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Medication Administration
Medication Administration

... Atropine has other uses - including cardiac ...
Heart Failure
Heart Failure

... Editorial - British guidelines on managing hypertension World Health Organization- International Society of Hypertension - 1999 WHO-ISH Guidelines for the management of Hypertension - Journal of Hypertension (see on line articles, Volume 17, Issue 2, pages 151 - 183, ...
Oh What a Relief It Is! - JumpSTART Pediatric MCI Triage Tool
Oh What a Relief It Is! - JumpSTART Pediatric MCI Triage Tool

... A note about “drug-seekers” Check with your medical director about his or her philosophy In general, EMS should NOT be attempting to determine if a patient is a drug-seeker Especially without an on-going familiarity with the patient Doing so may cause you to unfairly undertreat patients ...
lecture 11, part 1, beyond mendel, 042809c
lecture 11, part 1, beyond mendel, 042809c

... High cholesterol, known medically as hypercholesterolemia, is the result of a recessive allele (h). Homozygous dominant individuals (HH) do not have this disorder. Heterozygous individuals (Hh)—about one in 500 people—have blood cholesterol levels about twice normal. Homozygous recessive individuals ...
12th Lecture 1435
12th Lecture 1435

...  For urinary tract, respiratory infections and ulcerative colitis  Combined with pyrimethamine (which interferes with folic acid synthesis by inhibiting the enzyme dihydrofolate reductase) for drug-resistant malaria and for toxoplasmosis  Combined with trimethoprim (co-trimoxazole) for Pneumocyst ...
Handelsbanken lunch meeting
Handelsbanken lunch meeting

... – Patients will receive TMC435 (50 or 100 mg) for a duration of 12 or 24 weeks. – In treatment arms 1 and 2, subjects will receive 12 weeks of triple therapy with TMC435 once daily plus SoC followed by 12 weeks of treatment with SoC. – In treatment arms 3 and 4, patients will receive 24 weeks of tri ...
APO-DOXAZOSIN Doxazosin 1mg, 2mg and 4mg Tablets
APO-DOXAZOSIN Doxazosin 1mg, 2mg and 4mg Tablets

... Doxazosin improves insulin sensitivity in patients who have impairment. Administration of Doxazosin to patients with symptomatic Benign Prostatic Hyperplasia (BPH) results in a significant improvement in urodynamics. The effect of doxazosin in BPH is thought to result from selective blockade of the ...
For patients with genotype 1b infection and CrCl below 30 mL/min
For patients with genotype 1b infection and CrCl below 30 mL/min

... contraindication for renal transplantation Liver damage as determined by histologic severity is a strong predictor of liver failure and death after transplantation. in HCV positive patients without evidence of liver disease, we suggest that such patients should be allowed to make an informed choice ...
Phytochemistry 1
Phytochemistry 1

... Hyperforin is now thought to be the main active factor in St. John’s Wort that has beneficial effects on anxiety and depression. Hyperforin has strong reuptake inhibitor effects on all four of the mood neurochemicals (serotonin, norepinephrine, dopamine and GABA). It is also believed that Hyperforin ...
LENITIN
LENITIN

... bromazepam should be terminated by tapering the dose to minimize occurrence of withdrawal symptoms. Patients should be advised to consult with their physician before either increasing the dose or abruptly discontinuing the medication. Rebound phenomena have been described in the context of benzodiaz ...
Genetic Linkage and Genetic Maps tutorial
Genetic Linkage and Genetic Maps tutorial

... chromosome. But all the genes on the chromosome are incorporated in a single molecule of DNA. Genes are simply portions of the molecule (open reading frames or ORFs) encoding products that create the observed trait (phenotype). The rapid progress in DNA sequencing has produced complete genomes for h ...
fentaNYL (parenteral) - DavisPlus
fentaNYL (parenteral) - DavisPlus

... ● Monitor respiratory rate and BP frequently throughout therapy. Report ...
Genes direct (38k PDF)
Genes direct (38k PDF)

