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Is there a genetic susceptibility to engage in criminal acts?
Is there a genetic susceptibility to engage in criminal acts?

... are determined by many different factors. An individual’s risk of developing these disorders or displaying these traits is not determined simply by their genotype; environmental influences such as parenting style, socioeconomic status, and peer groups also play a role (Rutter et al. 1998; Gatzke & R ...
Licentiate Thesis_Heba Asem
Licentiate Thesis_Heba Asem

... SPION-Mn:ZnS-PLGA phantoms exhibited enhanced negative contrast with r2* relaxivity of 523 mM-1 s-1 . SPION-Mn:ZnS-PLGA-NPs have been successfully applied to enhance the contrast of liver in rat model. The biodegradable and biocompatible poly (ethylene glycol)-co-poly (caprolactone) (PEG-PCL) was us ...
Understanding Oral Bioavailability Challenges Associated With
Understanding Oral Bioavailability Challenges Associated With

... For poorly permeable drugs that are poorly soluble, identify the role of efflux transporters (if any), and then define approaches to the problems. problems Ê ...
(NSAIDs) classification, diagnosis and management
(NSAIDs) classification, diagnosis and management

... reactions to up to 30% after use of 1000 mg of paracetamol (41). In clinical practice, oral tolerance test should be performed with 500 mg of paracetamol before the drug is recommended for regular use. The preferential COX-2 inhibitors meloxicam and nimesulide are quite well tolerated by most (86–96 ...
Drug Development Pipeline
Drug Development Pipeline

... vaccines, blood and blood components, allergenics, somatic cells, gene therapy, tissues, and recombinant therapeutic proteins. Biologics can be composed of sugars, proteins, or nucleic acids or complex combinations of these substances, or may be living entities such as cells and tissues. Biologics a ...
prescribing alert
prescribing alert

... • Inhaled albuterol sulfate can produce paradoxical bronchospasm that may be life-threatening. It should be recognized that paradoxical bronchospasm, when associated with inhaled formulations, frequently occurs with the first use of a new canister • Fatalities have been reported in association wit ...
Genetics Part I - Napa Valley College
Genetics Part I - Napa Valley College

...  Before sexual reproduction can take place, the alleles in a parent must separate – this takes place during Anaphase I of Meiosis  So an egg or sperm only has one of the two alleles ...
A: Chapter 5: Heredity
A: Chapter 5: Heredity

... scientists understand why your eyes are the color that they are? Gregor Mendel was an Austrian monk who studied mathematics and science but became a gardener in a monastery. His interest in plants began as a boy in his father’s orchard where he could predict the possible types of flowers and fruits ...
Modified Mendelian ratios
Modified Mendelian ratios

... • A history student ask you what might be the genetic basis of a story in an ancient text: – Two people Jacob and Laban divided their flock of animals by coat colour Jacob took the unspotted goats and Laban the spotted goats but only Jacob’s flock increased in number giving both spotted and unspotte ...
Lidocaine Hydrochloride and Epinephrine
Lidocaine Hydrochloride and Epinephrine

... carcinogenic and mutagenic potential or the effect on fertility have not been conducted. Pregnancy: Teratogenic Effects. Pregnancy Category B. Reproduction studies have been performed in rats at doses up to 6.6 times the human dose and have revealed no evidence of harm to the fetus caused by lidocai ...
Drug-Coated Balloons for Coronary Artery Disease
Drug-Coated Balloons for Coronary Artery Disease

... (mean reference vessel diameter = 2.36 mm) de novo lesions in 120 patients.25 At 6 months, in-segment LLL was 0.28 mm in the intention-to-treat population. Most of the patients were treated with DCB alone; however, 28% of patients required BMS placement due to elastic recoil or severe dissection. In ...
Anesthetic Implications of Myasthenia Gravis
Anesthetic Implications of Myasthenia Gravis

... Epidemiology and Pathophysiology MYASTHENIA GRAVIS (MG) is an autoimmune disease characterized by weakness and fatigability of skeletal muscles, with improvement following rest. It may be localized to specific muscle groups or it may be generalized. The incidence is 50–142 cases per million populati ...
A: Chapter 5: Heredity
A: Chapter 5: Heredity

