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the extent of population exposure to assess clinical safety
the extent of population exposure to assess clinical safety

... should be performed unless otherwise justified. The polymerase chain reaction (PCR) may be appropriate for detection of sequences of these human viruses as well as for other specific viruses. The following is a brief description of a general framework and philosophical background within which the ma ...
20th European Congress of Clinical Microbiology and Infectious
20th European Congress of Clinical Microbiology and Infectious

... g., 20 mice/group) were infected intranasally with 10LD50 of influenza virus A/California/07/2009swl. In APcis 60 female Balb/c mice (10-12 g., 20 mice/group) were infected intranasally with 3LD50 of influenza virus A/NewCaledonia/20/99. In both studies ULDabIFNg given as water solution were adminis ...
Q5A(R1)
Q5A(R1)

... performed unless otherwise justified. The polymerase chain reaction (PCR) may be appropriate for detection of sequences of these human viruses as well as for other specific viruses. The following is a brief description of a general framework and philosophical background within which the manufacturer ...
Chapter 8 Foodborne Illnesses
Chapter 8 Foodborne Illnesses

... Some strains of Salmonella can cause more serious illness like typhoid fever. In a small number of cases, salmonella infection is dangerous and can be life threatening to infants, children, the elderly or people with immune system disorders. Most infections do not require treatment. Some people may ...
Hepatitis C pdf, 169kb
Hepatitis C pdf, 169kb

... Hepatitis C is a contagious liver disease that results from infection with hepatitis C virus (HCV). It can range in severity from a mild illness lasting a few weeks to a serious, lifelong illness. HCV is usually spread when blood from a person infected with HCV enters the body of someone who is not ...
Infection Control Policy 2015 [RTF, 123.0 KB]
Infection Control Policy 2015 [RTF, 123.0 KB]

... Note that live virus vaccines (measles, mumps, rubella and varicella) should not be administered to those who are pregnant and persons with pre-existing medical conditions causing immunocompromised. If pregnancy is being planned, it should be delayed for at least 28 days after last being administere ...
Requirements for Infection
Requirements for Infection

... Of all of the portals of entry, this is probably the most favorable to pathogens (Figure 5.2). We live in a cloud of potentially dangerous microbial pathogens, and the respiratory tract facilitates entry through breathing. Organisms can be found on droplets of moisture in the air and even on dust pa ...
Infectious diseases
Infectious diseases

... General measures to relieve itching associated with skin lesions include cool water soaks or compresses, and bathing with one cup of baking soda added to a bathtub of lukewarm water. Topical preparations such as nonprescription calamine lotion, antihistamines, or other lotions containing camphor, me ...
Cleaning and Disinfection Protocol
Cleaning and Disinfection Protocol

... This document has been developed in accordance with current applicable infection control and  regulatory guidelines.  It is intended for use as a guideline only.  At no time should this document replace  existing documents established by the facility unless written permission has been obtained from  ...
The Story Of smallpox
The Story Of smallpox

... where it multiplies and spreads to the lymphatic system. Within a few days, large pustules begin to appear all over the victim's skin. Starting with the hands and the face, and then spreading to cover the rest of the body, each blister is packed full of smallpox DNA. If punctured, these blisters bec ...
The Story Of smallpoxxx
The Story Of smallpoxxx

... where it multiplies and spreads to the lymphatic system. Within a few days, large pustules begin to appear all over the victim's skin. Starting with the hands and the face, and then spreading to cover the rest of the body, each blister is packed full of smallpox DNA. If punctured, these blisters bec ...
The Story Of... Smallpox
The Story Of... Smallpox

... genocide. Instead, Europeans were aided by a deadly secret weapon they weren't even aware they were carrying: Smallpox. Smallpox is a viral infection which usually enters the body through the nose or throat. From here the virus travels to the lungs, where it multiplies and spreads to the lymphatic s ...
Colds_flu_and_other_respiratory_infections_in_the_home
Colds_flu_and_other_respiratory_infections_in_the_home

... Current WHO and ECDC recommendations on measures to reduce the spread of influenza are based on the supposition that influenza mainly spreads from person-toperson by large droplets from an infected person coughing and sneezing, and by contact transmission. Understanding the relative importance of t ...
Obstetric and perinatal infections2012
Obstetric and perinatal infections2012

... pathologic changes. ...
Viral Hepatitis in Infants and Children
Viral Hepatitis in Infants and Children

