• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Substance use disorders: treatment with genetic potential?
Substance use disorders: treatment with genetic potential?

... 15-64 (roughly 53 million individuals) using amphetamines in 2013; crystal methamphetamine use has increased in North America and Europe in particular. Prevalence rates for psychoactive substances are difficult to estimate due to their transient and diverse use (United Nations Office on Drugs and Cr ...
Chronic pain - Calgary Emergency Medicine
Chronic pain - Calgary Emergency Medicine

... When you pass by the bed, she moans and clutches her arm. She is on methadone for chronic pain and has told the nurse she will need 250 mg of Demerol because she has a “high pain threshold”. She is febrile and has a markedly swollen arm with multiple recent needle tracks. When you touch the skin lig ...
Prescribing Information
Prescribing Information

... Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving beta-lactam antibacterial drugs. Before initiating therapy with ZERBAXA, make careful inquiry about previous hypersensitivity reactions to other cephalosporins, penicillins, or other bet ...
NCEA Level 1 Science (90948) 2013
NCEA Level 1 Science (90948) 2013

... • Possible disadvantages: need two parents that are able to reproduce, if conditions are stable could introduce variation, which may be counterproductive. • Gametes are sex cells (sperm and egg) which are formed in the testes and ovaries. During gamete formation (meiosis), the homologous chromosomes ...
Rx Deplete+Interactions
Rx Deplete+Interactions

... Drug-Nutrient Depletions & Known Interactions This booklet provides information to help you learn which vitamins and/or minerals are depleted by your medications. It also provides a general list of supplements that might be expected to interact with the drug, and thus need to be avoided while taking ...
Oral Candidiasis – A Review
Oral Candidiasis – A Review

... Clotrimazole which can be taken as is Lozenges and Amphotercin B as oral suspension (Pappas, 2004). Nystatin: It is another drug which can be used as a primary line of treatment. It is available as cream & oral suspensions. It is to be applied four times a day and allowed to act approximately for tw ...
Chapter 5: Heredity
Chapter 5: Heredity

... could predict the possible types of flowers and fruits that would result from crossbreeding two plants. Curiosity about the connection between the color of a pea flower and the type of seed that same plant produced inspired him to begin experimenting with garden peas in 1856. Mendel made careful use ...
oral proton pump inhibitors
oral proton pump inhibitors

... 19. Medicines and Healthcare Products Regulatory Agency. Drug Safety Update April 2012. Proton pump inhibitors in long-term use: reports of hypomagnesaemia. Available at: https://www.gov.uk/drug-safety-update/proton-pump-inhibitors-in-long-term-usereports-of-hypomagnesaemia(accessed December 2015) 2 ...
Mild trifunctional protein deficiency is associated with - UvA-DARE
Mild trifunctional protein deficiency is associated with - UvA-DARE

... three steps in the b-oxidation spiral of long-chain fatty acids. TFP deficiency causes a Reye-like syndrome, cardiomyopathy, or sudden, unexpected death. We delineated the molecular basis for TFP deficiency in two patients with a unique phenotype characterized by chronic progressive polyneuropathy a ...
b -agonists combination: why do we need more? EDITORIAL
b -agonists combination: why do we need more? EDITORIAL

... difference linked to a peculiar unknown mechanism of action of this drug? The study by MYO et al. [9] also raises a more generic question: do we need more studies testing the effects, the efficacy and the molecular mechanisms of this drug combination? Certainly yes, if we consider the improvement in ...
Degradation Studies
Degradation Studies

... two parts: Forced degradation testing and confirmatory testing. • The purpose of forced degradation testing studies is to evaluate the overall photosensitivity of the material for method development purposes and/or degradation pathway elucidation. This testing may involve the drug substance alone an ...
The Brown-Vialetto-Van Laere and Fazio Londe syndrome revisited
The Brown-Vialetto-Van Laere and Fazio Londe syndrome revisited

... oral riboflavin [6], and in one patient treatment was stopped already after 1 week due to lack of clinical improvement [7]. This last patient did demonstrate improvement in the following months but the relation between the improvement and the riboflavin supplementation has remained unclear. All thre ...
Antihomotoxic Mesotherapy in Sports Injuries of Soft Tissues.
Antihomotoxic Mesotherapy in Sports Injuries of Soft Tissues.

