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PHYSICOCHEMICAL CHARACTERIZATION AND IN-VITRO DISSOLUTION BEHAVIOR OF GLICLAZIDE –SOLUPLUS SOLID DISPERSIONS
PHYSICOCHEMICAL CHARACTERIZATION AND IN-VITRO DISSOLUTION BEHAVIOR OF GLICLAZIDE –SOLUPLUS SOLID DISPERSIONS

... reduces hepatic gluconeogenesis and increases insulin effects by acting at receptor or post‐receptor sites. It also inhibits platelet aggregation and increases fibrinolysis. However, the drawback of this potentially useful hypoglycemic agent is that it belongs to BCS class 2 and therefore is highly ...
N Gokal Counting the Costs
N Gokal Counting the Costs

Toward a Drug-Free University
Toward a Drug-Free University

... Immaculata University is in compliance with the DFSCA which requires colleges and universities to adopt and enforce policies that include sanctions for illegal alcohol and other drug use and to provide students and employees with appropriate information and services to back up those policies orienta ...
“Drug use on the rise”
“Drug use on the rise”

... Alcoholics Anonymous is based on this idea. Its founders and advocates believe that drug dependence should be treated as such. Others argue that there are no tests that diagnose alcoholism. ...
Improved delivery of fenoterol plus ipratropium bromide using
Improved delivery of fenoterol plus ipratropium bromide using

... design, 62 patients with stable bronchial asthma (mean forced expiratory volume in one second (FEV1) 63% predicted) were randomized at five study centres to receive five out of eight possible treatments: placebo, F/I 12.5/5, 25/10, 50/20, 100/40 or 200/80 mg delivered via Respimat1; F/I 50/20 or 100 ...
Public Assessment Report Irbesartan Elpen 75 mg, 150 mg, 300 mg
Public Assessment Report Irbesartan Elpen 75 mg, 150 mg, 300 mg

... If the patient gets any of these symptoms or gets short of breath, must stop taking Irbesartan Elpen and contact the doctor immediately. The frequency of the side effects listed below is defined using the following convention: Very common: may affect more than 1 in 10 people Common: may affect up to ...
PHYTOSOMES: A NOVEL DOSAGE FORM FOR ENHANCEMENT OF BIOAVAILABILITY OF  BOTANICALS AND NEUTRACEUTICALS Review Article   
PHYTOSOMES: A NOVEL DOSAGE FORM FOR ENHANCEMENT OF BIOAVAILABILITY OF  BOTANICALS AND NEUTRACEUTICALS Review Article   

... different phytoconstituents obtained from herbs are major problems  in  exploring  their  real  potentials  against  different  diseases.  So,  extensive research in the field  of herbal drug  delivery systems as a  means of improving the therapeutic indices of drugs is inevitable.    During the las ...
Preventing Medication Errors
Preventing Medication Errors

... to people who may intentionally go through your trash.  Put them in a sealable bag, empty can, or other container to prevent the medication from leaking or breaking out of a garbage bag.  Take advantage of community drug take-back programs  Before throwing out a medicine container, scratch out al ...
Genomics of Dyslipidemia → Trends in Cardiovascular Medicine
Genomics of Dyslipidemia → Trends in Cardiovascular Medicine

... Careful study of pts w/ monogenic disorders has helped us identify roles of cholesterol in atherosclerosis and molecules for drug targets Ex. Familial hypercholesterolemia ...
SKC660 STL_V9N10_1.qxd
SKC660 STL_V9N10_1.qxd

... placebo group. The development of anti-dsDNA antibodies was also higher in patients treated with etanercept when compared to those treated with placebo (15% and 4% respectively). Cases of drug-induced systemic lupus and subacute cutaneous lupus have been reported in the literature.14,15 After discon ...
quality control lect..
quality control lect..

... ensure proper contents compared to the labeled amount. Select a sample of 10 filled containers, and remove any labeling that might be altered in weight during the removal of the container contents. Thoroughly cleanse and dry the outside of the containers by a suitable means, and weigh individually. ...
Anti Ulceration and Anti Emetics
Anti Ulceration and Anti Emetics

... Unwanted effects of this class of drugs are uncommon. They may include headache, diarrhoea (both sometimes severe) and rashes. Dizziness, somnolence, mental confusion, impotence, gynaecomastia, and pain in muscles and joints have been reported. Proton pump inhibitors should be used with caution in p ...
and Pharmacodynamics (PD) of GBT440, a Novel Hemoglobin S
and Pharmacodynamics (PD) of GBT440, a Novel Hemoglobin S

