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annotated bibliography - Michigan State University
annotated bibliography - Michigan State University

... follow in the days following ecstasy use as well as general tiredness and hunger. Some women find that their periods become irregular or stop, while other have found that their periods become heavier and longer. Although MDMA does not produce a physical dependency, some users have become psychologic ...
AA vs. Aa and aa
AA vs. Aa and aa

... pig = Pr(qi = g | marker data) • Then, yi, given the marker data, follows a mixture of normal distributions, with known mixing proportions (the pig). • Use an EM algorithm to get MLEs of  = (A, H, B, ). • Measure the evidence for a QTL via the LOD score, which is the log10 likelihood ratio comp ...
Slide 1
Slide 1

... 12. Know the policies of your office regarding the administration of medication. 13. Give only the medication(s) that the physician has order in writing. Do not accept verbal order. 14. Check with the physician if you have any doubt about a medication or an order. 15. Avoid conversations or other di ...
pps
pps

... Typical diseases The search for pharmaceutical drugs used to be rather straight forward until recent times: A wealth of information about the disease, its causes, and the clinical symptoms were readily available. Thus the starting point for the pharmacological therapy was known. Example: inhibition ...
nhs dorset clinical commissioning group position
nhs dorset clinical commissioning group position

... should become available during 2016. It is worth noting that the rate of life threatening or fatal bleeding was lower with all four NOACs/DOACs than it was with warfarin even allowing for the lack of a currently available reversal agent for the NOACS. Patients taking warfarin receive regular INR tes ...
- UAW-GM Center For Human Resources
- UAW-GM Center For Human Resources

... The large profits from sales, plus the fact that these chemicals can be easily synthesized to stay one step ahead of control, indicate there is no incentive to discontinue retail distribution of synthetic cannabinoid products under the current statutory and regulatory scheme. ...
No Slide Title
No Slide Title

...  This was called 'Lamarckism' after its proposer JeanBaptiste Lamarck.  Darwin called this 'pangenesis’ but realised it had a key problem, (e.g. circumcision is not inherited). He argued that all units of the body produce 'gemmules' which can be passed on to the next generation.  Inheritance was ...
Chapter 10 Mendelian Genetics - An
Chapter 10 Mendelian Genetics - An

... The resultant F1 all had purple flowers. The F2 generation consisted of purple flowers and white flowers in a 3:1 ratio (Fig 14.3). Blending theory predicted that progeny should all be pale purple. Instead, F1 all had same traits as purple parent, and the white trait disappeared . o Purple is said t ...
Genetic Drift
Genetic Drift

... In population genetics, gene flow (also known as gene migration) is the transfer of alleles or genes from one population to another. Migration into or out of a population may be responsible for a marked change in allele frequencies (the proportion of members carrying a particular variant of a gene). ...
Modern Methods in Drug Discovery
Modern Methods in Drug Discovery

... Modern Methods in Drug Discovery WS06/07 ...
(30 MCQ answers). - Blackwell Publishing
(30 MCQ answers). - Blackwell Publishing

... clients who may initially be too depressed or anxious to participate fully in psychotherapy. In these cases, symptomatic relief through drug therapy may be adequate, but if it is not, the drugs will most likely alleviate the symptoms sufficiently to allow the person to participate in, and benefit fr ...
interaction chart - Science Based Health
interaction chart - Science Based Health

... Note: This chart includes potential interactions with anti-diabetic medications and tests, and takes into account other drugs that are commonly used to prevent or treat diabetic complications. Agents for pain control of diabetic neuropathy include tricyclic antidepressants, serotonin reuptake inhibi ...
the fork line method - Warner Pacific College
the fork line method - Warner Pacific College

... • In a cross between a black and a white guinea pig, all members of the F1 generation are black. The F2 generation is made up of approximately ¾ black and ¼ white guinea pigs. Diagram this cross an show the ...
Expanded Access For An Unapproved Drug
Expanded Access For An Unapproved Drug

... An unapproved test item (i.e., drug, biologic, or medical device) may only be used on human subjects through a Food and Drug Administration (FDA)-approved clinical study in which patients meet certain criteria and the test item is only used in accordance with an approved protocol by a clinical inves ...
Reading Guide 12 - Natural selection
Reading Guide 12 - Natural selection

... got to do with explaining how resistance happens? In class so far we have been generating a model that helps us to explain how HIV drug resistance might come about. Critical Thinking 1: Write down your Time 0, Time 1, Time 2 model of how you think HIV drug resistance happens, just as we did in class ...
To convert units (u) to kilograms (kg) the following conversion factors
To convert units (u) to kilograms (kg) the following conversion factors

... When viewing reports on-screen it is possible to hide the parameter selection area of the screen by clicking on the pair of upward pointing arrows located at the top right-hand corner. To view the parameters again click on the pair of downward pointing arrows. For both types of report the user can v ...
Chemotherapy Review 2002
Chemotherapy Review 2002

... EKG/echocardiogram (cardiomyopathy) 2 years after completing therapy then every 1-5 years depending on treatment ...
Identification of Genetic Loci Associated With Helicobacter
Identification of Genetic Loci Associated With Helicobacter

... Manhattan plot showing significance of association for all single-nucleotide polymorphisms (SNPs) with a minor allele frequency greater than 1% in the meta-analysis with the anti–Helicobacter pylori IgG phenotype defined as a dichotomous variable comparing samples with the highest 25% IgG titers vs ...
Drugs in pregnancy
Drugs in pregnancy

... but overall most women do not experience significant changes in seizure frequency • Some causes of increased seizure frequency ...
The Cytochrome P450 System: Helping to Teach Its
The Cytochrome P450 System: Helping to Teach Its

... phenytoin and rifampin may alter effects of drugs metabolized by P450 3A4 are commonly described in these drug advertisements. They also emphasize how lifestyle parameters may affect drug therapy. A description of an interaction between smoking and drug levels was found in the advertisement for Nico ...
A Quick Tour Through: Endocrinology
A Quick Tour Through: Endocrinology

... • • Oral contraceptives: Altered exposure may cause irregular bleeding but not increased risk of pregnancy. Advise patients not to discontinue oral contraceptives if spotting occurs. • CNS depressants including alcohol: Potentiate CNS depressant effects. Avoid concomitant use of alcohol. • Non-potas ...
Antibiotics court order based on what happened, and didn`t happen
Antibiotics court order based on what happened, and didn`t happen

... had been found on meat and meat products; and (5) the prevalence of antibiotic resistant bacteria in humans had increased…. The task force made several recommendations, including that (1) antibiotics used in human medicine be prohibited from use in animal feed unless they met safety criteria establi ...
N AA
N AA

... Basic ideas from Darwin • Variation: individuals are not all the same (Fig 21.5 in Purves shows how artificial selection reveals the genetic variation in a population) • Heredity: offspring resemble parents more than unrelated individuals • Selection: if resources are limited, not all offspring sur ...
December
December

... warning to be added to the drug label to highlight this information. Oral viscous lidocaine solution is not approved to treat teething pain, and use in infants and young children can cause serious harm, including death, indicates FDA in a June 2014 Safety Announcement. FDA advises health care provid ...
Note - Informatics
Note - Informatics

... discontinuous variants is called polymorphism (Greek; many forms). The various forms are called morphs. It is often found that morphs are determined by the alleles of a single gene. Why do populations show genetic polymorphism? Special types of natural selection can explain a few cases, but, in othe ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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