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... systemic therapy is usually ineffective in controlling the effusion, efforts have been made to manage the effusion locally. The most common method used to control the pleural effusion has been the injection of various agents into the pleural space in an attempt to effect fusion of the visceral and p ...
Lupaneta Pack
Lupaneta Pack

... because of the physiologic effect of the drug. Therefore, an increase in symptoms associated with endometriosis may be observed during the initial days of therapy, but these should dissipate with continued therapy. 5.8 Fluid Retention Because norethindrone acetate may cause some degree of fluid rete ...
AusPAR: Dapagliflozin - Therapeutic Goods Administration
AusPAR: Dapagliflozin - Therapeutic Goods Administration

... metformin on UGT1A9 activity or expression. However, compared with monotherapy, there was no effect on the exposure of metformin or dapagliflozin when provided in combination to rats. Furthermore, it is stated in the PI document for dapagliflozin that, in human subjects, co-administration of dapagli ...
Prescribing Information
Prescribing Information

... test to tell if your child’s diaper rash also has a yeast infection. Do not use VUSION Ointment on your child’s diaper rash unless your healthcare provider tells you that there is also a yeast infection. Do not use VUSION Ointment on any other children. Do not use VUSION Ointment on your child’s dia ...
PrCIPRO® XL - Bayer Canada
PrCIPRO® XL - Bayer Canada

... fluoroquinolone-associated tendinitis and tendon rupture is further increased in older patients usually over 60 years of age, in patients taking corticosteroid drugs, and in patients with kidney, heart, or lung transplants. Factors, in addition to age and corticosteroid use, that may independently i ...
Extended-Release Tablets, USP (SR)
Extended-Release Tablets, USP (SR)

... tablets (SR). Patients should be advised of the importance of participating in the behavioral interventions, counseling, and/or support services to be used in conjunction with bupropion hydrochloride extendedrelease tablets (SR) [see Medication Guide]. Patients who fail to quit smoking during an att ...
Towards efficient breeding
Towards efficient breeding

... • It generated extra gain by taking advantage of the time before the candidates reach their sexual maturity ...
Fortaz - GlaxoSmithKline
Fortaz - GlaxoSmithKline

... FORTAZ® is administered to a nursing mother. ...
Extended-Release Tablets, USP (SR)
Extended-Release Tablets, USP (SR)

... The pooled analyses of placebo-controlled trials in children and adolescents with MDD, obsessive compulsive disorder (OCD), or other psychiatric disorders included a total of 24 short-term trials of 9 antidepressant drugs in over 4,400 subjects. The pooled analyses of placebo-controlled trials in ad ...
Is ecstasy MDMA? - Department of Psychology
Is ecstasy MDMA? - Department of Psychology

... ually increased, so that by the early 1980s the proportion of MDMA samples exceeded those of MDA (Fig. 3 in Renfroe 1986). Shulgin and Nichols (1978) were the first to describe the human psychopharmacology of MDMA, a compound with an: “Occasional and erratic appearance in the illicit Street drug mar ...
Médecins sans Frontières application - WHO archives
Médecins sans Frontières application - WHO archives

... In 1996, a WHO Expert Committee concluded that Azithromycin 20mg/kg was as effective as 67 weeks of topical tetracycline eye ointment, and that it was well tolerated with good patient compliance. The only problem was its high cost, and the committee urged the manufacturer to “consider all possible m ...
Breining Institute
Breining Institute

... its controlled substance status, the chemicals to produce methamphetamine became difficult to obtain, and so different chemists learned how to alter the traditional recipe by using other street products. Further limitations of amphetamine type stimulants occurred by the passage of the Federal Domest ...
Actinomycosis: etiology, clinical features, diagnosis, treatment, and management Infection and Drug Resistance Dove
Actinomycosis: etiology, clinical features, diagnosis, treatment, and management Infection and Drug Resistance Dove

