Desmopressin Acetate Nasal Spray, 10 mcg per 0.1 mL
... duration of sleep and adequate, not excessive, water turnover. Patients with nasal congestion and blockage have often responded well to intranasal Desmopressin Acetate. The usual dosage range in adults is 0.1 mL (10 mcg) to 0.4 mL (40 mcg) daily, either as a single dose or divided into two or three ...
... duration of sleep and adequate, not excessive, water turnover. Patients with nasal congestion and blockage have often responded well to intranasal Desmopressin Acetate. The usual dosage range in adults is 0.1 mL (10 mcg) to 0.4 mL (40 mcg) daily, either as a single dose or divided into two or three ...
Comparison of Four-Drug Regimens and Pairs of Sequential Three
... managed with the use of the permitted drug substitutions (stavudine for zidovudine or lamivudine for didanosine), reductions in the doses, or the temporary discontinuation of the use of a drug.6,8 Peripheral neuropathy was assessed on the basis of a constellation of moderately severe symptoms (of gr ...
... managed with the use of the permitted drug substitutions (stavudine for zidovudine or lamivudine for didanosine), reductions in the doses, or the temporary discontinuation of the use of a drug.6,8 Peripheral neuropathy was assessed on the basis of a constellation of moderately severe symptoms (of gr ...
10 Rocuronium for Tracheal Intubation
... Time to 90 and 100% block was not significantly different between succinylcholine (30+7 seconds) and 1.2 mg/kg of rocuronium (33+5 seconds); both were significantly less than the 0.8 mg/kg group (46+8 seconds). Time to 25% recovery from 1.2 mg/kg of rocuronium was nearly 8 times longer than after su ...
... Time to 90 and 100% block was not significantly different between succinylcholine (30+7 seconds) and 1.2 mg/kg of rocuronium (33+5 seconds); both were significantly less than the 0.8 mg/kg group (46+8 seconds). Time to 25% recovery from 1.2 mg/kg of rocuronium was nearly 8 times longer than after su ...
(Dihydroergotamine mesylate) Nasal Spray 4 mg/mL
... Pharmacokinetic interactions have been reported in patients treated orally with other ergot alkaloids (e.g., increased levels of ergotamine) and macrolide antibiotics, principally troleandomycin, presumably due to inhibition of cytochrome P4503A metabolism of the alkaloids by troleandomycin. Dihydro ...
... Pharmacokinetic interactions have been reported in patients treated orally with other ergot alkaloids (e.g., increased levels of ergotamine) and macrolide antibiotics, principally troleandomycin, presumably due to inhibition of cytochrome P4503A metabolism of the alkaloids by troleandomycin. Dihydro ...
Adenosine Injection, USP
... Clinical studies of injected adenosine did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between elderly and younger patients. In general, ...
... Clinical studies of injected adenosine did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between elderly and younger patients. In general, ...
Official topic from UpToDate®, the clinical information service on the
... with severe exacerbations and increased mortality is illustrated by the following studies: In a randomized trial, more than 25,000 patients with asthma were assigned to receive the longacting beta agonist, salmeterol, or the short-acting beta agonist, albuterol [11]. There was a nonstatistically sig ...
... with severe exacerbations and increased mortality is illustrated by the following studies: In a randomized trial, more than 25,000 patients with asthma were assigned to receive the longacting beta agonist, salmeterol, or the short-acting beta agonist, albuterol [11]. There was a nonstatistically sig ...
The Strange Case of Strontium Ecklonia Cava Extract
... (KLS) in a mouse model of allergen-induced chronic lung inflammation and fibrosis. BALB/c mice, after intraperitoneal antigen sensitization on day 0 and day 14, were given weekly intranasal inhalations of antigen from day 1460. The antigen-treated and challenged mice developed an extensive eosinophi ...
... (KLS) in a mouse model of allergen-induced chronic lung inflammation and fibrosis. BALB/c mice, after intraperitoneal antigen sensitization on day 0 and day 14, were given weekly intranasal inhalations of antigen from day 1460. The antigen-treated and challenged mice developed an extensive eosinophi ...
Oral terbinafine and erectile dysfunction
... Lareb received seven reports of erectile dysfunction associated with the use of terbinafine, with positive dechallenges reported in four of them and a positive rechallenge in one patient. Latencies ranged from several hours to approximately four months. Since erectile dysfunction can have several ca ...
... Lareb received seven reports of erectile dysfunction associated with the use of terbinafine, with positive dechallenges reported in four of them and a positive rechallenge in one patient. Latencies ranged from several hours to approximately four months. Since erectile dysfunction can have several ca ...
