• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Efficacy and safety of a 12-week course of therapy with a new
Efficacy and safety of a 12-week course of therapy with a new

... Fluticasone distinguishes itself from other inhaled glycocorticosteroids by its high affinity with intracellular glycocorticosteroid receptor (18 times higher than dexamethasone), and its high lipophilic nature, which results in strong and long-lasting activity of the drug in the bronchi. Simultaneo ...
Special Management Challenges
Special Management Challenges

... • Her mother was an alcoholic Does the patient have a job? ...
Dopaminergic Key to Homeostasis and
Dopaminergic Key to Homeostasis and

... do not deliver the best form of therapy. Presently, the FDA has not approved any medications for the treatment of substance use disorders of cocaine, methamphetamine, or cannabis. There is an imperative for the development of safe and effective treatment for these drugs of choice. Before we delve in ...
Antiplatelet drugs compared - Consumer Reports Best Buy Drugs
Antiplatelet drugs compared - Consumer Reports Best Buy Drugs

... Six Groups Who Might Need an Antiplatelet Drug It’s useful to divide the population of people who need aspirin or another antiplatelet drug into six groups: ■ People who have risk factors that make them ...
Bruce Rubin
Bruce Rubin

... improves mucus clearance or pulmonary function (16). The aerosol is available in the United States but is often poorly tolerated by patients because of its sulfurous odor and because the pH of 2.2 is associated with bronchospasm. NAC is an antioxidant and has been used to treat acetaminophen overdos ...
Effect of Oral Pseudoephedrine on Blood Pressure and Heart Rate
Effect of Oral Pseudoephedrine on Blood Pressure and Heart Rate

... thomimetic agents can raise blood pressure (BP) to dangerous levels, whereas other reviews5,6 suggest that the danger from these medications is exaggerated. In November 2000, the US Food and Drug Administration recommended that medications that contain phenylpropanolamine be voluntarily recalled bec ...
2% XylocaineDENTAL with epinephrine 1:50000
2% XylocaineDENTAL with epinephrine 1:50000

... The plasma binding of lidocaine is dependent on drug concentration, and the fraction bound decreases with increasing concentratlon. At concentration of 1 to 4 µg of free base per mL, 60 to 80 percent of lidocaine is protein bound. Binding is also dependent on the plasma concentration of the alpha-l- ...
Multifactorial Traits
Multifactorial Traits

... do not produce single-gene phenotypic ratios. They all contribute to the phenotype, but without being dominant or recessive to each other. For example, the multiple genes that regulate height and skin color result in continuously varying phenotypes. Single-gene traits are instead discrete or qualita ...
Angiotensin receptor blocker (arb) antihypertensive dose
Angiotensin receptor blocker (arb) antihypertensive dose

... Hyperkalemia among Patients Recently Hospitalized for Heart Failure Who Were Receiving ACE Inhibitors. Each bar shows the rate. Original Article. The Effect of Irbesartan on the Development of Diabetic Nephropathy in Patients with Type 2 Diabetes. Hans-Henrik Parving, M.D., D.M.Sc., Hendrik. Diureti ...
Drug utilisation sub-committee (DUSC)
Drug utilisation sub-committee (DUSC)

... The decision to treat a patient is based on whether they are at risk for the development of cirrhosis and its consequences, liver failure and liver cancer. Clinical factors which are considered are the level of hepatitis B virus (HBV DNA) in the blood, alanine aminotransferase (ALT) levels and wheth ...
Preliminary, Open-Label, Pilot Study of Add-On Oral D
Preliminary, Open-Label, Pilot Study of Add-On Oral D

... disorders. Cannabis-induced anxiety disorders were also reported [7]. The exact amount of active compounds in inhaled or smoked marijuana vary between plants and preparations and while some homogeneity can be achieved under very strict conditions, it is mostly hard to set standards of potency and pu ...
PACKAGE LEAFLET CLINDAMYCIN capsules Clidamycin
PACKAGE LEAFLET CLINDAMYCIN capsules Clidamycin

... Clindamycin is contraindicated for patients with known hypersensitivity to lincozamides; patients with colitis and diarrhoea; severe impairment of the renal and liver functions; newborns and prematurely born infants. ...
Studies
Studies

