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Combining antidepressants
Combining antidepressants

... A recent review (2) suggested that improvement following antidepressant combination occurs within approximately 4-6 weeks, so it is worthwhile waiting this period of time to assess patient response. Most studies focused on the short-term outcome and little is known as to the recommended duration for ...
Document
Document

... Two additional major assumptions here: ...
genes
genes

... The Law of Segregation: the alleles for the same gene are separate and are inherited independantly of each other Example: T ...
Optimizing stroke prevention in atrial fibrillation:
Optimizing stroke prevention in atrial fibrillation:

... In the current issue of Europace, Vrijens et al. nicely highlight a changing perception of relationships between patients and health providers, from a passive patient role to ‘simply follow the physician’s instructions’ (that is, patient compliance) to an active bilateral participation in the proces ...
Genetic Testing - Partnership HealthPlan
Genetic Testing - Partnership HealthPlan

... A Treatment Authorization Request (TAR) is required for certain genetic testing as outlined in Attachment A. Please note PHC requirements may differ from California Department of Health Care Services (DHCS) Requirements. Please use PHC’s grid entitled Genetic Testing Requirements (Attachment A) for ...
Preview Sample 1
Preview Sample 1

... nonionized (neither positive nor negative) also pass through the GI membrane faster than those with a charge. DIF: Cognitive Level: Comprehension REF: 4 TOP: Nursing Process: Analysis MSC: CONTENT CATEGORY: Physiological Integrity: Pharmacological and Parenteral Therapies 4. A client asks why the or ...
GastroenteroloGy Advances in Hepatitis Research Halting Hepatitis C
GastroenteroloGy Advances in Hepatitis Research Halting Hepatitis C

... Plans are underway for a new Center for Hepatitis Research and Education, within the Division of Gastroenterology. The center will provide additional infrastructure to support basic, translational and clinical research endeavors; to train fellows and faculty and to provide optimal care and education ...
chapter11
chapter11

... Variations on Mendel’s Theme  Not all traits appear in Mendelian inheritance patterns • An allele may be partly dominant over a nonidentical partner, or codominant with it • Multiple genes may influence a trait; some genes influence many traits • The environments also influences gene ...
Lecture_15_Pop Dynamics_Humans_Part II
Lecture_15_Pop Dynamics_Humans_Part II

... People – In incomplete dominance, F1 hybrids have an appearance in between the phenotypes of the two parents. ...
Name: Date: ______ 1. All of the following are
Name: Date: ______ 1. All of the following are

... 82. The benzodiazepines, whether used for anxiety or as a hypnotic, all: A) belong to schedule 2 B) belong to schedule 3 C) belong to schedule 4 D) are not scheduled drugs ...
Application of Q QSAR in Drug Design and Drug D Discovery
Application of Q QSAR in Drug Design and Drug D Discovery

... Vol. 1 [1] May 2015; 27-31 ...
sheet#10,by farah odeh
sheet#10,by farah odeh

... relatives of the most severely affected patients.  If there is more than one affected close relative then the risks for other relatives are increased  Liability = quantitative trait that presents a genetic risk for a threshold trait  Individuals with a liability above threshold develop the trait ...
Human fertility gene found - Carole Ober
Human fertility gene found - Carole Ober

... increased male birth rate, resulting in an average of two more children per male over the span of a 25-year breeding period. All told, the polymorphism explained 4.3% of the variation in male birth rate -- a large amount for any single gene, Ober said. (By comparison, the 50-odd genes found to affec ...
2004 Guide to Psychiatric Drug Interactions
2004 Guide to Psychiatric Drug Interactions

... patient outcomes. The use of multiple psychiatric medications to treat patients is on the rise; there was a 15-fold increase in percentage of patients on three or more psychiatric medications being seen at the Biological Psychiatry Branch of the National Institute of Mental Health from the early 197 ...
Minal Patel Ppt
Minal Patel Ppt

... BY: PATEL MINAL NARAN U29/35243/2010 ...
PDF hosted at the Radboud Repository of the Radboud University
PDF hosted at the Radboud Repository of the Radboud University

... of pharmacy-initiated medication reviews is prominent among methods that have been advocated to reduce the extent and seriousness of such problems.[1-3] Drug treatments should be periodically reconsidered in terms of their adverse effects. Randomised controlled trials have partially confirmed that p ...
PPT File
PPT File

RECEPTORS
RECEPTORS

... Inverse agonist Inverse agonist can exist where an appreciable level of activation may exist even when no ligand is present For example: receptors for benzodiazepines, cannabinoids and dopamine ...
lab 8
lab 8

... DRUG DOSAGE BASED ON AGE • Neonate have immature renal and hepatic functions, while elderly in addition to diminished organ function, they frequently have concomitant pathologies, so age must be taken in consideration when determining the drug dosage. • In the past There were different rules used t ...
Human Traits
Human Traits

... Science Show - Gregor Mendel 100 Greatest Discoveries Mendel (First section) ...
Lesson on Mendelian Genetics
Lesson on Mendelian Genetics

...  i.e. When he crossed the purebred tall pea plant with the purebred ...
About this template - Centre for Hip Health and Mobility
About this template - Centre for Hip Health and Mobility

...  any tick for thrombosis risk should prompt thromboprophylaxis according to NICE guidance. Risk factors identified are not exhaustive. Clinicians may consider additional risks in individual patients and offer thromboprophylaxis as appropriate Step Three  review the patient-related factors against ...
Opioid Presentation (updated) [Compatibility Mode]
Opioid Presentation (updated) [Compatibility Mode]

... Response determined in relation to both efficacy AND side effects. Opioid titration (small IV doses) best method for estimating optimal starting dose. In adult patient. In adults AGE rather than weight has been shown to be a better predictor of opioid requirement. Elderly patients require lower dose ...
Heredity Inherited Traits
Heredity Inherited Traits

... • Phenotype – An individual’s observable traits (expression of the genotype) • What people can SEE when they look at you • Photograph = picture (what you see) like the Phenotype is the observable trait (what you see) ...
Case Report Warfarin-Induced Skin Necrosis
Case Report Warfarin-Induced Skin Necrosis

... patients with warfarin-induced skin necrosis are not actively bleeding, this dose may be slightly higher than necessary. Taking this information into consideration, the administration of 2 units of FFP for this patient appears appropriate. There are drawbacks to the use of FFP, including the storage ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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