... scientists understand why your eyes are the color that they are? Gregor Mendel was an Austrian monk who studied mathematics and science but became a gardener in a monastery. His interest in plants began as a boy in his father’s orchard where he could predict the possible types of flowers and fruits ...
Impact of genomics on dairy cattle breeding - VT Dairy
Impact of genomics on dairy cattle breeding - VT Dairy

... My definition of genomics is the study of the role of nucleic acid sequences in cellular DNA that are associated with animal (including human) performance or trait expression. For dairy cattle, one important current use of genome sequences is to predict genetic merit of dairy animals for economicall ...
How I treat with anticoagulants in 2012: new and old
How I treat with anticoagulants in 2012: new and old

... drug in the feces.20 Treatment with rivaroxaban was also associated with a significant increase of the risk for gastrointestinal bleeding16; hence, patients with intestinal angiodysplasia, inflammatory bowel disease, or diverticulosis, or those with a history of other forms of gastrointestinal bleed ...
ANTI RHEUMATIC DRUG SAFETY DURING PREGNANCY
ANTI RHEUMATIC DRUG SAFETY DURING PREGNANCY

... adequate, well-controlled studies in pregnant women. Or Animal reproduction studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus. C Animal studies have shown an adverse effect on the fetus, no studies in human ...
SPC
SPC

... • Lupus-like syndrome consisting of positive antinuclear antibody, arthralgia, arthritis, joint stiffness or joint swelling, and one or more of the following: fever, myalgia, hepatitis, rash, vasculitis. • Serum sickness-like syndrome consisting of fever, urticaria or rash, and arthralgia, arthritis ...
The Basics of Drug Development Science
The Basics of Drug Development Science

...  A challenge --not for the faint-hearted  Must embrace the Zen of Candidate Reduction It is never too early or late to eliminate a candidate and if you do-- kill it dead---put a stake through its heart, and bury it at midnight at a crossroads –No Regrets Allowed ...
Liver Enzymes and Bilirubin Levels During
Liver Enzymes and Bilirubin Levels During

... ttention Deficit Hyperactivity Disorder (ADHD) is the most common psychiatric disorder among children and adolescents. Atomoxetine is the first non stimulant medication that has been FDA approved for the treatment of ADHD. Several placebo-controlled trials showed good efficacy and tolerability of at ...
Dosage Patenting in Personalized Medicine
Dosage Patenting in Personalized Medicine

... metabolism, or elimination.15 Drug responses could also be affected by extrinsic factors associated with environment or culture such as medical practice, diet, or alcohol use.16 However, there are currently no known biomarkers or methods that can predict which group of patients will respond positive ...
Dragon Genetics -- Independent Assortment and Genetic Linkage
Dragon Genetics -- Independent Assortment and Genetic Linkage

... wings, but not the dominant allele F for firebreathing? Will any of the baby dragons have the dominant allele W for wings, but not the dominant allele H for big horns? Explain the difference between the inheritance of the wing and firebreathing genes vs. the inheritance of the wing and horn genes. ...
Zolpidem Mylan film-coated tablet ENG SmPC
Zolpidem Mylan film-coated tablet ENG SmPC

... Benzodiazepines or benzodiazapine-like agents may induce anterograde amnesia. The condition usually occurs several hours after ingesting the product. In order to reduce the risk, patients should ensure that they will be able to have an uninterrupted sleep of 8 hours (see section 4.8). Psychiatric an ...
ICU PharmD rotation
ICU PharmD rotation

... preparation of medications given via a number of different routes. Various examples include medications for injection, topical or injectable ophthalmic preparations, bladder instillations, medications for intrapleural administration and medications intended for epidural or intrathecal administration ...
RITALIN® (METHYLPHENIDATE): CLINICAL EXPERIENCES
RITALIN® (METHYLPHENIDATE): CLINICAL EXPERIENCES

... 0.2 mg./lb. are less effective. He noted a mild transient rise in blood pressure, and occasional nausea and retchmg and -emesis as the only side-effects of Ritalin therapy. He was favourably impressed with the effects of Ritalin on barbitaateinduced depression in the newborn infant. Carter and Malle ...
Functional Mapping - Center for Statistical Genetics
Functional Mapping - Center for Statistical Genetics

... • Traditional approach: treat traits measured at each time point as a univariate trait and do mapping with traditional QTL mapping approaches such as interval or composite interval mapping. • Limitations: – Single trait model ignores the dynamics of the gene expression change over time, and is too s ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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