EFNS guidelines on management of narcolepsy
... At low doses the main effect of amphetamine is to release dopamine and to a lesser extent norepinephrine and serotonine. At higher doses monoaminergic depletion and inhibition of reuptake occurs. The D-isomer of amphetamine is more specific for dopaminergic transmission and is a better stimulant compo ...
... At low doses the main effect of amphetamine is to release dopamine and to a lesser extent norepinephrine and serotonine. At higher doses monoaminergic depletion and inhibition of reuptake occurs. The D-isomer of amphetamine is more specific for dopaminergic transmission and is a better stimulant compo ...
Ro 11-2465 (cyan-imipramine), citalopram and their N
... should be regarded as an important argument for the NAergic hylW_thcsis of depression (Schildkraut 1t)65; Schildkraut and Kety 1967) rather than an argument for the 5-HT-ergicone. Literature data show that dcsmcthylcitalopram (D('IT), which is the main metabolite of C'lT in rats, mice, monkeys and i ...
... should be regarded as an important argument for the NAergic hylW_thcsis of depression (Schildkraut 1t)65; Schildkraut and Kety 1967) rather than an argument for the 5-HT-ergicone. Literature data show that dcsmcthylcitalopram (D('IT), which is the main metabolite of C'lT in rats, mice, monkeys and i ...
P r a c t i c a l M... L e u k e m i a R e...
... During the phase I study, a maximum daily dose of 1,000 mg was reached and there was no convincing dose-limiting toxicity. However, 11 of the 13 grade 3 toxicities with a suspected causal relationship to imatinib occurred at doses greater than 750 mg per day.6,7 In addition, at daily doses greater t ...
... During the phase I study, a maximum daily dose of 1,000 mg was reached and there was no convincing dose-limiting toxicity. However, 11 of the 13 grade 3 toxicities with a suspected causal relationship to imatinib occurred at doses greater than 750 mg per day.6,7 In addition, at daily doses greater t ...
ASCO 2011 NKTR-102 PopPK Poster
... proprietary polymer conjugation to improve the PK of its active metabolite SN38 resulting in significantly reduced Cmax and sustained exposure throughout the dosing interval. Methods: NKTR-102 was administered as a 90-min IV inf. to 94 pts: 76 pts at 58-245 mg/m2 wx3q4w, q14d or q21d, and 18 pts at ...
... proprietary polymer conjugation to improve the PK of its active metabolite SN38 resulting in significantly reduced Cmax and sustained exposure throughout the dosing interval. Methods: NKTR-102 was administered as a 90-min IV inf. to 94 pts: 76 pts at 58-245 mg/m2 wx3q4w, q14d or q21d, and 18 pts at ...
DOXYCYCLINE CAPSULES, USP
... Clostridium difficile associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including doxycycline, and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C. d ...
... Clostridium difficile associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including doxycycline, and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C. d ...
Simvastatin Decreased Coenzyme Q in the Left Ventricle and
... synthase (NOS) activity induced by L-NAME in the brain and kidney but not in the LV (Šimko et al. 2004). It may be supposed that decreased NOS activity in the LV with presumed reduction of NO synthesis and attenuated vasodilatative ability of coronary arteries may increase the oxidative stress in th ...
... synthase (NOS) activity induced by L-NAME in the brain and kidney but not in the LV (Šimko et al. 2004). It may be supposed that decreased NOS activity in the LV with presumed reduction of NO synthesis and attenuated vasodilatative ability of coronary arteries may increase the oxidative stress in th ...
development and validation of analytical methods for the
... Analytical method development on Prednisolone shall be carried out in collabration with M/s STRIDES ARCO LABS PVT LIMITED (Analytical service department). The analytical methods will be developed by using instruments like UV visible spectrometer, HPLC, and HPTLC. The data so obtained is treated stat ...
... Analytical method development on Prednisolone shall be carried out in collabration with M/s STRIDES ARCO LABS PVT LIMITED (Analytical service department). The analytical methods will be developed by using instruments like UV visible spectrometer, HPLC, and HPTLC. The data so obtained is treated stat ...
