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Primovist solution for injection ENG SmPC
Primovist solution for injection ENG SmPC

... The overall safety profile of Primovist is based on data from more than 1,900 patients in clinical trials, and from post-marketing surveillance. The most frequently observed adverse drug reactions ( 0.5 %) in patients receiving Primovist are nausea, headache, feeling hot, blood pressure increased, ...
B.Pharm Revised 2003-04 Final Year With Elective Subject
B.Pharm Revised 2003-04 Final Year With Elective Subject

... Study of prodrugs in solving problems related to stability, bioavailability and elegance of formulations. Design development and process validation methods for pharmaceutical operations involved in the production of pharmaceutical products with special reference to tablets, suspensions. Prospective ...
ANAESTHESIA AND LIVER DISEASE Dr Robert Ginsburg FRCA
ANAESTHESIA AND LIVER DISEASE Dr Robert Ginsburg FRCA

... a sulphur-containing antioxidant that has been shown to benefit patients with fulminant hepatic failure. NAC appears to improve oxygen delivery and consumption, and reduce base deficit. Renal Function Renal function is often impaired in these patients, so perioperative replacement therapy may be nee ...
Genetic testing - Science Museum
Genetic testing - Science Museum

... whether or not they have inherited the altered gene, but cannot predict when they will start to develop symptoms, which usually happens between the ages of 30 and 50. ...diabetes? There are two main types of diabetes. Type 1 diabetes develops when the insulin-producing cells in the body have been de ...
Techniques of Preparing Datasets for Visualizing Clinical Laboratory Data
Techniques of Preparing Datasets for Visualizing Clinical Laboratory Data

... A typical figure of distribution by visit and treatment for ALT (Alanine Aminotransferase) looks like the following . It includes four parts – the number of subjects who have the test results above the clinical concern level, the clinical concern level scatter plot, the box plot, and the number of s ...
The Role of Neuroimaging in Clinical Trials and Drug Discovery In
The Role of Neuroimaging in Clinical Trials and Drug Discovery In

... antagonizing DA D2 receptors (Seeman et al, 1976). It was later discovered with PET that clinically effective doses of typical neuroleptics occupy D2-like DA receptors in the human striatum in the range between 65 and 90% (Farde et al, 1992). The suggestion of a 'therapeutic window' between 60 and 8 ...
Prescribing Matters Please circulate to all prescribers, including
Prescribing Matters Please circulate to all prescribers, including

... Closely monitor for signs of pulmonary, hepatic, neurological, haematological, and gastrointestinal side effects during treatment. NB if not using the mr prep, plain capsules are cheaper than plain tablets, and the liquid is very expensive. Men B vaccination (Bexsero) for asplenic patients From May ...
ORIGINAL ARTICLE EFFICACY OF CINITAPRIDE HYDROGEN TARTARATE IN GERD Puneet Rijhwani
ORIGINAL ARTICLE EFFICACY OF CINITAPRIDE HYDROGEN TARTARATE IN GERD Puneet Rijhwani

... and nausea & vomiting from at the end of the study. (Fig. 1) The secondary efficacy variables were (1) Improvement in the mean intensity score of the symptoms (overall and individual) as estimated on a weekly basis. (Fig. 2) (2) Percentage of patients not requiring any rescue therapy (i.e., antacids ...
GROSSET_TBETHICS
GROSSET_TBETHICS

... • Beneficence – the patients should benefit, or at least not suffer, from being in the trial • Equipoise – when randomizing, the investigators must be equally comfortable with the alternative treatment arms • Justice – the benefits and burdens of research should be shared fairly to the extent possib ...
Management of Adverse Drug Reactions in Treatment of MDR-TB
Management of Adverse Drug Reactions in Treatment of MDR-TB

... every other week for at least the first month of treatment. 2. Creatinine clearance may be needed for high risk group patients. 3. If Serum potassium is low, check the Magnesium and Calcium levels. ...
Principles of Pharmacology - McGraw Hill Higher Education
Principles of Pharmacology - McGraw Hill Higher Education

