Anti- muscarinic agents
... • · During induction of anesthesia, there may be excessive vagal stimulation, which we want to eliminate. ...
... • · During induction of anesthesia, there may be excessive vagal stimulation, which we want to eliminate. ...
IDENTIFICATION AND MANAGEMENT OF WILDLIFE DAMAGE
... Hunting dogs are used for lethal control. State and local laws should be consulted prior to pursuing carnivors with dogs. Two types of dogs are commonly used ...
... Hunting dogs are used for lethal control. State and local laws should be consulted prior to pursuing carnivors with dogs. Two types of dogs are commonly used ...
HEPATOPROTECTIVE ACTIVITY OF AN ETHANOLIC EXTRACT OF STEMS OF ANISOCHILUS CARNOSUS AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN RATS
... reflected the depth of jaundice and the increase in transaminases and alkaline phosphate was the clear indication of the cellular leakage and loss of functional integrity of the cell membrane16. Since CCl4 involve activation by Cyt P‐450, subsequent damage to the hepatocellula ...
... reflected the depth of jaundice and the increase in transaminases and alkaline phosphate was the clear indication of the cellular leakage and loss of functional integrity of the cell membrane16. Since CCl4 involve activation by Cyt P‐450, subsequent damage to the hepatocellula ...
- Raw Steroid Powders
... A. Formestane is a synthetic steroidal substance with antineoplastic activity. Formestane binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens. ...
... A. Formestane is a synthetic steroidal substance with antineoplastic activity. Formestane binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens. ...
Title Francesca Tencalla and Bernard Marantelli, Monsanto
... GM plants may or may not pose risks to non-target organisms (NTO) in the environment. Risks vary considerably depending on the crop, the GM trait and/or the scope of use, therefore a ‘case-by-case’ approach to risk assessment is needed. Assessment of potential risks to NTO is a challenging scientifi ...
... GM plants may or may not pose risks to non-target organisms (NTO) in the environment. Risks vary considerably depending on the crop, the GM trait and/or the scope of use, therefore a ‘case-by-case’ approach to risk assessment is needed. Assessment of potential risks to NTO is a challenging scientifi ...
01 NEUROMUSCULAR BLOCKERS(BLOCK 1st year).
... DEPOLARIZING NEUROMUSCULAR BLOCKERS • SUCCINYLECHOLINE: • These drugs act like acetylcholine but persist at the synapse at higher concentration and for longer duration and constantly stimulate the receptor. (there is inhibition of repolarization) and the receptor become insensitive • First opening ...
... DEPOLARIZING NEUROMUSCULAR BLOCKERS • SUCCINYLECHOLINE: • These drugs act like acetylcholine but persist at the synapse at higher concentration and for longer duration and constantly stimulate the receptor. (there is inhibition of repolarization) and the receptor become insensitive • First opening ...
ANTIHELMINTHICS
... paralysis. Moves from venous plexus to small arteries and finally to lungs where they are encased hence death. Ova not affected. ...
... paralysis. Moves from venous plexus to small arteries and finally to lungs where they are encased hence death. Ova not affected. ...
MIGRAINE
... Metabolized in liver to active metabolites which have a higher affinity to 5HT1B & 1D receptors than the parent drug. Half- life for both 2-3hrs. Plasma protein binding 14%. ...
... Metabolized in liver to active metabolites which have a higher affinity to 5HT1B & 1D receptors than the parent drug. Half- life for both 2-3hrs. Plasma protein binding 14%. ...
Opioid-Induced Nausea
... 125mg PO day one prior to chemo, then 80 mg daily in the morning for 2 more days 1. Phenothiazines can cause extrapyramidal symptoms including dystonia and/or tardive dyskinesia 2. There is an increased risk of cardiotoxicity and prolongation of the QT interval with droperidol. Droperidol sho ...
