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CMS Annual DUR Report - 2010 - Michigan Department of Health
CMS Annual DUR Report - 2010 - Michigan Department of Health

... claim for aspirin where the recipient has a claim in their history for warfarin, and the dispensing pharmacist did not resubmit the claim with appropriate override codes in order to receive a paid claim. This is illustrated in Figure 2 (below). The ProDUR cost avoidance for FFY 2010 was $389,798,567 ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)

...  Before the experiment in test Diacerein at dose of 4.2mg/kg group showed mean reaction time was6.2, with SE of 0.095, Where as in standard1 Etoricoxib at dose of 15mg/kg group showed mean reaction time was 6.3 with SE of 0.172, Where as in standard 2 Meloxicam at dose of 0.642mg/kg group showed me ...
Cancer Pain - International Pain School
Cancer Pain - International Pain School

... always think of a reasonable alternative and symptomatic treatment. ...
Dragon Genetics - Chester Upland School District
Dragon Genetics - Chester Upland School District

... To test whether baby dragons with wings and baby dragons without wings will be equally likely to have big horns, you will carry out a simulation of the simultaneous inheritance of the genes for wings and horns. Since the father is homozygous (wwhh), you know that all of the father's sperm will be wh ...
Brain death
Brain death

... Disease of pupils Sedative drug used Severe pulmonary disease ...
FazaClo USPI Rev092015
FazaClo USPI Rev092015

... 450 mg per day (administered in divided doses) by the end of 2 weeks. Subsequently, the dose can be increased once weekly or twice weekly, in increments of up to 100 mg. The maximum dose is 900 mg per day. To minimize the risk of orthostatic hypotension, bradycardia, and syncope, it is necessary to ...
Anti-inflammatory, Antirheumatoid and Related Agents
Anti-inflammatory, Antirheumatoid and Related Agents

... GI lesions or peptic ulcer disease  Bleeding disorders ...
Genealogic Study in Down Syndrome
Genealogic Study in Down Syndrome

... Genealogies of 66 child with trisomy 21 (Down Syndrome) as diagnosed by chromosome analysis were constructed. The control group included 198 child (three controls for each patient) with no apparent genetic pathology matched in age and sex with the patients. Genealogies of the controls were also cons ...
Giant Pumpkin Genetics - St. Croix Grower`s Association
Giant Pumpkin Genetics - St. Croix Grower`s Association

... growing a dill ring, or going light, how do we go about breeding this out of this particular line? This is a challenge because we do not know concretely which characteristics are truly "genetic" and which are genetic traits subject to environmental influence (read: epigenetics). Dill rings are a cha ...
Genetic polymorphisms and drug interactions modulating
Genetic polymorphisms and drug interactions modulating

... Co-administration of the CYP3A inducer rifampin has been associated with negative urine oxycodone screening (Lee et al., 2006), as well as with a dramatic reduction in oxycodone exposure and pharmacodynamic effects in healthy volunteers (Nieminen et al., 2009). Inversely voriconazole increased oxyco ...
Congestive Heart Failure - UnitedHealthcareOnline.com
Congestive Heart Failure - UnitedHealthcareOnline.com

... across a broad range of patients (age, sex, etiology, and New York Heart Association class). Patients with lower ejection fractions appear to have the greatest benefit (4-6). Clinicians are encouraged to use doses that have been shown to reduce the risk of cardiovascular events in clinical trials (1 ...
information about Schwannomatosis here.
information about Schwannomatosis here.

... How is schwannomatosis diagnosed? Unless a person comes from a family with definite schwannomatosis, the diagnosis is only considered after the more likely possibility of NF2 has been excluded. Patients with suspicious symptoms are usually referred to one of the specialist Neurofibromatosis Centres, ...
mind altering… synthetic (designer) and naturally occuring
mind altering… synthetic (designer) and naturally occuring

... marketed as Cesamet. It was approved in 1985 by the U.S. Food and Drug Administration (FDA) for treatment of chemotherapy-induced nausea and vomiting that has not responded to conventional antiemetics. Though it was approved by the FDA in 1985, the drug only began marketing in the United States in 2 ...
Avances en el desarrollo de productos biológicos para
Avances en el desarrollo de productos biológicos para

... Drug addictions are complex disorders that require multiple approaches, including the use of pharmacotherapies. Currently, these therapies are based on “small” molecules or chemicals that penetrate the blood-brain barrier, reach the brain, and produce their effects on neurotransmitter systems. Unfor ...
UNIT V – MENDELIAN GENETICS
UNIT V – MENDELIAN GENETICS

... o If changes involve long stretches of DNA, known as chromosomal mutations o Point mutations – change in a gene involving a single nucleotide pair; 2 types  Substitution  Frameshift – due to addition or deletion of nucleotide pairs ...
Randomized Placebo-Controlled Crossover Trial of Tadalafil in Raynaud’s Phenomenon Secondary to
Randomized Placebo-Controlled Crossover Trial of Tadalafil in Raynaud’s Phenomenon Secondary to

... relationship had to agree to practice a medically acceptable form of contraception during the entire study. All study patients were required to discontinue certain prespecified concomitant medications before starting the 2-week pretreatment period. These medications included drugs used in the treatm ...
Overview of testing for Lynch syndrome/HNPCC
Overview of testing for Lynch syndrome/HNPCC

Speaker`s Notes
Speaker`s Notes

... For example, your pig may be extremely sick and you think that Q. T/F: One benefit of a VCPR is that your you need to give it a little more veterinarian will be able to assist you with medication than the medication withdrawal times and recordkeeping. label instructs you to give to A. TRUE make sure ...
The HapMap Project Tutorial
The HapMap Project Tutorial

... “snips”) are by far the most common form of genetic variation ...
octaplex - Octapharma Canada
octaplex - Octapharma Canada

... or more of these factors. In acquired deficiencies, PCCs have been used for the reversal of oral anticoagulation due to overdose or in case of emergency surgical interventions; in bleedings due to vitamin K deficiency; and for the treatment of bleeding disorders after major liver surgery, in severe ...
St John`s wort - Black Dog Institute
St John`s wort - Black Dog Institute

... However, it is unlikely to be effective in the treatment of melancholic (biological) depression. In general, St John’s wort has been recommended as a useful alternative to prescription antidepressant medication for the treatment of mild depression and can be bought over the counter. However, in a we ...
Gipson SfN 2010 - University of Kentucky
Gipson SfN 2010 - University of Kentucky

... •It appears that there is region-specificity in the prefrontal cortex with how methylphenidate, an ADHD medication, affects impulsive choice in delay discounting. Although methylphenidate has more than one mechanism of action, it has been found to inhibit reuptake of DA, similar to cocaine (Fleckens ...
Human Pregnane X Receptor - Clinical Cancer Research
Human Pregnane X Receptor - Clinical Cancer Research

... Results: The current study showed that paclitaxel, discodermolide, and an analogue of epothilone B, BMS-247550, induced CYP3A4 protein expression in HepG2 hepatoma cells. Transient transcription assays of a luciferase reporter in the presence and absence of a GAL4-steroid and xenobiotic receptor (SX ...
Drug-Related Hepatotoxicity
Drug-Related Hepatotoxicity

Introduction to Molecular Markers and their
Introduction to Molecular Markers and their

... –VNTRs -- variable number of tandem repeats (minisatellites) ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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