• Study Resource
  • Explore Categories
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Genetic testing in couples with infertility
Genetic testing in couples with infertility

FDA Supplement - Oregon State University Research Office
FDA Supplement - Oregon State University Research Office

... considered to be drugs when they are used to diagnose, cure, mitigate, treat, or prevent disease. Under FDA regulations, research that involves use of a drug other than the use of a marketed drug in the course of medical practice must have an Investigational New Drug (IND) Application, unless the st ...
• Some Key Concepts from “Drugs and the Brain” – Fall 2008
• Some Key Concepts from “Drugs and the Brain” – Fall 2008

... • Some Key Concepts from “Drugs and the Brain” – Fall 2008 • Useful as a guide for study; Not meant to be an exhaustive list • Lecture 1 (8/28) • ritual • myth, worldview • scientific materialism • shamanism • William James, radical empiricism • drug, psychoactive drug • pharmacology, psychopharmaco ...
Mendelian Genetics
Mendelian Genetics

Aging Biology and Geriatric Clinical Pharmacology
Aging Biology and Geriatric Clinical Pharmacology

... Aging is associated with dysregulation of apoptosis (Warner, 1997 ), and overall, it has been suggested that aging is mostly associated with up-regulation of apoptosis (Higami and Shimokawa, 2000 ). For example, brain apoptosis has been demonstrated in agerelated neurodegenerative diseases and with ...
Excess mortality in patients with asthma on long-acting b -agonists 2
Excess mortality in patients with asthma on long-acting b -agonists 2

... significantly (p,0.05) more frequently in the salmeterol group: 1) respiratory-related deaths (24 out of 13,176 versus 11 out of 13,179 cases, RR 2.2); 2) combined asthma-related death or lifethreatening experiences (37 versus 22 cases, RR 1.71); and 3) asthma-related deaths (13 versus three cases, ...
Fibromyalgia Information Foundation
Fibromyalgia Information Foundation

... HEALTH JOURNAL / By LEILA ABBOUD Staff Reporter of THE WALL STREET JOURNAL August 3,2004 ...
How to help if a patient can`t swallow
How to help if a patient can`t swallow

... dispersing is unlikely to cause any significant harm to the patient, evidence supporting this rational belief (based on a scientific understanding of the relative stability of the active ingredients) is currently limited. However, there are also some formulations with which it would generally consider ...
Treatment of poisoning caused by β
Treatment of poisoning caused by β

... of the pancreas.2 CCBs prevent the opening of these voltage-gated calcium channels and reduce calcium entry into cells during phase 2 of an action potential. CCBs exhibit different selectivity for cardiac versus vascular channels.2 Selectivity may relate in part to whether the drug binds to the chan ...
Two RANTES gene polymorphisms and their - dr
Two RANTES gene polymorphisms and their - dr

... haplotypes, are not associated with susceptibility to myocardial infarction and do not act as disease modifiers. • Further, our data do not support association between RANTES -403*A allele and MI as previously reported from LURIC (LUdwigshafen Risk and Cardiovascular health) and Hungarian cohorts. • ...
Cabergoline in acromegaly: a renewed role for dopamine agonist treatment?
Cabergoline in acromegaly: a renewed role for dopamine agonist treatment?

... hormonal values normalized during CAB treatment (at 0.5 mg/day). However, recently Abs et al. (20) have shown a marked GH/IGF-I decrease in 43 out of 64 unselected acromegalics with the normalization of hormonal values in 25 of them treated with individualized CAB doses. Our study showed that CAB tr ...
Antipyretic-analgesic and antiinflammatory drugs
Antipyretic-analgesic and antiinflammatory drugs

... • With many NSAIDs, the dosage required for chronic inflammatory disorders is usually greater than for simple analgesia and treatment may need to be continued for long periods; Treatment could be initiated with an agent known to have a low incidence of side-effects. If this proves unsatisfactory, mo ...
5 Things to Know About Prescriptions for Buprenorphine/Naloxone
5 Things to Know About Prescriptions for Buprenorphine/Naloxone

... diluted in a vehicle that does not lend itself to injection – such as orange flavored Tang® or other suitable drink), much of the framework for prescribing and dispensing is very similar. PAGE 36 ~ SPRING 2015 ~ PHARMACY CONNECTION ...
Central nervous system (including peripheral analgesics)
Central nervous system (including peripheral analgesics)