... – Incidence of HAV in U.S. has decreased by 75% since vaccine introduced in 1997 • Because humans are the only known reservoir for HAV, universal immunization strategies could hypothetically eradicate HAV ...
Virus Infection in Patients With Histiocytic Necrotizing Lymphadenitis
Virus Infection in Patients With Histiocytic Necrotizing Lymphadenitis

... HNLs examined, EBV DNA was detected in 11 (55%) of 20 HNL cases by PCR. Moreover, the EBV signal was located in 6 cases of PCR-positive HNL by ISH.6 Interestingly, because of discrepancies in the positive results among their collaborative laboratories, Hollingsworth et al6 suggested that a positive ...
Recreational Activities and Risk of Mosquito Borne Diseases
Recreational Activities and Risk of Mosquito Borne Diseases

... Apply only as much repellent as needed. Choose a product that will provide sufficient protection for the amount of time that you will be spending outdoors. Saturation does not increase repellent efficacy. Product labels often indicate the length of time that you can expect protection from a product ...
UPPER RESPIRATORY INFECTIONS (COLDS)
UPPER RESPIRATORY INFECTIONS (COLDS)

... Colds are viral, not bacterial infections of the upper respiratory tract. Symptoms can include:  a scratchy, sore throat  sneezing  nasal discharge, which is watery at first, then thick  tiredness  low grade fever <100°F  an overall sick feeling Colds are highly contagious. They are spread thr ...
Infectious Diseases
Infectious Diseases

... but also a public health and political consideration of congenital cytomegalovirus infection. As Dr. Harrison points out, cytomegalovirus infection is the “elephant in the living room” of congenital infections; it’s common, diagnosed only in its severest forms, and yet costly even for children who a ...
Appropriate Antibiotic Use by
Appropriate Antibiotic Use by

... Taking antibiotics when they are not needed can be harmful (see below). Data shows only a 1 in 4000 chance of helping an early upper respiratory infections, like colds, simple sore throat, and “flu” with and antibiotic. Each time you take an antibiotic, vulnerable bacteria are killed, but resilient ...
Infection Control Principles for Clinic Setting
Infection Control Principles for Clinic Setting

... Define all the steps that should be taken to prevent spread of infection from person to person or from contaminated environmental surfaces/healthcare items, when there is an anticipated contact with:  Blood  Body fluids  Secretions  Excretions, such as urine and faeces (excluding sweat) whether ...
Study of Biologic Attributes of Cuban Dengue 2 Virus after Serial
Study of Biologic Attributes of Cuban Dengue 2 Virus after Serial

... 27 amino acid alterations scattered throughout the genome.’ However, because it is not easy to determine which changes are actually responsible for loss of virulence and which may be unimportant, it would be useful to compare the sequences of different strains at different PDK passage levels.’ One o ...
Cell-based assays for diagnostics, drug and target
Cell-based assays for diagnostics, drug and target

... Pyrogens are fever-producing remnants from bacteria, viruses ...
Disease
Disease

... Intermediate carrier, transporting from reservoir to host Organisms with a membrane-bound nucleus and many membrane-bound organelles ( Including more complex plant and animal cells) Rod Shaped Bacteria A symbiotic relationship between organisms whereby BOTH benefit ...
Sexually transmitted diseases (STDs)
Sexually transmitted diseases (STDs)

... The signs and symptoms of syphilis may occur in four stages — primary, secondary, latent and tertiary. There's also a condition known as congenital syphilis, which occurs when a pregnant woman with syphilis passes the disease to her unborn infant. Congenital syphilis can be disabling, even life­thre ...
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Herpes simplex virus



Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpesvirus 1 and 2 (HHV-1 and HHV-2), are two members of the herpesvirus family, Herpesviridae, that infect humans. Both HSV-1 (which produces most cold sores) and HSV-2 (which produces most genital herpes) are ubiquitous and contagious. They can be spread when an infected person is producing and shedding the virus. Herpes simplex can be spread through contact with saliva, such as sharing drinks.Symptoms of herpes simplex virus infection include watery blisters in the skin or mucous membranes of the mouth, lips or genitals. Lesions heal with a scab characteristic of herpetic disease. Sometimes, the viruses cause very mild or atypical symptoms during outbreaks. However, as neurotropic and neuroinvasive viruses, HSV-1 and -2 persist in the body by becoming latent and hiding from the immune system in the cell bodies of neurons. After the initial or primary infection, some infected people experience sporadic episodes of viral reactivation or outbreaks. In an outbreak, the virus in a nerve cell becomes active and is transported via the neuron's axon to the skin, where virus replication and shedding occur and cause new sores. It is one of the most common sexually transmitted infections.
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