Target Predictions using LINCS Data
... Another common strategy is computational structural docking, in which the small molecules are docked onto multiple positions on the molecular structure of a protein, and the fitness of interaction are estimated through complex biophysical computations and molecular dynamic simulation [7, 13]. While ...
... Another common strategy is computational structural docking, in which the small molecules are docked onto multiple positions on the molecular structure of a protein, and the fitness of interaction are estimated through complex biophysical computations and molecular dynamic simulation [7, 13]. While ...
Experimental approaches to study plant cell walls during plant
... CELL IMAGING AND SPETROSCOPIC TECHNIQUES Advanced cellular imaging can be useful to investigate phenotypes linked to plant-microbe associations. Cellular imaging can be particularly important when applying a quantitative methodology to imaging techniques. Many microscopic techniques are available, i ...
... CELL IMAGING AND SPETROSCOPIC TECHNIQUES Advanced cellular imaging can be useful to investigate phenotypes linked to plant-microbe associations. Cellular imaging can be particularly important when applying a quantitative methodology to imaging techniques. Many microscopic techniques are available, i ...
Phosphorylation and concomitant structural changes in human 2
... conformational changes and allows the formation of oxidized dimers of HSP33. Oxidized form of HSP33 dimers shows a highly efficient chaperone activity, whereas under reducing condition, HSP33 existed as a monomer is inactive as a chaperone [21,22]. These results suggest that the structural changes cau ...
... conformational changes and allows the formation of oxidized dimers of HSP33. Oxidized form of HSP33 dimers shows a highly efficient chaperone activity, whereas under reducing condition, HSP33 existed as a monomer is inactive as a chaperone [21,22]. These results suggest that the structural changes cau ...
Histone H3 Phosphorylation Is Coupled to Poly-(ADP
... The signal transduction pathways activated during the commitment phase of oncotic cell death are insufficiently characterized. A pivotal event during the cell cycle is the timing of the initiation of DNA replication (S-phase entry). Rigid controls function to prevent repeated rounds of DNA replicati ...
... The signal transduction pathways activated during the commitment phase of oncotic cell death are insufficiently characterized. A pivotal event during the cell cycle is the timing of the initiation of DNA replication (S-phase entry). Rigid controls function to prevent repeated rounds of DNA replicati ...
Cytokinin Fig. 15
... formation in Arabidopsis The synthetic auxin 2,4-D promotes lateral root formation in Arabidopsis ...
... formation in Arabidopsis The synthetic auxin 2,4-D promotes lateral root formation in Arabidopsis ...
Dynamic Clamp
... A real cell can be connected to one or more in silico artificial cells. Synchronization between reciprocally connected cells in a network can be studied. Could be used for model validation. Model can be tested in vitro with a real cell. ...
... A real cell can be connected to one or more in silico artificial cells. Synchronization between reciprocally connected cells in a network can be studied. Could be used for model validation. Model can be tested in vitro with a real cell. ...
The Par3/Par6/aPKC Complex and Epithelial Cell Polarity
... epithelia Par3 is found at TJ and Par6/aPKC are at more apical apex [24], although this difference of localization is not prominent in 2D cultures [25]. In addition to its role in forming the Par complex, Par3 also has Par6/aPKC-independent functions. Par3 contains a conserved N-terminal domain (NT ...
... epithelia Par3 is found at TJ and Par6/aPKC are at more apical apex [24], although this difference of localization is not prominent in 2D cultures [25]. In addition to its role in forming the Par complex, Par3 also has Par6/aPKC-independent functions. Par3 contains a conserved N-terminal domain (NT ...
Transmembrane domains control exclusion of membrane proteins
... the absence of a cytosolic endocytic signal, access of a membrane protein to endosomal compartments is controlled at least in part by its TMD. Some TMDs allow surface proteins to reach endosomal compartments, others are more restricted to the cell surface. If both the transmembrane and the cytosolic ...
... the absence of a cytosolic endocytic signal, access of a membrane protein to endosomal compartments is controlled at least in part by its TMD. Some TMDs allow surface proteins to reach endosomal compartments, others are more restricted to the cell surface. If both the transmembrane and the cytosolic ...
Molecular Components of the Bacterial Cytoskeleton
... ε-tubulin. The best-characterised tubulins are α- and β-tubulin, which are the main components of microtubules. Microtubules are essential cytoskeletal elements that assemble in all eukaryotes, and are required for many intracellular transport events and for cell division. For example, microtubules ...
... ε-tubulin. The best-characterised tubulins are α- and β-tubulin, which are the main components of microtubules. Microtubules are essential cytoskeletal elements that assemble in all eukaryotes, and are required for many intracellular transport events and for cell division. For example, microtubules ...
Plantae - Stotts 5th Biology
... Fungi are heterotrophs. Most fungi feed on dead or decaying organic matter by secreting digestive enzymes into it and absorbing small food molecules into their bodies. They can be either multicellular (mushrooms) or unicellular (yeasts). ...
