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Cardiovascular Drugs ACE Inhibitor • Generic ends in “pril” • Works in the kidney (renin system) blocks angiotension I from forming angiotension II a strong vasoconstrictor • Generic names/trade name: quinapril (accupril), ramapril (altace), benazepril (lotensin), captopril (capoten), enalapril (vasotec), fosinopril (monopril), lisinopril (prinivil), ramipril (altace) This drug will: Lower BP Raise pulse Side Effects hypotension hyperkalemia AceInduced renal insufficience/failure Angioedema dry hacking cough CAN CAUSE FETAL DEATH Avoid if Hx of Renal artery stenosis I teach my patient that the benefit of this drug is: Lowers BP Strengthens a weak heart muscle Slows the progression of renal disease Prevents strokes Improve survival after MI I monitor the following blood pressure (what are my parameters) Renal Function: BUN&Creatinine Potassium level (K) = Angiotension II Receptor Antagonist • Generic ends in “sartan” • Works in the kidney – cousin to the ACE, blocks the action of angiotension II, permits relaxation and dilation of blood vessels. • Generic names/trade name: candesartan (atacand), irbesartan (avapro), olmesartan (benicar), losartan ( cozaar), valsartan (diovan), telmisartan (micardis), eprosartan (teveten) This drug will: Lower BP Raise pulse Side Effects hypotension hyperkalemia AceInduced renal insufficience/failure Angioedema CAN CAUSE FETAL DEATH I teach my patient that the benefit of this drug is: Lowers BP Strengthens a weak heart muscle Slows the progression of renal disease I monitor the following blood pressure (what are my parameters) Renal Function: BUN&Creatinine Potassium level (K) = Beta Blockers • Generic names end in “olol” • Beta1 cells in heart, eyes and kidneys. Beta 2 cells in lungs, gi tract, liver, uterus, blood vessels, and skeletal muscle. • Block Beta cells by blocking effect of norepinephrine and epinephrine. • Generic/trade name: Non-selective beta blockers affect B1 and B2 cells: propranolol (Inderal) affects heart, blood vessels and air passages Selective Beta blockers primarily block B1 cells:Atenolol (tenormin), nebivolol (bystolic), metoprolol tartrate (lopressor), metoprolol succinate (toprol xl), bisoprolol (zebeta), Block beta and alpha-1 receptors which add to blood vessel dilating effect: carvedilol, (coreg), Labetalol (Normodyne, Trandate). This drug will: Lower BP Lowers pulse I teach my patient the benefit of this drug: Lowers BP Antiarrythmic Strengthens weak heart muscle Lowers risk of second MI Angina Reduce production of aqueous humor Therefore reduce pressure for glaucoma Side effects: hypotension bradycardia (heart block) may worsen copd and DM I will monitor the following: BP Pulse Calcium Channel Blockers • Generic/trade name: differ in their duration action, elimination from body, and in their ability to affect heart rate and contraction. They dilate areteries. • Some have little affect on heart rate and contraction so they are safer to use in people with heart failure and bradycardia: felodipine (plendil), amlodipine (norvasc), nifedipine (procardia) These have greatest effect on heart and reduce the strength and rate of contraction, therefore they are used quite often for their antiarrythmic affect: diltiazem (cardizem), verapamil (calan, isoptin), This drug will: Lower BP Lower pulse Side effects: hypotension bradycardia ankle edema constipation I teach my patient I will monitor The benefit of this drug: BP Lowers BP pulse antiarrythmic No grapefruit juice 2hours ac Angina or 4 hours after CCB cyp4503a4 Pulmonary HTN LFT’s Raynauds, subarachnoid hemorrhage And prevention of migraines Antiarrhythmics • These can have mild antiarrhythmic effect to a very strong effect. • Drug will slow heart rate and hopefully keep the heart in normal sinus rhythm • Common ones you will see: Beta blockers/CCB • Lanoxin, sotalol (betapace), flecainide, • The most common and effective is: amiodarone (cordarone, nexterone, pacerone) • The