Amlo
... pressure (in both supine and standing positions) throughout the 24 hour interval. In patients with angina, once daily administration of amlodipine increases total exercise time, the delay of occurrence of anginal attack and the delay of the occurrence of a 1-mm ST interval. Amlodipine decreases both ...
... pressure (in both supine and standing positions) throughout the 24 hour interval. In patients with angina, once daily administration of amlodipine increases total exercise time, the delay of occurrence of anginal attack and the delay of the occurrence of a 1-mm ST interval. Amlodipine decreases both ...
http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021995s025lbl.pdf. Accessed January 24, 2013.
... For patients with mild renal insufficiency (creatinine clearance [CrCl] ≥50 mL/min, approximately corresponding to serum creatinine levels of ≤1.7 mg/dL in men and ≤1.5 mg/dL in women), no dosage adjustment for JANUVIA is required. For patients with moderate renal insufficiency (CrCl ≥30 to <50 mL/m ...
... For patients with mild renal insufficiency (creatinine clearance [CrCl] ≥50 mL/min, approximately corresponding to serum creatinine levels of ≤1.7 mg/dL in men and ≤1.5 mg/dL in women), no dosage adjustment for JANUVIA is required. For patients with moderate renal insufficiency (CrCl ≥30 to <50 mL/m ...
affinity biosensor for antitumoral drugs determination
... determination of anticancer platinum drugs, namely carboplatin. The anticancer activity of cis- dichloroamineplatinum (II) was discovered in 1969 [1], and successes with this compound were achieved in the treatment of testicular and ovarian cancer, both with cisplatin alone and in combination with o ...
... determination of anticancer platinum drugs, namely carboplatin. The anticancer activity of cis- dichloroamineplatinum (II) was discovered in 1969 [1], and successes with this compound were achieved in the treatment of testicular and ovarian cancer, both with cisplatin alone and in combination with o ...
Opioid Dependence Treatment and Guidelines
... Though originally developed in 1939, methadone was not widely used as a pain reliever until World War II, possibly because initial doses were too high which resulted in intolerable adverse effects. In 1947, Eli Lilly bought the commercial rights for methadone for $1 and coined the brand name “Doloph ...
... Though originally developed in 1939, methadone was not widely used as a pain reliever until World War II, possibly because initial doses were too high which resulted in intolerable adverse effects. In 1947, Eli Lilly bought the commercial rights for methadone for $1 and coined the brand name “Doloph ...
levetiracetam in sodium chloride injection
... In addition, 4 (0.5%) of treated patients attempted suicide compared to 0% of placebo patients. One of these patients completed suicide. In the other 3 patients, the events did not lead to discontinuation or dose reduction. The events occurred after patients had been treated for between 4 weeks and ...
... In addition, 4 (0.5%) of treated patients attempted suicide compared to 0% of placebo patients. One of these patients completed suicide. In the other 3 patients, the events did not lead to discontinuation or dose reduction. The events occurred after patients had been treated for between 4 weeks and ...
Screening of Methanol Extract and Ethyl Acetate Fraction of Abies
... effect (% MPE) is calculated from the formula, % MPE=(reaction time–basal time/Cut off time–basal time)×100. Statistics: The results have been expressed as mean±standard deviation (SD). The test drugs were compared with ...
... effect (% MPE) is calculated from the formula, % MPE=(reaction time–basal time/Cut off time–basal time)×100. Statistics: The results have been expressed as mean±standard deviation (SD). The test drugs were compared with ...
ANTIINFLAMMATORY AND ANTIBACTERIAL ACTIVITIES OF DIFFERENT EXTRACTS OF GYNANDROPSIS GYNANDRA
... The inflammation has long been recognized; the tissues become red, swollen, tender, or painful, there is local heat and the patient may be febrile. Inflammation can be categorized mainly as Chronic and Acute inflammatory disease. Acute and chronic inflammatory diseases are still one of the most impo ...
... The inflammation has long been recognized; the tissues become red, swollen, tender, or painful, there is local heat and the patient may be febrile. Inflammation can be categorized mainly as Chronic and Acute inflammatory disease. Acute and chronic inflammatory diseases are still one of the most impo ...
Piroxicam Capsules USP, 10 mg 100 count
... NSAIDs, including Piroxicam Capsules USP, can lead to onset of new hypertension or worsening of pre-existing hypertension, either of which may contribute to the increased incidence of CV events. Patients taking thiazides or loop diuretics may have impaired response to these therapies when taking NSA ...
... NSAIDs, including Piroxicam Capsules USP, can lead to onset of new hypertension or worsening of pre-existing hypertension, either of which may contribute to the increased incidence of CV events. Patients taking thiazides or loop diuretics may have impaired response to these therapies when taking NSA ...
