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diuretics
diuretics

... Prazosin, doxazosin and terazosin produce a competitive block of 1 adrenoreceptors. They decrease peripheral vascular resistance and lower arterial blood pressure by causing the relaxation of both arterial and venous smooth muscle. These drugs cause only minimal changes in cardiac output, renal blo ...
A | | b A
A | | b A

... neo-Mendelian Genetics • After re-discovery, Mendel’s postulates were applied to many genetic traits, ...
cytoplasmic inheritance 222
cytoplasmic inheritance 222

... • Patients who have this disorder experience rapid loss of vision in both eyes, resulting from the death of cells in the optic nerve. This loss of vision typically occurs in early adulthood (usually between the ages of 20 and 24), but it can occur any time after adolescence. There is much clinical v ...
National Essential Anaesthesia Drugs List (NEADL)
National Essential Anaesthesia Drugs List (NEADL)

... Safe Anaesthesia Liaison Group (SALG) issued guidance on its administration . This includes careful prescribing of paracetamol according to weight, age and comorbidities. It is also recommended that for patients weighing <33 kg, 50 ml vials should be used. Intravenous paracetamol remains under close ...
Weathering and Soil Formation Learning Targets
Weathering and Soil Formation Learning Targets

... Gene - a segment of DNA on a chromosome, that codes for a specific trait (instructions for making of a specific protein). DNA - genetic material that carries information about an organism. ...
Veritas myGenome Informed Consent Form
Veritas myGenome Informed Consent Form

... b. The report will provide interpretation on approximately 2000 genes as determined by Veritas Genetics. A complete list of current gene offerings can be found on the website (www.veritasgene.com). These genes are associated with specific genetic syndromes in various organ systems (i.e. ACMG 56, se ...
Prescription Sedatives (Canadian Drug Summary)
Prescription Sedatives (Canadian Drug Summary)

... perceptions of relative safety compared with illicit drugs, among other factors. Those who misuse sedatives might take the drug in ways other than prescribed (e.g., using more than prescribed or mixing the medication with alcohol) or tamper with the medication to achieve a more rapid and intense eff ...
Drug Metabolism Test Results
Drug Metabolism Test Results

... variation in CYP2D6 was assessed using a TaqMan® Copy Number Assay. The specific alleles detected by the assays are indicated in the accompanying table and include all common and most rare variants with known clinically significant effects on drug metabolism and are reported at analytical sensitivit ...
Achievement Standard
Achievement Standard

... Biological concepts and processes relating to variation in phenotype will be selected from:  the significance of an allele as an alternative version of a gene  the role of mutations in forming new alleles  the role of meiosis in generating gametes (students are not required to provide the names o ...
O`Brien et al. 1983. The cheetah is depauperate in genetic variation
O`Brien et al. 1983. The cheetah is depauperate in genetic variation

... O’Brien et al. 1983. The cheetah is depauperate in genetic variation - assumed to be result of small N, bottleneck, then inbreeding - highly vulnerable to disease outbreaks (50% mortality in one captive population) Merola, 1994. A reassessment of homozygosity …. - carnivores tend to show low levels ...
Parkinsonism-b
Parkinsonism-b

... It is excreted in the bile and feces. ADRs:Postural hypotension, nausea, somnolence Dyskinesias. Confusion, hallucinations, delusions, In order to minimize adverse effects, the dose is built up slowly over 2 or 3 months. Used for hyperprolactinemia. ...
Gastrointestinal pro..
Gastrointestinal pro..

... fewer septic complications, improved wound healing, decreased bacterial translocation across intestinal mucosa, and decreased catabolic response to injury1. ...
Clinical evaluation of colon specific drug delivery
Clinical evaluation of colon specific drug delivery

... Oral controlled drug deliveys system ADVANTAGES: Increased patient compliance  Reduction in dosing frequency  Reduced fluctuations in circulatory drug levels  Employ less total drug and eliminate local side effects  Better utilization of the drugs  More uniform effect  Better control over th ...
KCCOP Guidelines for Investigational Drug Management
KCCOP Guidelines for Investigational Drug Management

... The Satellite DARF form for Oral Agents and Study Drug that is administered are required by NCI for accurate drug accounting and must be filled out completely and correctly. The Drug Delivery Form was created by the NCORP-KC as an internal edit check system, and its accuracy is also important. Sites ...
Regulating Ambiguous Risks
Regulating Ambiguous Risks

... the FDA have recognized that there are some circumstances in which offlabel uses can be accepted medical practice or are part of the standard of care for the illness. Cancer and other life-threatening illnesses are particularly subject to off-label drug uses, since the trade-off between safety and e ...
Name Class Date Make Up #7 Applying Mendel`s Principles
Name Class Date Make Up #7 Applying Mendel`s Principles

... • two dominant alleles is 1/4 • one dominant allele and one recessive allele is 1/2 (1/4 + 1/4) Organisms that have two identical alleles for a gene are homozygous for that trait. If they have different alleles for the same gene, they are heterozygous for that trait. Physical traits are an organism’ ...
Hypertension Protocol
Hypertension Protocol

... sugar & get a FBS if age over 40 when patients return after 2-4 weeks on thiazide if not done in past year. Diabetes eventually occurs in most obese, hypertensive black patients, so try to prevent it or delay its onset with weight control! It is a nasty disease with poor available treatments. If HTN ...
Genetics - Garnet Valley
Genetics - Garnet Valley

... change in the DNA sequence ...
Questions and Answers for Pharmacists
Questions and Answers for Pharmacists

... appropriate documentation remains on file. If an ODB recipient chooses to exercise their personal preference for the brand therapy without trying one or more lower-cost generic drug products, pharmacists may continue to provide them with their choice and it will be the responsibility of the recipien ...
PowerPoint Presentation - Jim Hall
PowerPoint Presentation - Jim Hall

... Florida’s increasing heroin use should not be attributed to the crackdown on pill mills and reductions in doctor shopping. Without these supply-side strategies, heroin use would have likely increased even more, because prescription opioid abusers constitute the breeding ground for the nation’s hero ...
Onychomycosis of Fingernails Treated with Genesisplus Laser
Onychomycosis of Fingernails Treated with Genesisplus Laser

... responded excellently with one treatment. Fingernails are thinner than toenails, therefore, the number of treatments may be less and responses better [7]. ...
Calcium channel blocker toxicosis
Calcium channel blocker toxicosis

... rates have been reported in cats.3 Onset of action varies with the formulation. An animal that bites into and swallows a sustained-release product can show signs within five minutes, while one that swallows the product whole may not show signs for several hours. Distribution is extensive in all the ...
Pharm Basics High Yield
Pharm Basics High Yield

... Quantal dose response curves represent large number of individual patients or experimental animals response to various drug concentrations while observing a single set data point--e.g. lower bp 10 mmHg, speed HR by 10 bpm, etc. It is useful in determining a drug concentration that 50% of the populat ...
Lenalidomide (REVLIMID ) Celgene Corporation New Drug Application (021880)
Lenalidomide (REVLIMID ) Celgene Corporation New Drug Application (021880)

... mg/day or 10 mg/day lenalidomide • Excessive toxicity observed - 10 mg/day dose reduced and/or interrupted in 80% • Single-arm trial does not permit attribution of AEs to MDS or to the drug or to both • 80% of patients had grade 3 or 4 AEs • 38% of patients had SAEs ...
Slide set - Mediterranean Group for the Study of Diabetes
Slide set - Mediterranean Group for the Study of Diabetes

... Absolute HbA1c (gm/dl) appeared to be the most influential factor in the clustering process of the data of pGDM probands using two step ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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