• Study Resource
  • Explore Categories
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Class notes on epistasis and GWAI analysis
Class notes on epistasis and GWAI analysis

...  two-locus interactions in which neither locus has a detectable main effect were uncommon ...
Population Genetics
Population Genetics

... such as color, body size, territory size, or display behavior. Even when mate choice is not occurring, differential survival of particular phenotypes in particular environments may increase the probability that organisms with similar genotypes mate. In our bean-bag model, we will simulate non random ...
Introduction Rhizomelic chondrodysplasia punctata (RCDP) is a rare
Introduction Rhizomelic chondrodysplasia punctata (RCDP) is a rare

... These genes are involved in peroxisomal metabolism. Mutation of these genes causes defect in peroxisomal metabolism. As a result, plasmalogens which are required for normal brain and skeletal formation are abnormal resulting in clinical manifestions RCDP1, RCDP2, and RCDP3 are characterized by rhizo ...
Information for relatives and friends
Information for relatives and friends

... • No drugs affect the course of illness. • Some drugs may help particular symptoms: – Depression - antidepressants – obsessionality – anti–obsessional drugs i.e. clomipramine in low dose / Selective ...
Depression In Managed Care: Costs Of Selective Serotonin
Depression In Managed Care: Costs Of Selective Serotonin

... most common adverse effects of SSRIs include sexual dysfunction, nervousness, insomnia, drowsiness, fatigue, sweating, headache, and tremor. With the exception of sexual dysfunction, these effects generally are not severe enough to make the patient noncompliant and often subside as treatment continu ...
Final Chapter 20 Ppt
Final Chapter 20 Ppt

... coagulation should not be given during recteplase therapy because of increased risk for bleeding Tenecplase, similar in action to alteplase, reteplase and streptokinase, indicated in the treatment of AMI, administered in single dose IV bolus rather than multiple doses or continuous infusion required ...
Policy 10 Neuromuscular Blocking Drugs
Policy 10 Neuromuscular Blocking Drugs

... predetermined anesthetic dose (or a higher dose if indicated by clinical signs in an individual animal). A second method is to determine the anesthetic requirement for each animal, prior to administering the NMB drug. With this method, once NMB drugs are administered, the amount of anesthesia is nev ...
Population Genetics
Population Genetics

... the gene pool according to parental genotype/phenotype, and allowing only individuals within each gene pool to mate with each other. (a) Start with a population of 80 with the equilibrium count and genotypes calculated for part I, generation 0. Assume that the g allele is dominant over the y allele, ...
Population Phenotypes of Neuropsychiatric Copy Number Variants
Population Phenotypes of Neuropsychiatric Copy Number Variants

... result of multiple genetic and environmental factors7. – Including Psoriasis, Crohn’s Disease, and glomerulonephpritis Psychiatric Disorders, classified as a complex disease, are being researched in association to CNVs – CNVs may not be fully penetrant in the genome and only contribute a small respo ...
Court Dismisses Challenge to Prescription Drug Copayment
Court Dismisses Challenge to Prescription Drug Copayment

... © 2013 Hunton & Williams LLP. Attorney advertising materials. These materials have been prepared for informational purposes only and are not legal advice. This information is not intended to create an attorney-client or similar relationship. Please do not send us confidential information. Past succe ...
Phosphodiesterase inhibitors
Phosphodiesterase inhibitors

... inflammatory and immune cells, have proven potential as antiinflammatory drugs, especially in inflammatory pulmonary ...
Xolair for the treatment of chronic spontaneous urticuria (CSU
Xolair for the treatment of chronic spontaneous urticuria (CSU

... of urticaria. Since, European and American guidelines have provided guidance on its use in the  treatment of urticaria. In general, use of omalizumab is advised, along with ciclosporin A and  leukotriene receptor antagonists (LTRAs), as a third step in a stepped‐care model. First and second  steps i ...
to get the file - Chair of Computational Biology
to get the file - Chair of Computational Biology

... the remaining k-1 subsets as training set respectively. This gives you an average error from the k QSAR equations. In practice k = 10 has shown to be reasonable (= 10-fold cross validation) 6th lecture ...
Intratympanic steroid injection for inner ear disease
Intratympanic steroid injection for inner ear disease

