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moravek-arma1
moravek-arma1

... from paranoia in intoxication to schizophrenia – like psychosis. • Intoxication psychosis could last up to 2 months • Mostly with productive symptoms, but must be monitored for longer period • Differential diagnosis: in the stage of early (prodrome) symptoms of psychotic disorders, or schizophrenia, ...
5 points
5 points

... Drug X is given as i.v bolus of 200 mg (TID) dose. The concentration-time profile for the first three doses is shown. This patient has a clearance of 24L/hr (top graph). Another patient came in and was started on the same dosing regimen. However, this patient had a clearance 6 L/hr. What would his c ...
Intraspinal Drug Infusion for Chronic Pain
Intraspinal Drug Infusion for Chronic Pain

...  Missing or failed strain relief sleeve at pump connector on one-piece catheter  Several reports of small holes in one-piece catheter under pump. No reports of holes under the pump with the two-piece catheter ...
The Truth About LSD - Drug
The Truth About LSD - Drug

... rendering whole groups of people, including military forces, indifferent to their surroundings and situations, interfering with planning and judgment, and even creating apprehension, uncontrollable confusion and terror.” Experiments in the possible use of LSD to change the personalities of intellige ...
Antivirals
Antivirals

... The effectiveness of antivirals against the next pandemic influenza is unknown. Influenza is capable developing resistance to antiviral medication, and some strains are known to currently be resistant to Tamiflu. Hence the degree to which they may protect an organizations employees is unknown. The r ...
EVIDENCE-BASED BEST PRACTICES FOR THE TREATMENT OF
EVIDENCE-BASED BEST PRACTICES FOR THE TREATMENT OF

... created to consensually agree on evidence-based best practices for the treatment of bipolar disorder (BPD) in South Carolina. The panel recommended detailed treatment algorithms as the core of their best practices. The evidenced-based materials and algorithms developed and implemented in the Texas M ...
effects of cytochrome p450 enzyme inhibitors on the
effects of cytochrome p450 enzyme inhibitors on the

... such as genetic factors, sex, age, weight, and diseases. In addition, whenever two drugs are co-administered, a drug-drug interaction (DDI) may occur and affect drug concentration by influencing drug absorption, distribution, metabolism, or excretion. Inhibition of cytochrome P-450 (CYP) mediated me ...
2014 Personalized Medicine Module Presentation
2014 Personalized Medicine Module Presentation

... at normal doses and during normal use – Examples? • There are multiple causes for ADRs – environmental basis – genetic basis • Poor metabolizers can experience ADRs at normally therapeutic drug doses ...


... The use of herbal and alternative therapies is increasing all over the developed as well as the developing world. As pharmacological data on drug interactions involving herbal therapies becomes available, it is important to be familiar with the challenges that concomitant use of these medications ma ...
Genetics - Philadelphia Zoo
Genetics - Philadelphia Zoo

... Gibbons are apes that live in tropical rainforests in Asia, including the countries of Bangladesh, India, China, and Indonesia. They like to eat fruit, leaves, and some insects. They usually live around 20 years or more, but the record is 44 years! Gibbons live in small family groups, usually contai ...
LAB: REEBOP GENETICS (A review of Chapter 11.1, 11.2, 11.3
LAB: REEBOP GENETICS (A review of Chapter 11.1, 11.2, 11.3

... white flowered plants to produce PINK flowered offspring) the gene is said to be INCOMPLETELY DOMINANT. If a trait shows INCOMPLETE DOMINANCE, which genotype must an organism have to show the intermediate blended phenotype? A. PURE DOMINANT B. PURE RECESSIVE C. HETEROZYGOUS D. HOMOZYGOUS RECESSIVE W ...
Xolair - Scottish Medicines Consortium
Xolair - Scottish Medicines Consortium

... A Patient Access Scheme (PAS) was submitted by the company and assessed by the Patient Access Scheme Assessment Group (PASAG) as acceptable for implementation in NHS Scotland. Under the PAS, a simple confidential discount was offered on the list price. With the PAS, the ICER was estimated to be £19, ...
DO NOW - PBworks
DO NOW - PBworks