... Fungi are heterotrophs. Most fungi feed on dead or decaying organic matter by secreting digestive enzymes into it and absorbing small food molecules into their bodies. They can be either multicellular (mushrooms) or unicellular (yeasts). ...
Anemia - med.muni
... • The mature red blood cell is easily recognized because of its unique morphology. • At rest, the red blood cell takes the shape of a biconcave disc with a mean diameter of 8 µm, a thickness of 2 µm, and a volume of 90 fL. • It lacks a nucleus or mitochondria, and 33% of its contents is made up of a ...
... • The mature red blood cell is easily recognized because of its unique morphology. • At rest, the red blood cell takes the shape of a biconcave disc with a mean diameter of 8 µm, a thickness of 2 µm, and a volume of 90 fL. • It lacks a nucleus or mitochondria, and 33% of its contents is made up of a ...
Structure-Function Approach Identifies a COOH
... the active heparanase enzyme (9–11). Latent heparanase secretion is directed by an NH2-terminal signal peptide (Met1-Ala35). The secreted protein interacts rapidly and efficiently with cell surface HS proteoglycan (HSPG), low-density lipoprotein receptorrelated protein (LRP), and mannose 6-phosphate ...
... the active heparanase enzyme (9–11). Latent heparanase secretion is directed by an NH2-terminal signal peptide (Met1-Ala35). The secreted protein interacts rapidly and efficiently with cell surface HS proteoglycan (HSPG), low-density lipoprotein receptorrelated protein (LRP), and mannose 6-phosphate ...
Ordinal Position of Neurons in Cat Striate Cortex
... of values between each peak. The variability in conduction times for different dLGN axons can be estimated from the latencies to OR, stimulation of geniculate axon terminals isolated by the recording electrode in the cortex. The distribution of OR, latenties for these axons is shown in Fig. 2B where ...
... of values between each peak. The variability in conduction times for different dLGN axons can be estimated from the latencies to OR, stimulation of geniculate axon terminals isolated by the recording electrode in the cortex. The distribution of OR, latenties for these axons is shown in Fig. 2B where ...
- Haverford Scholarship
... only. Lysates used for precipitations shown in Fig. 7 were not precleared. The samplewas finallydivided and immunoprecipitated for 1 h at 4~ with the pAS beads precoated with the indicated antibody (beads were washed and swollen in 50 mM Tris, pH 8.5/150 mM NaC1, incubated overnight at 4~ with antib ...
... only. Lysates used for precipitations shown in Fig. 7 were not precleared. The samplewas finallydivided and immunoprecipitated for 1 h at 4~ with the pAS beads precoated with the indicated antibody (beads were washed and swollen in 50 mM Tris, pH 8.5/150 mM NaC1, incubated overnight at 4~ with antib ...
Parallels between tissue repair and embryo morphogenesis
... continued contraction of the LE cell actin cable and of the amnioserosal cells, interactions between opposing filopodial and lamellipodial protrusions appear to aid in drawing the two epithelial sheets towards one another and zipping them together. The final phase, termination (Fig. 3D), produces th ...
... continued contraction of the LE cell actin cable and of the amnioserosal cells, interactions between opposing filopodial and lamellipodial protrusions appear to aid in drawing the two epithelial sheets towards one another and zipping them together. The final phase, termination (Fig. 3D), produces th ...
PDF
... Hematodinium cell culture media were observed with AP (weak positive to strong positive) and napthol-AS-BI-phosphohydrolase (weak positive to positive). Cell culture media containing Hematodinium cells from the blue crab were observed to have only one enzyme, leucine arylamidase, with a measurable d ...
... Hematodinium cell culture media were observed with AP (weak positive to strong positive) and napthol-AS-BI-phosphohydrolase (weak positive to positive). Cell culture media containing Hematodinium cells from the blue crab were observed to have only one enzyme, leucine arylamidase, with a measurable d ...
cell-cycle progression and the generation of asymmetry in
... and intracellular stimuli75,76. The two components are sensor histidine kinases and response regulators. As shown in the figure (part a), activation of a histidine kinase leads to autophosphorylation on a conserved histidine residue. The phosphoryl group is then typically transferred to an aspartate ...
... and intracellular stimuli75,76. The two components are sensor histidine kinases and response regulators. As shown in the figure (part a), activation of a histidine kinase leads to autophosphorylation on a conserved histidine residue. The phosphoryl group is then typically transferred to an aspartate ...
Ice Adhesions in Relation to Freeze Stress1
... survival of -5 C supercooling. Maximum hardiness was attained after 3 weeks at 0 C. From seed to hardened cells was a sequence taking 9 to 10 weeks, about the same time required to produce a hardened plant from seed. Adhesion Energy. Three factors are involved in the interaction between ice, cell wa ...