Addition of an angiotensin receptor blocker to full-dose
... not completely prevent ACE-mediated angiotensin II formation. However, it is unknown whether supra-maximal doses of ACE-inhibitors might further suppress angiotensin II formation. There is experimental evidence against this hypothesis. In human arteries, even supra-physiological concentrations of AC ...
... not completely prevent ACE-mediated angiotensin II formation. However, it is unknown whether supra-maximal doses of ACE-inhibitors might further suppress angiotensin II formation. There is experimental evidence against this hypothesis. In human arteries, even supra-physiological concentrations of AC ...
(PSD) July 2016 PBAC Meeting
... submission were based on the 18 June 2015 database lock and were not confounded by cross-over. There were two key consequences of the early termination of the trial: The mean duration of therapy was likely to have been underestimated. Patients in both treatment arms (16.3% for nivolumab; 6.8% for ev ...
... submission were based on the 18 June 2015 database lock and were not confounded by cross-over. There were two key consequences of the early termination of the trial: The mean duration of therapy was likely to have been underestimated. Patients in both treatment arms (16.3% for nivolumab; 6.8% for ev ...
The case for long-acting antipsychotic agents in the post
... (CATIE) study, few patients remain on oral atypical agents to reap long-term benefits such as remission and possible neuroregeneration. ...
... (CATIE) study, few patients remain on oral atypical agents to reap long-term benefits such as remission and possible neuroregeneration. ...
Evaluation of Dependence and Withdrawal in Clinical Trials
... • This is a part of the evaluation of drug safety, which in some cases is critically important, especially, if the drug has to be abruptly withdrawn due to serious, life-threatening adverse events • Human dependence study should be considered another Phase 1 or 2 study. • A large number of dependenc ...
... • This is a part of the evaluation of drug safety, which in some cases is critically important, especially, if the drug has to be abruptly withdrawn due to serious, life-threatening adverse events • Human dependence study should be considered another Phase 1 or 2 study. • A large number of dependenc ...
Clenbuterol toxicity: a NSW Poisons Information Centre experience
... the eight episodes in which the dose was known, the median dose was 0.8 mg (range, 0.08–5000 mg). Thirty-six calls were from hospitals, two from paramedics, one from a general practice and 21 directly from the public. Caller background was not recorded on four occasions. Of the calls from the public ...
... the eight episodes in which the dose was known, the median dose was 0.8 mg (range, 0.08–5000 mg). Thirty-six calls were from hospitals, two from paramedics, one from a general practice and 21 directly from the public. Caller background was not recorded on four occasions. Of the calls from the public ...
Protocol Template Guidelines
... and associated Federal regulations, and all applicable University research requirements. The rest of the introduction is broken out into subsections. Example language for the first paragraph under “Introduction” and before the section “1.1 Background”: This document is a protocol for a human researc ...
... and associated Federal regulations, and all applicable University research requirements. The rest of the introduction is broken out into subsections. Example language for the first paragraph under “Introduction” and before the section “1.1 Background”: This document is a protocol for a human researc ...
Zentel - FiloBase
... mg/kg/day) in eight neurocysticercosis patients. Praziquantel: In the fed state, praziquantel (40 mg/kg) increased mean maximum plasma concentration and area under the curve of albendazole sulfoxide by about 50% in healthy subjects (n=10) compared with a separate group of subjects (n=6) given albend ...
... mg/kg/day) in eight neurocysticercosis patients. Praziquantel: In the fed state, praziquantel (40 mg/kg) increased mean maximum plasma concentration and area under the curve of albendazole sulfoxide by about 50% in healthy subjects (n=10) compared with a separate group of subjects (n=6) given albend ...
Studies of a benzoporphyrin derivative with Pluronics and D. Dolphin
... Abstract: The synthetic route for the benzoporphyrin derivatives produces two regioisomers in equimolar quantities (ring A and B isomers). A derivative of the A-ring product, BPD-MA (benzoporphyrin-derivative monoacid ring A, verteporfin), has recently been approved in North America and Europe for t ...
... Abstract: The synthetic route for the benzoporphyrin derivatives produces two regioisomers in equimolar quantities (ring A and B isomers). A derivative of the A-ring product, BPD-MA (benzoporphyrin-derivative monoacid ring A, verteporfin), has recently been approved in North America and Europe for t ...
Priority Issues From the AAMI/FDA Infusion Device Summit
... unknown. A sampling of Baird’s synthesis of MAUDEreported incidents with PCA infusion pumps, shown in Figure 1, highlights this shortcoming. Baird presented similar findings about other types of infusion devices. MAUDE is a self-reporting system that might not contain all the necessary information a ...