newest one: Multaq may cause liver failure if used long term • This drug will: slow the heart rate is used to help maintain sinus rhythm . Side effects are drug specific All can cause: bradycardia. Used with caution in heart failure. Caution with any 2nd or 3rd degree heart block if no pacemaker present. Amiodarone: causes hypothyroid, interstitial lung changes, visual disturbances, and potentiates coumadin, liver damage I teach my patient That the benefit of this drug is: Helps rate control your heart Helps to maintain sinus rhythm I will closely monitor: Heart rate If on amiodarone coumadin (INR) , TFT, LFT’s, CXR with PFT’s, eye exam along fundoscopy exam, BP and ECG ****Amiodarone is very effective anti arrhythmic with many side effects will see it often due to it is cheap Multaq newer but more expensive used with extreme caution with any one with hx of CHF you wont see this one as often due to cost and concern over long term use due to liver failure. Diuretics • • • Potassium wasting versus potassium sparing. Thiazide (HCTZ) mild used genererally first for HTN treatment (minimal effect on K but still check) Metazolone (zaroxolyn) boosts loop use with caution will really make them increase urine output and waste K must give 30 minutes prior to loop to work!!!!!! Loop Furosemide, torsemide(demadex), Bumetanide(bumex) lowers bp and decreases edema • Potassium sparing: triamterene, Spironolactone (aldactone) Aldactone used in CHF with decreased EF < 35-40 patients it increases long term survival used to decrease aldosterone levels in CHFer’s This drug will: Increase urine output Side effects: hypokalemia hyperkalemia w/k sparing hypotension dehydration I teach my patient That the benefit of this drug is: Decrease blood pressure Decrease edema (lungs and legs) I will closely monitor: BP K BUN Creatinine Antiplatelet aggregration • • • • Aspirin (ASA) 81mg, 162mg or 325mg Clopidogrel (plavix) 75mg Prasugrel (effient) 10mg daily (5mg if wt<60kg) If s/p PCI with Stent placement must remain on above for at least 12 months minimum generally ASA325 + plavix or effient x 90 days, then ASA 81mg + plavix or effient. Do not stop unless you speak with cardiologist and are told to do so. If they are stopped high risk for restenosis of drug eluting stent • Effient and plavix cost about $185 dollars for 30 day supply very expensive. Anti platelets • ASA reduces production of platelets ASA: Bleeding/tinnitus • Effient/plavix prevents platelet aggregation effient not advised if pateint is >75 years old, actively bleeding, recent CVA/TIA, wt<60kg. For Effients and Plavix bleeding and hemorrhage • Prevents MI’s and embolic CVA/TIA S/P PCI with drug eluting stent: these patient must remain on asa plus one of the antiplatelets as previously described for at least one year with no interruption in therapy monitor for bleeding Actively Bleeding labs: H&H Can the patient form a clot labs: Plt Anticoagulants • Warfarin (Coumadin) afib, aflutter thromboembolism/stroke prophylaxis, mechanical valve, DVT, VTE prophylaxis with hip/knee replacements QD dosing. Vit K reverses now given orally not IM • Dabigatran (Pradaxa) • afib/aflutter thromboembolism/stroke prophylaxis When switching from coumadin to pradaxa INR has to be < 2 BID dosing No antidote • Rivaroxaban (Xarelto) afib, aflutter thromboembolism/stroke prophylaxis, DVT • • prophylaxis with hip/knee replacements when switching from coumadin to Xarelto INR has to be < 3., DVT prophylaxis post op hip start 6-10h post op once hemostasis is established X 35 days DVT prophylaxis post op knee start 6-10h post op once hemostasis is established X 12 days No antidote Anticoagulants • Coumadin: inhibits Vit K dependent Bleeding coagulation factor synthesis. Pradaxa: reversibly inhibits thrombin Xarelto: selectively blocks active site of factor Xa, thus inhibiting blood coagulation Prevents Embolic events Types of embolic events? If on Coumadin watch INR Assess for bleeding: H&H Oral Antidiabetic