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... are a major challenge for clinical medicine and drug discovery. Pathology is the result of multiple factors, which include environmental, genetic, and epigenetic imbalance in excitatory or inhibitory neurotransmission and alteration in modulatory neurotransmitter pathways (e.g., dopaminergic, cholin ...
... are a major challenge for clinical medicine and drug discovery. Pathology is the result of multiple factors, which include environmental, genetic, and epigenetic imbalance in excitatory or inhibitory neurotransmission and alteration in modulatory neurotransmitter pathways (e.g., dopaminergic, cholin ...
pharmaceutical compounding-nonsterile preparations
... • therapeutic appropriateness and route of administration, including local and systemic biological disposition • legal limitations, if any 2. A Master Formulation Record should be created before compounding a preparation for the first time. This record shall be followed each time that preparation is ...
... • therapeutic appropriateness and route of administration, including local and systemic biological disposition • legal limitations, if any 2. A Master Formulation Record should be created before compounding a preparation for the first time. This record shall be followed each time that preparation is ...
THE TITLE: Pharmacokinetic Drug Interaction with Gemfibrozil
... accuracy, precision, extraction recovery, selectivity and stability. Calibration was performed by a least squares linear regression method and correlation coefficient was determined. The lowest concentration on the calibration curve with detector response five times greater than the blank human plas ...
... accuracy, precision, extraction recovery, selectivity and stability. Calibration was performed by a least squares linear regression method and correlation coefficient was determined. The lowest concentration on the calibration curve with detector response five times greater than the blank human plas ...
zidovudine and lamivudine - WHO archives
... more than 90% of infected persons live in the developing world3. In 2001, 5 million persons worldwide became infected with HIV, and 3 million others died from HIV/AIDS-related causes. In sub-Saharan Africa, the region most severely affected by HIV, 28.1 million individuals are living with this infec ...
... more than 90% of infected persons live in the developing world3. In 2001, 5 million persons worldwide became infected with HIV, and 3 million others died from HIV/AIDS-related causes. In sub-Saharan Africa, the region most severely affected by HIV, 28.1 million individuals are living with this infec ...
Drug effects on salivary glands: dry mouth
... Finally, the consequences of dry mouth such as caries may be used as a surrogate marker. For example, persons taking three or more prescription medications had a higher Root Caries Index (RCI) than those taking none, one or two drugs, and people who took antidepressants and antiulcer drugs had highe ...
... Finally, the consequences of dry mouth such as caries may be used as a surrogate marker. For example, persons taking three or more prescription medications had a higher Root Caries Index (RCI) than those taking none, one or two drugs, and people who took antidepressants and antiulcer drugs had highe ...
Republic of Palau - World Health Organization
... FUNCTION IS IMPAIRED The use of drugs in patients with reduced renal function can give rise to problems for several reasons: -failure to excrete the drug or its metabolite may produce toxicity - sensitivity to some drugs is increased even if elimination is not impaired - many side effects are poorly ...
... FUNCTION IS IMPAIRED The use of drugs in patients with reduced renal function can give rise to problems for several reasons: -failure to excrete the drug or its metabolite may produce toxicity - sensitivity to some drugs is increased even if elimination is not impaired - many side effects are poorly ...
EBOLA and FDA: reviewing the response to the 2014 outbreak, to
... field and outlines both the need for accreting evidence of their safety and efficacy as well as the ethical mandate to conduct rigorous human subjects research in the midst of a public health emergency. Section III briefly reviews the standard FDA-approval process and highlights challenges to the ar ...
... field and outlines both the need for accreting evidence of their safety and efficacy as well as the ethical mandate to conduct rigorous human subjects research in the midst of a public health emergency. Section III briefly reviews the standard FDA-approval process and highlights challenges to the ar ...
Clinical Pharmacy Department Clinical Pharmacy Modul 3
... C. Streptomycin D. Erythromycin E. None of the above ANSWER: B In the treatment of acute diarrhea A. antibiotics are worst avoided in non-pathogenic diarrhea B. antibiotics are worst avoided in viral gastroenteritis C. oral rehydration should not be used for initial therapy D. electrolytes and gluco ...
