Combinatorial Platinum(IV)-Peptide/Co-drug Conjugates as Multimodal Targeted Anticancer Agents.
... properties of the prodrug. Our group has developed several techniques to access new platinum(IV) prodrug modalities with highly customized mode of actions.1,2 Very recently, we employed this approach to develop compounds that can target and illicit an immunological response, thereby achieving the ve ...
... properties of the prodrug. Our group has developed several techniques to access new platinum(IV) prodrug modalities with highly customized mode of actions.1,2 Very recently, we employed this approach to develop compounds that can target and illicit an immunological response, thereby achieving the ve ...
Genotype Discrimination: The complex case for some legislative protection. Henry T. Greely. 149 U. Pa. L. Rev. 1483 (May 2001)
... genes found in other primates, mammals, animals, or broader sets of life forms. Any two humans, on average, will be identical in their DNA sequences 99.9% of the time and 99.99% of the time in the regions of genes that contain the genetic code for constructing proteins (the so-called exons). The few ...
... genes found in other primates, mammals, animals, or broader sets of life forms. Any two humans, on average, will be identical in their DNA sequences 99.9% of the time and 99.99% of the time in the regions of genes that contain the genetic code for constructing proteins (the so-called exons). The few ...
Prescrire`s Response (112)
... The participants did not understand the significance of the term dalanate in neladenoson dalanate, corresponding to a L-alanyl-L-alaninate ester, a term that they did not found in the list of radicals and which has had a different meaning in dalanated insulin. As the rules for constructing INNs for ...
... The participants did not understand the significance of the term dalanate in neladenoson dalanate, corresponding to a L-alanyl-L-alaninate ester, a term that they did not found in the list of radicals and which has had a different meaning in dalanated insulin. As the rules for constructing INNs for ...
Genetic Assimilation and Canalisation in The Baldwin Effect
... Though both these points may often be true in natural populations, and Hinton and Nowlan’s model includes both, they are quite separate issues. Reviewing the literature on the Baldwin Effect and phenotypic plasticity in general, a question is raised regarding the difference between genetic assimila ...
... Though both these points may often be true in natural populations, and Hinton and Nowlan’s model includes both, they are quite separate issues. Reviewing the literature on the Baldwin Effect and phenotypic plasticity in general, a question is raised regarding the difference between genetic assimila ...
The Wahlund Effect and F Statistics -- The Interaction of - IB-USP
... females considered together because mtDNA is maternally inherited. In all, the (ploidy coeff.) times (effective size) of mtDNA should be only 1/4 that of autosomal DNA (isozymes). Likewise, the Y-chromosome is also 1/4 relative to the diploid autosomal system. Taking this information into considerat ...
... females considered together because mtDNA is maternally inherited. In all, the (ploidy coeff.) times (effective size) of mtDNA should be only 1/4 that of autosomal DNA (isozymes). Likewise, the Y-chromosome is also 1/4 relative to the diploid autosomal system. Taking this information into considerat ...
Perspective Herb–Drug Interactions: Challenges and Opportunities
... associate and dissociate rapidly from the enzyme is termed timedependent inhibition (TDI). Mechanism-based inhibition (MBI), often observed as TDI, is characterized by irreversible or quasi-irreversible noncovalent binding of a reactive metabolite to the enzyme (Grimm et al., 2009). Such binding can ...
... associate and dissociate rapidly from the enzyme is termed timedependent inhibition (TDI). Mechanism-based inhibition (MBI), often observed as TDI, is characterized by irreversible or quasi-irreversible noncovalent binding of a reactive metabolite to the enzyme (Grimm et al., 2009). Such binding can ...
- Sankara Nethralaya
... larger cohort of over 7000 eyes there was nominal evidence of association and a shallower anterior chamber depth (ACD) when all data were meta-analyzed (β = −0.033, P = 0.021). However, when multiple testing was considered, the observation was non-significant.10 In another recent GWAS study from a la ...
... larger cohort of over 7000 eyes there was nominal evidence of association and a shallower anterior chamber depth (ACD) when all data were meta-analyzed (β = −0.033, P = 0.021). However, when multiple testing was considered, the observation was non-significant.10 In another recent GWAS study from a la ...
