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Roach: Introductory Clinical Pharmacology
Roach: Introductory Clinical Pharmacology

... – Instruct family members in care of patient before, during, and after seizure – Explain importance of restricting some activities until seizures are controlled by drugs – Assist patient in looking for other modes of transportation in order to continue typical activities or employment – Review adver ...
Meiosis
Meiosis

... I can compare and contrast genotype and phenotype I can identify homozygous and heterozygous alleles I can successful solve all types of punnett squares including; monohybrid crosses, dihybrid crosses, test crosses, incomplete dominance & codominance I know which chromosomes are involved in sex dete ...
CYP2B6, CYP2D6, and CYP3A4 Catalyze the Primary Oxidative
CYP2B6, CYP2D6, and CYP3A4 Catalyze the Primary Oxidative

... PHX is formulated as a racemic mixture of (⫹)- and (⫺)enantiomers (Pexsig; Sigma Pharmaceuticals, Clayton, VIC, Australia), and six 4-monohydroxy metabolites are possible, composed of one pair each of cis-, trans1-, and trans2-4-monohydroxy PHX enantiomers (Fig. 1) that coelute chromatographically ( ...
SBN Investor Presentation
SBN Investor Presentation

... currently available to management. Such forward looking statements involve known and unknown risks, uncertainties, and other factors which may cause the actual results or performance of Sun Biomedical to be materially different from the results or performance expressed or implied by such forward loo ...
Superficial fungal infections
Superficial fungal infections

... Reduced fungal membrane ergosterol concentrations result in damaged, leaky cell membranes. The toxicity of these drugs depends on their relative affinities for mammalian and fungal cytochrome P450 enzymes. The triazoles tend to have fewer side effects, better absorption, better drug distribution in b ...
Population Genetics and the Hardy-Weinberg Equation
Population Genetics and the Hardy-Weinberg Equation

... Hardy-Weinberg Example • In a population of 100 people 28 of them were found to have freckles and 72 were not. We learned in class during our genetics unit that having freckles is a recessive trait and not having them is because of a dominant trait. If this population is in genetic equilibrium then ...
File
File

... • An allele is said to be dominant if it is always expressed in the appearance of an organism • E.g. the allele, T, for tall plants in pea is dominant to that for short plant, t. • Hence, with the pair of alleles, TT or Tt, the plants will always be tall. This shows the dominant allele is T • The ef ...
What is Population Genetics?
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... – Microsatellites = tandem repeats; genotyping & population structure – Allozymes = variations of proteins; population structure – RAPDs = short segments of arbitrary sequences; genotyping – RFLPs = variants in DNA exposed by cutting with restriction enzymes; genotyping, population structure – AFLPs ...
HUMAN POPULATION GENETICS population evolution
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... • The smaller the sample, the greater the chance of deviations from the expected result Î sampling error Îimportant factor in the genetics of small populations. • If a new generation draws its alleles at random, then the larger the sample size, the better it will represent the gene pool of the previ ...
Final Lecture
Final Lecture

... – Microsatellites = tandem repeats; genotyping & population structure – Allozymes = variations of proteins; population structure – RAPDs = short segments of arbitrary sequences; genotyping – RFLPs = variants in DNA exposed by cutting with restriction enzymes; genotyping, population structure – AFLPs ...
Southern African Human Genome Project
Southern African Human Genome Project

... genome-wide analysis of the genetic makeup of the Coloured population in the Western Cape, studying 959 individuals from the Western Cape. They showed that the major ancestry of this population was Khoesan (32-43%), Bantu-speaking Africans (20-36%), European (21-28%), with a small Asian component (9 ...
1) Genetic Drift Genetic Drift - population with stable size ~ 10
1) Genetic Drift Genetic Drift - population with stable size ~ 10

