• Study Resource
  • Explore Categories
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Product information - XATRAL® SR
Product information - XATRAL® SR

... Care should be taken when alfuzosin is administered to patients with symptomatic orthostatic hypotension or in patients on antihypertensive medication or nitrates. Use with caution in patients with acquired or congenital QT prolongation or who are taking medications that prolong the QT interval. Xat ...
observational assessments - Faculty of Pharmacy, Cairo University
observational assessments - Faculty of Pharmacy, Cairo University

... The ability of a rodent to maintain balance and keep pace with a rotating rod has been used to assess motor function. The rotarod consists of a circular rod about 75 cm long, divided into 6 sections to allow simultaneous testing of 6 mice; the rod is attached to a motor rotating the rod at a constan ...
MSR for 07 12 12 no methadone
MSR for 07 12 12 no methadone

... demographic and other relevant measures. Healthcare expenditures were calculated for the 6month periods before and after the index naltrexone drug claim (or matched date for controls). Univariate and multivariate analyses were used to compare the groups on key characteristics and ...
GeneticsandHeredity - Winston Knoll Collegiate
GeneticsandHeredity - Winston Knoll Collegiate

... • Experimented with “pea plants”. • Used pea plants because: • They were available and were pure breeding (offspring identical to themselves). ...
Punnett Squares - webersciencewiki
Punnett Squares - webersciencewiki

... If you are told that a man and a woman are having a baby and you want to figure out what their child’s traits might be there are some things you must know about the parents first. You are told that having ear lobes that are attached to the head is dominant over having ear lobes that are unattached t ...
Populations Student Notes Part 2
Populations Student Notes Part 2

... relationship that shows that allele frequencies will not change from generation to generation, as long as certain conditions are met: ...
General background text Pharmacogenetics - CYP3A4
General background text Pharmacogenetics - CYP3A4

... in question and the combination with environmental factors such as co-medication, diet and disease conditions. Variations can exist in a population for the DNA that encodes for a protein. Variations can result in alleles that encode for proteins with no or reduced activity. The simplest form of vari ...
What is Population Genetics?
What is Population Genetics?

...  Usually labeled p and q = 1 – p For more than 2 alleles  Usually labeled pA, pB, pC ...  … subscripts A, B and C indicate allele name ...
Glossary of Research Terms
Glossary of Research Terms

... ADAMHA Alcohol, Drug Abuse, and Mental Health Administration; reorganized in October 1992 as the Substance Abuse and Mental Health Services Administration (SAMHSA). ADAMHA included the National Institute of Mental Health (NIMH), the National Institute on Alcohol Abuse and Alcoholism (NIAAA), the Nat ...
Palliative Care Symptom Guide
Palliative Care Symptom Guide

Determining When Human Subject Research
Determining When Human Subject Research

product monograph - aralez pharmaceuticals
product monograph - aralez pharmaceuticals

... mg/kg, which is 17-times the human dose. While effects in animals are not always predictive of human effects, at dose levels of 30 mg/kg and greater, female rats were observed to mate less frequently than untreated animals (see TOXICOLOGY). Use in Children The safety for use of pindolol in children ...
Valium - Genentech
Valium - Genentech

... mg/m2 basis). Cleft palate and encephalopathy are the most common and consistently reported malformations produced in these species by administration of high, maternally toxic doses of diazepam during organogenesis. Rodent studies have indicated that prenatal exposure to diazepam doses similar to th ...
Keolax Prescribing Information
Keolax Prescribing Information

... in plasma levels of these drugs. The ability to drive or operate machinery may be impaired in individuals who are particularly sensitive to the effects of Clobazam or in patients taking high doses of the drug. Clobazam should be used in reduced doses in patients with impaired renal or hepatic functi ...
Anthropology 7 Problem Set #2
Anthropology 7 Problem Set #2

... they meet up with each other in a zygote on average every 1/1000 x 1/1000 times, which is 1 in 1,000,000. At this point, the rate of entry balances the rate of exit, and there is an equilibrium. So, at a locus like this, the chance of having a homozygous genetic defect is only 1 in 1,000,000. This i ...
Neonatal Drug Withdrawal - Peyton Manning Children`s Hospital
Neonatal Drug Withdrawal - Peyton Manning Children`s Hospital

... are oral morphine or methadone (94% first choice in UK, 83% first choice in US).  Paragoric is no longer used because it contains a multiple other opioids as well as camphor, anise oil, alcohol, and benzoic acid.  Tincture of opium contains a 25 fold higher concentration of morphine than currently ...
Hallucinogens - People Server at UNCW
Hallucinogens - People Server at UNCW

... Are doses used in preclinical research too high? • neurotoxic doses in non-humans (5-20 mg/kg twice or more/day for several days) are generally higher than would be typical of human use. • However, people often take several tablets at a time or throughout a night’s binge and a tablet may contain up ...
A new way of ordering endophenotypes for relevance to a disease
A new way of ordering endophenotypes for relevance to a disease

... • Matrices of empirical estimates of identity-by-descent allele sharing at points throughout the genome for every relative pair were computed • Once genome-wide significant localization was made, formal single degree of freedom likelihood ratio tests for pleiotropy were performed to test the specifi ...
chp 4 Notes
chp 4 Notes

... • Ex: coat color in rodents – natural coat color in wild rodents is a greyish color (produced by alternating bands of black and yellow – agouti pattern) – Aids in camouflage – Found in mice, squirrels, etc – Other colorations exist, but are recessive to agouti » (A/– agouti; a/a nonagouti) ...
Inappropriate drug use and mortality in community
Inappropriate drug use and mortality in community

... performed in young healthy volunteers, a population in whom, unlike the elderly, the MDRD and Cockcroft-Gault equations perform equally well for estimating true GFR. 3, 27, 30 Because the former has clearly been shown to perform better than the latter in the elderly, 27 this prompted recommendations ...
Drug Doses in Renal Failure
Drug Doses in Renal Failure

...  Mycophenolate Mofetil  Glucocorticoids ...
March 2014
March 2014

... The PBAC considered the submission’s claim that the FDC is superior in terms of comparative effectiveness and equivalent in terms of safety over either of the components given as monotherapy was reasonable. The PBAC noted that the incremental gain in FEV1 for this comparison was below the minimum cl ...
MULTAQ Dosing Card
MULTAQ Dosing Card

... decreased AV-node conduction). MULTAQ increases exposure to digoxin Consider discontinuing digoxin. If digoxin treatment is continued, halve the dose of digoxin, monitor serum levels closely, and observe for toxicity • Postmarketing cases of increased INR with or without bleeding events have been ...
The epidemiology of hypertension in Hong Kong
The epidemiology of hypertension in Hong Kong

the pathology of handwriting as a result of drug abuse. a case study
the pathology of handwriting as a result of drug abuse. a case study

... connections and conditioned reflexes, drugs acting as an external factor which corrupts the way letters are made. Altered writing will depend primarily on age and also other factors (internal and / or external) that may change the individual’s handwriting. Internal factors refer to the preexisting n ...
< 1 ... 773 774 775 776 777 778 779 780 781 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2026
  • DMCA
  • Privacy
  • Terms
  • Report