COMFORTIS®-Cats
... to control dogs by the end of the 24-day study. COMFORTIS was not associated with any clinically significant changes in hematology, blood coagulation or urinalysis parameters; however, mild elevations in ALT occurred in all dogs treated with COMFORTIS. By day 24, ALT values had returned to near base ...
... to control dogs by the end of the 24-day study. COMFORTIS was not associated with any clinically significant changes in hematology, blood coagulation or urinalysis parameters; however, mild elevations in ALT occurred in all dogs treated with COMFORTIS. By day 24, ALT values had returned to near base ...
Drugs in pregnancy
... during pregnancy. Salicylates readily cross the placenta, but a 2002 meta-analysis did not find evidence of an overall increase in risk of congenital defects associated with first trimester use of aspirin .Although some case-control studies have reported associations between human congenital malform ...
... during pregnancy. Salicylates readily cross the placenta, but a 2002 meta-analysis did not find evidence of an overall increase in risk of congenital defects associated with first trimester use of aspirin .Although some case-control studies have reported associations between human congenital malform ...
Product Monograph - AstraZeneca Canada
... Clinical studies of TENORMIN did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between elderly and younger patients. In general, dose sele ...
... Clinical studies of TENORMIN did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between elderly and younger patients. In general, dose sele ...
RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES KARNATAKA
... 5. Patients with body mass index more than 28kg/m2. 6. Patients having absolute contraindication for spinal anaesthesia like raised intracranial pressure, severe hypovolaemia, bleeding diathesis and local infection. 7. Patient’s refusal. 8. Surgeries with vertical incision. ...
... 5. Patients with body mass index more than 28kg/m2. 6. Patients having absolute contraindication for spinal anaesthesia like raised intracranial pressure, severe hypovolaemia, bleeding diathesis and local infection. 7. Patient’s refusal. 8. Surgeries with vertical incision. ...
human genome research
... On June 26th 2000, scientists in the UK and US announced that they had completed a 'working draft' of the sequence of the human genome (all the DNA contained in the full set of human chromosomes). This consisted of the finished (99.99% accurate) sequence for around one quarter of the total code (inc ...
... On June 26th 2000, scientists in the UK and US announced that they had completed a 'working draft' of the sequence of the human genome (all the DNA contained in the full set of human chromosomes). This consisted of the finished (99.99% accurate) sequence for around one quarter of the total code (inc ...
Thrombocytopenia-absent radius (TAR) syndrome due to compound
... RNA decay and splicing [31]. It has a crucial role during embryonic developmental [32]. The level of Y14 was found to be significantly lower in the platelets of TAR patients. It is noteworthy, that Y14 may regulate the expression of genes involved in the proliferation of hematopoietic cells. However ...
... RNA decay and splicing [31]. It has a crucial role during embryonic developmental [32]. The level of Y14 was found to be significantly lower in the platelets of TAR patients. It is noteworthy, that Y14 may regulate the expression of genes involved in the proliferation of hematopoietic cells. However ...
parent `B` - University of Washington
... 8a. What are the genotypes of the spores within each of the two types of asci? 8b. Are the lys and met genes linked? If so, what is the map distance between them? 8c. If you could extend this analysis to many more asci, you would eventually find some asci with a different pattern. For these asci, de ...
... 8a. What are the genotypes of the spores within each of the two types of asci? 8b. Are the lys and met genes linked? If so, what is the map distance between them? 8c. If you could extend this analysis to many more asci, you would eventually find some asci with a different pattern. For these asci, de ...
Status Epilepticus in CHildren
... Intubation and intravascualr monitoring usually required • Thiopental • Active metabolites which can accumulate; Possibly higher adverse reactions than pentobarbital • Intravenous anesthetic; Risk of hypotension, apnea and bradycardia • Contraindicated in child on ketogenic diet ...
... Intubation and intravascualr monitoring usually required • Thiopental • Active metabolites which can accumulate; Possibly higher adverse reactions than pentobarbital • Intravenous anesthetic; Risk of hypotension, apnea and bradycardia • Contraindicated in child on ketogenic diet ...
