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Meeting Minutes AAPIFDA Pediatric Exclusivity Provisions of the FDA Modernization
Meeting Minutes AAPIFDA Pediatric Exclusivity Provisions of the FDA Modernization

... committees. An alternative maybe to place a pediatrician on each existing advisory committee. When needed, these pediatricians may be called together to form a subcommittee to address specific pediatric issues. ...
Abuse of Prescription and Over-the-Counter Medications
Abuse of Prescription and Over-the-Counter Medications

... medications, 34% were adverse reactions associated with medical use, 10% were accidental ingestion, and 8% were suicide attempts. The rates were higher for the 12- to 17-year-old age group than for patients aged 18 or older. Over two thirds (68%) of the visits involved nonmedical use of these 2 drug ...
ISMP Medication Safety Alert! Community/Ambulatory Care Edition
ISMP Medication Safety Alert! Community/Ambulatory Care Edition

... leaflets in Spanish exemplified this.3 The parents were asked to read the medication label and the information sheet and then answer questions regarding the medication and proper dosing. Of the 100 participants in the study, only 22% would have given a correct dose of medication to their child and o ...
Analgesic
Analgesic

... the aspect of addiction development  indicated in case of pain of medium intensity in such conditions like other opioid analgesics. In case of strong pain its administration is limited as in case of increasing of dose of the drug excitation appears  it can cause increasing of blood pressure and ta ...
Analyze genetic testing results to predict
Analyze genetic testing results to predict

... learn more about her risk of passing this gene on to her child. Her doctor assures her that simple genetic testing can identify whether or not she and Aaron are carriers for the disease, but Gina and Aaron have many unanswered questions. They never thought that deciding to have a baby could be so co ...
05 Evolution 2010
05 Evolution 2010

... Change in allele frequency in a population through time… • What must be present for natural selection to cause evolutionary change? ...
Course Competencies Template – Form 112
Course Competencies Template – Form 112

... 9. Differentiating between essential genes and both dominant and recessive lethal alleles. 10. Explaining the environmental influences on gene expression. 11. Listing examples of non-Mendelian inheritance. ...
Course Competencies Template – Form 112
Course Competencies Template – Form 112

... 9. Differentiating between essential genes and both dominant and recessive lethal alleles. 10. Explaining the environmental influences on gene expression. 11. Listing examples of non-Mendelian inheritance. ...
Stimulant fact sheet
Stimulant fact sheet

... — tragically — about four per million children die suddenly of cardiac arrhythmias each year. The fatalities in the Canadian report included cases of overdose, congenital cardiac disease, and other unusual factors — all of which make it impossible to decisively answer the question of whether Adderal ...
DestinationRx FAQs
DestinationRx FAQs

... How does a Healthcare Exchange work? Typically, a Healthcare Exchange sets standard benefit types and uses premium information as well as other cost-sharing information, such as deductibles and co-pay levels to present an apples-to-apples comparison to consumers so that they can compare the relative ...
Bioavailability
Bioavailability

... application), it first must enter the bloodstream and then be distributed to its site of action. To be effective, the drug must leave the vascular space and enter the intercellular or intracellular spaces or both.The rate at which a drug reaches its site of action depends on two rates: absorption an ...
Gastro05-GIPharm1
Gastro05-GIPharm1

Chapter 9
Chapter 9

... all offspring CWCR pink color, which is intermediate between 2 homozygous. We don’t identify them as dominant or recessive because when they are together neither dominates. Codominanceheterozygous shows both traits at the same time. Sickle-cell disease is homozygous recessive, it’s characterized by ...
notes
notes

... • About 1 in 21 Caucasians is a carrier for CF ...
Mendel and the Gene Idea
Mendel and the Gene Idea

...  Because each individual carries two alleles, there are six possible genotypes and four possible blood types ...
1990: Postgraduate specialization in Pediatrics, University of Rome
1990: Postgraduate specialization in Pediatrics, University of Rome

... Abuse of drugs in sportsmen: general concepts, screening methods and confirmation tests. Introduction to Pharmacogenetics: the need for predictive pharmacogenetics-based therapeutic recommendations. Applications in oncology, gastroenterology, rheumatology, psychiatry, acute and chronic pain, cardio ...
Chapter 13
Chapter 13

... obtain information about the distance between genes on a chromosome. - this is genetic mapping This type of mapping is based on genetic ...
london cancer networks - London Cancer Alliance
london cancer networks - London Cancer Alliance

... APPLICATION FORM to access Cancer Drug Fund Only fully completed forms will be accepted. This route of funding applies for the list of drugs identified by the London Cancer New Drugs Group for funding when used in accordance with the previously agreed and listed criteria. All eligibility criteria li ...
When drug therapy gets old: pharmacokinetics and
When drug therapy gets old: pharmacokinetics and

... expression of which is associated with multidrug resistance (Robert, 1999). There is evidence that patients older than 56 years and afflicted with acute myeloid leukemia are more often positive for the multidrug resistance-associated protein-1 (mrd-1) than younger patients. Mdr-1 gene expression and ...
COURSE TITLE: DRUG-RELATED ADVERSE EFFECTS OF CLINICAL IMPORTANCE
COURSE TITLE: DRUG-RELATED ADVERSE EFFECTS OF CLINICAL IMPORTANCE

... osteolytic bone metastases of both breast cancer and multiple myeloma, and Paget’s disease of the bone. Clinical Importance/ Ocular Concerns: This class of medicine has been reported to cause anterior uveitis and nonspecific conjunctivitis. There are case reports of episcleritis, nerve palsy, ptosis ...
Exists but still being developed
Exists but still being developed

... The national policy context • 2010 drug strategy: • “Substitute prescribing continues to have a role to play in the treatment of heroin dependence, both in stabilising drug use and supporting detoxification. Medically-assisted recovery can, and does, happen. ... • However, for too many people cur ...
Drugs and Toxicology
Drugs and Toxicology

... for analysis Toxicologists must be able to analyze small amounts of drug and isolate them from a complex biological matrix In contrast to the work typically done by drug chemists, a toxicologists needs quantitative information in order to determine if the amount is consistent with a therapeutic dose ...
Sedation and Analgesia - Maricopa Medical Center
Sedation and Analgesia - Maricopa Medical Center

... Lorazepam is a benzodiazepine of intermediate duration of action and may be administered as an infusion or by intermittent bolus injection. Like other benzodiazepines, it has anticonvulsant properties. Given its terminal elimination half-life (10-20 hr), it is the benzodiazepine of choice for prolon ...
Exam 5 Review - Iowa State University
Exam 5 Review - Iowa State University

... D) no gene flow 15. If the allele frequencies in a population are A: 0.6 and a: 0.4. what is the frequency of the Aa genotype if the population is in Hardy-Weinberg equilibrium? A) 1.0 B) 0.52 C) 0.36 D) 0.48 16. Using the same data what is the frequency of the AA genotype? A) 1.0 B) 0.52 C) 0.36 D) ...
Examples
Examples

... • Traits carried on the X chromosome – Who will show more X-linked disorders, males or females? Why? • Males – b/c they only have one X (XY) so it doesn’t matter if trait is dominant or recessive – Examples: • Colorblindness – carried on X-chromosome • Hemophilia – impaired blood clotting ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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