... The FDA issued a final monograph for labeling of all internal analgesics on April 29, 2009. Even though acetaminophen does not affect blood platelets, all acetaminophen products must contain a warning by April 2010 that a physician or pharmacist should be consulted if the individual is taking warfar ...
Group 1 - Random Sampling
Group 1 - Random Sampling

... have heights greater than or equal to 171.00 cm and 156.75 cm. From the total population, the middlemost values for males and females are: 169. 35 cm and 157.00 cm. Comparing it to the sample population, again we can see that the values are quite near or close to each other. The frequently appearing ...
Primer on estimating withdrawal times after extralabel drug
Primer on estimating withdrawal times after extralabel drug

... extended to comply with AMDUCA and ensure that use involves admi~tering the drug to a diseasedanianimals being treated are void of violative tissue mal whosepathophysiologicstateresults in a doubling residues?The following 2 conditions of extralabeluse of the' tissue half-life? Now, the WDT should b ...
Toward 2015
Toward 2015

... is expected to occur during the next few years. Since July 2012, the new EU pharmacovigilance legislation has required that all adverse drug reactions from medication errors at the EU level be reported to EudraVigilance, the EU database of adverse drug reactions. Since then, the number of side effec ...
A Case Report of Neutrophilic Eccrine Hidradenitis in a Patient
A Case Report of Neutrophilic Eccrine Hidradenitis in a Patient

... perianal abscess and fistula which were treated with antibiotics and fistulotomy. He was next given cytarabine 1.5 g/m2 continuous infusion for four days as second consolidation chemotherapy. On the second day of the infusion, the patient developed a generalised maculopapular rash which was attribut ...
Mendelian Inheritance
Mendelian Inheritance

... The gene for aldehyde dehydrogenase (ADH) is incompletely dominant. A woman who is heterozygous for this gene (ADH+/ADH) marries a man who is homozygous for the normal allele (ADH+/ ADH+). What is the probability that they will have heterozygous children? ...
Butisol Sodium - Meda Pharmaceuticals
Butisol Sodium - Meda Pharmaceuticals

... levels of CNS mood alteration from excitation to mild sedation, to hypnosis, and deep coma. Overdosage can produce death. Barbiturates depress the sensory cortex, decrease motor activity, alter cerebellar function, and produce drowsiness, sedation, and hypnosis. Barbiturate-induced sleep differs fro ...
Hypersensitivity reactions to anticancer agents: Data mining of the
Hypersensitivity reactions to anticancer agents: Data mining of the

... adverse events, from such a large database. Recently developed data mining tools for pharmacovigilance have been successful at detecting signals that could not be found by individual case reviews and that warrant further investigation together with continuous surveillance. For this reason, data mini ...
Chapter 23
Chapter 23

... • Chromosomal mutations that delete, disrupt, or rearrange many loci are typically harmful • Duplication of small pieces of DNA increases genome size and is usually less harmful • Duplicated genes can take on new functions by further mutation • An ancestral odor-detecting gene has been duplicated ma ...
Document
Document

... gamete formation, does the segregation of one pair of alleles have any affect on the segregation of a different pair of alleles? In other words, does the gene that determines if a pea plant is tall or dwarf have any affect on the gene for seed color? ...
Genetics of Beef Cattle: Moving to the genomics era Matt Spangler
Genetics of Beef Cattle: Moving to the genomics era Matt Spangler

... confusion. For those who have not yet adopted thirty-year-old technology such as EPD, the inherent selection mistakes that have been made in the past will only be exacerbated in the future when the accuracy of genetic predictions of young animals is increased. And, as molecular-based EPD are develop ...
PLEXION® Cleanser - Mission Pharmacal
PLEXION® Cleanser - Mission Pharmacal

... harm when administered to a pregnant woman. This product should be used by a pregnant woman only if clearly needed or when potential benefits outweigh potential hazards to the fetus. Nursing Mothers: It is not known whether this drug is excreted in human milk. Because many drugs are excreted in huma ...
< 1 ... 544 545 546 547 548 549 550 551 552 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report