... The treatment of injuries in sportsmen requires the employment of products that cause minimal secondary effects and which, at the same time, achieve a total recuperation of the person as soon as possible. This study was carried out in order to evaluate whether the use of antihormotoxic drugs such as ...
Opioid Induced Hyperalgesia
Opioid Induced Hyperalgesia

... I hope this has given some insight into some of the challenges in treating pain I hope this helps you recognize OIH (HD) ...
Prescribing Information
Prescribing Information

... potential benefit justifies the potential risk to the fetus. Nursing Mothers It is not known if topically applied IOPIDINE 1% Ophthalmic Solution is excreted in human milk. Decision should be made to discontinue nursing temporarily for the one day on which IOPIDINE 1% Ophthalmic Solution is used. Pe ...
Canagliflozin, a New Sodium-Glucose Co
Canagliflozin, a New Sodium-Glucose Co

... a focus on key factors that will continue to need evaluation as new medications or clinical data become available regarding safety, efficacy, and long-term outcomes for patients with type 2 diabetes.4,5 Due to the progressive nature of type 2 diabetes, monotherapy with oral agents is associated with ...
Effect of Ularitide on Cardiovascular Mortality in Acute Heart Failure
Effect of Ularitide on Cardiovascular Mortality in Acute Heart Failure

... heart failure and rapid worsening of preexisting heart failure are two of the most common causes of hospitalization worldwide.1 The disorder in each case is characterized by intravascular volume expansion and ventricular distention, which may cause myocardial injury in the absence of coronary artery ...
Molecular Genetics of Alcohol-Related Brain Damage
Molecular Genetics of Alcohol-Related Brain Damage

... Several mechanisms have been implicated in the pathogenesis of thiamine deficiency such as oxidative stress, glutamatemediated excitotoxicity and focal lactic acidosis. Hazell and colleagues extensively studied the role of glutamate neurotoxicity triggered by thiamine deficiency. Their findings show ...
pdf version here - Health Sciences Authority
pdf version here - Health Sciences Authority

... level of consciousness, are disorientated, suffer from sleep disturbances and memory impairment.] These neuropsychiatric adverse events were reported to occur primarily in children and adolescent patients. The events were also reported to occur very shortly after taking the first dose or first few d ...
What are effective medication combinations for dyslipidemia?
What are effective medication combinations for dyslipidemia?

... effects for combined dyslipidemia (SOR: A). Most combination therapies increase the risk of intolerance or side effects, including myopathy. The statin/gemfibrozil combination has the highest risk of myopathy, whereas statin/ ezetimibe or statin/bile acid sequestrant have the ...
Genetics of Corn Chi Square Lab
Genetics of Corn Chi Square Lab

... donated by each parent in the corresponding box. One offspring has been done for you as an example. Now list the possible phenotypes in the spaces below the Punnett square. REMEMBER: a phenotype is how the offspring will look. If an individual's genotype is heterozygous, the dominant trait will be e ...
Ecstasy and Party Drugs
Ecstasy and Party Drugs

... • unlikely that most people who use ecstasy will require long-term interventions. Ecstasy & Party Drugs ...
Akamin
Akamin

... dizziness or vertigo have been reported with minocycline therapy. Patients who experience these symptoms should be cautioned about driving vehicles or using hazardous machinery while on minocycline therapy. These symptoms may disappear during therapy and usually disappear rapidly when the drug is di ...
as a PDF
as a PDF

... sources. Features specific to an application are only present in form of certain gene configurations in individuals in later stages of the evolutionary process. The combination of genetic material from different sources is therefore only possible by combining individuals, for example with a cross-ov ...
FORMULATION AND EVALUATION OF ORODISPERSIBLE FILM OF SILDENAFILCITRATE Research Article
FORMULATION AND EVALUATION OF ORODISPERSIBLE FILM OF SILDENAFILCITRATE Research Article

... for those who have an active life style[8].In disease conditions such as motion sickness, sudden episodes of attacks of coughing and repeated emesis and swallowing[9], conventional tablets become difficult. Orally disintegrating dosage forms can serve as an effective alternative mode of drug deliver ...
< 1 ... 320 321 322 323 324 325 326 327 328 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report