• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Dr. Tausif Ahmed [Compatibility Mode]
Dr. Tausif Ahmed [Compatibility Mode]

... – Pharmacometrics – still an emerging science – Science that quantifies drug, disease, and trial information to aid efficient drug development and/or regulatory decisions – Pharmacometrics - a collection of model-based approaches used to • extract from data & organize our understanding of a system’s ...
CONTENTS - Health Sciences Authority
CONTENTS - Health Sciences Authority

... Recently, the US Food and Drug Administration (FDA) issued an alert informing healthcare professionals that serious and sometimes fatal hypersensitivity reactions caused by abacavir therapy are significantly more common in patients with the human leukocyte antigen (HLA) allele, HLA-B*5701. This aler ...
Slide 1
Slide 1

... extracts highly-fit and effectively linked BBs  repeats (1) selection and (2) gene deletion  only O(l) computations to converge ...
TARGETING THE CREB PATHWAY FOR MEMORY ENHANCERS
TARGETING THE CREB PATHWAY FOR MEMORY ENHANCERS

... again enhanced four-day memory after two, but not five, training trials. • Stated another way, the PDE4 inhibitors enabled memory to form following less than half the normal amount of training. ...
Accel-Heal® at a glance commissioners
Accel-Heal® at a glance commissioners

... Why should clinicians use Accel-Heal? At Synapse – the home of Accel-Heal we know that every wound has the potential to become complex. Accel-Heal brings clinicians a tool to heal wounds before they become complex, as well as a long awaited breakthrough to healing those that have already become non ...
Association
Association

... contribution to variation in any single phenotype  Prior probability that a variant selected at random will influence a given trait is very ...
Computational Biology 15
Computational Biology 15

... linked chromosomal region is essential for obtaining new information about a disease or biological process. The process of identifying genetic loci within linked chromosomal regions is difficult and often unproductive, which has been a source of frustration for many (50). However, the following thre ...
Pharmacology - aztraumacenter
Pharmacology - aztraumacenter

... acidosis; myasthenia gravis; hypothermia ...
Predictors of 6-month major adverse cardiac events among 30
Predictors of 6-month major adverse cardiac events among 30

... Background: Drug eluting stents (DES), by significantly reducing restenosis rates, have expanded indication of percutaneous coronary intervention to complex lesions in high risk patients. But the advent of DES have raised concerns regarding later occurring stent thrombosis, especially very late sten ...
Remove catheter - ANNA Jersey North Chapter 126
Remove catheter - ANNA Jersey North Chapter 126

... Blood flow - may affect drug transfer Dwell time Residual renal function Dialysate dextrose concentration- increase causes more ultrafiltration • Generally, high drug absorption but low drug clearance for PD ...
Lecture 10 Slides – Chiaretti Paper
Lecture 10 Slides – Chiaretti Paper

... 6 patients who did not respond to induction therapy and 25 patients who achieved CR. ...
iNTRO TO GENETICS PowerPoint
iNTRO TO GENETICS PowerPoint

... • Genes for different traits can segregate independently during the formation of gametes (sex cells). • Mendel wondered if the gene for one trait, such as pea color, had anything to do with another trait such as pea shape. ...
Genetics Vocabulary
Genetics Vocabulary

... The chemical factors in your DNA that determine your traits Genes for things give us codons which we use to make proteins and proteins help us express those traits! ...
William Hellenbrand, M.D., Director of Pediatric Cardiology
William Hellenbrand, M.D., Director of Pediatric Cardiology

... device exemption (HDE) application, which is similar in both form and content to a premarket approval (PMA) application. However, unlike a PMA application, an HDE application is not required to contain the results of scientifically valid clinical investigations demonstrating that the device is effec ...
KING SC SPALDING
KING SC SPALDING

... 500 mg strength . The new proposed strength, 750 mg, will provide practitioners with a convenient, intermediate alternative to the currently approved strengths. The proposed drug product is intended for use only as described in the Indications and Dosage and Administration sections of the currently ...
HTN - Ronna
HTN - Ronna

... • You are rounding outside the room of Ned Flanders, a 75 yo man transferred out of the unit yesterday after a LGI bleed secondary to diverticulitis. He also has a hx of HTN, HLP, and renal cell CA in the distant past. The med student presents a BP of 162/88, and tells you that his BP had been 150-1 ...
document
document

... DPP-4 (dipeptidyl peptidase IV) is an enzyme that's responsible for inactivating hormones in your gut called incretins (glp-1). These helpful incretin hormones cause your pancreas to produce more insulin and your liver to stop producing glucose. By depressing or inhibiting the DPP-4 enzyme that inac ...
DISRUPTING GENETIC EQUILIBRIUM
DISRUPTING GENETIC EQUILIBRIUM

... predator is introduced. Predator can easilty capture the large, visible lizards and the small slower lizards. Thus, selection against these extremes body types reduces the size range in lizards ...
Community Provider
Community Provider

Antimycobacterial drugs
Antimycobacterial drugs

...  Patient is not tolerating the drugs first line drugs.  Resistance ...
Linkage Analysis - The Blavatnik School of Computer Science
Linkage Analysis - The Blavatnik School of Computer Science

... Ultimate Goal: Linkage Mapping With the following few minor problems: – It’s impossible to make controlled crosses in humans. – Human progenies are rather small. – The human genome is immense. The distances between genes are large on average. ...
Genetics and Personality
Genetics and Personality

... Contains between 30,000 and 40,000 genes  All are located on 23 pairs of chromosomes  The body contains roughly 100 trillion copies of the human genome  The Human Genome Project ...
BIOLOGY I Study Guide # 5: Topic – Genetics 1 Name: Define:
BIOLOGY I Study Guide # 5: Topic – Genetics 1 Name: Define:

... a. The inheritance of biological characteristics is determined by genes that are passed from parents to their offspring. b. Two or more forms of the gene for a single trait can never exist. c. The copies of genes are segregated from each other when gametes are formed. d. The alleles for different ge ...
Section 6.4 Introduction in Canvas
Section 6.4 Introduction in Canvas

... A gene is a segment of DNA that tells the cell how to make a particular polypeptide. The location of a gene on a chromosome is called a locus. A gene has the same locus on both chromosomes in a pair of homologous chromosomes. In genetics, scientists often focus on a single gene or set of genes. Geno ...
Patients Perspective Towards Mail Order Services
Patients Perspective Towards Mail Order Services

... • FDA approved as adjunct to diet and exercise to control blood glucose. • Also studied in combination with metformin, SU, insulin, pioglitazone • Can be used as second line, after metformin ( because metformin is more studied and approved as first line), however, its cost should be considered. ...
< 1 ... 975 976 977 978 979 980 981 982 983 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report