汤慧芳_大环内酯类&林可霉素
汤慧芳_大环内酯类&林可霉素

... • The combination drug penetrates macrophages and polymorpho nucleocytes, a property that is important, because VRE are intracellular. Levels in the CSF are low. Both compounds undergo metabolism. • The products are less active than the parent in the case of quinupristin and are equally active in th ...
No Slide Title - Open.Michigan
No Slide Title - Open.Michigan

... We have reviewed this material in accordance with U.S. Copyright Law and have tried to maximize your ability to use, share, and adapt it. The citation key on the following slide provides information about how you may share and adapt this material. Copyright holders of content included in this materi ...
Venlafaxine - NHS Trafford CCG
Venlafaxine - NHS Trafford CCG

... Potent CYP3A4 inhibitors e.g. ketoconazole ,erythromycin or drug combinations that inhibit both CYP3A4 and CYP2D6 should only be coadministered with venlafaxine when strictly indicated because of the possibility of clinically important interactions in patients with a ‘poor metaboliser’ phenotype. Sp ...
Narcotics and OD`s Uppsala University, Sweden, November 25th
Narcotics and OD`s Uppsala University, Sweden, November 25th

... rates from overdoses, and as a response to this ongoing public health crisis the Norwegian Government launched a national overdose prevention campaign in 2014. The overdose prevention campaign included multiple strategies to reduce overdoses, and this is important as opioid using populations at risk ...
Back_to_basics_pharmacology 1, 2 and 3 2011
Back_to_basics_pharmacology 1, 2 and 3 2011

... ■ If the Contin wears off before the 8 to 12 hours have passed, the ...
Antidepressant drugs - Dr Lynch
Antidepressant drugs - Dr Lynch

... Murray & Lopez eds. The Global Burden of Disease. Harvard University Press, 1996 ...
full Prescribing Information
full Prescribing Information

... Asacol HD has been evaluated in 896 patients with ulcerative colitis in controlled studies. Three six- week, active-controlled studies were conducted comparing Asacol HD 4.8 grams per day with mesalamine-delayed release tablets 2.4 grams per day in patients with mildly to moderately active ulcerativ ...
Eastern Association of Electroencephalographers, 68th Annual
Eastern Association of Electroencephalographers, 68th Annual

... (p.delV23_K56). This is the second most common mutation underlying EPM1, and the most common point mutation. The husband has no potential EPM1-causing sequence alterations. Conclusion: Although ULD is often confused with JME in the early stages of the disease, it is rare to find patients with ULD at ...
ARVs and communities in crisis
ARVs and communities in crisis

... Before ARV drugs became available, it was possible to treat these ancillary infections, but not the HI virus itself. ARVs work by slowing the replication of HIV in the body. Different types of drugs suppress the process at different stages of the HIV lifecycle, making it necessary to take two - or p ...
Depression and Suicide
Depression and Suicide

... Murray & Lopez eds. The Global Burden of Disease. Harvard University Press, 1996 ...
DIPLOMES
DIPLOMES

... To analyse the influence of excessive alcohol consumption on the disease expression in patients homozygous for the main mutation (C282Y) ...
1 Introduction to pharmacology and drug administration
1 Introduction to pharmacology and drug administration

... ingredient until it reaches the duodenum. Sublingual tablets are placed under the tongue for absorption, while buccal tablets are administered between the cheek and gum. Like tablets, capsules and caplets deliver a measured dose of medication (for example 250 mg), although capsules and caplets are g ...
SUMMARY NOTIFICATION INFORMATION FORMAT FOR THE RELEASE OF GENETICALLY MODIFIED HIGHER PLANTS
SUMMARY NOTIFICATION INFORMATION FORMAT FOR THE RELEASE OF GENETICALLY MODIFIED HIGHER PLANTS

... involved in the host-pathogen interaction, the expression of the NB-LRR genes can occur at the earlier or later stages of the infection process. The effect of the cisgene in S. tuberosum cv. Desiree is that it will display strong resistance to P. infestans, in contrast to the highly P. infestans sus ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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