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Primovist solution for injection, prefilled syringe ENG SmPC
Primovist solution for injection, prefilled syringe ENG SmPC

... The overall safety profile of Primovist is based on data from more than 1,900 patients in clinical trials, and from post-marketing surveillance. The most frequently observed adverse drug reactions ( 0.5 %) in patients receiving Primovist are nausea, headache, feeling hot, blood pressure increased, ...
Jennifer F`s Answer Key
Jennifer F`s Answer Key

... serotonin syndrome sx’s are agitation, confusion, disorientation, anxiety, hallucinations, poor concentration…); withdrawal syndrome sx’s are dizziness, HA, nausea, anxiety, tremors…and you can only get withdrawal syndrome when ur taken off Prozac, which was not the case in the question  13) C-Ace ...
Therapeutic Categories
Therapeutic Categories

11-15-04 Anti-infective Agents short form
11-15-04 Anti-infective Agents short form

... • Totally dependent on the metabolic system of the human host cells • Attach to cell membranes to inject viral DNA or RNA into the cell • Enter nucleus to direct production of more viruses according to the nucleic acid blue print • Cells rupture to “shed” new viruses to infect ...
Psychotropic (Psychoactive) drugs
Psychotropic (Psychoactive) drugs

... Unwanted effects • unwanted effects occuring during therapeutic use ---Influence on manual skills (such as driving performance) due to drowsiness, confusion, amnesia and impaired coordination --- enhance of depressant action of other drugs (in a more than additive way) --- breath center depression ...
Genetics - Easy Plan Book
Genetics - Easy Plan Book

... 1851 – worked with pea plants to study the effects of crossing plants with certain traits with others. Came up with a couple of rules, and ideas of how heredity works. ...
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Study Notes

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Problem Set 8 Genetics 371 Winter 2010 1. In a population
Problem Set 8 Genetics 371 Winter 2010 1. In a population

... This is a hard, thought question that we haven’t considered in class or quiz section. A recessive cancer-predisposing mutation would likely be in a tumor suppressor gene since both copies have to be inactivated. That inheritance doesn’t show a dominant pattern (like BRCA1 mutation) might suggest low ...
Major Depressive Disorders
Major Depressive Disorders

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Small Population Breeds- Genetic Diversity
Small Population Breeds- Genetic Diversity

... breeds with small populations. The concern is whether there is enough genetic variation within a breed’s gene pool to maintain health and vitality. Breeders should be concerned about genetic diversity, because there are examples where damage has been done to a breed due to breeding practices. Restri ...
Antipsychotic Use in Pregnancy 2013
Antipsychotic Use in Pregnancy 2013

... women with schizophrenia have higher pregnancy risks (fetal distress, low birth weight, and congenital anomalies) and it is not known if these can be attributed to the medical condition itself, or if medications contribute to these outcomesi. Alternatively, for those who wish to discontinue medicati ...
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Entry slip hypercholesterolemia names Meuwese, M.C., Mooij, H. et

... should provide detailed structure/ diagrams, indicating macromolecular components) What is the proposed function of the endothelial glycocalyx? Therefore why were they testing patients with familial hypercholesterolemia? ...
Towards better patient care: drugs to avoid in 2016
Towards better patient care: drugs to avoid in 2016

... clinical trials and animal pharmaco­ toxicology studies, and any pharmacological affiliation. Marketing authorisation of a new drug does not signify that its harm-­ benefit balance has been fully documented. Indeed, rare but serious adverse effects may only emerge after several years of routine use ...
key issues in biotechnology
key issues in biotechnology

... Furthermore, this new knowledge is in the public domain and therefore freely available to scientists who are able to access it, and have the ability to analyse and use it. Future benefits will undoubtedly include improved drug and vaccine development. However, there are societal implications flowing ...
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Pharmacognosy_Topic_1_What_is_Pharmacognosy

... produces an unwanted effect, this is also referred to as an adverse reaction. (Braun & Cohen 2005 pp.28-35) ...
Half-Life
Half-Life

...  Half-Life: The time it takes a substance to decrease to half of a previous value.  Half-Life is a good predictor of how long a substance will exist.  Drug Half-Life: The time required for the total amount of a drug in blood to diminish by half, once the drug reaches its peak concentration. See P ...
Missing Heritability
Missing Heritability

... CNVs: Impact of large variants (deletions, duplications and inversions) that are individually rare but collectively common CNPs: Several hundred genes that map to regions of CNP duplications. These genes are highly variable among individuals, enriched in genes associated with drug detoxification, im ...
GENETICS
GENETICS

... Assumes equal chance of alleles in gametes Female gametes on side, male gametes above Fill in the boxes below and to the right to find the possible genotypes of offspring. • Gives chances of each possibility out of 4. ...
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Durand and Barlow Chapter 10: Substance-Related

... – Used medicinally or to increase body mass – Users may engage in cycling or stacking – Steroids do not produce a high ...
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Coenzyme Q10 - Meridian Kinesiology

... talk to a healthcare professional that is up to date on current CoQ10 research and the benefits of preventative and therapeutic treatment. ...
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Lamb Mechanisms Drug Action

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Uppers, Downers & All Arounders

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Signal Detection in EudraVigilance
Signal Detection in EudraVigilance

... products and the same AEs. See Annex 2. In a standard log-linear model these effects would be fitted as terms specific to each known association. This would be simple if reduction to a 2 dimensional table proves possible but, if not, may require careful selection of marginal tables of fairly large d ...
Pitfalls in Companion Diagnostics
Pitfalls in Companion Diagnostics

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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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