... • Answer the following questions on page___ of your notebook in complete sentences. 1.Which parent gave the brown hair allele for hair color? 2. What is the phenotype of the offspring’s hair color? 3. What is the phenotype of the offspring’s hairline on their forehead? 4. Will the offspring be able ...
The Microbial Pharmacy: FDA Approved Medicines
The Microbial Pharmacy: FDA Approved Medicines

... the first statin approved by the US FDA for clinical use for the reduction of blood cholesterol levels in patients.(2) The Chinese claimed that red yeast rice had a variety of biological activities, including being useful to treat cardiovascular problems.(1) The second historic and commonly used fun ...
DMPI UPDATE JULY 20 FINAL
DMPI UPDATE JULY 20 FINAL

... adverse events reported at doses up to 40 mg/m2. Dose limiting toxicity (DLT) defined by thrombocytopenia (low platelet counts) was observed in two of six (33%) of patients at 50 mg/m2. Generally, DLT-related symptoms resolved rapidly and spontaneously without concomitant treatment, although one pat ...
a closer look at fibromyalgia and its management
a closer look at fibromyalgia and its management

... Cyclobenzaprine, an amitriptyline analog with central muscle relaxant properties, has been considered for FMS despite limited evidence of its effectiveness. It has no apparent advantage over other tricyclic compounds for most patients, and its muscle relaxant activity generally ceases after 4 to 8 d ...
ANXIOLYTIC ACTIVITY OF JESSICA – A POLYHERBAL FORMULATION  Research Article
ANXIOLYTIC ACTIVITY OF JESSICA – A POLYHERBAL FORMULATION Research Article

... becoming increasingly prevalent in modern society, requiring new therapeutic approaches and treatments [2-3].Panic disorder affects about 6 million adults and is twice as common in women as men and often being in late adolescence or early adulthood [4]. Currently the most preferred treatment for anx ...
Prescription Drug Abuse
Prescription Drug Abuse

... 1. What sort of long-term effects can taking performanceenhancing drugs have on the muscles and the rest of the body? What about psychological and social consequences? 2. Should professional athletes who use performanceenhancing drugs be punished? 3. Would it be acceptable to use performance- enhanc ...
Statins forever: Is anything set to topple this class`s mighty reign?
Statins forever: Is anything set to topple this class`s mighty reign?

... There are also a small number of early stage CETPi’s still under active development, including Chong Kun Dang’s Phase I compound, CKD-519, Kowa’s Preclinical K-312 and Dexa Medica’s DLBS1449 (albeit, the only active trial, a Phase II/III, for this compound was recently withdrawn prior to enrolment, ...
A model for self-treatment of four sub
A model for self-treatment of four sub

... By extension, this general model of self-diagnosis, self-treatment and self-monitoring (S-DTM) could potentially be extended to other areas of psychiatry and medicine in which symptoms are the focus and where effective treatments are available without prescription. Indeed, as well as being used to a ...
Introduction to Genetics
Introduction to Genetics

... What is the genotype for a woman that is Heterozygous? What is the genotype for a male that is has the dominant trait? What is the genotype for a man with the recessive trait? ...
Chapter 25 Muscle Relaxants
Chapter 25 Muscle Relaxants

... Usually subsides when injury heals ...
CREB regulation of BK channel gene expression underlies rapid
CREB regulation of BK channel gene expression underlies rapid

... Detect sequences by Real time PCR ...
Chap3_110718_textbook
Chap3_110718_textbook

... How do we decide whether a chi-square statistic is likely too large to be due to sampling effects alone? To do this, we compare the chi-square value for our experiment to a previously calculated probability distribution for all possible chi-square values. This distribution shows the probability of o ...
pharm 22 A [4-20
pharm 22 A [4-20

... a. Also used with aspirin for percutaneous coronary intervention b. Can interact with P450 drugs: statins, proton pump inhibitors, etc. c. Also GI effects Drawbacks of prasugrel? a. High bleeding risk in patients over 75 years or under 60 kg 3 antagonists of GP IIb-IIIa? What is their common, clinic ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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