... 125mg PO day one prior to chemo, then 80 mg daily in the morning for 2 more days 1. Phenothiazines can cause extrapyramidal symptoms including dystonia and/or tardive dyskinesia 2. There is an increased risk of cardiotoxicity and prolongation of the QT interval with droperidol. Droperidol sho ...
PowerPoint-presentation
... Magnus Alm Rosenblad, CMB: A sneak peak at genes in barnacles (Swedish: havstulpan) Fredrik Gunnarsson, ZOO: Effects of low pH in two fish species – a proteomic study Henrik Johansson, IVM: Effects on ocean acidification on periphyton communities Fika Departure by bus to the Department of Zoology ...
... Magnus Alm Rosenblad, CMB: A sneak peak at genes in barnacles (Swedish: havstulpan) Fredrik Gunnarsson, ZOO: Effects of low pH in two fish species – a proteomic study Henrik Johansson, IVM: Effects on ocean acidification on periphyton communities Fika Departure by bus to the Department of Zoology ...
Powerpoint Presentation Toxicology Lecture
... TGN1412 is a monoclonal antibody (MAB) designed to bind CD28 protein to activate leucocytes ...
... TGN1412 is a monoclonal antibody (MAB) designed to bind CD28 protein to activate leucocytes ...
Age of Rocks, Fossils, Adaptations, and Geologic Time Study Guide
... B. Layers of sediment cover the organism before the organism can decay or be eaten. C. Mineral rich water seeps into the cells of the organism. D. The minerals stay in the cells and harden---forming the fossil. The sediment becomes rock. E. The rock is weathered and eroded and fossil is eventually e ...
... B. Layers of sediment cover the organism before the organism can decay or be eaten. C. Mineral rich water seeps into the cells of the organism. D. The minerals stay in the cells and harden---forming the fossil. The sediment becomes rock. E. The rock is weathered and eroded and fossil is eventually e ...
Nimesulide: patients still exposed to a risk of severe hepatitis
... severe liver damage continue to accumulate and many other valid therapeutic options exist. If paracetamol is inadequately ineffective, oral ibuprofen is the NSAID with the best risk-benefit balance when used at standard doses. ...
... severe liver damage continue to accumulate and many other valid therapeutic options exist. If paracetamol is inadequately ineffective, oral ibuprofen is the NSAID with the best risk-benefit balance when used at standard doses. ...
Hyperlipotrotinemia
... LDL receptors in liver, plasma LDLC clearance ( by 20-55%) Higher doses of atorvastatin and simvastatin triglyceride levels (LDL receptor - Apo-E in VLDL) Some statins may HDL-C levels ...
... LDL receptors in liver, plasma LDLC clearance ( by 20-55%) Higher doses of atorvastatin and simvastatin triglyceride levels (LDL receptor - Apo-E in VLDL) Some statins may HDL-C levels ...
CNS Neurotransmitters
... receptors • Five subunits, each with four transmembrane domains (like nAChR) • Most have two alpha (α),two beta (β), one gamma (γ) subunit • α1 β2 γ2 is predominant in mammalian brain but there are different combinations in specific brain regions ...
... receptors • Five subunits, each with four transmembrane domains (like nAChR) • Most have two alpha (α),two beta (β), one gamma (γ) subunit • α1 β2 γ2 is predominant in mammalian brain but there are different combinations in specific brain regions ...
Document
... receptors • Five subunits, each with four transmembrane domains (like nAChR) • Most have two alpha (α),two beta (β), one gamma (γ) subunit • α1 β2 γ2 is predominant in mammalian brain but there are different combinations in specific brain regions ...
... receptors • Five subunits, each with four transmembrane domains (like nAChR) • Most have two alpha (α),two beta (β), one gamma (γ) subunit • α1 β2 γ2 is predominant in mammalian brain but there are different combinations in specific brain regions ...