... the public, and thereby make recommendations to Ministers on if, and how, those services should be regulated. The HGC did this by setting up a Working Group in early 2002, and this report is the outcome of a year of close examination of the social and ethical issues associated with new genetic testi ...
HGSS Chapters 11 & 12: Modern Gene Hunting (incomplete)
HGSS Chapters 11 & 12: Modern Gene Hunting (incomplete)

... • Haplotype Block: Series of adjacent alleles in strong disequilibrium. • Logic: Instead of genotyping all 37 polymorphisms, genotype one in each block. • If there is a “hit,” then go back and genotype the other polymorphisms in that block. ...
Isoniazid, rifampicin and pyrazinamide plasma concentrations 2 and
Isoniazid, rifampicin and pyrazinamide plasma concentrations 2 and

... than expected ranges, could therefore aid in avoiding drug resistance as well as unnecessary costs. In the case of PZA, the majority of our patients had concentrations within the target range, which is perhaps due to the wide reference range for PZA (20–50 μg /ml). The prevalence of low drug plasma ...
Gene Section CDA (Cytidine Deaminase)  Atlas of Genetics and Cytogenetics
Gene Section CDA (Cytidine Deaminase) Atlas of Genetics and Cytogenetics

... On the other hand, controvertial results on the effects of activities have been obtained for 79A>C (Lys27Gln). The recombinant enzyme with Gln27 retained its catalytic activities for cytidine and ara-C as substrates (Yue et al., 2003), while showing reduced activity with increased Km value in the ca ...
Advances in Managing Parkinson`s Disease
Advances in Managing Parkinson`s Disease

... ‘Wearing off’ affects are dose dependant ‘On-off’ affects have no known cause, but it is thought to be because of several factors: disease progression, end of dosing, and the body’s response to medication. Apomorphine** (Apokyn) is used for on-off periods in patients with optimized levodopa/carbidop ...
Acarbose —(Precose)
Acarbose —(Precose)

... acetaminophen plus oxycodone was superior to patient controlled morphine for the relief of post cesarean pain. There are no obvious differences in clearance at term. Chronic abuse and overdose are the most common problems. The damage appears secondary to free radical toxicity with consumption of glu ...
Slide 1
Slide 1

... Adverse effects include nausea, dizziness, vomiting, abdominal pain, diarrhoea, and loss of appetite. More rarely, hallucinations, seizures, and psychoses are observed. ...
Clinical Feature: Diagnosis and Genetic Variance in Familial
Clinical Feature: Diagnosis and Genetic Variance in Familial

... Phenotypic variation in FH may also be modulated by ApoE polymorphisms, and variable alleles of this apoprotein (E2,E3, orE4) may have different penetrance in FH subjects versus normal.24,25 Gene-gene and gene-environment interactions play a prominent role in phenotypic expression of the disease. Cl ...
Smoking Cessation and Chronic Mental Illness
Smoking Cessation and Chronic Mental Illness

...  Requires ongoing rather than acute care  Examples: ...
file (Parkinsons Disease Topic
file (Parkinsons Disease Topic

... Dopamine agonists (ropinirole and pramipexole) are only FDA-approved agents for RLS Carbidopa/levodopa may decrease the incidence of nighttime leg movements ...
Major Depressive Disorder presented by
Major Depressive Disorder presented by

... 1. Pratt LA et al. Depression, psychotropic medication, and risk of myocardial infarction. Prospective data from the Baltimore ECA follow-up. Circulation. 1996;94(12):3123-3129. 2. Ziegelstein RC et al. Patients with depression are less likely to follow recommendations to reduce cardiac risk during ...
pharma 2
pharma 2

... Start talking about somatostatin, its an inhibitory hormone for GH and it consists of 14 a.a, also it has a very short half life which means we cant use it as a drug, that’s why they developed an analogue drug (octreotide) Octreotide on the other hand consists of 8 a.a with one substituted D- a.a (a ...
Bronchial Asthma: Use of Inhalant Glucocorticoids and
Bronchial Asthma: Use of Inhalant Glucocorticoids and

... disease must be eliminated from households. The same is necessary for moulds. Against house dust mites at least encasings should be used, possible in conjunction with other measures. In general, avoidance measures are the first step in asthma therapy, a step without any risk of side effects. For pha ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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