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Selection and Biotechnology: the best of both worlds
Selection and Biotechnology: the best of both worlds

... To date, most genetic progress for quantitative traits in livestock has been made by selection on phenotype or on estimates of breeding values (EBV) derived from phenotype, without knowledge of the number of genes that affect the trait or the effects of each gene. In this quantitative genetic approa ...
LIMIX: genetic analysis of multiple traits
LIMIX: genetic analysis of multiple traits

... The goal of genetic analyses of quantitative traits is to determine the sources of phenotypic variation, attributing it to effects of single loci, polygenic background and confounding factors. Linear mixed models (LMMs) have emerged as a powerful approach for this purpose and have been successfully ...
2016 MPhA MTM Symposium
2016 MPhA MTM Symposium

... causes. Pneumonia rates were 3.2% (n=53) vs. 4.8% (n=80) in the intervention vs. comparator group, respectively [P=0.02]. *Graded using the modified Medical Research Council scale FEV1 = forced expiratory volume in 1 second; FVC = forced vital capacity ...
Centronuclear Myopathy Testing for Families
Centronuclear Myopathy Testing for Families

... How much does the testing cost and will my child’s health insurance cover it? The cost for sequencing MTM1 is $1200 per gene, the cost for sequencing BIN1 is $1440 per gene, the cost for sequencing DNM2 is $1560 per gene, and the cost for sequencing RYR1 is $2200. The cost for deletion/duplication t ...
General Medicine Pharmacotherapy Card
General Medicine Pharmacotherapy Card

... 2. Impaired stomach motility may contribute to nausea(patient feels full all the time); refer to Table C: Pro-Motility Agents. 3. Monitor patient and reassess need for anti-emetics every few days. Many patients will not need continuing doses of anti-emetics unless dose is rapidly increased. 4. Switc ...
Identifying Pseudobulbar Affect in Alzheimer`s
Identifying Pseudobulbar Affect in Alzheimer`s

... 1. Have you been more tearful since the stroke than you were beforehand? Have you actually cried more in the past month (not just felt like it)? 2. Does the weepiness come on suddenly, at times when you aren’t expecting it? (Suddenly means without warning or within only a few moments, and not afte ...
off-label use - Moodle Lille 2
off-label use - Moodle Lille 2

... Off-label prescribing should better serve the patient’s needs than “onlabel” prescription of an alternative medicine. ...
Does Activation of the TALl Gene Occur in a Majority
Does Activation of the TALl Gene Occur in a Majority

... MYC activation is likely to be a critical, if not essential, step in the development of Burkitt’s lymphoma. A variety of distinct chromosome translocations are observed in the malignant cells of patients with T-cell acute lymphoblastic leukemia (T-ALL).6.7 At least nine different proto-oncogenes are ...
Product Development Issues of Powders for Injection
Product Development Issues of Powders for Injection

... Figure 1: Classification of powders for injection. The particle-size distribution should be controlled at the sterile bulk drug manufacturing facility. Attempts to modify danger lies. Scientists must understand the nuances and mi- particle-size distribution by milling and sieving could seriously cro ...
Dopa- responsive dystonia
Dopa- responsive dystonia

... develop symptoms. Children of a parent with the DYT5 mutation have a 50% chance of inheriting the mutation. At this time, there is no way to predict whether a person with the mutation will go on to develop dystonia. The gene abnormality in DRD causes a problem with the brain’s production of the chem ...
Substance abuse in pregnancy
Substance abuse in pregnancy

... Local Messages*UTHSCSA LIBRARIES OWN JOURNAL. CLICK LIBRARY HOLDINGS FOR VOLS OWNED* AbstractThe vascular placental pathology (VPP) is associated with many etiologies. Some are the consequence of a maternal genetic or acquired predisposition. Others are associated with a chronic maternal disease (hy ...
Lab - Population Genetics and Evolution
Lab - Population Genetics and Evolution

... 6. What major assumption(s) of Hardy Weinberg equilibrium were not strictly followed in this simulation? What was the effect of not following these assumptions? 7. Is this population undergoing MICROEVOLUTION? State why or why not? Case 2 (What Hardy Weinberg equilibrium condition does this study vi ...
Learn more
Learn more

