• Study Resource
  • Explore Categories
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
UKMi Benzodiazepine Dose Equivalents
UKMi Benzodiazepine Dose Equivalents

... should be interpreted using clinical and pharmaceutical knowledge. b. These equivalents do not agree with those used by some authors. They are firmly based on clinical experience but may vary between individuals. Ashton also provides equivalent doses of benzodiazepines not prescribed in the UK. Limi ...
here - Drinker Biddle & Reath LLP
here - Drinker Biddle & Reath LLP

... clarify that data, whether derived from new clinical studies, reports of adverse events, or new analyses of previously submitted data (e.g., meta-analyses) needs to be of a ‘different type or greater severity or frequency than previously included in submissions to FDA.’” ...
Professional Practice Guideline 10 `Antipsychotic medications as a
Professional Practice Guideline 10 `Antipsychotic medications as a

... comorbid with dementia such as major depression require specific and appropriate pharmacotherapy. 2. Choosing an antipsychotic Antipsychotics differ with respect to efficacy and side effects. The decision regarding which antipsychotic to use is a clinical one based on a careful risk–benefit analysis ...
Erythroxylum coca
Erythroxylum coca

... Cannabinoid receptor knockouts have little overt differences to normal mice. They don’t show these effects of THC and anandamide: (1) decreased pain responses and (2) decreased heart rate. --------------------------------------------------5. But NMDA receptor knockouts die at birth: an uninformative ...
Profile: Oxycodone - CESAR
Profile: Oxycodone - CESAR

... Oxycodone is a semi-synthetic opiate and the active ingredient in a number of prescription pain relief medications. OxyContin, a time-release formula of oxycodone, is available in doses ranging from 10 to 80 mg, and is intended for long-term relief of severe pain. The medications Percocet, Percodan, ...
Neil Venardos, Michael J. Weyant, Thomas B. Reece, Xianzhong
Neil Venardos, Michael J. Weyant, Thomas B. Reece, Xianzhong

... • Approximately 3 million people in the United States currently take warfarin • Warfarin has been identified as an instigator of calcification in blood vessels • Long term use of this drug is associated with aortic valve calcification • Aortic valve interstitial cells (AVICs) have been implicated in ...
WORKING WITH THE FIGURES
WORKING WITH THE FIGURES

... selection. Does the variance of the trait appear to have changed as a result of selection? Explain. Answer: The phenotypic variance of the trait does not appear to have changed as a result of selection. Neither the range nor the shape of the phenotypic distribution have changed, so the variance woul ...
Mechanism of action, Pharmacokinetics, Indications and
Mechanism of action, Pharmacokinetics, Indications and

... to gastrointestinal bleeding). Periodic blood tests can detect reduced blood counts early on to avoid these problems. Patients older than 65 may be at increased risk for some side effects, especially infections and gastrointestinal bleeding. People who have had ulcers or other serious gastrointestin ...
Prescription Opioid Addiction:
Prescription Opioid Addiction:

... 2.14 million new users that year. Prescription painkillers are the second most common initiation drug after marijuana; of the estimated 2.7 million teenagers and adults who experimented with illicit drugs for the first time in 2007, 19% of them did so with prescription painkillers,1 leading many to ...
Ch3 Pharmacokinetics pharmacodynamics
Ch3 Pharmacokinetics pharmacodynamics

... • PASSIVE DIFFUSION: the movement of drug molecules from an area of high to low concentration • __________ the concentration gradient. • The majority of drug movement occurs this way. Drug moves from the site of administration (________ concentration) to other areas of the body (________ concentrati ...
Protein Data Bank Advisory Committee
Protein Data Bank Advisory Committee

... • Early detection of side-effects (J&J) • Late detection of side-effects (torcetrapib) • Lead optimization (e.g., SERMs, Optima, Limerick) • Drugomes (TB, P. falciparum, T. cruzi) Applications ...
Slide 1
Slide 1

... • Patients should be monitored for symptomatic relief of ulcer pain as well as potential adverse effects and drug interactions related to drug therapy. • Ulcer pain typically resolves in a few days when NSAIDs are discontinued and within 7 days upon initiation of antiulcer therapy. • The persistence ...
Antibiotics
Antibiotics