... unknown. A sampling of Baird’s synthesis of MAUDEreported incidents with PCA infusion pumps, shown in Figure 1, highlights this shortcoming. Baird presented similar findings about other types of infusion devices. MAUDE is a self-reporting system that might not contain all the necessary information a ...
urticaria
... It would seem that the combination of H1 and H2 antihistamines would provide optimal effects. The results of studies are conflicting but generally show that the combination is only slightly more effective than an H1-blocking agent used alone. ...
... It would seem that the combination of H1 and H2 antihistamines would provide optimal effects. The results of studies are conflicting but generally show that the combination is only slightly more effective than an H1-blocking agent used alone. ...
To reduce the development of drug-resistant bacteria and maintain the... FLAGYL and other antibacterial drugs, FLAGYL (metronidazole) tablets
... Symptomatic Trichomoniasis. FLAGYL is indicated for the treatment of T. vaginalis infection in females and males when the presence of the trichomonad has been confirmed by appropriate laboratory procedures (wet smears and/or cultures). Asymptomatic Trichomoniasis. FLAGYL is indicated in the treatmen ...
... Symptomatic Trichomoniasis. FLAGYL is indicated for the treatment of T. vaginalis infection in females and males when the presence of the trichomonad has been confirmed by appropriate laboratory procedures (wet smears and/or cultures). Asymptomatic Trichomoniasis. FLAGYL is indicated in the treatmen ...
Pharmacological Treatment of Urinary Incontinence
... Urinary incontinence has an observed prevalence of 25%, and this tends to increase with age.1 Normal functions of the female lower urinary tract are the storage of urine within the bladder and the timely release during micturition at appropriate intervals. Bladder and urethra act together as a funct ...
... Urinary incontinence has an observed prevalence of 25%, and this tends to increase with age.1 Normal functions of the female lower urinary tract are the storage of urine within the bladder and the timely release during micturition at appropriate intervals. Bladder and urethra act together as a funct ...
Use of Methadone for the Treatment of Diabetic
... not need to be symmetric, and since the pain of diabetic neuropathy oftentimes worsens at night, we frequently give a larger dose at bedtime or at any other time of the day when pain tends to increase, such as when individuals are up and about. Titration of the scheduled doses may occur every 4 –7 d ...
... not need to be symmetric, and since the pain of diabetic neuropathy oftentimes worsens at night, we frequently give a larger dose at bedtime or at any other time of the day when pain tends to increase, such as when individuals are up and about. Titration of the scheduled doses may occur every 4 –7 d ...
Prescribing Information
... restriction of joint motion, fever and malaise are suggestive of septic arthritis. If the diagnosis of sepsis is confirmed, appropriate antimicrobial therapy should be instituted. Since complications of glucocorticosteroid treatment are dependent on dose, size and duration of treatment, a risk/benef ...
... restriction of joint motion, fever and malaise are suggestive of septic arthritis. If the diagnosis of sepsis is confirmed, appropriate antimicrobial therapy should be instituted. Since complications of glucocorticosteroid treatment are dependent on dose, size and duration of treatment, a risk/benef ...
IMC Analysis Pfizer`s Zoloft 1 IMC ANALYSIS
... company's serotonin reuptake inhibitor antidepressant, Sertraline (Zoloft), because it does not carry the proper warning information (Rosack, 2005). Officials in the FDA's Division of Drug Marketing, Advertising, and Communications targeted a print ad for Zoloft that ran in the New York Times on Oct ...
... company's serotonin reuptake inhibitor antidepressant, Sertraline (Zoloft), because it does not carry the proper warning information (Rosack, 2005). Officials in the FDA's Division of Drug Marketing, Advertising, and Communications targeted a print ad for Zoloft that ran in the New York Times on Oct ...
INSTILLAGEL
... lidocaine and amiodarone. Patients treated with Class III antiarrhythmic drugs (e.g. amiodarone) should be kept under close surveillance and ECG monitoring should be considered, since cardiac effects of these drugs and lidocaine may be additive. β-blockers: Propranolol has been reported to reduce in ...
... lidocaine and amiodarone. Patients treated with Class III antiarrhythmic drugs (e.g. amiodarone) should be kept under close surveillance and ECG monitoring should be considered, since cardiac effects of these drugs and lidocaine may be additive. β-blockers: Propranolol has been reported to reduce in ...
CH3 N N CF3 S NH O O
... to inflammatory stimuli. This leads to the synthesis and accumulation of inflammatory prostanoids, in particular prostaglandin E2, causing inflammation, edema and pain. Celecoxib acts as an anti-inflammatory, analgesic, and antipyretic agent in animal models by blocking the production of inflammator ...
... to inflammatory stimuli. This leads to the synthesis and accumulation of inflammatory prostanoids, in particular prostaglandin E2, causing inflammation, edema and pain. Celecoxib acts as an anti-inflammatory, analgesic, and antipyretic agent in animal models by blocking the production of inflammator ...
Bad Pharma
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Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.