Abuse, National Institutes of Health, U.S. Department of Health and Human Services. They are in the public domain and may be reproduced without permission. Citation of the source is appreciated. Instructions: After r ...
Hair Analysis for Cocaine: The Requirement for Effective Wash
Hair Analysis for Cocaine: The Requirement for Effective Wash

... light drug user might be interpreted as negative due to aggressive washing, this outcome is greatly preferred to false positives and erroneous quantitations that must result from inadequate washing methods. A problem that some laboratories may have experienced is the use of ineffective methods for e ...
Comparing Inhaled Corticosteroids
Comparing Inhaled Corticosteroids

... related to a decrease in airway inflammation.13 The longterm use of inhaled corticosteroids has been shown to reduce both airway inflammation and secondary airway remodeling.14 The fundamentally important role of inhaled corticosteroids in treating asthma has been demonstrated by several studies, wh ...
PGY1 - ASHP Media
PGY1 - ASHP Media

... Programs. Users of this document will want to refer to the accompanying glossary to assure a shared understanding of terms. The order in which the required educational outcomes is presented in this document does not suggest relative importance of the outcome, amount of time that should be devoted to ...
Nancy Caroline`s Emergency Care in the Streets, Seventh Edition
Nancy Caroline`s Emergency Care in the Streets, Seventh Edition

... 2. Use appropriate terminology related to pharmacology. (pp 546-548) 3. List the components of a drug profile. (pp 546-548) 4. Identify airway management medications used by the paramedic, including indications, contraindications, dosages, adverse reactions and side effects, and interactions. (pp 54 ...
Poonam et al - Galaxy of Pharmaceutical Innovations
Poonam et al - Galaxy of Pharmaceutical Innovations

... the bad taste. For example, sweeteners could not achieve taste masking of oral formulation of ibuprofen due to its dominating taste. Coating is more efficient technology for aggressively bitter drugs even though coating imperfections, if present, reduce the efficiency of the technique9. Similarly, m ...
Traumeel Zeel Injection Booklet
Traumeel Zeel Injection Booklet

... 2 Orlandini, A., Rossi, M., Setti, M., The Effectiveness of Zeel® Injection Solution and new Research Methods in Rheumatology. Biologische Medizin. Vol. 26 (4) 1997, 164-165. ...
Diagnosis, Prevention and Management of Statin Adverse Effects
Diagnosis, Prevention and Management of Statin Adverse Effects

... of adverse effects, when is re-challenge/de-challenge with the same statin inappropriate or futile? • Patient refuses to re-try the same drug, even at a lower daily dose or intermittently. • Symptoms are significant, convincing, plausible and typical of statin side effects (mainly myalgia) and have ...
Adverse effects and Drug Interactions Associated with Inhaled
Adverse effects and Drug Interactions Associated with Inhaled

... animal models has shown that prolonged use of marijuana may lead to physical dependence and a withdrawal syndrome upon discontinuation. Several mechanisms are thought to play a part in the drug reward system, and the resulting cannabis abuse or dependence. There are two types of cannabinoid receptor ...
Stroke Prevention in Atrial Fibrillation (SPAF): Pocket Reference
Stroke Prevention in Atrial Fibrillation (SPAF): Pocket Reference

... self-limited AF associated with an acute illness or secondary cause. It is intended only as a general reference to supplement the existing ...
Antipsychotic Drugs - Pharmacological Reviews
Antipsychotic Drugs - Pharmacological Reviews

... the treatment of schizophrenia (Creese et al., 1976; Seeman et al., 1976). No such correlation of the daily dose was seen with the potencies of the drugs at other receptors, including D1 dopamine receptors. These observations were made before the identification of multiple dopamine receptor subtypes ...
The poster sessions are an important highlight of these conferences
The poster sessions are an important highlight of these conferences

... Abstract: DS is a multi-targeted TKI of BCR ABL and SRC w. significant activity in pts with CML CP resistant or intolerant of IM. Phase II trial to study efficacy and safety of DS in pts with previously untreated CML CP Methods: Preliminary objective was to estimate the proportion of pts attaining ...
Docetaxel in non-small cell lung cancer
Docetaxel in non-small cell lung cancer

... gemcitabine at 1000 mg/m2 days 1 and 8 [23]. This regimen has been studied in three Phase III trials compared with platinum doublets. Docetaxel/vinorelbine association has a significant toxicity and especially high hematological toxicity, despite the use of prophylactic granulocyte colony-stimulatin ...
Infusion reactions associated with use of biologic
Infusion reactions associated with use of biologic

... doi:10.5348/OCY-2014-6-RA-2 ...
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Bad Pharma



Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.
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