Evaluation of the efficacy of albendazole sulphoxide and
... The morphological alterations on the parasites of T. crassiceps after the different drug treatments were observed by light microscopy. We found that the control cysts remained unaltered during the experiment, showing the classical movements and normal appearance. The first effects of the treatment w ...
... The morphological alterations on the parasites of T. crassiceps after the different drug treatments were observed by light microscopy. We found that the control cysts remained unaltered during the experiment, showing the classical movements and normal appearance. The first effects of the treatment w ...
Volume 13.4
... Administration (FDA) was born, having originally been the US Department of Agriculture Bureau of Chemistry, then the Food, Drug and Insecticide Administration and finally the FDA. The FDA can enforce the standards established by the USP for the pharmaceutical industry or the standards it develops. T ...
... Administration (FDA) was born, having originally been the US Department of Agriculture Bureau of Chemistry, then the Food, Drug and Insecticide Administration and finally the FDA. The FDA can enforce the standards established by the USP for the pharmaceutical industry or the standards it develops. T ...
Cannabidiol: Pharmacology and potential therapeutic role
... useful. It is of small value as an adjunct to bromide, but is sometimes of considerable service given separately. It may be noted that the action of Indian hemp presents many points of resemblance to that of belladonna; it is capable of causing also delirium and sleep, first depression and then acce ...
... useful. It is of small value as an adjunct to bromide, but is sometimes of considerable service given separately. It may be noted that the action of Indian hemp presents many points of resemblance to that of belladonna; it is capable of causing also delirium and sleep, first depression and then acce ...
Interchangeability and study design
... Bioavailability means the rate and extent to which the active substance or therapeutic moiety is absorbed from a pharmaceutical form and becomes available at the site of action. ...
... Bioavailability means the rate and extent to which the active substance or therapeutic moiety is absorbed from a pharmaceutical form and becomes available at the site of action. ...
Tenofovir disoproxil fumarate / Emtricitabine
... Gender: Tenofovir and emtricitabine pharmacokinetics are similar in male and female patients. Patients with Impaired Renal Function: The pharmacokinetics of tenofovir and emtricitabine are altered in subjects with renal impairment (See PRECAUTIONS, Renal Impairment). In subjects with creatinine clea ...
... Gender: Tenofovir and emtricitabine pharmacokinetics are similar in male and female patients. Patients with Impaired Renal Function: The pharmacokinetics of tenofovir and emtricitabine are altered in subjects with renal impairment (See PRECAUTIONS, Renal Impairment). In subjects with creatinine clea ...
7 Data required for the NOPSAD collection-
... The National Opioid Pharmacotherapy Statistics Annual Data (NOPSAD) collection is an administrative by-product collection (that is, secondary use). Data are collated in each jurisdiction from information already collected for the purposes of administering or providing a service (that is, primary use ...
... The National Opioid Pharmacotherapy Statistics Annual Data (NOPSAD) collection is an administrative by-product collection (that is, secondary use). Data are collated in each jurisdiction from information already collected for the purposes of administering or providing a service (that is, primary use ...
Nies_ArchToxicol_Jul2016 - U-PGx
... C57BL/6J genome build 37 and resulted in frame-shift errors. Of note, the so-called murine Mate2 proteins described by an independent research group are more closely related to human MATE1 than to human MATE2/2K. As previously suggested (Hiasa et al. 2007; Yonezawa and Inui 2011b), it would be reaso ...
... C57BL/6J genome build 37 and resulted in frame-shift errors. Of note, the so-called murine Mate2 proteins described by an independent research group are more closely related to human MATE1 than to human MATE2/2K. As previously suggested (Hiasa et al. 2007; Yonezawa and Inui 2011b), it would be reaso ...
Fexofast Presentation
... effect within 2 to 4 hours and lasting a minimum of 12 hours. There was no evidence of tolerance to these effects after 28 days of dosing. In dose ranging studies, fexofenadine hydrochloride was shown to relieve the symptoms of seasonal allergic rhinitis, significantly reducing total symptom scores ...
... effect within 2 to 4 hours and lasting a minimum of 12 hours. There was no evidence of tolerance to these effects after 28 days of dosing. In dose ranging studies, fexofenadine hydrochloride was shown to relieve the symptoms of seasonal allergic rhinitis, significantly reducing total symptom scores ...
