• Study Resource
  • Explore Categories
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
2007_03_01-Burton-Drugs_of_Abuse
2007_03_01-Burton-Drugs_of_Abuse

... • 42F brought to ED after being found confused by roomate. C/o cough and chills x1wk. Last night out “partying” with friends, and this a.m. difficult to awaken. • O/e: 38.5 HR 124 BP 98/72 sats 91%r/a ...
6.1-BIO-GEN-gentics.punnetsquares
6.1-BIO-GEN-gentics.punnetsquares

... True… but is it a trait? Families passed the tradition down. A long neck was a way to attract good husbands. Is it possible for a woman to pass on the trait of a long neck to her children? Why or why not? Write down your thoughts! ...
A Seminar on Invitro Invivo Correlation
A Seminar on Invitro Invivo Correlation

... Case by case ...
Genetics - the science of heredity
Genetics - the science of heredity

... Lets say for instance your maternal grandmother does not have a widow’s peak and her husband (your maternal grandfather) does but his mother didn’t (your great grandmother) making him a heterozygote. Your father’s two brothers (your uncles) didn’t have a widow’s peak, but his sister did Thus 50% of ...
iMap Exercise ()
iMap Exercise ()

... clones offers to sequence BAC clones containing some of the chromatin genes you are studying. This is terrific, because most of your genes are repesented only as cDNA sequences and it would be useful to have genomic sequence information. Your job is to identify which BAC clones to sequence. ...
Pain in Cancer Patients
Pain in Cancer Patients

... • Do not under-estimate the patient’s condition based on his denial. ...
RRYY - My CCSD
RRYY - My CCSD

... 1. Gregor Mendel - “Father of Genetics” • Austrian monk, teacher, scientist, gardener • Formulated basic laws of heredity in the early 1860s ...
Use of Chemotherapy plus a Monoclonal Antibody (Trastuzumab
Use of Chemotherapy plus a Monoclonal Antibody (Trastuzumab

... cardiac dysfunction in patientswho were receiving the combination of an anthracycline, cyclophosphamide,and trastuzumab. ...
Yu-GO
Yu-GO

... genes for each term. There are 463 genes that have correlations of >0.5 with ‘NAD biosynthesis’, and 363 genes with ‘NADH metabolism’. The two groups share 117 genes. These 117 genes serve as the bridges that link the two terms. However, there are only two cross-term correlations >0.5. We note that ...
A Cough with an Adrenal Surprise
A Cough with an Adrenal Surprise

Position paper on potential medication errors in the context of
Position paper on potential medication errors in the context of

... Introduction of a product that differs from an authorised/established product regarding concentration or strength, pharmaceutical form or composition or has a different administration device or is intended to be used in a different patient population or indication, etc. may in general be seen as a v ...
"פורמט עלון זה נקבע ע"י משרד הבריאות ותוכנו נבדק ואושר"
"פורמט עלון זה נקבע ע"י משרד הבריאות ותוכנו נבדק ואושר"

... The symptoms of toxicity from papaverine hydrochloride often result from vasomotor instability and include nausea, vomiting, weakness, central nervous system depression, nystagmus, diplopia, diaphoresis, flushing, dizziness, and sinus tachycardia. In large overdoses papaverine is a potent inhibitor ...
Gene Mapping, Linked & Unlinked Genes
Gene Mapping, Linked & Unlinked Genes

Leroy et. Al. Gabon 96 phylogeny
Leroy et. Al. Gabon 96 phylogeny

... showing that the Booue! -96 strain belongs to the Zaire subtype. However, the genetic diversity observed between EBOV NP subtypes was lower than that found in the analysis of GP. The mean nucleotide distances in the NP gene between the Zaire and Sudan subtypes are around 30 %, compared to 70 % in th ...
Gene Linkage Genetics
Gene Linkage Genetics

... ts May 23, 2017 Tuesday, ...
N receptors
N receptors

Definition of Evolution Evolutionary Force
Definition of Evolution Evolutionary Force

... isolated since the drift event) 2. Use several loci to reconstruct recent evolutionary history and population structure prior to initiating association study, and then choose populations accordingly or use as a control set of loci in the association study. ...
Knowledge
Knowledge

... A. ratio between drug dose and plasma drug concentration B. ratio between drug absorption and bioavailability C. drug distribution between systemic circulation and muscles D. amount of drug that reach the systemic circulation E. relationship between bioavailability and excretion 5. In the case of re ...
P16_Zhang_QT - American Statistical Association
P16_Zhang_QT - American Statistical Association

... • A ‘thorough QT/QTc study’ is negative when the study drug is non-inferior to placebo in terms of the effect of QT/QTc interval. • If all the one-sided 95% upper limits of the time-matched mean difference between the drug and placebo after baseline adjustment are below  (the non-inferiority margin ...
Get to Know an Enzyme: CYP3A4
Get to Know an Enzyme: CYP3A4

... known to be CYP3A4 inducers. CYP3A4 inducers tend to lower plasma concentrations of CYP3A4 substrates, resulting in reduced efficacy of the substrate. This type of drug interaction is probably more frequent than commonly realized, because reduced drug effect may simply be attributed to lack of patie ...
MiraLax - GI Care for Kids
MiraLax - GI Care for Kids

... MiraLax is often used for months to years in a pediatric gastroenterology practice, even though the manufacturer’s labeling suggests treatment periods for 5 days. Although MiraLax is marketed for short-term use, there are studies in children and adults confirming its safety and effectiveness for lon ...
Chapter 12 - papademas.net
Chapter 12 - papademas.net

... • A: no risk to the fetus in any trimester • B: no adverse effect demonstrated in animals; no human studies available • C: – studies with animals show adverse reaction – no human studies available ...
Communicating Project and Portfolio Risks and Rewards
Communicating Project and Portfolio Risks and Rewards

...  Capitalized cost for one NME launched: $ 1.8 billion Source: Nature Review_Drug discovery_Volume 9_March 2010 : How to improve R&D Productivity: the pharmaceutical industry’s grand challenge? ...
Effect of Dextromethorphan, Diphenhydramine, and
Effect of Dextromethorphan, Diphenhydramine, and

... respiratory tract infections (URIs), and each year results in more ambulatory health care visits than any other symptom in the United States.” [Interesting] “The use of codeine or dextromethorphan (DM) [Robitussin, Vicks 44], the most common over-the- counter (OTC) antitussive, for treatment of coug ...
- Wiley Online Library
- Wiley Online Library

... Genetic modifications affecting the rate and/or time of onset of spoIIR expression were shown to affect the sporulation process of only a subset of the population. Quantifying the induction of a transcriptional reporter for SpoIIR by time-lapse microscopy revealed that variation in the rate and dela ...
< 1 ... 462 463 464 465 466 467 468 469 470 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report