Ketofol_in_the_ED
... Willman EV, Andolfatto G. A Prospective Evaluation of “Ketofol” (Ketamine/Propofol Combination) for Procedural Sedation and Analgesia in the Emergency Department. Ann Emerg Med. 2007; 49(1): 23-30. Andolfatto G, Willman E. A Prospective Case Series of Single-syringe Ketamine-Propofol (Ketofol) for E ...
... Willman EV, Andolfatto G. A Prospective Evaluation of “Ketofol” (Ketamine/Propofol Combination) for Procedural Sedation and Analgesia in the Emergency Department. Ann Emerg Med. 2007; 49(1): 23-30. Andolfatto G, Willman E. A Prospective Case Series of Single-syringe Ketamine-Propofol (Ketofol) for E ...
Reversal of Anticoagulants at UCDMC
... Idarucizumab alone, FEIBA™ is the institutions preferred adjunct, however Transexmic Acid is an alternate option to FEIBA™ with use at the discretion for the attending physician. Experience with the use of either FEIBA™ or Tranexamic Acid with Idarucizumab is very limited Hemodialysis can remove ...
... Idarucizumab alone, FEIBA™ is the institutions preferred adjunct, however Transexmic Acid is an alternate option to FEIBA™ with use at the discretion for the attending physician. Experience with the use of either FEIBA™ or Tranexamic Acid with Idarucizumab is very limited Hemodialysis can remove ...
A59/9 - World Health Organization
... appropriate for most low-resource settings. Nevertheless, sickle-cell disorders should be covered by health-service planning in all countries where they are common. All components of prevention and treatment should be considered together, existing initiatives should be supported, and services should ...
... appropriate for most low-resource settings. Nevertheless, sickle-cell disorders should be covered by health-service planning in all countries where they are common. All components of prevention and treatment should be considered together, existing initiatives should be supported, and services should ...
drugs and cosmetics (iind amendment) rules, 2005
... depend upon the nature and objective of the study. Permission to carry out these trials shall generally be given in stages, considering the data emerging from earlier Phase(s); (d) application for permission to initiate specific phase of clinical trial should also accompany Investigator’s brochure, ...
... depend upon the nature and objective of the study. Permission to carry out these trials shall generally be given in stages, considering the data emerging from earlier Phase(s); (d) application for permission to initiate specific phase of clinical trial should also accompany Investigator’s brochure, ...
Toxicokinetics of Emerging Drugs of Abuse: In vivo and in vitro
... The N-acetylation reactions of (A) and (B) use acetyl-CoA as cofactor and leading generally to inactivation of carcinogens or drugs. The O-acetyl transferase reaction (C) also uses acetylCoA as cofactor but the N,O-transfer reaction (D) occurs without acetyl-CoA as a cofactor. The both last reaction ...
... The N-acetylation reactions of (A) and (B) use acetyl-CoA as cofactor and leading generally to inactivation of carcinogens or drugs. The O-acetyl transferase reaction (C) also uses acetylCoA as cofactor but the N,O-transfer reaction (D) occurs without acetyl-CoA as a cofactor. The both last reaction ...
Tramadol and hiccups
... Hiccups can be acute or persistent. In most cases acute hiccups disappear spontaneously. Persistent hiccups may continue for more than 48 hours and can lead to severe complications, such as sleeping disorders, eating disorders, exhaustion and depressed reactions. Patients suffering from hiccups also ...
... Hiccups can be acute or persistent. In most cases acute hiccups disappear spontaneously. Persistent hiccups may continue for more than 48 hours and can lead to severe complications, such as sleeping disorders, eating disorders, exhaustion and depressed reactions. Patients suffering from hiccups also ...
Epinephrine and local anesthesia revisited
... animal) who had taken a TCA for less than 3 weeks compared to subjects taking a TCA more than 3 weeks. There is a presumption that adrenergic down-regulation also occurs in the periphery, but cardiac effects are centrally mediated. The reader may note that in all the above studies by Boakes et al,43 ...
... animal) who had taken a TCA for less than 3 weeks compared to subjects taking a TCA more than 3 weeks. There is a presumption that adrenergic down-regulation also occurs in the periphery, but cardiac effects are centrally mediated. The reader may note that in all the above studies by Boakes et al,43 ...
update on antiplatelet therapy in the treatment and prevention
... Clopidogrel patients had an event rate of 6.8% and placebo patients had an event rate of 7.3%. CHARISMA demonstrated no significant benefit long term when clopidogrel is added to aspirin. Rates of severe bleeding were similar but clopidogrel patients experienced significantly higher rates of moderat ...
... Clopidogrel patients had an event rate of 6.8% and placebo patients had an event rate of 7.3%. CHARISMA demonstrated no significant benefit long term when clopidogrel is added to aspirin. Rates of severe bleeding were similar but clopidogrel patients experienced significantly higher rates of moderat ...
