• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Is the Role of the Small Intestine in First
Is the Role of the Small Intestine in First

... normal volunteers (Melander et al., 1977b). However, the blood flow change is not the sole cause responsible for the increased bioavailability after a meal. For example, it is difficult to explain how a standardized breakfast could increase the bioavailability of hydralazine 2to 3-fold (Melander et ...
hMg-CoA-reductase inhibitors and neuropathy: reports to the
hMg-CoA-reductase inhibitors and neuropathy: reports to the

... inhibitors to reduce cholesterol levels in the framework of the primary and secondary prevention of atherosclerosis. Furthermore, HMG-CoA-reductase inhibitors reduce the risk of stroke and peripheral vascular disorders.1 The Heart Protection Study showed a significant reduction in the risk of cardio ...
complaint  - AboutLawsuits.com
complaint - AboutLawsuits.com

... duty to monitor amiodarone after it was approved for marketing. Specifically, Defendants have a continuing duty of pharmacovigilance. Among these requirements, Defendants must seek information relating to negative health effects in patients while on amiodarone and maintain, investigate, evaluate, an ...
The geography of introgression in a patchy
The geography of introgression in a patchy

... (say microsatellites). We therefore need strong selection coefficients. Although it might appear more realistic to model many loci that conjugate their effects to form a strong barrier to interspecific gene flow, we used a more tractable model with just two loci, each with a strong selective coeffic ...
Genetic Variation of the Major Histocompatibility Complex DRB3.2
Genetic Variation of the Major Histocompatibility Complex DRB3.2

... system is among the most polymorphic. In the present study, polymorphism of the BoLA- DRB3.2 locus in three Bos indicus breeds viz., Sahiwal, Rathi and Hariana was studied by polymerase chain reaction restriction fragment length polymorphism technique using the enzymes RsaI, Bst Y1 and Hae III. Both ...
(PSD) March 2015 PBAC meeting
(PSD) March 2015 PBAC meeting

... same diagnostic criteria for multiple sclerosis, had similar baseline characteristics, and similar relapse rates in the placebo arm. Relapse rate reduction: Glatiramer acetate 20 mg/mL versus 40 mg/mL Glatiramer acetate 20 mg/mL versus placebo Glatiramer acetate Placebo 20 mg/mL ...
Metabolic Syndrome
Metabolic Syndrome

... • LV dysfunction (along with new  blocker) • Previous MI (along with new  blocker) ...
The geography of introgression in a patchy environment and the
The geography of introgression in a patchy environment and the

... (say microsatellites). We therefore need strong selection coefficients. Although it might appear more realistic to model many loci that conjugate their effects to form a strong barrier to interspecific gene flow, we used a more tractable model with just two loci, each with a strong selective coeffic ...
Neonatal Abstinence Syndrome: Improving short term outcomes by
Neonatal Abstinence Syndrome: Improving short term outcomes by

... sedation. Abrupt cessation of clonidine may result in sympathetic over-activity. Clinical symptoms include increased blood pressure, heart rate, tremors, agitation and diaphoresis. Side effects can be prevented by tapering the dose prior to discontinuation of the medication {33}. In our study, infan ...
It`s All In the Family
It`s All In the Family

... professionals who specialize in providing information about inherited conditions. A genetic counselor can help someone with the decision on whether or not to be tested. A genetic counselor can also help someone understand the test results and explain the results to their family. We recommend calling ...
Medical Marijuana: the future
Medical Marijuana: the future

DEVELOPMENT AND EVALUATION OF PARACETAMOL TASTE MASKED ORALLY
DEVELOPMENT AND EVALUATION OF PARACETAMOL TASTE MASKED ORALLY

... increased consumer choice for the reason of rapid disintegration or dissolution, self-administration even without water or chewing8. A major component of success in orally disintegrating tablets is good taste. If the product does not taste good, patients and physicians will find an alternative produ ...
Diabetic Hypertension targetted Rx. by Dr. Sarma
Diabetic Hypertension targetted Rx. by Dr. Sarma

lecture17
lecture17

... To account for the genome-wide search, compare the observed LOD scores to the distribution of the maximum LOD score, genome-wide, that would be obtained if there were no QTL anywhere. ...
BENZOX AC BAR PRESCRIBING INFORMATION Benzoyl Peroxide
BENZOX AC BAR PRESCRIBING INFORMATION Benzoyl Peroxide

