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... Polymorphism: multiple forms of a gene are commonly found in a population (all studied populations are “wildly” polymorphic) • chromosomal polymorphisms • immunological polymorphisms • protein polymorphisms ...
CHAPTER 11 QUICK LAB
CHAPTER 11 QUICK LAB

... 1. Shuffle the cards and hold the deck face down. Turn over 40 cards to represent the alleles of 20 offspring produced by random matings in the initial population. 2. Separate the 40 cards by suit. Find the allele frequencies for the offspring by calculating the percentage of each suit. 3. Suppose a ...
Antimalarial Drug Toxicity: A Review
Antimalarial Drug Toxicity: A Review

... and central nervous system effects may arise following excessive infusion or from accumulation following oral administration. Severe hypotension may develop if the drug is injected too rapidly. A single dose of quinine of 13 g is capable of causing serious and potentially fatal intoxication in adult ...
iCup Dx - TigerOfficer.com
iCup Dx - TigerOfficer.com

... »» Long shelf-life ...
03.Organism`s level of realiization of genetic information. Gene
03.Organism`s level of realiization of genetic information. Gene

... dominance because the gene that makes the antibodies only creates half of the necessary antibodies which creates a vulnerability in the individual to get Tay-Sachs. • One parent has a large lip protrusion, the other parent has a small lip protrusion and the child has an average lip protrusion. • One ...
Patterns of Inheritance - (www.ramsey.k12.nj.us).
Patterns of Inheritance - (www.ramsey.k12.nj.us).

... Exploring Mendelian Genetics • Does segregation of one set of alleles influence the segregation of another pair of alleles? • Mendel’s Two Factor (dihybrid) Crosses – Followed two traits at a time. – Same method as his original single-factor crosses – Cross-pollinated to produce the F1 and allowed ...
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... C. Both parents must be considered when calculating probability D. To find probability, multiply the separate probabilities of the two events ...
nervous-system
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Forensic Drug Testing Part 1: Screening
Forensic Drug Testing Part 1: Screening

... History of workplace drug testing • 1960s – 1970s: The Department of Defense begins testing military personnel for illegal drug use. • 1986: President Reagan establishes the “Federal Drug-Free Workplace”. • 1988: Mandatory Guidelines for Federal Workplace Drug Testing Programs is published in the F ...
Pharmacology MCQs: 07/05/02
Pharmacology MCQs: 07/05/02

... b. Allergies to amide local anaesthetics are more common than with the ester Las c. Prilocaine is the most cardiotoxic amide LA d. Cocaine is an amide LA which is often used as a drug of abuse e. The half life of lignocaine may be increased 3 to 4 fold in a patient with severe liver disease ...
Introduction to Genetic Models
Introduction to Genetic Models

... Genetic Heterogeneity is common for complex traits, Genetic heterogeneity - The presence of apparently similar characters for which the genetic evidence indicates that different genes or different genetic mechanisms are involved in different pedigrees. In clinical settings genetic heterogeneity refe ...
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210_Blanks_lecture3_drugs

... Occupies nicotinic ___________receptors and leads to paralysis Examples: Effects on NT Reuptake Dopamine reuptake inhibitors Cocaine, ___________, Ritalin Serotonin reuptake inhibitors ___________ More on this later in the class Basic Principles of Drug Effects Drugs may or may not have different ef ...
Exam 1 - Solutions (10 points) 1. Find the equation of a line through
Exam 1 - Solutions (10 points) 1. Find the equation of a line through

... 2. A calculus textbook dropped from the top of a 240 ft. tall building speeds up as it falls. It strikes the ground 3.87 seconds later. a. Draw a graph of the height of the book above the ground (measured in feet) as a function of the time since it was dropped (measured in seconds). Include labels a ...
Fighting the Rx Epidemic: A Prescription For Work Comp | White Paper
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... with some states developing incentives and rules that steer physicians to pain management training. For instance, the state of Washington is giving free education to physicians. In 2011, it changed the Continuing Medical Education (CME) offering for opioid and pain management training from three to ...
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... Before each Taxotere® treatment, all patients treated with Taxotere® must receive another medicine called dexamethasone. This drug can help reduce the risk of fluid retention (edema) and allergic reactions. ...
Physicochemical Properties - Near East University Docs
Physicochemical Properties - Near East University Docs

... Diethylether (Ether U.S.P.) Methylphenylether (Anisole) Solubility (g/100gH2O ...
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... PAL, CMDA and SOR/98-282 regulations as they relate to the design, manufacture, distribution and sale of regulated products. CAPA Team Leader overseeing overhaul of deficient CAPA process and remediation activities. Develop and manage internal audit program. Performance of FDA mock audits in prepara ...
CHAPTER 4
CHAPTER 4

... – Show simple inheritance patterns – Are controlled by single genes on autosomes Recessive Disorders • Most human genetic disorders are recessive. • Individuals who have the recessive allele but appear normal are carriers of the disorder. Dominant Disorders • Some human genetic disorders are dominan ...
Cholesterol metabolism pathway
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... Cognitive change and Alzheimer's disease risk Chandra A. Reynolds, PI Jonathan A. Prince, Co-PI Project Description: The etiologies of normative cognitive change and Alzheimer’s disease (AD) in late adulthood are not fully understood. Outside of the gene encoding apoE, consistent candidate gene asso ...
Pain management in palliative care
Pain management in palliative care

... the two drugs. This again is a huge area of controversy and any equianalgesic tables should be considered with caution as there is lack of comprehensive data and interpatient variation. Special caution should be exercised when converting a patient from high dose morphine to another opioid as the rec ...
Prescribing Information
Prescribing Information

... See full prescribing information for complete boxed warning. Respiratory depression and death have occurred in children who received codeine following tonsillectomy and/or adenoidectomy and had evidence of being ultra-rapid metabolizers of codeine due to a CYP2D6 polymorphism. (5.1) ---------------- ...
Answers to Punnett Square Worksheet
Answers to Punnett Square Worksheet

... ...
May 2011, Number 5  - UF Health Professionals
May 2011, Number 5 - UF Health Professionals

... To convert a patient from another topical preparation to Androgel®, simply use the standard prescribing information. The typical starting dose is 5 mg (1 packet); however, a patient who is on a large dose of a topical testosterone could be converted to 10 mg (2 packets). The dose is usually given in ...
Drugs Discovered through Serendipity in the Laboratory
Drugs Discovered through Serendipity in the Laboratory

... information about any of the trials was released until 1946. It was then revealed that HN2 and HN3 had produced useful results in patients with Hodkgin’s disease, lymphomas or chronic leukaemias, although there was doubt concerning whether they had any superiority over Xrays properly applied to soli ...
Opioid Prescribing: Many Questions and Few Answers
Opioid Prescribing: Many Questions and Few Answers

...  Little mention of abuse deterrent medications  Benzodiazepine use with opioids  Significant increase in deaths and ER visits  Acute pain leading to chronic therapy  Methadone  Offering naloxone to patients at risk  High dose opioids ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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