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cox-2 selective nsaids…
cox-2 selective nsaids…

... Ibuprofen and naproxen are among the most commonly used NSAIDs in the United States because of their effectiveness, adverse effect profile, cost, and over-the-counter availability There is a ceiling to the analgesic effects of NSAIDs but not to their antiinflammatory effects, although adverse effect ...
filgrastim 12 million units - Scottish Medicines Consortium
filgrastim 12 million units - Scottish Medicines Consortium

... each chemotherapy cycle, or until the nadir had passed and absolute neutrophil count (ANC) was >3 x 109/L. The primary endpoint, duration of severe neutropenia (DSN), defined as ANC <0.5 x 109/L, during cycle one, was assessed in the per protocol (PP) population that comprised all randomised patien ...
Drugs that reverse disease transcriptomic signatures are more
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... baseline (for simplicity of explanation, we refer to these mice as ‘healthy’ despite their genetic deficiency). The untreated 16-week HFD group (henceforth designated ‘untreated HFD’ for brevity) was considered representative of an elevated risk to develop cardiovascular disease. To assess the succe ...
Drugs That Act in the Central Nervous System
Drugs That Act in the Central Nervous System

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CHAPTER 22 Population Genetics

... because most phenotypes are the result of multiple genes, and there was no technique available to determine allele frequencies. 2. Protein electrophoresis separates proteins on the basis of size, charge and conformation, and so often can separate the gene products of different alleles. 3. The amount ...
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投影片 1

... Building a fuzzy system with genetic algorithm • This method do not need an existing fuzzy system. This approach determines all the parameters of a fuzzy system by genetic algorithms without any priori knowledge. • Thus, the chromosomes used in this method usually include most of the parameters suc ...
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... rather than “Dose Cost”. By the way, where does the standard cost come from? Copyright: ©2005 by Elsevier Inc. All rights reserved. ...
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basic concepts and importance of various pharmacokinetic parameters
basic concepts and importance of various pharmacokinetic parameters

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Extrapolating from animal studies to the efficacy in humans of a
Extrapolating from animal studies to the efficacy in humans of a

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... controls (so-called splinter skills) to phenomenal savant abilities. These skills often include visuospatial, computational, mnemonic, and musical talents. Individuals with PWS are often regarded as gifted at solving jigsaw puzzles. It is possible, therefore, that there is a biological and genetic b ...
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Genetics_Discussion

... A man and woman marry. They have five children, 2 girls and 3 boys. The mother is a carrier of hemophilia, an X-linked disorder. She passes the gene on to two of the boys who died in childhood and one of the daughters is also a carrier. Both daughters marry men without hemophilia and have 3 children ...
Genetic Art - Northwestern University
Genetic Art - Northwestern University

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Chemotherapy: Nuts and Bolts of Acute Issues
Chemotherapy: Nuts and Bolts of Acute Issues

... STOP the infusion. Evaluate for other causes of altered mental status Methylene blue: acts as an electron accepting agent, thereby correcting derangement in mitochondrial flavoproteins. It prevents encephalopathy by a different mechanism when used prophylactically, namely oxidation of excessive NADH ...
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... Lets Try a Monohybrid together! 1) Daffy Duck is heterozygous for black feathers. Daisy Duck is homozygous for yellow feathers. Set up a punnett square and determine probabilities of their potential offspring. (Both genotype and phenotype ratios!) ...
FDA Supplement - Oregon State University Research Office
FDA Supplement - Oregon State University Research Office

... considered to be drugs when they are used to diagnose, cure, mitigate, treat, or prevent disease. Under FDA regulations, research that involves use of a drug other than the use of a marketed drug in the course of medical practice must have an Investigational New Drug (IND) Application, unless the st ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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