... C. Streptomycin D. Erythromycin E. None of the above ANSWER: B In the treatment of acute diarrhea A. antibiotics are worst avoided in non-pathogenic diarrhea B. antibiotics are worst avoided in viral gastroenteritis C. oral rehydration should not be used for initial therapy D. electrolytes and gluco ...
WHICH MUSCLE RELAXANT TO CHOOSE FOR INDUCTION OF
... Inadequate reversal of the neuromuscular blockade for muscle relaxants is partly responsible. It has been demonstrated that residual neuromuscular blockade is less likely with intermediate- or short-acting muscle relaxants. This author wonders why long-acting muscle relaxants are given to facilitate ...
... Inadequate reversal of the neuromuscular blockade for muscle relaxants is partly responsible. It has been demonstrated that residual neuromuscular blockade is less likely with intermediate- or short-acting muscle relaxants. This author wonders why long-acting muscle relaxants are given to facilitate ...
Document
... nursing women results in negligible systemic exposure to budesonide in breast-fed infants. In a pharmacokinetic study the estimated daily infant dose was 0.3% of the daily maternal dose for both dose levels, and the average plasma concentration in infants was estimated to be 1/600th of the concentra ...
... nursing women results in negligible systemic exposure to budesonide in breast-fed infants. In a pharmacokinetic study the estimated daily infant dose was 0.3% of the daily maternal dose for both dose levels, and the average plasma concentration in infants was estimated to be 1/600th of the concentra ...
1 The Current State and the Issues of Antibody Drugs Introduction
... orally. These drugs have a long history of research and development and a number of them have become “blockbusters,” with sales of over 100 billion yen. These small molecule drugs are effective in treating certain types of diseases: however, they are not as effective in treating others. Many biomedi ...
... orally. These drugs have a long history of research and development and a number of them have become “blockbusters,” with sales of over 100 billion yen. These small molecule drugs are effective in treating certain types of diseases: however, they are not as effective in treating others. Many biomedi ...
Xyrem - Annexes - European Commission
... Sodium oxybate has a major influence on the ability to drive and use machines. For at least 6 hours after taking sodium oxybate, patients must not undertake activities requiring complete mental alertness or motor co-ordination, such as operating machinery or driving. When patients first start taking ...
... Sodium oxybate has a major influence on the ability to drive and use machines. For at least 6 hours after taking sodium oxybate, patients must not undertake activities requiring complete mental alertness or motor co-ordination, such as operating machinery or driving. When patients first start taking ...
6 Acyclovir for Neonatal and Pediatric Viral Infections
... mg every 8 hours for 7 days.3 There are only case reports on the use of valacyclovir and famciclovir in children at this time. More work is needed to define the optimal pediatric dose. Summary Acyclovir has been used in the United States for nearly 20 years, yet there is still new information being ...
... mg every 8 hours for 7 days.3 There are only case reports on the use of valacyclovir and famciclovir in children at this time. More work is needed to define the optimal pediatric dose. Summary Acyclovir has been used in the United States for nearly 20 years, yet there is still new information being ...
Week 8 Review Pharmacology
... _____________________comes prepackaged in syringe with an air bubble, you keep it in to avoid bruising, lasts longer than heparin. ____, ______&_______ may increase bleeding w/ warfarin (anticoagulants) _____, _________& ___________may decrese the effects of warfarin client teaching for anticoagulan ...
... _____________________comes prepackaged in syringe with an air bubble, you keep it in to avoid bruising, lasts longer than heparin. ____, ______&_______ may increase bleeding w/ warfarin (anticoagulants) _____, _________& ___________may decrese the effects of warfarin client teaching for anticoagulan ...
(G6PD) Deficiency
... aspirin: in a review found that low dose 400mg aspirin in G6PD deficient pxs caused haemolytic episodes in 2 out of 40 cases….but open to much ...
... aspirin: in a review found that low dose 400mg aspirin in G6PD deficient pxs caused haemolytic episodes in 2 out of 40 cases….but open to much ...
Bad Pharma
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Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.