... endocochlear potential [11,12]. The primary concern in usage of systemic steroids has been potential side effects [5], ranging from minor to potentially life-threatening. Systemic steroid therapy has been associated with hyperglycemia, hypertension, hypokalemia, peptic ulcer, osteoporosis, immune su ...
The Making of a CYP3A Biomarker Panel for Guiding
The Making of a CYP3A Biomarker Panel for Guiding

... performed in Asian populations. However, the effect of CYP3A4*1G on mRNA/protein level remains uncertain. In reporter gene assays, the minor G allele resulted in reduced transcription [36], suggesting a loss of function. However, the G allele was associated with lower dose-adjusted blood levels (AUC ...
Mendelian Genetics - hills
Mendelian Genetics - hills

...  “nature vs. nurture”  Identical twins separated at birth are studied  If ...
Treatment issues for psychiatric comorbidities of epilepsy
Treatment issues for psychiatric comorbidities of epilepsy

... disorder itself. In fact, it is mandatory to identify the various elements that may contribute to psychiatric symptoms, such as psychosocial issues [4] , adverse effects of antiepileptic drugs (AEDs) [6] and neurobiological factors directly related to seizures [7] . Systematic data on treatment stra ...
10.1 Case Report Forms
10.1 Case Report Forms

1.0 PURPOSE 2.0 DEFINITION 3.0 RESPONSIBILITY 3.0 CROSS
1.0 PURPOSE 2.0 DEFINITION 3.0 RESPONSIBILITY 3.0 CROSS

... 1.1 To establish guidelines to identify and standardize the handling and use of High-Alert Medications in patient-care areas, and to outline the steps necessary to increase awareness of these medications to prevent errors that may result from confusion thereby improving patient safety. ...
Drugs for Bronchial Asthma, Antitussives, Expectorants
Drugs for Bronchial Asthma, Antitussives, Expectorants

... bronchodilation by acting through β2 adrenergic receptors.  Useful in acute attack of asthma (0.2-0.5 ml of 1:1000 solution given s.c.  Its use decline due to serious cardiac side effects. ...
Natural Supplements Proven To Lower Cholesterol
Natural Supplements Proven To Lower Cholesterol

... to increase risk for heart attack, stroke and other cardiovascular diseases. Individuals should strive to achieve a fasting blood cholesterol level below 3.9 mmol/L(150 mg/d) and a fasting triglyceride level below 1.13 mmol/L (100 mg/dL) to maximize their protection against heart attack and stroke. ...
Drug List - The North Carolina Office of EMS
Drug List - The North Carolina Office of EMS

... Only Medications included in the 2012 NCCEP Protocols are included in this document. For a full list of medications approved for use by EMS professionals, please refer to the North Carolina Medical Board document entitled: Approved Medications for Credentialed EMS Personnel. Individual systems shoul ...
OHIO Medicaid Coverage of Medications for the Treatment of Opioid
OHIO Medicaid Coverage of Medications for the Treatment of Opioid

... Ohio Medicaid covers Suboxone, buprenorphine/naloxone tablets, and buprenorphine tablets under FFS and MC plans with the following limitations:  In order to approve Suboxone, buprenorphine/naloxone tablets, and buprenorphine tablets for the treatment of opioid use disorder, patients must be enrolle ...
Do THE BENEFITS OUTWEIGH THE RISKS?
Do THE BENEFITS OUTWEIGH THE RISKS?

... also been plagued with problems in recent years. Presently, more drugs are being pulled off the market than ever before because of safety concerns. This has been followed by a wave oflawsuits aimed at correcting the error of allowing such drugs on the market in the first place. As a result, the phar ...
Association study of the estrogen receptor I gene (ESR1) in anorexia
Association study of the estrogen receptor I gene (ESR1) in anorexia

... Lifetime prevalence in women ranges between 0.9 and 3.5 for different types of EDs.1 Because of this low prevalence only a small number of women will be affected in the population, of the total 2,810 controls approximately 165 could be affected. Additional analyses, not reported here, show that taki ...
< 1 ... 432 433 434 435 436 437 438 439 440 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report