... al., 2000), which speaks to the need to ensure both good general education in a distribution program and for clear discussion of the effects of the medication after it has been administered, particularly if the patient is not to be hospitalized. Survey data indicate that few drug users would use mor ...
Memorandum
Memorandum

... abnormalities. No physical defects or behavioral abnormalities were noted at any time during the three months of treatment. The rats were allowed a recovery. period of approximately 120 days after the 90 days of treatment prior to sacrifice. Observationsfor all rats at the time of sacrifice were nor ...
Medication Payment Assistance in Ontario
Medication Payment Assistance in Ontario

... It is important to budget from quarter to quarter during the TDP fiscal year. Any unpaid deductible amount in a quarter is “rolled over” (automatically added) to the next quarter. However, unpaid deductible amounts are not carried forward to the next program year. The enrolment start date requires c ...
Chapter 3: Forming a New Life: Conception, Heredity, and
Chapter 3: Forming a New Life: Conception, Heredity, and

... Conception We are approaching a point at which scientists will be able to clone (make a genetic copy of) a human being, and this has created a great deal of controversy in ensuring that research in the area is based on firm ethical principles (see Box 3-1). Until then, every person’s biological begi ...
Focus on the Foundation:
Focus on the Foundation:

... The methodology is also unique. Every participant is given a chest CT scan. The scans are then used to divide COPD into a range of structural subtypes. The principal investigators believe this will have the effect of radically changing the way COPD is understood and treated. “COPD is largely not und ...
prescribing_Oct_10_07 - School of Medicine
prescribing_Oct_10_07 - School of Medicine

... Mr. Connor is 80 years old. He has coronary artery disease, congestive heart failure, hypertension, and Alzheimer’s dementia. His wife is the primary caregiver. He is increasingly agitated, suspicious, and verbally abusive. He has difficulty sleeping at night and has wandered from the house on two o ...
A Review on Mouth Dissolving Film
A Review on Mouth Dissolving Film

... After disintegrating in mouth, enhanced the clinical effect of drug through pre-gastric absorption from mouth pharynx and esophagus as the saliva passes down into the stomach. In such cases, bioavailability of drug is considerably greater than those observed from conventional tablet dosage form. Mor ...
The Place of Liver Transplantation in HIV-infected Patients
The Place of Liver Transplantation in HIV-infected Patients

Complaint 1
Complaint 1

... only for the management of breakthrough cancer pain in patients with malignancies who are already receiving and who are tolerant t~ opioid therapy for their underlying persistent cancer pain. Patients cdnsidered opioid tolerant are those who are taking at least 60 mg morphine/tlay, 50 /-lg transdenn ...
3rd Most Costly Disease: Alzheimer`s Disease
3rd Most Costly Disease: Alzheimer`s Disease

... Intracranial mass lesion, recent CVA, or recent MI can complicate the safe administration of ECT. Informing patient and family about potential memory disturbance associated with ECT will help them understand and tolerate this usually transient aspect of treatment. Demented patients may experience in ...
DOA 6+2 cup - Drug Testing Australia
DOA 6+2 cup - Drug Testing Australia

... pH: Normal urine pH ranges from 4.5 to 8.0. Values below pH 4.0 or above pH 9.0 are indicative of adulteration. Specific Gravity: Random urine may vary in specific gravity from 1.003 – 1.030. Normal adults with normal diets and normal fluid intake will have an average urine specific gravity of 1.016 ...
Methadone Maintenance Treatment (MMT)
Methadone Maintenance Treatment (MMT)

... addiction, and it had no or only limited efficacy in treating dependence on other substances of abuse.22 Dole wrote, “the most that can be said is that there seems to be a specific neurobiological basis for the compulsive use of heroin by addicts and that methadone taken in optimal doses can correct ...
QA135_4chondroitin_DI
QA135_4chondroitin_DI

... animal studies have suggested that chondroitin prolongs bleeding time (10), but significant Available through NICE Evidence Search at www.evidence.nhs.uk ...
< 1 ... 325 326 327 328 329 330 331 332 333 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report