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Profile Documents Logout
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Word file (37 KB )
Word file (37 KB )

... corresponds to a gene. The rows and columns are displayed in the order given by the clustering output trees in the two dimensions. Not all genes are retained in the clustering analysis, only 5,000 significant genes with more than two-fold regulation and significance of regulation p < 0.01 in more th ...
Linked Data as a Starting Point for Knowledge Discovery
Linked Data as a Starting Point for Knowledge Discovery

... – Clopidogrel (chebi:37941) associated with Endothelin signaling pathway (pharmgkb:PA164728163). Endothelins are proteins that constrict blood vessels and raise blood pressure. Clopidogrel inhibits platelet aggregation and prolongs bleeding time. ...
prialt - Who we are
prialt - Who we are

... Commercial Approvals for NanoCrystal Technology  The first United States approval of a product produced incorporating the NanoCrystal technology occurred in August 2000: Wyeth’s first solid-dose formulation of the immunosuppressant Rapamune® (sirolimus) received marketing approval from the U.S. Foo ...
Evaluation of the effect of nitrous oxide and hydroxyzine in
Evaluation of the effect of nitrous oxide and hydroxyzine in

... Behavior management of the uncooperative pediatric patient who requires comprehensive dental treatment is enhanced frequently by using sedation. Oral and inhalation routes of sedative administration are the most convenient for use in children, and are the most popular amongpediatric dentists. 1-4 Hy ...
drug treatment for ibs
drug treatment for ibs

... consistency from the Bristol Stool Scale.28 (Type 1-7) However, it is recommended that treatment is sought for symptoms, not subtypes – which can change over time.3, ...
sloan_sz_aaem_barcel..
sloan_sz_aaem_barcel..

... There are an estimated 2.5 million patients with epilepsy in the US, based on a prevalence of about 6.6 per 1000 Americans.1 Up to 28% of all epilepsy patients require treatment in Emergency Departments annually.2 In addition to these patients who have an established seizure diagnosis, another 150,0 ...
Management of Diarrhea-predominant Irritable Bowel Syndrome
Management of Diarrhea-predominant Irritable Bowel Syndrome

... of the condition. In addition to a familial relationship, other postulated etiologies for IBS include disturbances in GI motility, mucosal barrier disruption, visceral hypersensitivity, dysfunction of the gut-brain axis (neurohormonal interactions between the CNS and the gut), and a stress response ...
Autosomal dominant familial Mediterranean fever in Northern
Autosomal dominant familial Mediterranean fever in Northern

... and a higher risk of AA amyloidosis [3–7], the most serious complication of FMF [6, 8–10]. Regular prophylactic colchicine has proven very effective in suppressing FMFrelated inflammation, thereby both preventing and treating AA amyloidosis. FMF is typically inherited in an autosomal recessive fashi ...
First-time  treatment  with  steroids  in ... comparison  of  the  effects  of ...
First-time treatment with steroids in ... comparison of the effects of ...

... with inhaled BDP and oral prednisone have been compared to each other in 12 asthmatics. It should be pointed out that the study is not placebo-controlled. Based on the analysis for each individual, possible carry-over effects between the treatment periods were not found. The chosen doses of the drug ...
Population genetics
Population genetics

... Use the table on the next page to keep record of the genotypes of you and 2 other people. If possible, use siblings and parents to get the best explanation possible for your traits. Hitchhikers thumb – “distal hyper-extensibility of the thumb” Some people will be able to bend the distal joint back t ...
Zopiclone/Eszopiclone
Zopiclone/Eszopiclone

... under the Controlled Substance Act in the U.S. The potential for abuse and toxicity due to overdose has been observed for both drugs.Human urine and blood remain important matrix types for testing of drugs of abuse. These two drugs can be found in both matrices as parent and metabolite forms. Data f ...
Genetic Inheritance in Humans | Principles of Biology from Nature
Genetic Inheritance in Humans | Principles of Biology from Nature

... environment plays a strong role in determining phenotype and that some phenotypes can be inherited through mechanisms other than gene sequence variations (known as epigenetics). Asthma, for example, is an inflammatory disease that researchers believe involves both inherited genes and environmental ...
Dow, Graham: The limitation of genome wide association studies
Dow, Graham: The limitation of genome wide association studies

... variants
 that
 are
 commonplace
 are
 the
 result
 of
 mutations
 that
 took
 place
 many
 generations
 ago,
 and
 spread
 throughout
 human
 genealogy
 either
 through
 genetic
 drift
 or
 selection.
 
