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Norpramin (desipramine)
Norpramin (desipramine)

... Most cases of major depression can be treated successfully, usually with medication, psychotherapy, or both. The combination of psychotherapy and antidepressants is very effective in treating moderate to severe depression. The medications improve mood, sleep, energy, and appetite, while therapy stre ...
Chapter 6 - Angelfire
Chapter 6 - Angelfire

... • The strength of pedigrees is that they can show recessive traits in the family, but the weakness is that most genetic experiments are usually done with hundreds of offspring, whereas humans might only have one or two children. • The end result is a probability of a certain genetic disorder occurri ...
Dana Neel - Personalized Medicine: Cancer Prevention, Diagnosis, Prognosis and Targeted Therapy
Dana Neel - Personalized Medicine: Cancer Prevention, Diagnosis, Prognosis and Targeted Therapy

... genetic bases of the two diseases could be completely different, and the appropriate treatment for one may not be right for the other.iv Personalized medicine would allow a doctor to use a patient’s genetic composition to better understand the “molecular classification of cancer subtypes…” and “imp ...
Midterm review - February 26, 2004
Midterm review - February 26, 2004

... Lipophilic drugs tend to have large volumes of distribution which means they tend to exert their effects quickly and then redistribute into fat (ie propofol). As a consequence, they stick around and slowly leach out of the fat into the plasma. This may or may not be significant enough to cause linge ...
Redesign of a clinical decision support system for a drug - drug interaction alert
Redesign of a clinical decision support system for a drug - drug interaction alert

... El Hospital Italiano de Buenos Aires (HIBA) is a university hospital of high complexity founded in 1853 belongs to a nonprofit health network including a second hospital, 25 outpatient centers and 150 private clinics distributed in the city of Buenos Aires. The infrastructure is complete with 750 in ...
Expanding the clinical spectrum of SLC29A3 gene defects
Expanding the clinical spectrum of SLC29A3 gene defects

... a milder form of SLC29A3 associated defects. Similar intra-familial variability was recently reported by Broshtilova et al. They described two siblings, the younger showed the full range manifestations of H syndrome, whereas his older brother presented with only diabetes mellitus. Both brothers were ...
NTBC - International Conference on Rare Diseases and Orphan Drugs
NTBC - International Conference on Rare Diseases and Orphan Drugs

... causing progressive liver failure and liver cancer in young children. Fewer than 100 children in the United States are affected by HT-1. Nitisinone is an orphan drug. Orphan products are developed to treat rare diseases, or conditions that affect fewer than 200,000 people in the U.S. The Orphan Drug ...
tiered orders of approval
tiered orders of approval

... and nutraceuticals market – for every person who takes a supplement that’s medically warranted, experts say more of us are taking something because our neighbor or colleague swears by it. Over the last decade, sales of vitamins, minerals, and nutritional and herbal supplements (VMHS) have surged and ...
Patient Education DIAZEPAM
Patient Education DIAZEPAM

Intra venous anesthetics
Intra venous anesthetics

... Barbiturates: Thiopental is a weak analgesic but a potent anesthetic. It is an ultra-short-acting barbiturate and has high lipid solubility. When agents such as thiopental and methohexital are administered intravenously, they quickly enter the CNS and depress function, often in less than 1 minute. T ...
Botox Hyperhidrosis - NHS Vale of York CCG
Botox Hyperhidrosis - NHS Vale of York CCG

... The marketing authorisation for Botox states that repeat injections of axillary hyperhidrosis should be administered when effects from previous injections subside. Treatment response has been reported to persist for 4-7 months. NICE – Not considered ...
Psychopharmacology
Psychopharmacology

... – LSD: agonist of 5-HT2A – Ectasy: agonist for serotonin and agonist for noradrenaline ...
HEMATOLOGy & ONCOLOGy
HEMATOLOGy & ONCOLOGy

... patients might see the same drug as “worth the risk,” or hope that even if it doesn’t work for everyone it could work for them. In the end, the panel must balance all of this as it makes its decisions. Meanwhile, back in Michigan, Dr. Hussain heads another committee that focuses on a different aspec ...
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... Studied in patients who have the condition it is intended to treat ...
Aalborg Universitet systems
Aalborg Universitet systems

... availability of more potent drugs, increasing the likelihood for drug interactions. Time and route have become critical in administering the right drug to the right patient at the right dose. Many Western healthcare authorities have decided to implement computerised physician order entry (CPOE) syst ...
QUICK MEMO 9, [ ‘ROM
QUICK MEMO 9, [ ‘ROM

... coming to the conclusion that the FDA is not only inadvertently responsible for the problem, they are unable or unwilling to help with a solution. Because the FDA does not have sufficient resources to effectively do all the things that it is trying to do, I propose that its major emphasis in the app ...
CNS Depressants - Wayne State University
CNS Depressants - Wayne State University

... Chronic use depletes these ...
Important side effects to be considered when choosing antipsychotic
Important side effects to be considered when choosing antipsychotic

...  Dopamine receptor blocking activity in the brain:. D1 and D5 receptors activate adenylyl cyclase, often exciting neurons, whereas D2, D3 and D4 receptors inhibit adenylyl cyclase, or mediate membrane K+ channel opening leading to neuronal hyperpolarization. The neuroleptic drugs bind to these rece ...
Test Information Sheet
Test Information Sheet

... the literature to date, almost all of whom have had two identifiable variants in the CYP17A1 gene by sequencing. Variant Spectrum: Most variants in the CYP17A1 gene are missense, nonsense, or frameshift variants, although a few splice site variants have been reported. Variants are scattered througho ...
91157 Demonstrate understanding of genetic variation and
91157 Demonstrate understanding of genetic variation and

... to describe, and describing characteristics of, or providing an account of, genetic variation and change. Demonstrate in-depth understanding involves providing reasons as to how or why genetic variation and change occurs. Demonstrate comprehensive understanding involves linking biological ideas abou ...
Schedule 8 medicines prescribing code
Schedule 8 medicines prescribing code

ranolazine - Physicians Academy
ranolazine - Physicians Academy

Lecture 01 - Cal State LA
Lecture 01 - Cal State LA

... nations have not raised prices on drugs. Richer nations are subsidizing poorer nations (anti-HIV drugs, for example). How do companies make up for increased costs but no price increases? •Consumer approval of the industry has declined (79% approval in 1997; 44% approval in 2004) Focus on diseases of ...
THE SLOW DEATH OF LETHAL INJECTION
THE SLOW DEATH OF LETHAL INJECTION

... healthy behaviours in children. But how has children’s health, and particularly their health related lifestyle behaviours, changed over time? Given media reports such as those about 10 month old children being treated by the NHS for obesity3 or children under 11 being admitted to emergency departmen ...
A SAS Macro to Present a Summary Table of the Number of Patients Having Experienced Adverse Events in a Clinical Trial
A SAS Macro to Present a Summary Table of the Number of Patients Having Experienced Adverse Events in a Clinical Trial

... The table can be custom formatted since the formats of the different table columns as well as the row title space 4 can be passed to the macro as macro parameters. The macro allows the presention of only a subset of the adverse events, such as all events related to the study drug or all serious adv ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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