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CNS Depressants and Antidepressants
CNS Depressants and Antidepressants

... intensify the action of GABA- very safe, even in overdose ...
You will not need to use your Illinois medical card to get your
You will not need to use your Illinois medical card to get your

... and the Rx Buying Club to ensure everyone has access to affordable prescriptions. And now with the new Medicare drug benefit starting next year, Illinois is once again stepping up to make sure that you don’t lose any of the benefits you’ve come to expect. The new Medicare drug benefit will change th ...
LT6: I can explain sex-linked patterns of inheritance in terms of some
LT6: I can explain sex-linked patterns of inheritance in terms of some

... c. Offspring Posters: List genotypes and draw phenotypes d. Review grades while drawing e. Homework (due Friday): What is the life cycle of Drosophila melanogaster, how does it live (food, environment, etc.), and why is it used in so many scientific studies? This should be at least one paragraph in ...
SPC
SPC

... trimetazidine modified release tablet (b.i.d.) added to 50 mg atenolol (o.d.) for 8 weeks produced a significant increase (+34.4s, p=0.03) in the time to 1-mm ST-segment depression in exercise tests, in a sub-group of patients (n=173), when compared to placebo, 12 hours after taking the drug. A sign ...
How to prepare and use gradient plates. David Perkins Background
How to prepare and use gradient plates. David Perkins Background

... Petri plates with a continuous gradient of concentrations from one side to the other were described by Szybalski and Bryson (1952). It was used by them to select bacterial mutants that had acquired increased resistance to antibiotics. It can be used to estimate tolerances and to obtain a semi-quanti ...
How are Traits Passed from Parents to Offspring
How are Traits Passed from Parents to Offspring

... A trait is a characteristic such as color or size that is inherited by an offspring from its parents. The genes that control a trait come in pairs, one gene from each parent. We represent these gene pairs by writing a combination of two capital letters. For example, if one parent contributes a gene ...
Genetic Inheritace - San Juan Unified School District
Genetic Inheritace - San Juan Unified School District

... Multiple Alleles: the presence of more than two alleles for a genetic trait • Blood Type – Human blood type is governed by the presence of 3 different alleles: •A •B •O ...
Table 17. Specific Drug Information for ER/LA Opioid
Table 17. Specific Drug Information for ER/LA Opioid

... Opioid-naive patients: initiate treatment with 10 mg every 12 hours. Titrate using a minimum of 1- to 2-day intervals. Hepatic impairment: start with one-third to one-half the usual dosage. Renal impairment (creatinine clearance <60 mL/min): start with onehalf the usual dosage.  Consider use of oth ...
Alcohol
Alcohol

... closes Na+ & Ca++ channels  depression of CNS, adrenergic activity   BP and  HR • Acetaldehyde is a byproduct of alcohol metabolism. Large amounts of acetaldehyde combine with dopamine and serotonin to produce a substance that is highly addictive. ...
5-Antifungal Chemotherapy
5-Antifungal Chemotherapy

... ergosterol in the cell membrane. Which drug probably would not work against this pathogen (due to development of resistance) if to be prescribed ? ...
Bez nadpisu
Bez nadpisu

... synergy and enhanced duration of response • Adverse events include increased risk of infection, hypersensitivity reactions, and formation of auto-antibodies ...
Biology of Laboratory Rodents
Biology of Laboratory Rodents

... – DNA sequence that encodes for a specific protein product – gene “expression” means protein product is being made via transcription and translation (DNA to RNA to protein) ...
Evolution of Populations
Evolution of Populations

... This small population size means that the colony may have: • reduced genetic variation from the original population. • a non-random sample of the genes in the original population. For example, the Afrikaner population of Dutch settlers in South Africa is descended mainly from a few colonists. Today, ...
Best Practices: Prescription Drugs and Chronic Pain
Best Practices: Prescription Drugs and Chronic Pain

... • No generic substitutions for brand-name drugs • DAW doesn’t matter if the brand-name drug was dispensed ...
Rodney Ferry testimony - Oregon Legislative Information System
Rodney Ferry testimony - Oregon Legislative Information System

... out in the guidance, these companies would then have three years to fully implement these changes.” Since there is approximately 495 million people and pets in the US and somewhere in the neighborhood of 10 billion or more farm animals (20 times the people and pet population) it is not overly surpri ...
B1 Revision H
B1 Revision H

... the drug are given to begin with. If there are no problems, further clinical trials are done to find the optimum dose for the drug. Clinical trials are not without risk. Sometimes severe and unexpected side-effects occur. Most substances do not pass all of the tests and trials, so drug development i ...
MYH-associated polyposis fact sheet
MYH-associated polyposis fact sheet

... DNA testing is commercially available and warranted in individuals with more than 10 polyps but who do not have a mutation in the APC gene. Since the clinical features of MAP are similar to those of FAP/AFAP, FAP/AFAP should first be ruled out by testing for a mutation in APC. If no mutation is foun ...
Are all angiotensin-converting enzyme inhibitors
Are all angiotensin-converting enzyme inhibitors

... referred to as “me-too” drugs. Due to a lesser financial investment, the latter may be available at a lower cost. Good reasons exist for grouping drugs, however, there is no accepted definition of the term “class effect.” Although members of a drug class share main actions, they may have clinically ...
off-label drug use: pros and cons - Albany Law Journal of Science
off-label drug use: pros and cons - Albany Law Journal of Science

... drug use. Some patients are willing to take those risks for undocumented efficacy and potential for side effects because, well, what’s the alternative? The alternative is I’m going to die of my underlying disease. So there’re certainly disease populations where there are issues. Even veterinary medi ...
Tiered 15/30/50 Var Pharmacy Plan
Tiered 15/30/50 Var Pharmacy Plan

... A drug formulary is a list of preferred medications used to treat various medical conditions. The formulary for this plan is known as the Preferred Drug List (PDL). The PDL is used to help control rising healthcare costs while ensuring that you receive medications of the highest quality. It is a gui ...
Slides 2
Slides 2

... Acts by inhibiting microtubule synthesis. Mebendazole is indicated for use in: Ascariasis, ...
GWAS_lecture_Nov_2010_SB
GWAS_lecture_Nov_2010_SB

... to better understand organismal phenotypes ...
Cystic Fibrosis and genetic testing
Cystic Fibrosis and genetic testing

... Digestive symptoms People with CF are also not able to secrete the enzymes into their gut that are needed to digest food properly. This means it is very hard for them to extract the nutrition they need from the food they eat. ...
Presentation
Presentation

... independently of each other ...
Media:GWAS_lecture__Nov_2011_SB
Media:GWAS_lecture__Nov_2011_SB

... to better understand organismal phenotypes ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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