ETO-Thesis-Final 061214. - JScholarship
... metabolism of dapivirine is unknown, and understanding the metabolism of tenofovir is particularly important because it is a prodrug that must be phosphorylated intracellularly to yield the active metabolite, tenofovir diphosphate. Dapivirine and tenofovir diphosphate must be present in the colorect ...
... metabolism of dapivirine is unknown, and understanding the metabolism of tenofovir is particularly important because it is a prodrug that must be phosphorylated intracellularly to yield the active metabolite, tenofovir diphosphate. Dapivirine and tenofovir diphosphate must be present in the colorect ...
Nutmeg - Utah Poison Control Center
... induce psychogenic experiences. However, when quantities of 5-20 grams (1-3 tablespoons) of nutmeg powder or 1-3 nutmeg seeds are ingested on an empty stomach, central nervous system and gastrointestinal effects can be seen. Symptoms occur approximately 2 to 6 hours after ingestion but effects can l ...
... induce psychogenic experiences. However, when quantities of 5-20 grams (1-3 tablespoons) of nutmeg powder or 1-3 nutmeg seeds are ingested on an empty stomach, central nervous system and gastrointestinal effects can be seen. Symptoms occur approximately 2 to 6 hours after ingestion but effects can l ...
Initial dose per day (mg)
... High GI/high CV risk: should not receive NSAIDs, including COX-2 inhibitors High GI/low CV risk: should receive a COX-2 inhibitor PLUS a PPI or misoprostol Moderate GI/low CV risk: should receive a COX-2 inhibitor alone or a conventional NSAID PLUS a PPI or misoprostol. Moderate GI/high CV r ...
... High GI/high CV risk: should not receive NSAIDs, including COX-2 inhibitors High GI/low CV risk: should receive a COX-2 inhibitor PLUS a PPI or misoprostol Moderate GI/low CV risk: should receive a COX-2 inhibitor alone or a conventional NSAID PLUS a PPI or misoprostol. Moderate GI/high CV r ...
sodium valproate in childhood epilepsy
... incidence cases are partial seizures. Partial and generalised seizures vary with age. Generalised seizures have the highest incidence in the first year of life. With the exception of absence seizures, for which incidence rates peak in 5-10 year olds, the incidence of generalised seizures in childhoo ...
... incidence cases are partial seizures. Partial and generalised seizures vary with age. Generalised seizures have the highest incidence in the first year of life. With the exception of absence seizures, for which incidence rates peak in 5-10 year olds, the incidence of generalised seizures in childhoo ...
Sarcoidosis and MIF gene polymorphism:
... further work in a larger patient cohort will be required to definitively address this. Recent data has described a G to C single nucleotide polymorphism (SNP) at position -173 of the MIF gene, which has been found in vitro to be associated with increased levels of MIF gene transcription [25]. An ass ...
... further work in a larger patient cohort will be required to definitively address this. Recent data has described a G to C single nucleotide polymorphism (SNP) at position -173 of the MIF gene, which has been found in vitro to be associated with increased levels of MIF gene transcription [25]. An ass ...
Epclusa - Gilead
... received EPCLUSA for 12 weeks. EPCLUSA was studied in placebo- and activecontrolled trials [see Clinical Studies (14.2)]. The proportion of subjects who permanently discontinued treatment due to adverse events was 0.2% for subjects who received EPCLUSA for 12 weeks. The most common adverse reactions ...
... received EPCLUSA for 12 weeks. EPCLUSA was studied in placebo- and activecontrolled trials [see Clinical Studies (14.2)]. The proportion of subjects who permanently discontinued treatment due to adverse events was 0.2% for subjects who received EPCLUSA for 12 weeks. The most common adverse reactions ...
Final Protocol - Medical Services Advisory Committee
... Bone formation exceeds bone resorption from birth until the age of approximately 20 years. At the end of this period, peak bone mass is achieved and between the ages of 20 and 40 is roughly maintained through equilibrium between bone formation and resorption (Marcus et al 2008). However, the rate o ...
... Bone formation exceeds bone resorption from birth until the age of approximately 20 years. At the end of this period, peak bone mass is achieved and between the ages of 20 and 40 is roughly maintained through equilibrium between bone formation and resorption (Marcus et al 2008). However, the rate o ...
EU Core Safety Profile
... severe and/or acute cases have included hallucination, syncope, seizure, coma, respiratory arrest, and death. Withdrawal symptoms seen on discontinuation of sertraline treatment Withdrawal symptoms when treatment is discontinued are common, particularly if discontinuation is abrupt (see section 4.8) ...
... severe and/or acute cases have included hallucination, syncope, seizure, coma, respiratory arrest, and death. Withdrawal symptoms seen on discontinuation of sertraline treatment Withdrawal symptoms when treatment is discontinued are common, particularly if discontinuation is abrupt (see section 4.8) ...
