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Quick Overview of Bioinformatics - What's New?
Quick Overview of Bioinformatics - What's New?

... B. Bloom (1995) A microbial minimalist. Nature 378:236 ...
Obsessive-Compulsive Disorder: An Overview for
Obsessive-Compulsive Disorder: An Overview for

... (1) repetitive behaviors (e.g., hand washing, ordering, checking) or mental acts (e.g., praying, counting, repeating words silently) that the person feels driven to perform in response to an obsession, or according to rules that must be applied rigidly (2) the behaviors or mental acts are aimed at ...
1 Solu-Medrol® methylprednisolone sodium
1 Solu-Medrol® methylprednisolone sodium

... succinate, and may be unrelated to the speed or duration of infusion. Persons who are on drugs which suppress the immune system are more susceptible to infections than healthy individuals. Chicken pox and measles, for example, can have a more serious or even fatal course in non-immune children or ad ...
Firing up the nature/nurture controversy: bioethics and genetic
Firing up the nature/nurture controversy: bioethics and genetic

... bioethicists using them might inadvertently promote genetic determinism, is that they are unrepresentative of the kind of information that we can, and presumably will be able to, obtain for the majority of diseases with a genetic component that might affect most human beings.31–33 Diseases such as c ...
PopCycle Tutorial
PopCycle Tutorial

... bar graph now shows you how many zygotes of each genotype we should expect. If your Punnett square prediction was not correct, try to figure out why. 7. Shepherd the zygotes from the ideal population around their life cycle—to juveniles with 100 % survival, to adulthood with no migration, and to the ...
Pramipexole in the Management of Restless Legs Syndrome
Pramipexole in the Management of Restless Legs Syndrome

... by a single physician. However, a prospective study would be ideal in more accurately determining the long-term benefits and risks of the medication. Second, we did not use quantitative instruments to measure efficacy, augmentation, or adverse reactions, but an RLS severity scale has only recently b ...
Medications for Treating Alcohol Dependence
Medications for Treating Alcohol Dependence

... and headache. More severe reactions could include myocardial infarction, congestive heart failure, respiratory depression, and death. Because of the potential for a severe alcohol–disulfiram interaction, disulfiram is contraindicated in patients who are receiving or have recently received metronidaz ...
Overview of Drug Testing g g Methods
Overview of Drug Testing g g Methods

... testing can give a record of use over a period of months, not days. • Tests T can be b confirmed fi db by GC/MS GC/MS. • There is some question of ethnic bias as dark hair concentrates metabolites better than light hair. pe s e ~ $ $150-200/test 50 00/test – “onezees” o e ees • Expensive available. ...
Genotype and Phenotype Powerpoint
Genotype and Phenotype Powerpoint

1-25-17 PPT
1-25-17 PPT

2610//16 1 Allele-specific expression, ASE [1] Defini8on of allele
2610//16 1 Allele-specific expression, ASE [1] Defini8on of allele

... •  Homozygous variant: the two alleles are idenBcal to each other •  Heterozygous variant: the two alleles are different •  “Ref.” = the allele is the same as for the reference genome •  “Alt.” = alternate = the allele is different from the reference genome •  SNV is one type of variant, others i ...
Introduction to Pharmacokinetics and Pharmacodynamics
Introduction to Pharmacokinetics and Pharmacodynamics

... based on the concept that pharmacologic response is closely related to drug concentration at the site of action. For certain drugs, studies in patients have provided information on the plasma concentration range that is safe and effective in treating specific diseases—the therapeutic range (Figure 1 ...
Interferonlambda and therapy for chronic hepatitis C virus infection
Interferonlambda and therapy for chronic hepatitis C virus infection

... • Doctors often combine different antiviral drugs to better combat the virus. For example, interferon treatment may often be combined with other antiviral drugs like Lamivudine in the case of hepatitis B infection or Ribavirin for people with hepatitis C infection. ...
Document
Document

... Long-term cocaine or amphetamine use does not produce tolerance and is even likely to produce sensitization to the effects of the drug. Withdrawal from cocaine does not cause physical symptoms, but it does cause unpleasant feelings, including dysphoria and decreased ability to feel pleasure. ...
GENETICS REVIEW
GENETICS REVIEW

... Bb - Purple ...
Genetica per Scienze Naturali aa 04
Genetica per Scienze Naturali aa 04

... In fact, we can define one genetic map unit (m.u.) as that distance between genes for which one product of meiosis in 100 is recombinant. Put another way, a recombinant frequency (RF) of 0.01 (1 percent) is defined as 1 m.u A map unit is today referred to as a centimorgan (cM) in honor of Morgan A d ...
Full Version - TS
Full Version - TS

... Over the past several months, various advocacy groups around Europe - in close collaboration with the European Society for the study of TS (ESSTS) have embarked on a unified campaign to celebrate the second annual European Tourette Awareness day. On June 7th – the birthday of the renowned Tourette S ...
Approaches using molecular imaging... PET in Clinical microdose
Approaches using molecular imaging... PET in Clinical microdose

... considerable drawback, however, stems from the fact that relatively few drug molecules contain fluorine in their native structure. Consequently, despite the rather short half-life of 11C (20.4 min), the majority of PET microdose studies have relied on 11C-labeled drug molecules. A commonly employed m ...
Long Term Study of Ritalin
Long Term Study of Ritalin

... psychostimulants. However, little long-term evidence is available, and controversy remains about whether these conditions are worsened by stimulant use." The authors state that the most prominent long term side effect was decreased appetite: "The current data also documented that stimulant medicatio ...
C2005/F2401 Lect #22 - Columbia University
C2005/F2401 Lect #22 - Columbia University

... arrow (2) will increase as the distance between alpha and beta increases (up to a point)*. As distance & the number of recombinants increases, linkage decreases. How linkage and distance are treated numerically will be discussed later. d. Multiple crossovers: For now we are ignoring multiple conside ...
22q11.2 Deletion (DiGeorge) Syndrome: a mother`s open letter
22q11.2 Deletion (DiGeorge) Syndrome: a mother`s open letter

... and, regardless of my being a medical doctor, I felt lost. I felt my son would be lost, too, and that both his future and mine were doomed. I am a doctor and I did the only thing I knew to do then: I looked for scientific information and read all the papers I could find to understand what was happen ...


... Traditionally, EMS has immobilized all patients with potential spinal injury to include backboards and associated adjuncts (B/AA). However, studies indicate that traditional spinal immobilization with B/AA has risks and may even cause harm in select cases. As such, the spinal immobilization protocol ...
PDF full-Text - Journal of Investigational Allergology and Clinical
PDF full-Text - Journal of Investigational Allergology and Clinical

... hydrochloride, 0.25 g; chlorbutol, 10 mg/mL; and eucalyptol, niaouli essence, cholesterin, and undiluted paraffin). All the compounds tested negative except for neomycin sulphate, which produced an 18-mm wheal. SPTs performed with other aminoglycoside antibiotics (tobramycin and gentamicin) were neg ...
No Slide Title
No Slide Title

... Ensure only approved devices are released POs are reviewed to ensure ambiguities & errors are resolved… Ensure stock that deteriorates over time is properly controlled & expired devices are not distributed Maintain distribution records that ID ...
Slides - Clinical Trial Results
Slides - Clinical Trial Results

... Post-PCI VerifyNow P2Y12 Assay (PRU) 2 - 4 hours after 1st MD of clopidogrel 75 mg at day 1 post-PCI ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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