... Mrs. Del Rosario tells you she does not take any medication when you are taking her history. When you question her further, she says she takes an OTC pain medication occasionally and routinely take several herbal supplements. What should you tell her? ANSWER: You should tell her it is important to r ...
IMPERIAL COLLEGE SCHOOL OF MEDICINE
IMPERIAL COLLEGE SCHOOL OF MEDICINE

... F. Dopamine receptor agonist (longer half life) Metaclopramide F. Dopamine receptor antagonist. 2. The discovery of a phaeochromocytoma is a medical emergency ...
curriculum vitae
curriculum vitae

... that receive, clean and house all the ITN mechanistic data. Manages a team of biostatisticians that analyze all ITN mechanistic data in conjunction with clinical information. Responsible for building and implementing a web portal with the architecture behind it to merge clinical and mechanistic data ...
Lospan Prescribing Information
Lospan Prescribing Information

... to the fetus. Lactation: Baclofen is excreted in breast milk. However, evidence suggests that the quantities are so small that no undesirable effect on the infant would be expected. ...
valproic acid - Fakultas Farmasi Unand
valproic acid - Fakultas Farmasi Unand

... • KL is a 51-year-old, 75-kg (5 ft 10 in) male with tonic-clonic seizures who requires therapy with oral valproic acid. He has normal liver function and takes no medications that induce hepatic enzymes. Suggest an initial valproic acid dosage regimen designed to achieve a steady-state valproic acid ...
Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease

... Principal of Mix & Match Combination therapy • My role here is that of a shopping assistant really recommending ways in which a patient may mix and match medications to achieve goals…challenging given the $$ involved ...
Morphine Sulphate MOR Drugs
Morphine Sulphate MOR Drugs

... injured patients is a clinical one. It is essential however, that any such patient who receives analgesia is closely monitored as opiates may cause disproportionate respiratory depression and hence increase intracranial pressure. Acute alcohol intoxication. All opioid drugs potentiate the central ne ...
handout
handout

... Most psychopharmacological agents are not really syndrome specific- the brain is too complex Theories of action change and are often either wrong or incomplete Drugs can affect gene function, some are being applied to specific behavioral phenotypes ...
Genetic Crosses
Genetic Crosses

... • Extra-nuclear genes are present as small circles of DNA in mitochondria and chloroplasts (both of which reproduce by themselves passing on their genes) • Since, pollen does not contain these organelles and mitochondria are in the tail of the sperm, only the head joins with the egg, this means that ...
Punnett Squares
Punnett Squares

... PHENOTYPES, AND PUNNETT SQUARES ...
Cardiovascular Therapeutics Watch Column
Cardiovascular Therapeutics Watch Column

Slide 1 - TeacherTube
Slide 1 - TeacherTube

... • Each trait – an expressed characteristic is produced by a pair of hereditary factors collectively know as GENES. Within a chromosome, there are many genes, each of which controls the inheritance of a particular trait. • A GENE is a segment of a chromosome that produces a particular trait. For exam ...
Lecture notes of International Edcation Local Anesthetics Definition
Lecture notes of International Edcation Local Anesthetics Definition

... duration and depth of pain control while increasing the anesthetic blood concentration and potential for overdose (toxic reaction). Distribution: Once in the blood, local anesthetics are distributed to all tissues. Brain, head, liver, lungs, kidneys and spleen have high levels of local anesthetics d ...
Tegretol (Equtro as well)
Tegretol (Equtro as well)

... May cause ECG abnormalities; use caution in patients with conduction abnormalities; AV heart block, including second and third degree block, reported following carbamazepine treatment; effect occurred generally, but not solely, in patients with underlying EKG abnormalities or risk factors for conduc ...
NOURIAST Tablets 20 mg
NOURIAST Tablets 20 mg

... Signs, symptoms: Dyskinesia and hallucination may occur as acute symptoms of overdosage. Treatment: Gastric lavage and symptomatic treatment according to symptoms should be performed. General supportive treatment should be indicated in a hospitalization setting, as needed. 9. Precautions concerning ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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