... Unfortunately, due to tolerance many patients on chronic opioid therapy do not get relief at the lower doses over time. • Population studies have shown from a population perspective that patients with the same nociceptive pain generators in general do better when not treated with opioids than when t ...
Hot Flashes - Indiana Pharmacists Alliance
Hot Flashes - Indiana Pharmacists Alliance

Your Doctor Discussion Guide from A VONEX
Your Doctor Discussion Guide from A VONEX

... associated with AVONEX. AVONEX can cause serious side effects. Tell your healthcare provider right away if you have any of the symptoms listed below while taking AVONEX. • Behavioral health problems including depression, suicidal thoughts or hallucinations. Some people taking AVONEX may develop moo ...
Long-Acting Opioids and Short-Acting Opioids
Long-Acting Opioids and Short-Acting Opioids

... Although review of clinical trial data suggests that many patients discontinue long-term opioid therapy due to either insufficient pain relief or adverse effects, the same studies establish that there are many patients who clearly respond well [15]. Both issues, while often not completely analyzed du ...
Hot Flashes - Indiana Pharmacists Alliance
Hot Flashes - Indiana Pharmacists Alliance

... According to data from the Women’s Health Initiative, which of the following is a benefit of using estrogen to treat hot flashes? 1. Increase or maintenance of bone mass 2. Decrease in cardiovascular risk because of increase in good cholesterol 3. Decrease in the risk of endometrial cancer 4. All of ...
Migraine - Bradford VTS
Migraine - Bradford VTS

... 5HT-anatagonist is an effective prophylactic treatment ( Clin Pharmacol Ther 1966 ! ) but can have serious side effects like retroperitoneal fibrosis and therefore should be limited to 6mg/d for no longer than 6 months. Also leg pain is very common. Others Amitriptyline is an effective prophylactic ...
PredniSONE Tablets USP, 1 mg, 2.5 mg, 5 mg, 10 mg, 20 mg, and
PredniSONE Tablets USP, 1 mg, 2.5 mg, 5 mg, 10 mg, 20 mg, and

... associated with the use of corticosteroids alone or in combination with other immunosuppressive agents that affect cellular immunity, humoral immunity, or neutrophil function.1 These infections may be mild, but may be severe and at times fatal. With increasing doses of corticosteroids, the rate of o ...
Pharmacology 7 – Neuromuscular Blocking Drugs
Pharmacology 7 – Neuromuscular Blocking Drugs

... What is the neurotransmitter at the skeletal neuromuscular junction and on which receptor type does it act? Define the nature of the antagonism of tubocurarine on the effects of acetylcholine (ACh) at the motor end-plate. Draw a log dose-response curve showing the response of skeletal muscle to incr ...
Opioids
Opioids

... • morphine and its congeners are metabolized primarily in the liver • Half-life is prolonged in patients with impaired renal function Use in Patients with Endocrine Disease -adrenal insufficiency (Addison's disease) and hypothyroidism (myxedema) – -prolonged and exaggerated responses to opioids. ...
Prescribing Information
Prescribing Information

... RAPIVAB has not been studied in nursing mothers. It is not known whether RAPIVAB is excreted in human milk. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for RAPIVAB and any potential adverse effects on the breastfed child from the ...
ABCs - LSD
ABCs - LSD

... (You think that you see, hear, or smell things not learn how to solve problems, handle their that are not actually there.) emotions, and become mature, responsible • Trivial matters may suddenly seem important, adults. making you feel as if you are going through • When used by pregnant women, LSD ma ...
Flintstones Sex Linked - Kenwood Academy Freshmen Biology
Flintstones Sex Linked - Kenwood Academy Freshmen Biology

... Pebbles and BamBam have a baby what is the probability of the baby being colorblind? Use a Punnett square to provide evidence. ...
chapter 1 anti-inflammatory drugs in the 21st century
chapter 1 anti-inflammatory drugs in the 21st century

... high risk of myocardial infarctions and the exacerbation of symptoms of hypertension and elevation of blood pressure led to the worldwide dramatic withdrawal of one of the leading members of the coxib class, rofecoxib, by the Merck Company on September 29, 2004 (Rainsford, 2005b). This has been foll ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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