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Randomized trial of lottery-based incentives to improve warfarin
Randomized trial of lottery-based incentives to improve warfarin

... of new methods of enhancing adherence. Partly due to its narrow therapeutic range and partly due to the lack of symptoms associated with the conditions it treats, adherence to warfarin therapy and anticoagulation control is generally poor. 3,4 Low rates of adherence not only have direct effects in t ...
DSUR Template - CTT55 - Leeds Teaching Hospitals NHS Trust
DSUR Template - CTT55 - Leeds Teaching Hospitals NHS Trust

... the risks identified in the reporting period and the anticipated benefits. You should make a clear statement that the potential benefits still outweigh the risks even with the new information taken into account. You should detail how any amendments have mediated risk in the previous year. 19. Summar ...
sanofi-aventis Canada Inc. Date of Revision: 2150 St. Elzear Blvd. West
sanofi-aventis Canada Inc. Date of Revision: 2150 St. Elzear Blvd. West

... RIFADIN (rifampin) increases the requirements for anticoagulant drugs of the coumarin type. This effect is not observed until the fifth day following initiation of treatment. The decrease in prothrombin time usually lasts between 5 and 7 days, and is the result of RIFADIN’s ability to cause inductio ...
LONG-TERM USE OF INTRATHECAL DROPERIDOL AS AN EXCELLENT ANTIEMETIC IN NONMALIGNANT
LONG-TERM USE OF INTRATHECAL DROPERIDOL AS AN EXCELLENT ANTIEMETIC IN NONMALIGNANT

... we hoped for the lowest effective dose, with the least number of negative side effects, no toxicity and as close to the nausea centers as possible. The chemoreceptor trigger zone (CTZ) has been known, so far, to have at least five kinds of receptors that may activate nausea. It would be very interes ...
powerpoint - McGill University
powerpoint - McGill University

... which had been under BZ or ML treatment “An allele frequency of ≥65% was detected in one of the two flocks in 13 (29%) of the 45 farms examined. On many farms (24, 25, 33, 36, 37, 39, 42, 43 and 44) the allele frequency was similar in both the BZ and ML treated flocks” ...
clinical calculations nurses
clinical calculations nurses

... ×× Back to basics chapter uses a step-by-step approach to ensure understanding of basic numeracy – fully tested by nursing lecturers and their students ×× Self-assessment tests throughout each chapter enable you to monitor your ...
The Dangers of Beta-Blockers and Epinephrine
The Dangers of Beta-Blockers and Epinephrine

Drug and Therapeutics Committees
Drug and Therapeutics Committees

... Rational drug use requires that the patients receive drugs appropriate to their clinical needs in doses that meet their individual requirements (right dose, right intervals and right duration). These drugs must be of acceptable quality, and available and affordable, at the lowest cost to patients an ...
auranofin - Oxford Academic
auranofin - Oxford Academic

... The two basic ligands of auranofin, namely triethylphosphine oxide and 2,3,4,6-tetra-o-acetyl-1-thiob--glucopyranosato were without biological activity and gold sodium thiomalate, gold thioglucose and thiomalic acid did not affect rat paw oedema significantly. Auranofin was shown to suppress adjuva ...
Glucosine 625 mg film-coated tablet ENG SmPC
Glucosine 625 mg film-coated tablet ENG SmPC

... No specific drug interaction studies have been performed. However the physical-chemical pharmacokinetic properties of glucosamine sulphate suggest a low potential for interactions. In addition glucosamine sulphate was found not to inhibit or to induce any of the major human CYP450 enzymes. In fact, ...
Tegretol® (carbamazepine)
Tegretol® (carbamazepine)

... delay (20%). The risk of birth defects is increased when carbamazepine is combined with other medications (in particular valproate) because the level of toxic metabolites is increased. In order to decrease this risk, exposure to carbamazepine during the first three months should be avoided if possib ...
In the scientific literature, which countries first appeared term
In the scientific literature, which countries first appeared term

