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quarterly news
quarterly news

... The benefits of breast feeding for both mother and child are numerous. Research suggests the hormones and antibodies in breast milk help to reduce the incidence of certain conditions such as asthma, lower respiratory infections, and type-2 diabetes in breast fed babies. For mothers, breast feeding h ...
beta blocker in combination with Other Antihypertensives
beta blocker in combination with Other Antihypertensives

... their targets on one drug alone. The remainder needed up to five drugs. This trial confirms that more aggressive treatment targets are safe and effective in preventing cardiovascular events. A judicious approach to prescribing would therefore suggest the use of low-dose combination products early in ...
TechTalkCEJanENG - Canadian Healthcare Network
TechTalkCEJanENG - Canadian Healthcare Network

... articles he/she would like. Although it takes practice to use this database well for complex drug information questions (to get familiar try the online tutorial), even an inexperienced user can find valuable drug information. At the time of publication, a search for Sativex® on PubMed reveals seven ...
Nardil - Pfizer
Nardil - Pfizer

... depressive symptoms should be adequately screened to determine if they are at risk for bipolar disorder; such screening should include a detailed psychiatric history, including a family history of suicide, bipolar disorder, and depression. It should be noted that Nardil is not approved for use in tr ...
Analgesic Use Disorders among Orthopedic and
Analgesic Use Disorders among Orthopedic and

... In the beginning of the 1950s there was a need for a pain reliever that did not have the drug dependency effects of the morphine group and was more effective than paracetamol and acetylsalicylic acid (ASA) and derivates. Initially dextropropoxyphene (DXP) appeared to meet these criteria. DXP is stru ...
measuring behavior – variation
measuring behavior – variation

09_Instructor_Guide - Fullfrontalanatomy.com
09_Instructor_Guide - Fullfrontalanatomy.com

... mom—O, the baby—B, potential father 1—A, potential father 2—AB. Which man is the most likely father? Write an explanation to justify your answer. Suggested answer: The mom is type O, which is recessive (ii). Since the baby is type B blood, his genotype must be (IBi). The real father had to have cont ...
Presentation
Presentation

... both parents. c. The disorder is sex linked and inherited only from the father. d. The disorder could occur only as a mutation in the child because neither parent ...
Bacterial Comparative Genomics
Bacterial Comparative Genomics

... Genome-Wide Association Studies (GWAS) Basic anatomy of GWAS: • Count alleles for each polymorphic site • Evaluate allele with Chisquared or Fisher’s exact test • Correct for multiple comparisons Countless more complex variations of GWAS exist Fundamentally the same idea as an “enrichment test” ...
presentation_6-18-2012-21-57
presentation_6-18-2012-21-57

... Although uncertainty remains, little evidence exists to suggest that any of the investigated drugs are safe in cardiovascular terms. Naproxen seemed least harmful. ...
Machine Learning in Computational Biology CSC 2431
Machine Learning in Computational Biology CSC 2431

... —  Integration mostly done in the feature space – if there is signal in a combination of features, it’ll be lost —  Focusing on consensus – what if there is complementary information? ...
Guidelines for the Use of Subcutaneous
Guidelines for the Use of Subcutaneous

... 6. Commonly used drugs given SC in Palliative Care It is important to understand that the licensing process regulates the activities of pharmaceutical companies and not the prescribing practice of a qualified prescriber. If an untoward incident occurs with a licensed product in an approved clinical ...
Ethical, Legal, and Professional Challenges Posed By “Controlled
Ethical, Legal, and Professional Challenges Posed By “Controlled

... of use. If the provider is concerned about a particular class of medications, they should recount the various names of medications within that class to the patient rather than just naming one or using medical jargon. Some individuals will later state that they did not understand what the provider me ...
Chapter 28
Chapter 28

... Fentanyl is an opiod with which of the following characteristic: a. long acting, highly lipophilic and synthetic compound b. short acting, highly lipophilic and synthetic compound c. long acting, non- lipophilic and synthetic compound d. short acting, non- lipophilic and synthetic compound True or F ...
Sleeping pills and minor tranquillisers
Sleeping pills and minor tranquillisers

... and diarrhoea Benzodiazepines are present in breast milk, and may build up in the baby’s body and cause side effects Ref:http://www.mind.org.uk/information-support/drugs-and-treatments/sleeping-pills-and-minor-tranquillisers/aboutbenzodiazepines/#.WAXcFeArLIU ...
save - Tufts Center for the Study of Drug Development
save - Tufts Center for the Study of Drug Development

full text pdf
full text pdf

... Metamizole (dipyrone) is a popular analgetic, non-opioid drug, commonly used in human and veterinary medicine. In some cases, this agent is still incorrectly classified as a non-steroidal anti-inflammatory drug (NSAID). Metamizole is a pro-drug, which spontaneously breaks down after oral administrat ...
U.S. Prescribing Information - Concordia International Corp.
U.S. Prescribing Information - Concordia International Corp.

... respiratory tract infection, cough, epistaxis and diarrhea. The adverse reactions reported for the whole 12-month trial period, which included the open-label extension, were similar in type and frequency to the reactions observed during the 12-week period. Alfuzosin hydrochloride was not studied in ...
Economic and Microbiologic Evaluation of Single
Economic and Microbiologic Evaluation of Single

... employee exposure to chemotherapy. Studies have demonstrated that settings in which chemotherapy is prepared and administered have documented environmental contamination.9 The implementation of CSTDs can lead to lower employee uptake and exposure to chemotherapy.10 De Prijck et al11 tested the conce ...
Adverse drug reactions - Center for Health in Aging
Adverse drug reactions - Center for Health in Aging

... Identify the pitfalls that are associated with the transition of patients from the acute care setting to other settings of care. ...
Variation in Gene Expression
Variation in Gene Expression

... known to mate and produce offspring that express polydactyly. Thus one parent must carry at least one dominant allele (P allele) and its genotype is probably Pp. This parent with the Pp genotype exhibits reduced penetrance for the P allele. Penetrance - the frequency of expression of an allele when ...
Evaluation of Efficacy and Safety of Gasex Syrup in Functional
Evaluation of Efficacy and Safety of Gasex Syrup in Functional

... multifactorial syndrome complex, many therapeutic interventions have been studied. However, there is no clinically effective and safe medication that can be recommended in the management of functional dyspepsia. This study was conducted to evaluate the clinical efficacy and safety of Gasex syrup in ...
Overview of Chapter 11
Overview of Chapter 11

... eat normal diet will be mentally retarded, but those who eat special diet will have normal intelligence 3.3 Heredity Is Not Destiny ...
Ankylosing Spondylitis (HLA-B27) Genotyping
Ankylosing Spondylitis (HLA-B27) Genotyping

... anterior uveitis, psoriatic arthritis, and inflammatory bowel disease) or to test at-risk relatives for a known HLA-B27 mutation. Human Leukocyte Antigen (HLA) B27 (subtypes B*2701-2759) [1] is a class I surface antigen encoded by the B locus in the major histocompatibility complex (MHC) on chromoso ...
Raising Healthy Teens
Raising Healthy Teens

... Marijuana has long been praised as a drug that does not create addiction and thus does not present real health risks. However, recent research has shown the opposite to be true. It has been proven that around 9% of people who use marijuana will become dependent on it. The number increases to about 1 ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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