... General — Benzox AC Bar 2.5% are for external use only. If severe irritation develops, discontinue use and institute appropriate therapy. After reaction clears, treatment may often be resumed with less frequent application. These preparations should not be used in or near the eyes or on mucous membr ...
ALENDRONIC ACID 70MG TABLETS PL 15922/0087
ALENDRONIC ACID 70MG TABLETS PL 15922/0087

... Since alendronic acid is rapidly taken-up by bone shortly after administration, plasma levels are below the level of quantification, thereby ruling-out a conventional bioequivalence study with measurement of plasma levels of the drug. It is also known that the mean terminal half-life of elimination ...
Hardy-Weinberg Equilibrium – The Basic Model of Population
Hardy-Weinberg Equilibrium – The Basic Model of Population

... Testing for Deviation from HardyWeinberg Expectations • A 2test can be used to determine if a population is significantly different from the expectations of Hardy-Weinberg equilibrium. • If we have a series of genotype counts from a population, then we can compare these counts to the ones predict ...
Estrogen receptor β gene polymorphisms and susceptibility to
Estrogen receptor β gene polymorphisms and susceptibility to

... leiomyomas when compared with autologous myometrial tissue [7–11]. In 1996, the second estrogen receptor, ERb, was identified which is coded by the ESR2 gene. Like ERa, ERb also was reported to be expressed at higher levels in leiomyomas when compared with matched myometrium [12]. There are studies ...
Table 2
Table 2

... are highly variable, the genetic etiologies of BAV are equally diverse and vary from complex inheritance in families to sporadic cases without any evidence of inheritance. In this paper, the authors discuss current concepts in BAV genetics and propose a roadmap for unraveling unanswered questions ab ...
Word version - Health Sciences Authority
Word version - Health Sciences Authority

... Change of Drug Product Name 1. There is no change to the product (formulation, release and shelf-life specifications, manufacturing source and process) except for the product name change. 2. No confusion with another drug product either when spoken or written. 3. The new name does not (i) suggest gr ...
MODERN TASTE CONCEALING TECHNIQUES IN
MODERN TASTE CONCEALING TECHNIQUES IN

... 3.1 Taste masking with flavors and sweeteners Masking of bitter taste by use of sweeteners is the simple approach. But this approach is not very successful for highly bitter drugs. Sweeteners and flavors are generally being used along with other taste masking techniques to improve the efficiency of ...
EA_QA312.3_levothyroxineseakelp
EA_QA312.3_levothyroxineseakelp

... thyroid disorders, mainly hypothyroidism and hyperthyroidism. This effect has been attributed to the iodine contained in these products (1, 2, 4-7). Several case reports about this association have been published (1, 4). Mechanism of Interaction The normal daily iodine requirement ranges from 100 to ...
FLUOXETINE-GA 20 mg - Actavis think smart medicine
FLUOXETINE-GA 20 mg - Actavis think smart medicine

... action (antidepressants), isolated cases of suicidal ideation and suicidal behaviours have been reported during fluoxetine therapy or early after treatment discontinuation. The risk must be considered in all depressed patients. Although a causal role for Fluoxetine-GA in inducing such events has not ...
Prescribing Information
Prescribing Information

... asthmatic patients during and after transfer from systemic corticosteroids to less systemicallyavailable inhaled corticosteroids. After withdrawal from systemic corticosteroids, a number of months are required for recovery of hypothalamic-pituitary-adrenal (HPA) function. Patients who have been prev ...
Effect of St John`s Wort on Drug Metabolism by Induction of
Effect of St John`s Wort on Drug Metabolism by Induction of

... ©2003 American Medical Association. All rights reserved. ...
< 1 ... 164 165 166 167 168 169 170 171 172 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report