... A. Preparations different manufacturing plants B. Preparations made by manufacturers of different countries C. Preparations are making one plant, but in different series D. Preparations are making one plant, but one series E. Preparations different manufacturing plants, Preparations are making one p ...
F 1 generation - Zanichelli online per la scuola
F 1 generation - Zanichelli online per la scuola

... What Mendel called “factors” are now known as genes. A gene can occur in alternative variants, called alleles. The alleles for a gene can be the same (then the organism is homozygous for the trait) or different (then the organism is heterozygous for the trait). When two different alleles are present ...
Name of the medicinal product Zyloric 100 mg Tablets Zyloric 300
Name of the medicinal product Zyloric 100 mg Tablets Zyloric 300

... allopurinol, patients should exercise caution before driving, using machinery or participating in dangerous activities until they are reasonably certain that allopurinol does not adversely affect performance. 4.8 Undesirable effects For this product there is no modern clinical documentation which ca ...
UKMi FAQ 18 - NHS Evidence Search
UKMi FAQ 18 - NHS Evidence Search

An open-label, randomized, crossover study to assess anti-inflammatory effect
An open-label, randomized, crossover study to assess anti-inflammatory effect

... prevention of disease progression is still difficult in many patients, leading to a continued search for treatment methods that will improve patient outcomes. Non-biologic forms of treatment that are still being investigated include the use of statins as an adjunct therapy due to their reported anti ...
methadone and buprenorphine
methadone and buprenorphine

... Biological, psychological, social and economic factors influence when and why a person starts taking illicit opioids. Use of opioids can quickly escalate to misuse (repeated use despite adverse consequences) and then dependence (opioid tolerance, withdrawal symptoms, compulsive drug-taking). The ‘Di ...
Guidelines for Subcutaneous Infusion Device Management in
Guidelines for Subcutaneous Infusion Device Management in

... management in palliative care to treat pain and other distressing symptoms when other routes are inappropriate or ineffective. These devices are power driven devices that deliver medications at a controlled rate, providing symptom control via continuous subcutaneous infusion of drugs However, their ...
Intravenous Anaesthesia
Intravenous Anaesthesia

... required for deep sedation. This means that the clinician administering propofol or fospropofol must be competent to recognize a state of general anesthesia and rescue a patient experiencing any of the complications of general anesthesia. ...
GENETIC CHARACTERIZATION OF NITRA RABBITS AND ZOBOR
GENETIC CHARACTERIZATION OF NITRA RABBITS AND ZOBOR

... In an attempt to characterize the two rabbit breeds concerning the shift on the genetic level we studied microsatellite and genetic markers associated with coat color. These two local rabbit breeds, Nitra rabbit (Ni) and Zobor rabbit (Zo) with different phenotypes have a common origin. Based on the ...
the 2012 genentech oncology trend report
the 2012 genentech oncology trend report

Erasmus Partner Universities of Ankara University Faculty of
Erasmus Partner Universities of Ankara University Faculty of

... of hot summers and mild winters. July and August are the hottest months with temperatures around 30°C. The humidity is a little high during summer in these regions. Temperatures increase a few degrees when traveling to the south and water temperatures also become warmer. The swimming season is from ...
Defining the biological bases of individual differences in musicality
Defining the biological bases of individual differences in musicality

... that is likely to have at least some basis in biology. Concomitantly, recent efforts to catalogue comprehensively the natural variability in modern human genomes have revealed a surprising degree of variation within populations, affecting virtually every genetic locus in some way [9,10]. Thus, human ...
Chapter 4 () - The Kidney Foundation of Canada
Chapter 4 () - The Kidney Foundation of Canada

... disease. Some medications slow down the progression of kidney disease or manage the complications of kidney disease. Others reduce the risk of heart disease or stroke. It is very important to take your medications as prescribed and the information in this chapter focuses on helping you to do that. ...
Recognition of drug-induced pulmonary disease and
Recognition of drug-induced pulmonary disease and

... Disclosure of Discussions of Off-Label and Investigational Uses of Drugs: This activity may contain discussion of unlabeled/unapproved use of drugs in the United States and will be noted if it occurs. The content and views presented in this educational program are those of the faculty and do not nec ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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