CAIX: A Potential Target for Cancer Therapy
... understanding of the mechanism of CAIX inhibitors in combination with standard treatment options. An alternative novel therapeutic target involved in multiple intracellular pathways may therefore be sAC (Chapter 7). The use of sAC inhibition in cancer is however still relatively new, since only limi ...
... understanding of the mechanism of CAIX inhibitors in combination with standard treatment options. An alternative novel therapeutic target involved in multiple intracellular pathways may therefore be sAC (Chapter 7). The use of sAC inhibition in cancer is however still relatively new, since only limi ...
5 Genetic Analysis of Kidney Disease in Mice
... genes in these small regions were tested using two expression databases to determine if the genes were expressed in the tissues relevant to the phenotype. Those genes meeting this criterion were then examined for coding sequence differences using first a database and then actual sequencing. These ge ...
... genes in these small regions were tested using two expression databases to determine if the genes were expressed in the tissues relevant to the phenotype. Those genes meeting this criterion were then examined for coding sequence differences using first a database and then actual sequencing. These ge ...
Studies of a benzoporphyrin derivative with Pluronics and D. Dolphin
... pKa value did not change with time of analysis. For the example presented in Fig. 4, the measured pKa was 6.4. For solutions without Pluronic, 2 exhibits only one peak around 718 nm, which decreases with time at lower pH. To estimate these pKas, absorbance as a function of pH was used. Measurements ...
... pKa value did not change with time of analysis. For the example presented in Fig. 4, the measured pKa was 6.4. For solutions without Pluronic, 2 exhibits only one peak around 718 nm, which decreases with time at lower pH. To estimate these pKas, absorbance as a function of pH was used. Measurements ...
CNS Drug Design: Balancing Physicochemical
... should have no in vivo efficacy.27 To explain this phenomenon, several hypotheses, such as glucuronide 2 activation of a new and not yet discovered receptor subtype, have been proposed.24 However, this apparent paradox could also be explained by considering the unbound (free) rather than total drug co ...
... should have no in vivo efficacy.27 To explain this phenomenon, several hypotheses, such as glucuronide 2 activation of a new and not yet discovered receptor subtype, have been proposed.24 However, this apparent paradox could also be explained by considering the unbound (free) rather than total drug co ...
Is the Role of the Small Intestine in First
... normal volunteers (Melander et al., 1977b). However, the blood flow change is not the sole cause responsible for the increased bioavailability after a meal. For example, it is difficult to explain how a standardized breakfast could increase the bioavailability of hydralazine 2to 3-fold (Melander et ...
... normal volunteers (Melander et al., 1977b). However, the blood flow change is not the sole cause responsible for the increased bioavailability after a meal. For example, it is difficult to explain how a standardized breakfast could increase the bioavailability of hydralazine 2to 3-fold (Melander et ...
Is the Role of the Small Intestine in First
... normal volunteers (Melander et al., 1977b). However, the blood flow change is not the sole cause responsible for the increased bioavailability after a meal. For example, it is difficult to explain how a standardized breakfast could increase the bioavailability of hydralazine 2to 3-fold (Melander et ...
... normal volunteers (Melander et al., 1977b). However, the blood flow change is not the sole cause responsible for the increased bioavailability after a meal. For example, it is difficult to explain how a standardized breakfast could increase the bioavailability of hydralazine 2to 3-fold (Melander et ...
Outline - leader
... 2. How do the characteristics of the study population compare to those who are frail? By virtue of the strong association between multimorbidity and frailty, frail older adults are almost always excluded from large-scale clinical trials, which generates uncertainty about the applicability of trial ...
... 2. How do the characteristics of the study population compare to those who are frail? By virtue of the strong association between multimorbidity and frailty, frail older adults are almost always excluded from large-scale clinical trials, which generates uncertainty about the applicability of trial ...
Use of Pharmacokinetics and Pharmacodynamics to Optimize
... to attain the PD target value for a successful clinical outcome. A high-dose regimen of each of these drugs has been approved for severe infections. The high-dose ciprofloxacin regimen increases the frequency of dosing (400 mg iv t.i.d., compared with the traditional regimen of 400 mg iv b.i.d.), w ...
... to attain the PD target value for a successful clinical outcome. A high-dose regimen of each of these drugs has been approved for severe infections. The high-dose ciprofloxacin regimen increases the frequency of dosing (400 mg iv t.i.d., compared with the traditional regimen of 400 mg iv b.i.d.), w ...
complaint - AboutLawsuits.com
... duty to monitor amiodarone after it was approved for marketing. Specifically, Defendants have a continuing duty of pharmacovigilance. Among these requirements, Defendants must seek information relating to negative health effects in patients while on amiodarone and maintain, investigate, evaluate, an ...
... duty to monitor amiodarone after it was approved for marketing. Specifically, Defendants have a continuing duty of pharmacovigilance. Among these requirements, Defendants must seek information relating to negative health effects in patients while on amiodarone and maintain, investigate, evaluate, an ...