(1) - PhUSE Wiki
... Due to the normal variance between different populations, multiple researchers using different groups of subjects have derived different formulas even when fitting their respective data to the same mathematical function. The most commonly used historical population-based correction formulae were pro ...
... Due to the normal variance between different populations, multiple researchers using different groups of subjects have derived different formulas even when fitting their respective data to the same mathematical function. The most commonly used historical population-based correction formulae were pro ...
12 Fluconazole – A Review of Its Use in Children
... intravenous dosage forms. The bioavailability of the oral dosage forms is estimated to be greater than 90%. After oral administration, fluconazole serum concentrations peak within 1 to 2 hours. Fluconazole is widely distributed throughout the body, including the central nervous system. It is only 10 ...
... intravenous dosage forms. The bioavailability of the oral dosage forms is estimated to be greater than 90%. After oral administration, fluconazole serum concentrations peak within 1 to 2 hours. Fluconazole is widely distributed throughout the body, including the central nervous system. It is only 10 ...
11 The Use of Melatonin in Children with Sleep Disturbances
... discontinued therapy without the return of insomnia. In one child, melatonin was stopped due to lack of effect. One child developed generalized epilepsy 4 months into the study, but causality with melatonin was not suggested. Later that year, Dodge and Wilson published an additional randomized, doub ...
... discontinued therapy without the return of insomnia. In one child, melatonin was stopped due to lack of effect. One child developed generalized epilepsy 4 months into the study, but causality with melatonin was not suggested. Later that year, Dodge and Wilson published an additional randomized, doub ...
2015.06.25_Vancomycin DS
... Renal dysfunction slows excretion of vancomycin. In anephric patients, the average half-life of elimination is 7.5 days. The distribution coefficient is from 0.3 to 0.69 L/kg. There is no apparent metabolism of the drug. Vancomycin is not effectively removed by either haemodialysis or peritoneal dia ...
... Renal dysfunction slows excretion of vancomycin. In anephric patients, the average half-life of elimination is 7.5 days. The distribution coefficient is from 0.3 to 0.69 L/kg. There is no apparent metabolism of the drug. Vancomycin is not effectively removed by either haemodialysis or peritoneal dia ...
Targeted Tuberculin Testing and Treatment of Latent Tuberculosis Infection
... recommendation (A, B, or C) and the quality of evidence supporting the recommendation (I, II, or III). Four regimens are recommended for the treatment of adults with LTBI. (See Tables 8 and 10 for detailed recommendations, dosages, and contraindications.) ...
... recommendation (A, B, or C) and the quality of evidence supporting the recommendation (I, II, or III). Four regimens are recommended for the treatment of adults with LTBI. (See Tables 8 and 10 for detailed recommendations, dosages, and contraindications.) ...
product monograph isoptin sr
... Because of the drug’s negative inotropic effect, ISOPTIN® SR should not be used in patients with poorly compensated congestive heart failure. Heart failure patients with ejection fraction higher than 40% should be treated with adequate doses of digoxin and/or diuretics before starting ISOPTIN® SR tr ...
... Because of the drug’s negative inotropic effect, ISOPTIN® SR should not be used in patients with poorly compensated congestive heart failure. Heart failure patients with ejection fraction higher than 40% should be treated with adequate doses of digoxin and/or diuretics before starting ISOPTIN® SR tr ...
Stability considerations in liquid dosage forms extemporaneously
... milligrams per kilogram of body weight and most children under six years of age cannot swallow tablets (15, 16). A survey (14) into the informational needs of hospital compounding pharmacists providing pharmaceutical care to paediatric patients at 57 sites in the USA and Canada listed 76 extemporane ...
... milligrams per kilogram of body weight and most children under six years of age cannot swallow tablets (15, 16). A survey (14) into the informational needs of hospital compounding pharmacists providing pharmaceutical care to paediatric patients at 57 sites in the USA and Canada listed 76 extemporane ...
Lithium Carbonate Extended-Release Tablets 300mg
... Concurrent use of calcium channel blocking agents with lithium may increase the risk of neurotoxicity in the form of ataxia, tremors, nausea, vomiting, diarrhea, and/or tinnitus. Concurrent use of metronidazole with lithium may provoke lithium toxicity due to reduced renal clearance. Patients receiv ...
... Concurrent use of calcium channel blocking agents with lithium may increase the risk of neurotoxicity in the form of ataxia, tremors, nausea, vomiting, diarrhea, and/or tinnitus. Concurrent use of metronidazole with lithium may provoke lithium toxicity due to reduced renal clearance. Patients receiv ...
Bad Pharma
.JPG?width=300)
Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.