Carbamazepine Toxicity - Anticonvulsant structurally similar to TCA`s
... glutathione. With an overdose, glutathione stores are exhausted and this allows the toxic reactive metabolite to accumulate and bind to hepatocytes. Note: alcoholics are at increased risk for toxicity at lower doses because of increased P450 enzyme activity and decreased glutathione stores. Clinical ...
... glutathione. With an overdose, glutathione stores are exhausted and this allows the toxic reactive metabolite to accumulate and bind to hepatocytes. Note: alcoholics are at increased risk for toxicity at lower doses because of increased P450 enzyme activity and decreased glutathione stores. Clinical ...
PowerPoint Presentation - Lecture 13
... functions, tissue growth & healing • Body needs only a small amt. of vitamins daily easily obtained through a well-balanced diet • Vitamin supplements not necessary if a well-balanced diet consumed • Vitamin deficiencies can cause cellular and organ dysfunction - may result in slow recovery from ill ...
... functions, tissue growth & healing • Body needs only a small amt. of vitamins daily easily obtained through a well-balanced diet • Vitamin supplements not necessary if a well-balanced diet consumed • Vitamin deficiencies can cause cellular and organ dysfunction - may result in slow recovery from ill ...
8. Anti-cholinergics
... Persists at receptor at high concentration, because it is not destroyed by AChE at the Nm junction “Desensitizes” the end plate by occupying the receptors and causing a “persistent depolarization” leads to flaccid paralysis of muscle Rapid onset and short duration of action (4-5 minutes) than other ...
... Persists at receptor at high concentration, because it is not destroyed by AChE at the Nm junction “Desensitizes” the end plate by occupying the receptors and causing a “persistent depolarization” leads to flaccid paralysis of muscle Rapid onset and short duration of action (4-5 minutes) than other ...
Aminoglycosides
... Lack activity against most anaerobic or facultative bacteria and activity against G+ve# organisms is limited * in combination # Strept pyogenes is highly resistant ...
... Lack activity against most anaerobic or facultative bacteria and activity against G+ve# organisms is limited * in combination # Strept pyogenes is highly resistant ...
（3）
... Used for the treatment of skeletal muscle spasms caused by central or peripheral diseases. ...
... Used for the treatment of skeletal muscle spasms caused by central or peripheral diseases. ...
Toxicodynamics
Toxicodynamics, termed pharmacodynamics in pharmacology, describes the dynamic interactions of a toxicant with a biological target and its biological effects. A biological target, also known as the site of action, can be binding proteins, ion channels, DNA, or a variety of other receptors. When a toxicant enters an organism, it can interact with these receptors and produce structural or functional alterations. The mechanism of action of the toxicant, as determined by a toxicant’s chemical properties, will determine what receptors are targeted and the overall toxic effect at the cellular level and organismal level.Toxicants have been grouped together according to their chemical properties by way of quantitative structure-activity relationships (QSARs), which allows prediction of toxic action based on these properties. endocrine disrupting chemicals (EDCs) and carcinogens are examples of classes of toxicants that can act as QSARs. EDCs mimic or block transcriptional activation normally caused by natural steroid hormones. These types of chemicals can act on androgen receptors, estrogen receptors and thyroid hormone receptors. This mechanism can include such toxicants as dichlorodiphenyltrichloroethane (DDE) and polychlorinated biphenyls (PCBs). Another class of chemicals, carcinogens, are substances that cause cancer and can be classified as genotoxic or nongenotoxic carcinogens. These categories include toxicants such as polycyclic aromatic hydrocarbon (PAHs) and carbon tetrachloride (CCl4). The process of toxicodynamics can be useful for application in environmental risk assessment by implementing toxicokinetic-toxicodynamic (TKTD) models. TKTD models include phenomenas such as time-varying exposure, carry-over toxicity, organism recovery time, effects of mixtures, and extrapolation to untested chemicals and species. Due to their advantages, these types of models may be more applicable for risk assessment than traditional modeling approaches.