... How long for? How frequently? What route? – In general, you should avoid “overdoing it” Microbiologists spend as much time telling people when to stop antibiotics as when to start! – Switch from i-v to oral therapy as soon as you can – Treat UTIs for just three days ...
File
File

... • There are over eight million combinations possible from the 23 chromosomes you inherit from your mom and 23 you inherit from your dad. • The passing of traits from parents to offspring is called heredity. ...
Objective 6 Polygenic Inheritance
Objective 6 Polygenic Inheritance

... Objective 6 - Describe a simple model for polygenic inheritance and explain why most polygenic characters are described in quantitative terms. ...
Recent Trends in Challenges to Forensic Evidence Used in Criminal
Recent Trends in Challenges to Forensic Evidence Used in Criminal

... jewelry cleaner, or plant food, and have caused significant abuse, addiction, overdoses, and emergency room visits They are labeled “not for human consumption” to mask their intended purpose and avoid Food and Drug Administration regulatory oversight of the manufacturing process ...
MOLLY- "NOT YOUR BEST FRIEND"
MOLLY- "NOT YOUR BEST FRIEND"

... fluid samples. In terms of pharmacokinetics, MDMA undergoes hepatic metabolism mediated by COMT and CYP2D6 to form MDA and several other metabolites. MDMA is eliminated majorly through the urinary route. Detection windows for MDMA in urine and oral fluid are 1-3 days and 1 day, respectively. Molly i ...
Triumeq
Triumeq

... Triumeq is a combination of three antiHIV drugs. Such combinations are called antiretroviral therapy, or ART. For more information on ART, see CATIE’s A Practical Guide to HIV Drug Treatment. For many people with HIV, the use of ART has increased their CD4+ cell counts and decreased the amount of HI ...
Methods - ResearchGate
Methods - ResearchGate

... and never attack people. In the street, you can see some people sell guinea pig. Someone raise it in their home as a pet. It has a shortcoming: it can not synthesize Vitamin C by itself. So it needs to get Vit C from food. You need to feed it with some cabbage, carrot etc . Guinea pig is very sensit ...
fycompa - Health Net
fycompa - Health Net

... generalized seizures in patients with epilepsy aged 12 years and older Adjunctive therapy for the treatment of primary generalized tonic-clonic seizures in patients with epilepsy aged 12 years and older ...
Overview of Alpha-blockers in Hypertension : Reappraisal of
Overview of Alpha-blockers in Hypertension : Reappraisal of

... increasingly being recognised as a major cause of stroke, renal and cardiovascular disease. It has not seen the emergence of any new molecules for the management of this silent killer. It has received less public health initiative compared to the Big 4 due to the perceived ease of diagnosis and mana ...
Opthea Reports Positive Phase 1/2A Clinical Results for OPT
Opthea Reports Positive Phase 1/2A Clinical Results for OPT

... EYLEA® (Regeneron/Bayer), which also targets VEGF-A but not VEGF-C/-D first marketed in November 2011 for the treatment of wet AMD, were over $US5.4BN in 2016. Approximately half of the people receiving Lucentis®/EYLEA® are classified as non-responders or ‘poor’ responders and do not experience a si ...
Therapeutic Drug Monitoring of Antiepileptic Drugs in the 21st Century
Therapeutic Drug Monitoring of Antiepileptic Drugs in the 21st Century

... of epilepsy supports the rationale for an individual targeted interval [34]. A patient-specific, relatively narrow concentration interval could be determined based on two blood samplings performed during satisfactory control of seizures, at some distance to take the variability into consideration. S ...
Genetic Epidemiology of Airway Disease
Genetic Epidemiology of Airway Disease

... • Call rate has moderate effect on power (for nearly perfect call rates) • Call rate has large effect on number of false positives (for nearly perfect call rates) Situation even worse for multi-stage designs! ...
mendel and the gene idea - Phillips Scientific Methods
mendel and the gene idea - Phillips Scientific Methods

...  Mixing of foreign blood  clumping  death  Rh factor: protein found on RBC’s (Rh+ = has protein, Rh- = no protein) ...
< 1 ... 777 778 779 780 781 782 783 784 785 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2026
  • DMCA
  • Privacy
  • Terms
  • Report