... survival of -5 C supercooling. Maximum hardiness was attained after 3 weeks at 0 C. From seed to hardened cells was a sequence taking 9 to 10 weeks, about the same time required to produce a hardened plant from seed. Adhesion Energy. Three factors are involved in the interaction between ice, cell wa ...
Heat Shock Response and Protein Degradation
... synthesis and reduced degradation. The downstream effect of HSF2 activation by proteasome inhibitors is the induction of the same set of heat shock genes that are induced during heat shock by HSF1, thus revealing that HSF2 affords the cell with a novel heat shock gene-regulatory mechanism to respond ...
... synthesis and reduced degradation. The downstream effect of HSF2 activation by proteasome inhibitors is the induction of the same set of heat shock genes that are induced during heat shock by HSF1, thus revealing that HSF2 affords the cell with a novel heat shock gene-regulatory mechanism to respond ...
Theranostics Using C-Arm X-Ray Imaging to Guide Local Reporter
... bioluminescent signal emission from the PFOB-encapsulated MSCs confirmed as compared to non-encapsulated, naked MSCs, but over 90% of injection sites of PFOB-encapsulated MSCs were visible on c-arm CT. The latter aided in successful targeting of the reporter probe to injection sites using convention ...
... bioluminescent signal emission from the PFOB-encapsulated MSCs confirmed as compared to non-encapsulated, naked MSCs, but over 90% of injection sites of PFOB-encapsulated MSCs were visible on c-arm CT. The latter aided in successful targeting of the reporter probe to injection sites using convention ...
Tensile Properties of Arabidopsis Cell Walls Depend on Both a
... composition to the mechanical properties of an organ, we must account for the contributions of turgor, cell-cell adhesion, the relative density of the foam (distribution of material between symplast and apoplast), and cell wall structure. The availability of Arabidopsis mutants with cell wall phenot ...
... composition to the mechanical properties of an organ, we must account for the contributions of turgor, cell-cell adhesion, the relative density of the foam (distribution of material between symplast and apoplast), and cell wall structure. The availability of Arabidopsis mutants with cell wall phenot ...
Sensitizing B Cells for TLR2 Ligands Cell
... analysis revealed that surface protein A (SpA), similar to BCR cross-linking with anti-human Ig, sensitizes B cells for the recognition of cell wall-associated TLR2-active lipopeptides (LP). In marked contrast to TLR7- and TLR9-triggered B cell stimulation, stimulation with TLR2-active LP and SpA or ...
... analysis revealed that surface protein A (SpA), similar to BCR cross-linking with anti-human Ig, sensitizes B cells for the recognition of cell wall-associated TLR2-active lipopeptides (LP). In marked contrast to TLR7- and TLR9-triggered B cell stimulation, stimulation with TLR2-active LP and SpA or ...
Intracellular distribution of histone mRNAs in human fibroblasts studied
... the eukaryotic genome (reviewed in refs. 1 and 2). For most histones, the coupling of protein synthesis with DNA synthesis during the S phase of the cell cycle is well established (3-6). This cell cycle-dependent synthesis of core and H1 histones is controlled primarily by the level of available his ...
... the eukaryotic genome (reviewed in refs. 1 and 2). For most histones, the coupling of protein synthesis with DNA synthesis during the S phase of the cell cycle is well established (3-6). This cell cycle-dependent synthesis of core and H1 histones is controlled primarily by the level of available his ...
Chloroplast and reactive oxygen species involvement in apoptotic
... 2000; Reape and McCabe, 2008). The mitochondrion has been shown to regulate PCD in a number of ways; for example, cytochrome c is released early in the PCD process (Balk et al., 1999). Cytochrome c is a component of the electron transport chain and one effect of its release is the production of reac ...
... 2000; Reape and McCabe, 2008). The mitochondrion has been shown to regulate PCD in a number of ways; for example, cytochrome c is released early in the PCD process (Balk et al., 1999). Cytochrome c is a component of the electron transport chain and one effect of its release is the production of reac ...
Cytokinesis
Cytokinesis (cyto- + kinesis) is the process during cell division in which the cytoplasm of a single eukaryotic cell is divided to form two daughter cells. It usually initiates during the early stages of mitosis, and sometimes meiosis, splitting a mitotic cell in two, to ensure that chromosome number is maintained from one generation to the next. After cytokinesis two (daughter) cells will be formed that are exact copies of the (parent) original cell. After cytokinesis, each daughter cell is in the interphase portion of the cell cycle. In animal cells, one notable exception to the normal process of cytokinesis is oogenesis (the creation of an ovum in the ovarian follicle of the ovary), where the ovum takes almost all the cytoplasm and organelles, leaving very little for the resulting polar bodies, which then die. Another form of mitosis without cytokinesis occurs in the liver, yielding multinucleate cells. In plant cells, a dividing structure known as the cell plate forms within the centre of the cytoplasm and a new cell wall forms between the two daughter cells.Cytokinesis is distinguished from the prokaryotic process of binary fission.