... A summary of the p20 and p50 values observed in SCD subjects after 28 days of dosing. A dose-dependent decrease in p20 and p50 is observed, showing that increasing levels of drug leads to increased oxygen affinities. Sidak's multiple comparisons tests were used to measure statistical significance ...
View PDF - G3: Genes | Genomes | Genetics
View PDF - G3: Genes | Genomes | Genetics

... arrayed collection, the other candidates are available on request for specific genes if an investigator is interested in an allelic series. In total we have assembled a collection containing ts alleles in 600 unique essential genes, representing .50% of all essential genes in yeast. Importantly, this ...
(Brompheniramine Maleate 2 mg, Pseudoephedrine
(Brompheniramine Maleate 2 mg, Pseudoephedrine

... tract, with peak plasma concentration after single, oral dose of 4 mg reached in 5 hours; urinary excretion is the major route of elimination, mostly as products of biodegradation; the liver is assumed to be the main site of metabolic transformation. Pseudoephedrine acts on sympathetic nerve endings ...
Heart Failure Medication Titration Protocols - sha
Heart Failure Medication Titration Protocols - sha

... Status of Heart Failure • The ACC/AHA guidelines advise to avoid: • NSAIDs can cause sodium retention and peripheral vasoconstriction and can attenuate the efficacy and enhance the toxicity of diuretics and ACEIs. • Antiarrhythmic agents can have cardiodepressant effects and may promote arrhythmia; ...
Preventing Medication Errors - The Center for Life Enrichment
Preventing Medication Errors - The Center for Life Enrichment

... to people who may intentionally go through your trash.  Put them in a sealable bag, empty can, or other container to prevent the medication from leaking or breaking out of a garbage bag.  Take advantage of community drug take-back programs  Before throwing out a medicine container, scratch out al ...
Product Monograph - Takeda Canada Inc.
Product Monograph - Takeda Canada Inc.

... hepatic insufficiency, dose adjustment is not necessary in this population. There is limited data available in patients with severe hepatic impairment. An increased exposure in patients with severe hepatic impairment is expected and these patients should therefore be monitored for potential systemic ...
Osteoporosis Update
Osteoporosis Update

... – Treatment of moderate/severe vasomotor symptoms of menopause – Treatment of moderate/severe symptoms of vulvar and vaginal atrophy associated with menopause – Consider topical preparations to treat vaginal symptoms rather than oral ET/HT ...
70-ORGANIC PHARMACEUTICAL CHEMISTRY III
70-ORGANIC PHARMACEUTICAL CHEMISTRY III

... correlation of structure with drug action, fate of the drugs in the organism, sites of loss, therefore duration of drug action. Aim is also to familiarise the students with relations governing molecules acting on CNS and the central nervous system site of action, as well as the involved neurotransmi ...
SOLUBILITY AND DISSOLUTION ENHANCEMENT OF POORLY WATER SOLUBLE GLIMEPIRIDE
SOLUBILITY AND DISSOLUTION ENHANCEMENT OF POORLY WATER SOLUBLE GLIMEPIRIDE

... increases rapidly. It is widely used with the discovery and approval of several new types of oral antidiabetic drugs with different mechanism of pharmacological action. Many of the drugs belong to class II of the biopharmaceutical classification system showing poor solubility and high permeability. ...
(1)Simple partial seizures 单纯局限性发作
(1)Simple partial seizures 单纯局限性发作

... grad mal, partial seizures with complex symptomatology first choice 2. Central algesia: trigeminal neuralgia more effective than phenytoin 3. mania(躁狂症)and depression 4. 尿崩症 ...
Management of delirium in children and adolescents
Management of delirium in children and adolescents

... than acute inpatient aggression. • As per our search, only one study has attempted to observe the effects of risperidone in treating the aggression in an inpatient unit. ...
FORMULATION AND OPTIMIZATION OF OCULAR POLY-D, L-LACTIC ACID NANO DRUG
FORMULATION AND OPTIMIZATION OF OCULAR POLY-D, L-LACTIC ACID NANO DRUG

... diagnostic techniques and novel therapeutic agents continue to provide ocular delivery systems with high therapeutic efficacy. Traditional ophthalmic solution, suspension, and ointment dosage forms no longer constitute optimal therapy for various diseases (1). Nanoparticles offers various advantages ...
Clofazimine (Lamprene, B663) in the Treatment of Lepromatous
Clofazimine (Lamprene, B663) in the Treatment of Lepromatous

... years in doses now considered to be too low, often on a weekly or twice weekly basis, and, on their own admission, with long periods of non-compliance. While some of the drugs listed in Table 1 may not have had a significant effect on the final outcome, the use of a rapidly-acting bactericidal drug ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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