... disease such as emphysema, chronic bronchitis, and bronchiectasis, and patients with pulmonary sequelae following tuberculosis, are considered to also be at risk for pulmonary actinomycosis.30 The mechanism of immune response in actinomycosis remains unclear, but some factors, by altering this respo ...
Elicited hippocampal theta rhythm: a screen for anxiolytic and
Elicited hippocampal theta rhythm: a screen for anxiolytic and

... and will argue that their action on the ascending systems that elicit and control theta makes a significant contribution to their behavioural and clinical profile. From this, we suggest that reticular-elicited theta can be used to detect both anxiolytic and, perhaps also, procognitive drugs. The hip ...
Exelon WS-119-121-G PI highlighted EN
Exelon WS-119-121-G PI highlighted EN

... discontinued. Discontinuation should also be considered when evidence of a therapeutic effect is no longer present. Individual response to rivastigmine cannot be predicted. However, a greater treatment effect was seen in Parkinson’s disease patients with moderate dementia. Similarly a larger effect ...
Recent changes in Europe`s MDMA/ecstasy market
Recent changes in Europe`s MDMA/ecstasy market

... alerts on both high-dose MDMA tablets and adulterated tablets, and evidence of low but potentially rising numbers of MDMA-related hospital admissions, and even deaths in some countries. ...
NUX VOMICA
NUX VOMICA

... method, It is an excellent but imperfect pharmaceutical preparation, its process being too tedious to permit of profitable manipulation on a small scale. Owing to the fact that the element of time plays such an important part in the exhaustion of the drug, and the process demands such an amount of a ...
Dyslipidemia update by Dr Sarma
Dyslipidemia update by Dr Sarma

...  Headache, Myalgia, Fatigue, GI intol. Flu-like symptoms  Increase in liver enzymes – serious problems are very rare  Occurs in 0.5 to 2.5% of cases in dose-dependent manner  Myopathy occurs in 0.2 to 0.4% of patients ...
Prescribing Info - American Regent
Prescribing Info - American Regent

... The physical and chemical compatibility of acetylcysteine solutions with certain other drugs that might be concomitantly administered by nebulization, direct instillation, or topical application has been studied. Acetylcysteine should not be mixed with certain antibiotics. For example, the antibioti ...
ADHD  Parents Medication Guide Prepared by:
ADHD Parents Medication Guide Prepared by:

... well as children with a family history of tics should not be treated with a stimulant medication. However, in randomized controlled trials, tics did not appear to worsen at any greater rate on stimulants than on placebo or clonidine (a non-stimulant medication that is often prescribed to treat tics ...
LUPANETA PACK
LUPANETA PACK

... because of the physiologic effect of the drug. Therefore, an increase in symptoms associated with endometriosis may be observed during the initial days of therapy, but these should dissipate with continued therapy. 5.8 Fluid Retention Because norethindrone acetate may cause some degree of fluid rete ...
Everolimus Novartis tablet ENG SmPC
Everolimus Novartis tablet ENG SmPC

... Patients receiving Everolimus Novartis may require dose adjustments based on blood concentrations achieved, tolerability, individual response, change in co-medications and the clinical situation. Dose adjustments can be made at 4-5 day intervals (see Therapeutic drug monitoring). Special population ...
BOTULINUM TOXINS A AND B
BOTULINUM TOXINS A AND B

... Botulinum toxin type A and B are cosmetic when used to improve appearance, or in the absence of physiological functional impairment that would be improved by their use. Most UnitedHealthcare Certificates of Coverage (COCs) and Summary Plan Descriptions (SPDs) exclude benefit coverage for cosmetic se ...
Sedation Analgesia
Sedation Analgesia

... co-morbid conditions, in diverse settings produces a series of questions regarding safety and effectiveness. The administration of sedation and analgesia for diagnostic and therapeutic procedures has therefore evolved into a unique discipline that is practiced by clinicians with varying skills and t ...
Emerging Drug Trends- Salvia Divinorum
Emerging Drug Trends- Salvia Divinorum

... slurred speech, chills, nausea, decreased heart rate, and a lack of coordination. Though the Mazatecs have been using Salvia for centuries, the long-term effects of the herb remain unknown and have not been fully investigated. ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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