Medications • Can insulin be given via oral route? • Remember that people with type 2 diabetes tend to have two problems that lead to increased sugar (glucose) in the bloodstream: • They don't make enough insulin to move glucose into cells where it belongs. • The body's cells become "resistant" to insulin (insulin resistance), meaning they don't take in glucose as well as they should. • • • • Oral antidiabetic medications work three different ways Stimulates pancrease to produce insulin Makes cells more sensitive to insulin Decreases the GI tract’s absorption of glucose. Sulfonylureas. Increase insulin production • These diabetes pills lower blood sugar by stimulating the pancreas to release more insulin. • They include: Glucotrol (glipizide), Glucotrol XL (extended release), DiaBeta (glyburide), Micronase (glyburide), Glynase PresTab (glyburide), and Amaryl (glimepiride). These drugs can cause a decrease in the hemoglobin A1c (HbA1c) of up to 1%-2%. Sulfonylureas Side effects • • • • Hypoglycemia (low blood sugar) Upset stomach Skin rash or itching Weight gain Biguanides. Make cells more receptive • These diabetes pills improve insulin's ability to move sugar into cells especially into the muscle cells. They also prevent the liver from releasing stored sugar. • Used along with diet and exercise. • Biguanides should not be used in people who have kidney damage or heart failure because of the risk of precipitating a severe build up of lactic acid (called lactic acidosis) in these patients. Biguanides can decrease the HbA1c 1%-2%. • An example includes: metformin (Glucophage, Glucophage XR, Riomet, Fortamet, and Glumetza). Side effects: • • • • Upset stomach (nausea, diarrhea) Metallic taste in mouth Vit B12 deficiency Lactic Acidosis Thiazolidinediones Makes the cells use insulin better • Actos (pioglitazone) • Avandia (rosiglitazone) can only be used if client has already been on it and has had risks and benefits reviewed and they decide to stay on it. Due to increased risk of heart failure and CVS events • Typical reductions in glycolated hemoglobin (A1C) values are 1.5–2.0%. Alpha-glucosidase inhibitors • Precose (acarbose) and Glyset (miglitol). • These drugs block enzymes that help digest starches, slowing the rise in blood sugar. • They can lower hemoglobin A1c by 0.5%1%. Side effects of Alpha-glucosidase inhibitors • Diarrhea, nausea, cramps or gas Meglitinides, stimulate release of insulin • Prandin (repaglinide) and Starlix (nateglinide). • The effects of these diabetes pills depend on the level of glucose. They are said to be glucose dependent. • High sugars make this class of diabetes medicines release insulin. • This is unlike the sulfonylureas that cause an increase in insulin release, regardless of glucose levels, and can lead to hypoglycemia Side effects of meglitinides include: • Hypoglycemia (low blood sugar) • Stomach upset Dipeptidyl peptidase IV (DPP-IV) inhibitors increasing insulin secretion from the pancreas and reducing sugar production (great for lowering postprandial blood sugar) • Januvia (sitagliptin), Onglyza (saxagliptin), and Tradjenta (linagliptin), Galvus (Vildagliptin) . • DPP-4 (dipeptidyl peptidase IV) is an enzyme that's responsible for inactivating hormones in your gut called incretins (glp-1). These helpful incretin hormones cause your pancreas to produce more insulin and your liver to stop producing glucose. By depressing or inhibiting the DPP-4 enzyme that inactivates incretins, DPP-4 inhibitors promote higher levels of incretins (glp-1) to keep your blood glucose in the normal range, especially after meals. • DPP-IV inhibitors control sugar without causing weight gain. The medication may be taken alone or with other medications such as metformin. DPP-4 inhibitor Side effects • During the clinical studies, the most common side effects were: • cold like symptoms, stuffy nose, sore throat, coughing, high cholesterol, high triglycerides and weight gain. • Hypoglycemia when used with metformin.