 Rare
 SNPs,
 on
 the
 other
 hand,
 have
 arisen
 from
 recent
 mutations,
 even
 some
 within ...
Quiz 6
Quiz 6

... In 1990, the Asian shore crab was introduced to the southern coast of Maine. As of today, Asian shore crabs have not migrated to the waters off northern Maine. Asian shore crabs are more aggressive than green crabs, and were able to break the thicker shells the mussels developed in response to the g ...
Urinary Metabolite Tests for Adherence to Direct
Urinary Metabolite Tests for Adherence to Direct

... interferon/ribavirin in patients with hepatitis C infection reported that 54.9% of all patients discontinued treatment early. For the first-generation DAA boceprevir, Gordon et al published an analysis of adherence in the SPRINT-2 and RESPOND-2 trials. Adherence above 80% was reported for 63% of the ...
1-28-17 PPT
1-28-17 PPT

... Which of the following correctly describes the life cycle of malaria in the human? a. Schizonts, sporozoites, merozoites, gametocytes b. Sporozoites, schizonts, merozoites, gametocytes c. Sporozoites, merozoites, gametocytes, schizonts d. Merozoites, sporozoites, gametocytes, schizonts ...
Newly Approved Anticoagulants
Newly Approved Anticoagulants

... – Blocks vitamin K dependent clotting factors creation, by inhibiting the vitamin vitamin K epoxide reductase complex 1 (VKORC1) – Vitamin K epoxside is responsible for the regeneration of vitamin K in the vitamin K cycle by blocking VKORC1 – Inhibit vitamin K epoxide reducatase thus interfering wit ...
to the PDF file. - Romanian Journal of Legal Medicine
to the PDF file. - Romanian Journal of Legal Medicine

... Beaver and colleagues examined 2196 individuals from the National Longitudinal Study of Adolescent Health and found that 2R and 3R male carriers are 1.94 times more likely to belong to a gang and 1.82 times more likely to use weapons for fighting, compared to 3.5R, 4R and 5R carriers [27]. In additi ...
40 Complementary and Alternative Medical Treatment for Depression
40 Complementary and Alternative Medical Treatment for Depression

... by Congress in the Dietary Supplement Health and Education Act (DSHEA) of 1994. The dietary ingredient may include several products, such as vitamins, minerals, herbs or other botanicals, amino acids, and enzymes. Dietary supplements (DS), which can be found in many forms, including tablets, capsule ...
Mendel`s Theory
Mendel`s Theory

... When gametes are formed, the alleles for each gene in an individual separate independently of one another. Thus, gametes carry only one allele for each inherited trait. When gametes unite during fertilization, each gamete contributes one allele. Parents can only contribute one allele because of the ...
Michael pieces together
Michael pieces together

... mechanisms and effects of cardiovascular and respiratory drugs. While the focus is predominantly on disorders of the pulmonary system, the inter-relatedness of the two systems requires a review of the medications focused on heart problems. Since the respiratory system cannot be disassociated from ca ...


... While exposure of wt sGC-overexpressing cells to HMR1766 led to higher cGMP levels, BAY 58-2667 was a more potent sGC activator. Mutating His to Phe at β1 105 abolished sGC responsiveness to sodium nitroprusside (SNP), due to heme loss. In contrast, BAY 58-2667 and HMR-1766 activated heme-free H105F ...
DNA-Based Technologies
DNA-Based Technologies

... markers can be used to assign calves to their individual sires based on the inheritance of markers. Sires pass on only one of the two marker alleles that they carry for each gene. If a calf does not have a marker allele in common with a sire at a particular gene, then that sire is excluded as being ...
P1 Genotype - misskuenneth
P1 Genotype - misskuenneth

... The blood type of parents is often used as evidence in paternity cases. Given below are the blood types of mothers and their children who are involved in a paternity suit. Your job, as an expert for the defense, is to determine all possible blood types for the father and to determine the blood type ...
Page 1 - Mr Waring`s Biology Blog
Page 1 - Mr Waring`s Biology Blog

... (correct gametes, offspring genotypes and link with phenotypes based on incorrect parent genotype = 3 marks) ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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