Academic paper: A Diarylquinoline Drug Active on the ATP
... human volunteers. Mutants selected in vitro suggest that the drug targets the proton pump of adenosine triphosphate (ATP) synthase. After AIDS, tuberculosis (TB) is the leading cause of infectious disease mortality in the world, with 2 million to 3 million deaths per year (1). The TB and HIV epidemi ...
... human volunteers. Mutants selected in vitro suggest that the drug targets the proton pump of adenosine triphosphate (ATP) synthase. After AIDS, tuberculosis (TB) is the leading cause of infectious disease mortality in the world, with 2 million to 3 million deaths per year (1). The TB and HIV epidemi ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)
... The most commonly used analgesic among the students was paracetamol. This is similar to other studies [7,8]. Ibuprofen, aspirin and diclofenac were also used but not as frequently as paracetamol. The frequent use of paracetamol may be associated with the fact that it is cheap, can be procured withou ...
... The most commonly used analgesic among the students was paracetamol. This is similar to other studies [7,8]. Ibuprofen, aspirin and diclofenac were also used but not as frequently as paracetamol. The frequent use of paracetamol may be associated with the fact that it is cheap, can be procured withou ...
Module 1. Clinical pharmacology of drugs affecting the
... 81. A patient you follow in clinic has a well-known heroin abuse problem. Drugs which could potentially prevent an abstinence withdrawal syndrome during hospitalization include: methadone, nalbuphine, butorphanol A. morphine, nalbuphine, methadone B. methadone, nalbuphine C. nalbuphine, butorphanol ...
... 81. A patient you follow in clinic has a well-known heroin abuse problem. Drugs which could potentially prevent an abstinence withdrawal syndrome during hospitalization include: methadone, nalbuphine, butorphanol A. morphine, nalbuphine, methadone B. methadone, nalbuphine C. nalbuphine, butorphanol ...
1995+MCauley+Raveill.. - University of Virginia Information
... et al. (1994) describe the methods and discuss the results of the first several years of this study, which has been continued since that report. Briefly, populations are censused by driving and walking along approximately 150 km of roadside in early June. At this time the plants are in peak flower a ...
... et al. (1994) describe the methods and discuss the results of the first several years of this study, which has been continued since that report. Briefly, populations are censused by driving and walking along approximately 150 km of roadside in early June. At this time the plants are in peak flower a ...
AHA/ADA Consensus Statement
... In a 52-week study comparing rosiglitazone to a sulfonylurea (glyburide, median dose 7.5 mg/d), a mean weight gain of 1.9 kg was observed in both the sulfonylurea group and the rosiglitazone group at the 4-mg daily dose, and a 2.9-kg weight gain was observed at the rosiglitazone 8-mg daily dose.4 Wh ...
... In a 52-week study comparing rosiglitazone to a sulfonylurea (glyburide, median dose 7.5 mg/d), a mean weight gain of 1.9 kg was observed in both the sulfonylurea group and the rosiglitazone group at the 4-mg daily dose, and a 2.9-kg weight gain was observed at the rosiglitazone 8-mg daily dose.4 Wh ...
Editorial Response: Single Daily Dosing of Aminoglycosides
... age of patients receiving SDD therapy was 33 years. This finding does not allow a judgment as to whether SDD can be applied safely to older patients who may have more underlying conditions and reduced renal function. A recently published study found a trend towards increased nephrotoxicity in elderl ...
... age of patients receiving SDD therapy was 33 years. This finding does not allow a judgment as to whether SDD can be applied safely to older patients who may have more underlying conditions and reduced renal function. A recently published study found a trend towards increased nephrotoxicity in elderl ...
rtf - PAGE meetings
... interaction models. Estimation was performed in NONMEM. Results: The database included 87 studies, totalling 59775 patients across 228 treatment arms (including 72 placebo arms). These trials reported 1080 FEV1 values, each representing the mean in an arm, at a certain time during the study. Study d ...
... interaction models. Estimation was performed in NONMEM. Results: The database included 87 studies, totalling 59775 patients across 228 treatment arms (including 72 placebo arms). These trials reported 1080 FEV1 values, each representing the mean in an arm, at a certain time during the study. Study d ...